MIC26_HUMAN
Evidence for PS localization
Functions
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MIC26_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 36.6197 | 4 | no |
| GO:0046872 | metal ion binding | 36.6197 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 33.8028 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 33.8028 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 33.8028 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 32.3944 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 28.1690 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 28.1690 | 5 | no |
| GO:0000166 | nucleotide binding | 21.1268 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MIC26_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 35.2113 | 4 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 35.2113 | 4 | no |
| GO:0045333 | cellular respiration | 35.2113 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 35.2113 | 4 | no |
| GO:0006996 | organelle organization | 33.8028 | 4 | yes |
| GO:0009060 | aerobic respiration | 33.8028 | 6 | no |
| GO:0019646 | aerobic electron transport chain | 32.3944 | 6 | no |
| GO:0022900 | electron transport chain | 32.3944 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 32.3944 | 5 | no |
| GO:0006163 | purine nucleotide metabolic process | 32.3944 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 32.3944 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 32.3944 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 32.3944 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 32.3944 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 30.9859 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 30.9859 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 30.9859 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.9859 | 4 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 30.9859 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 29.5775 | 5 | no |
| GO:0007005 | mitochondrion organization | 28.1690 | 5 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 28.1690 | 4 | no |
| GO:0090407 | organophosphate biosynthetic process | 28.1690 | 4 | no |
| GO:0006164 | purine nucleotide biosynthetic process | 26.7606 | 6 | no |
| GO:0009152 | purine ribonucleotide biosynthetic process | 26.7606 | 7 | no |
| GO:0009165 | nucleotide biosynthetic process | 26.7606 | 6 | no |
| GO:0009260 | ribonucleotide biosynthetic process | 26.7606 | 6 | no |
| GO:0046390 | ribose phosphate biosynthetic process | 26.7606 | 5 | no |
| GO:0072522 | purine-containing compound biosynthetic process | 26.7606 | 5 | no |
| GO:1901137 | carbohydrate derivative biosynthetic process | 26.7606 | 4 | no |
| GO:1901293 | nucleoside phosphate biosynthetic process | 26.7606 | 5 | no |
| GO:0061024 | membrane organization | 22.5352 | 4 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 22.5352 | 5 | no |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 22.5352 | 6 | no |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 22.5352 | 6 | no |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 22.5352 | 7 | no |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 22.5352 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.1268 | 4 | no |
| GO:0006754 | ATP biosynthetic process | 21.1268 | 8 | no |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 21.1268 | 6 | no |
| GO:0009145 | purine nucleoside triphosphate biosynthetic process | 21.1268 | 7 | no |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 21.1268 | 7 | no |
| GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 21.1268 | 8 | no |
| GO:0046034 | ATP metabolic process | 21.1268 | 7 | no |
| GO:0007006 | mitochondrial membrane organization | 19.7183 | 5 | yes |
| GO:0071702 | organic substance transport | 19.7183 | 4 | yes |
| GO:0007007 | inner mitochondrial membrane organization | 18.3099 | 6 | yes |
| GO:0042407 | cristae formation | 14.0845 | 7 | yes |
| GO:0006869 | lipid transport | 2.8169 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC13_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| PARI_HUMAN | [view interactions] | High throughput | no | yes |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK2_HUMAN | [view interactions] | High throughput | no | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC6_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX7A2_HUMAN | [view interactions] | High throughput | no | no |
| HEM6_HUMAN | [view interactions] | High throughput | no | no |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOG_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| HIG2A_HUMAN | [view interactions] | High throughput | no | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| IDI1_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| MICU2_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| NCLN_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIA30_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXA1L_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN4_HUMAN | [view interactions] | High throughput | no | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2513_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| SCMC2_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT9_HUMAN | [view interactions] | High throughput | no | yes |
| SIM12_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| TI17B_HUMAN | [view interactions] | High throughput | no | no |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T126B_HUMAN | [view interactions] | High throughput | no | yes |
| TM242_HUMAN | [view interactions] | High throughput | no | yes |
| TOM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC3_HUMAN | [view interactions] | High throughput | no | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |