Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MIC26_HUMAN

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MIC26_HUMAN
GO:0046872 metal ion binding 34.6667 4 no
GO:0015399 primary active transmembrane transporter activity 30.6667 4 no
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 30.6667 5 no
GO:0003954 NADH dehydrogenase activity 22.6667 4 no
GO:0003955 NAD(P)H dehydrogenase (quinone) activity 21.3333 5 no
GO:0008137 NADH dehydrogenase (ubiquinone) activity 21.3333 4 no
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 21.3333 4 no
GO:0050136 NADH dehydrogenase (quinone) activity 21.3333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in MIC26_HUMAN
GO:0022607 cellular component assembly 37.3333 4 no
GO:0015980 energy derivation by oxidation of organic compounds 34.6667 4 no
GO:0045333 cellular respiration 34.6667 5 no
GO:0006996 organelle organization 33.3333 4 yes
GO:0009060 aerobic respiration 33.3333 6 no
GO:0022900 electron transport chain 33.3333 4 no
GO:0022904 respiratory electron transport chain 33.3333 5 no
GO:0019646 aerobic electron transport chain 32.0000 6 no
GO:0043933 protein-containing complex organization 30.6667 4 no
GO:0065003 protein-containing complex assembly 30.6667 5 no
GO:0007005 mitochondrion organization 28.0000 5 yes
GO:0033108 mitochondrial respiratory chain complex assembly 24.0000 6 no
GO:0061024 membrane organization 22.6667 4 yes
GO:0031323 regulation of cellular metabolic process 22.6667 4 no
GO:0048522 positive regulation of cellular process 21.3333 4 no
GO:0010257 NADH dehydrogenase complex assembly 21.3333 6 no
GO:0032981 mitochondrial respiratory chain complex I assembly 21.3333 7 no
GO:0071702 organic substance transport 20.0000 4 yes
GO:0007006 mitochondrial membrane organization 18.6667 5 yes
GO:0007007 inner mitochondrial membrane organization 17.3333 6 yes
GO:0042407 cristae formation 12.0000 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in MIC26_HUMAN
DOID:574 peripheral nervous system disease 2.6667 3 no
DOID:700 mitochondrial metabolism disease 2.6667 3 no
DOID:870 neuropathy 2.6667 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CEP85_HUMAN [view interactions] High throughput no no
MIA40_HUMAN [view interactions] High throughput no yes
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
CLPB_HUMAN [view interactions] High throughput no yes
COA7_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
CX7A2_HUMAN [view interactions] High throughput no no
HEM6_HUMAN [view interactions] High throughput no no
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
ECSIT_HUMAN [view interactions] High throughput no yes
NUCG_HUMAN [view entry] [view interactions] High throughput yes yes
EXOG_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
CCHL_HUMAN [view interactions] High throughput no yes
HIG2A_HUMAN [view interactions] High throughput no yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
HYOU1_HUMAN [view interactions] High throughput no yes
IDI1_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
LRC40_HUMAN [view entry] [view interactions] High throughput yes yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
MICU1_HUMAN [view interactions] High throughput no yes
MICU2_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
MPC2_HUMAN [view interactions] High throughput no yes
RT31_HUMAN [view interactions] High throughput no yes
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
MTX3_HUMAN [view interactions] High throughput no yes
NCLN_HUMAN [view interactions] High throughput no yes
NDUAD_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
CIA30_HUMAN [view interactions] High throughput no yes
NDUF3_HUMAN [view interactions] High throughput no yes
NDUF4_HUMAN [view interactions] High throughput no yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB9_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS8_HUMAN [view interactions] High throughput no yes
NSDHL_HUMAN [view interactions] High throughput no yes
NUBP2_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
OCAD2_HUMAN [view interactions] High throughput no yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
OXA1L_HUMAN [view interactions] High throughput no yes
PDIA4_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP3_HUMAN [view interactions] High throughput no no
PTCD3_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN4_HUMAN [view interactions] High throughput no yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
CMC2_HUMAN [view entry] [view interactions] High throughput yes yes
SCMC1_HUMAN [view interactions] High throughput no no
SCMC2_HUMAN [view interactions] High throughput no yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT9_HUMAN [view interactions] High throughput no yes
SIM12_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
SUN1_HUMAN [view interactions] High throughput no yes
TIM13_HUMAN [view interactions] High throughput no yes
TI17B_HUMAN [view interactions] High throughput no no
TIM29_HUMAN [view interactions] High throughput no no
TIM44_HUMAN [view interactions] High throughput no yes
TIM8A_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
T126A_HUMAN [view entry] [view interactions] High throughput yes yes
T126B_HUMAN [view interactions] High throughput no yes
TM242_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
UQCC3_HUMAN [view interactions] High throughput no yes
SYYM_HUMAN [view interactions] High throughput no no
YMEL1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TIDC1_HUMAN [view interactions] High throughput no yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
MIC13_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
HSPB2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
EMC2_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
SPG21_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
PARI_HUMAN [view interactions] High throughput no yes
GSX1_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
SDHB_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
ABCBA_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
ADCK2_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
ASSY_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3B_HUMAN [view interactions] High throughput no yes
ATN1_HUMAN [view interactions] High throughput no yes
BIRC2_HUMAN [view interactions] High throughput no yes
BMP2K_HUMAN [view interactions] High throughput no yes
BWNIN_HUMAN [view interactions] High throughput no yes
MTX1_HUMAN [view entry] [view interactions] Computational yes yes
TOM40_HUMAN [view interactions] Computational no yes
CHC10_HUMAN [view interactions] Computational no yes
NDUB5_HUMAN [view interactions] Computational no yes
TOM5_HUMAN [view interactions] Computational no yes
NDUAC_HUMAN [view entry] [view interactions] Computational yes yes
APOA1_HUMAN [view interactions] Computational no no
NDUB6_HUMAN [view entry] [view interactions] Computational yes yes
MIC10_HUMAN [view interactions] Computational no yes
ATPD_HUMAN [view interactions] Computational no yes
QCR7_HUMAN [view entry] [view interactions] Computational yes yes