MIC26_HUMAN
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MIC26_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 34.6667 | 4 | no |
GO:0015399 | primary active transmembrane transporter activity | 30.6667 | 4 | no |
GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 30.6667 | 5 | no |
GO:0003954 | NADH dehydrogenase activity | 22.6667 | 4 | no |
GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 21.3333 | 5 | no |
GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 21.3333 | 4 | no |
GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 21.3333 | 4 | no |
GO:0050136 | NADH dehydrogenase (quinone) activity | 21.3333 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MIC26_HUMAN |
---|---|---|---|---|
GO:0022607 | cellular component assembly | 37.3333 | 4 | no |
GO:0015980 | energy derivation by oxidation of organic compounds | 34.6667 | 4 | no |
GO:0045333 | cellular respiration | 34.6667 | 5 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | yes |
GO:0009060 | aerobic respiration | 33.3333 | 6 | no |
GO:0022900 | electron transport chain | 33.3333 | 4 | no |
GO:0022904 | respiratory electron transport chain | 33.3333 | 5 | no |
GO:0019646 | aerobic electron transport chain | 32.0000 | 6 | no |
GO:0043933 | protein-containing complex organization | 30.6667 | 4 | no |
GO:0065003 | protein-containing complex assembly | 30.6667 | 5 | no |
GO:0007005 | mitochondrion organization | 28.0000 | 5 | yes |
GO:0033108 | mitochondrial respiratory chain complex assembly | 24.0000 | 6 | no |
GO:0061024 | membrane organization | 22.6667 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 22.6667 | 4 | no |
GO:0048522 | positive regulation of cellular process | 21.3333 | 4 | no |
GO:0010257 | NADH dehydrogenase complex assembly | 21.3333 | 6 | no |
GO:0032981 | mitochondrial respiratory chain complex I assembly | 21.3333 | 7 | no |
GO:0071702 | organic substance transport | 20.0000 | 4 | yes |
GO:0007006 | mitochondrial membrane organization | 18.6667 | 5 | yes |
GO:0007007 | inner mitochondrial membrane organization | 17.3333 | 6 | yes |
GO:0042407 | cristae formation | 12.0000 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in MIC26_HUMAN |
---|---|---|---|---|
DOID:574 | peripheral nervous system disease | 2.6667 | 3 | no |
DOID:700 | mitochondrial metabolism disease | 2.6667 | 3 | no |
DOID:870 | neuropathy | 2.6667 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CEP85_HUMAN | [view interactions] | High throughput | no | no |
MIA40_HUMAN | [view interactions] | High throughput | no | yes |
KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLPB_HUMAN | [view interactions] | High throughput | no | yes |
COA7_HUMAN | [view interactions] | High throughput | no | yes |
COX15_HUMAN | [view interactions] | High throughput | no | yes |
COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CX7A2_HUMAN | [view interactions] | High throughput | no | no |
HEM6_HUMAN | [view interactions] | High throughput | no | no |
CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOG_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
CCHL_HUMAN | [view interactions] | High throughput | no | yes |
HIG2A_HUMAN | [view interactions] | High throughput | no | yes |
DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
IDI1_HUMAN | [view interactions] | High throughput | no | yes |
LACTB_HUMAN | [view interactions] | High throughput | no | yes |
LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MICU1_HUMAN | [view interactions] | High throughput | no | yes |
MICU2_HUMAN | [view interactions] | High throughput | no | yes |
MMS19_HUMAN | [view interactions] | High throughput | no | yes |
MPC2_HUMAN | [view interactions] | High throughput | no | yes |
RT31_HUMAN | [view interactions] | High throughput | no | yes |
C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTX3_HUMAN | [view interactions] | High throughput | no | yes |
NCLN_HUMAN | [view interactions] | High throughput | no | yes |
NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CIA30_HUMAN | [view interactions] | High throughput | no | yes |
NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OXA1L_HUMAN | [view interactions] | High throughput | no | yes |
PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTBP3_HUMAN | [view interactions] | High throughput | no | no |
PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCO1_HUMAN | [view interactions] | High throughput | no | yes |
SFXN4_HUMAN | [view interactions] | High throughput | no | yes |
CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CMC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCMC1_HUMAN | [view interactions] | High throughput | no | no |
SCMC2_HUMAN | [view interactions] | High throughput | no | yes |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNT9_HUMAN | [view interactions] | High throughput | no | yes |
SIM12_HUMAN | [view interactions] | High throughput | no | yes |
SNP29_HUMAN | [view interactions] | High throughput | no | yes |
SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUN1_HUMAN | [view interactions] | High throughput | no | yes |
TIM13_HUMAN | [view interactions] | High throughput | no | yes |
TI17B_HUMAN | [view interactions] | High throughput | no | no |
TIM29_HUMAN | [view interactions] | High throughput | no | no |
TIM44_HUMAN | [view interactions] | High throughput | no | yes |
TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
T126B_HUMAN | [view interactions] | High throughput | no | yes |
TM242_HUMAN | [view interactions] | High throughput | no | yes |
TOM70_HUMAN | [view interactions] | High throughput | no | yes |
TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
UQCC3_HUMAN | [view interactions] | High throughput | no | yes |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC13_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
OMA1_HUMAN | [view interactions] | High throughput | no | no |
PARL_HUMAN | [view interactions] | High throughput | no | yes |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
SPG21_HUMAN | [view interactions] | High throughput | no | yes |
CENPM_HUMAN | [view interactions] | High throughput | no | yes |
PARI_HUMAN | [view interactions] | High throughput | no | yes |
GSX1_HUMAN | [view interactions] | High throughput | no | no |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADCK2_HUMAN | [view interactions] | High throughput | no | yes |
AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASSY_HUMAN | [view interactions] | High throughput | no | yes |
ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
ATN1_HUMAN | [view interactions] | High throughput | no | yes |
BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
BWNIN_HUMAN | [view interactions] | High throughput | no | yes |
MTX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TOM40_HUMAN | [view interactions] | Computational | no | yes |
CHC10_HUMAN | [view interactions] | Computational | no | yes |
NDUB5_HUMAN | [view interactions] | Computational | no | yes |
TOM5_HUMAN | [view interactions] | Computational | no | yes |
NDUAC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
APOA1_HUMAN | [view interactions] | Computational | no | no |
NDUB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MIC10_HUMAN | [view interactions] | Computational | no | yes |
ATPD_HUMAN | [view interactions] | Computational | no | yes |
QCR7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |