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NDUAD_HUMAN

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NDUAD_HUMAN
GO:0015399 primary active transmembrane transporter activity 53.4483 4 yes
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 50.0000 5 yes
GO:0003954 NADH dehydrogenase activity 41.3793 4 yes
GO:0003955 NAD(P)H dehydrogenase (quinone) activity 39.6552 5 yes
GO:0008137 NADH dehydrogenase (ubiquinone) activity 39.6552 4 yes
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 39.6552 4 yes
GO:0050136 NADH dehydrogenase (quinone) activity 39.6552 5 yes
GO:0046872 metal ion binding 29.3103 4 no
GO:0017076 purine nucleotide binding 13.7931 4 yes
GO:0032555 purine ribonucleotide binding 13.7931 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 13.7931 4 yes
GO:0005524 ATP binding 10.3448 5 yes
GO:0030554 adenyl nucleotide binding 10.3448 5 yes
GO:0032559 adenyl ribonucleotide binding 10.3448 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NDUAD_HUMAN
GO:0009060 aerobic respiration 51.7241 6 no
GO:0015980 energy derivation by oxidation of organic compounds 51.7241 4 no
GO:0022900 electron transport chain 51.7241 4 no
GO:0022904 respiratory electron transport chain 51.7241 5 no
GO:0045333 cellular respiration 51.7241 5 no
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0019646 aerobic electron transport chain 48.2759 6 no
GO:0043933 protein-containing complex organization 44.8276 4 yes
GO:0065003 protein-containing complex assembly 41.3793 5 yes
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 36.2069 7 no
GO:0033108 mitochondrial respiratory chain complex assembly 34.4828 6 yes
GO:0010257 NADH dehydrogenase complex assembly 32.7586 6 yes
GO:0032981 mitochondrial respiratory chain complex I assembly 32.7586 7 yes
GO:0006996 organelle organization 25.8621 4 yes
GO:0031323 regulation of cellular metabolic process 25.8621 4 yes
GO:0071702 organic substance transport 25.8621 4 yes
GO:0048522 positive regulation of cellular process 24.1379 4 no
GO:0048523 negative regulation of cellular process 24.1379 4 yes
GO:0009893 positive regulation of metabolic process 22.4138 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 22.4138 4 yes
GO:0071705 nitrogen compound transport 22.4138 4 yes
GO:0080090 regulation of primary metabolic process 22.4138 4 yes
GO:0010646 regulation of cell communication 20.6897 4 yes
GO:0060255 regulation of macromolecule metabolic process 20.6897 4 yes
GO:0009966 regulation of signal transduction 18.9655 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 18.9655 5 yes
GO:0008104 protein localization 17.2414 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 17.2414 5 yes
GO:0010941 regulation of cell death 17.2414 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 17.2414 5 yes
GO:0042981 regulation of apoptotic process 17.2414 6 yes
GO:0043067 regulation of programmed cell death 17.2414 5 yes
GO:0051128 regulation of cellular component organization 17.2414 4 yes
GO:0051246 regulation of protein metabolic process 17.2414 5 yes
GO:0009889 regulation of biosynthetic process 15.5172 4 yes
GO:0009894 regulation of catabolic process 15.5172 4 yes
GO:0031326 regulation of cellular biosynthetic process 15.5172 5 yes
GO:0043085 positive regulation of catalytic activity 15.5172 4 yes
GO:0009968 negative regulation of signal transduction 13.7931 5 yes
GO:0010468 regulation of gene expression 13.7931 5 yes
GO:0010648 negative regulation of cell communication 13.7931 5 yes
GO:0015031 protein transport 13.7931 4 yes
GO:0023057 negative regulation of signaling 13.7931 4 yes
GO:0043066 negative regulation of apoptotic process 13.7931 7 yes
GO:0043069 negative regulation of programmed cell death 13.7931 6 yes
GO:0048585 negative regulation of response to stimulus 13.7931 4 yes
GO:0051247 positive regulation of protein metabolic process 13.7931 6 yes
GO:0051336 regulation of hydrolase activity 13.7931 4 yes
GO:0060548 negative regulation of cell death 13.7931 5 yes
GO:1902531 regulation of intracellular signal transduction 12.0690 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 12.0690 5 yes
GO:0010950 positive regulation of endopeptidase activity 12.0690 7 yes
GO:0010952 positive regulation of peptidase activity 12.0690 6 yes
GO:0030162 regulation of proteolysis 12.0690 6 yes
GO:0045862 positive regulation of proteolysis 12.0690 7 yes
GO:0051345 positive regulation of hydrolase activity 12.0690 5 yes
GO:0052547 regulation of peptidase activity 12.0690 5 yes
GO:0052548 regulation of endopeptidase activity 12.0690 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 10.3448 7 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 10.3448 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 10.3448 8 yes
GO:2001141 regulation of RNA biosynthetic process 10.3448 6 yes
GO:0006355 regulation of DNA-templated transcription 10.3448 6 yes
GO:0006886 intracellular protein transport 10.3448 4 yes
GO:0007005 mitochondrion organization 10.3448 5 yes
GO:0009892 negative regulation of metabolic process 10.3448 4 yes
GO:0031324 negative regulation of cellular metabolic process 10.3448 5 yes
GO:0033365 protein localization to organelle 10.3448 5 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 10.3448 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 10.3448 8 yes
GO:0051252 regulation of RNA metabolic process 10.3448 5 yes
GO:0061024 membrane organization 10.3448 4 yes
GO:0071310 cellular response to organic substance 10.3448 4 yes
GO:1901701 cellular response to oxygen-containing compound 8.6207 4 yes
GO:0009890 negative regulation of biosynthetic process 8.6207 5 yes
GO:0033993 response to lipid 8.6207 4 yes
GO:1902532 negative regulation of intracellular signal transduction 6.8966 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 6.8966 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 6.8966 8 yes
GO:2001233 regulation of apoptotic signaling pathway 6.8966 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 6.8966 6 yes
GO:0001558 regulation of cell growth 6.8966 4 yes
GO:0006839 mitochondrial transport 6.8966 4 yes
GO:0007006 mitochondrial membrane organization 6.8966 5 yes
GO:0009896 positive regulation of catabolic process 6.8966 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 6.8966 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 6.8966 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 6.8966 6 yes
GO:0045892 negative regulation of DNA-templated transcription 6.8966 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6.8966 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 6.8966 5 yes
GO:0051253 negative regulation of RNA metabolic process 6.8966 6 yes
GO:0072594 establishment of protein localization to organelle 6.8966 4 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 5.1724 6 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 5.1724 7 yes
GO:0007007 inner mitochondrial membrane organization 5.1724 6 yes
GO:0034097 response to cytokine 5.1724 4 yes
GO:0042176 regulation of protein catabolic process 5.1724 5 yes
GO:0070585 protein localization to mitochondrion 5.1724 6 yes
GO:0071396 cellular response to lipid 5.1724 5 yes
GO:0072655 establishment of protein localization to mitochondrion 5.1724 5 yes
GO:0030308 negative regulation of cell growth 3.4483 5 yes
GO:0045732 positive regulation of protein catabolic process 3.4483 6 yes
GO:0045926 negative regulation of growth 3.4483 4 yes
GO:0071345 cellular response to cytokine stimulus 3.4483 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NU4M_HUMAN [view interactions] Low throughput no yes
NDUA7_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUA3_HUMAN [view interactions] Low throughput no yes
NDUS6_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB5_HUMAN [view interactions] Low throughput no yes
NDUS8_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUA6_HUMAN [view interactions] Low throughput no no
NDUA2_HUMAN [view entry] [view interactions] Low throughput yes yes
ACPM_HUMAN [view interactions] Low throughput no yes
UBE3A_HUMAN [view interactions] Low throughput no yes
NDUV3_HUMAN [view interactions] Low throughput no yes
NDUBB_HUMAN [view interactions] Low throughput no yes
NDUA1_HUMAN [view interactions] Low throughput no yes
NDUBA_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB9_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB1_HUMAN [view interactions] Low throughput no yes
NU1M_HUMAN [view interactions] Low throughput no yes
NDUB6_HUMAN [view entry] [view interactions] Low throughput yes yes
NU6M_HUMAN [view interactions] Low throughput no no
NDUB8_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB2_HUMAN [view interactions] Low throughput no yes
NU4LM_HUMAN [view interactions] Low throughput no no
NU2M_HUMAN [view entry] [view interactions] Low throughput yes no
NDUB4_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUAB_HUMAN [view interactions] Low throughput no no
NDUC1_HUMAN [view interactions] Low throughput no yes
NDUB7_HUMAN [view entry] [view interactions] Low throughput yes yes
NU3M_HUMAN [view interactions] Low throughput no yes
NU5M_HUMAN [view interactions] Low throughput no no
NDUAA_HUMAN [view entry] [view interactions] Low throughput yes yes
HTRA2_HUMAN [view interactions] Low throughput no yes
NOD2_HUMAN [view interactions] Low throughput no yes
NDUAC_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUS4_HUMAN [view interactions] Low throughput no yes
NDUS5_HUMAN [view interactions] Low throughput no yes
NDUB3_HUMAN [view interactions] Low throughput no yes
NDUA9_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] Low throughput yes no
NDUC2_HUMAN [view interactions] Low throughput no yes
NDUV1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] Low throughput yes no
NDUS2_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUV2_HUMAN [view entry] [view interactions] Low throughput yes yes
CYTN_HUMAN [view interactions] High throughput no no
NMES1_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
OPA3_HUMAN [view interactions] High throughput no yes
CHC10_HUMAN [view interactions] High throughput no yes
COQ9_HUMAN [view interactions] High throughput no yes
CLN6_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ESR1_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TR61B_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
PARL_HUMAN [view interactions] High throughput no yes
EXOS6_HUMAN [view interactions] High throughput no no
DNLI4_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ICT1_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
RTEL1_HUMAN [view interactions] High throughput no no
DUS1_HUMAN [view interactions] High throughput no no
MTMRC_HUMAN [view interactions] High throughput no yes
UQCC1_HUMAN [view interactions] High throughput no yes
ACADV_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
AAR2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
ERCC8_HUMAN [view interactions] High throughput no no
HBAZ_HUMAN [view interactions] High throughput no no
ASC_HUMAN [view interactions] High throughput no no
CLPB_HUMAN [view interactions] High throughput no yes
KCNK1_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
DJC30_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
SPRTN_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
BLM_HUMAN [view interactions] High throughput no yes
DIC_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
MRM1_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CC90B_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET17_HUMAN [view interactions] High throughput no yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
XRN1_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
NDUF4_HUMAN [view interactions] High throughput no yes
S22AK_HUMAN [view interactions] High throughput no no
S22AC_HUMAN [view interactions] High throughput no no
ATP5J_HUMAN [view interactions] High throughput no yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
TIM23_HUMAN [view interactions] High throughput no yes
NDUF3_HUMAN [view interactions] High throughput no yes
TRXR2_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
YMEL1_HUMAN [view interactions] High throughput no yes
T126B_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
ECSIT_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
CIA30_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
KLH21_HUMAN [view interactions] High throughput no no
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
ERC6L_HUMAN [view interactions] High throughput no yes
NICA_HUMAN [view interactions] High throughput no yes
LMBL3_HUMAN [view interactions] High throughput no yes
TAPT1_HUMAN [view interactions] High throughput no yes
LCAP_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA2_HUMAN [view interactions] High throughput no no
GOT1B_HUMAN [view interactions] High throughput no yes
KSR2_HUMAN [view interactions] High throughput no yes
VATD_HUMAN [view entry] [view interactions] High throughput yes yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
QCR9_HUMAN [view interactions] Computational no no
QCR10_HUMAN [view interactions] Computational no no
COX7C_HUMAN [view interactions] Computational no yes
CX6A2_HUMAN [view interactions] Computational no no
CYB_HUMAN [view interactions] Computational no yes
COX1_HUMAN [view interactions] Computational no yes
OLFM4_HUMAN [view interactions] Computational no no
QCR8_HUMAN [view interactions] Computational no yes
FXRD1_HUMAN [view interactions] Computational no no
ATP5I_HUMAN [view interactions] Computational no yes
NDUCR_HUMAN [view interactions] Computational no yes
ATP5H_HUMAN [view interactions] Computational no yes
QCR2_HUMAN [view entry] [view interactions] Computational yes yes
QCR7_HUMAN [view entry] [view interactions] Computational yes yes
ATPD_HUMAN [view interactions] Computational no yes
ATPK_HUMAN [view interactions] Computational no yes
COX5A_HUMAN [view entry] [view interactions] Computational yes yes
SDHB_HUMAN [view interactions] Computational no yes
COX5B_HUMAN [view entry] [view interactions] Computational yes yes
QCR1_HUMAN [view entry] [view interactions] Computational yes yes
QCR6_HUMAN [view interactions] Computational no yes
CY1_HUMAN [view entry] [view interactions] Computational yes yes