CPT2_HUMAN
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed, PubMed). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CPT2_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 32.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 28.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 28.0000 | 6 | no |
GO:0043169 | cation binding | 24.0000 | 4 | no |
GO:0046872 | metal ion binding | 24.0000 | 5 | no |
GO:0043168 | anion binding | 24.0000 | 4 | no |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 16.0000 | 4 | yes |
GO:0008374 | O-acyltransferase activity | 8.0000 | 5 | yes |
GO:0008458 | carnitine O-octanoyltransferase activity | 8.0000 | 7 | yes |
GO:0016406 | carnitine O-acyltransferase activity | 8.0000 | 6 | yes |
GO:0016414 | O-octanoyltransferase activity | 8.0000 | 6 | yes |
GO:0016415 | octanoyltransferase activity | 8.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CPT2_HUMAN |
---|---|---|---|---|
GO:0019752 | carboxylic acid metabolic process | 44.0000 | 5 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 44.0000 | 6 | yes |
GO:0043436 | oxoacid metabolic process | 44.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
GO:0006631 | fatty acid metabolic process | 36.0000 | 4 | yes |
GO:0006635 | fatty acid beta-oxidation | 36.0000 | 6 | yes |
GO:0009062 | fatty acid catabolic process | 36.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 36.0000 | 4 | yes |
GO:0016042 | lipid catabolic process | 36.0000 | 4 | yes |
GO:0016054 | organic acid catabolic process | 36.0000 | 4 | yes |
GO:0019395 | fatty acid oxidation | 36.0000 | 5 | yes |
GO:0030258 | lipid modification | 36.0000 | 4 | yes |
GO:0034440 | lipid oxidation | 36.0000 | 5 | yes |
GO:0044242 | cellular lipid catabolic process | 36.0000 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 36.0000 | 5 | yes |
GO:0072329 | monocarboxylic acid catabolic process | 36.0000 | 6 | yes |
GO:0009966 | regulation of signal transduction | 36.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 32.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 32.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 32.0000 | 5 | no |
GO:0043067 | regulation of programmed cell death | 32.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 32.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 32.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 32.0000 | 5 | no |
GO:0008104 | protein localization | 28.0000 | 4 | no |
GO:0010648 | negative regulation of cell communication | 28.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 28.0000 | 4 | no |
GO:0051049 | regulation of transport | 28.0000 | 4 | no |
GO:0071702 | organic substance transport | 24.0000 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
GO:0010468 | regulation of gene expression | 24.0000 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 24.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 24.0000 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 24.0000 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 24.0000 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 24.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 24.0000 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 24.0000 | 6 | no |
GO:0006796 | phosphate-containing compound metabolic process | 24.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 24.0000 | 4 | no |
GO:0120161 | regulation of cold-induced thermogenesis | 16.0000 | 4 | yes |
GO:0120162 | positive regulation of cold-induced thermogenesis | 16.0000 | 5 | yes |
GO:0006577 | amino-acid betaine metabolic process | 12.0000 | 4 | yes |
GO:0001701 | in utero embryonic development | 8.0000 | 6 | yes |
GO:0006839 | mitochondrial transport | 8.0000 | 4 | yes |
GO:0009437 | carnitine metabolic process | 8.0000 | 5 | yes |
GO:0009792 | embryo development ending in birth or egg hatching | 8.0000 | 4 | yes |
GO:0015711 | organic anion transport | 8.0000 | 5 | yes |
GO:0015849 | organic acid transport | 8.0000 | 5 | yes |
GO:0043009 | chordate embryonic development | 8.0000 | 5 | yes |
GO:0046942 | carboxylic acid transport | 8.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
ICT1_HUMAN | [view interactions] | High throughput | no | yes |
APJ_HUMAN | [view interactions] | High throughput | no | yes |
ATPD_HUMAN | [view interactions] | High throughput | no | yes |
NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCL1_HUMAN | [view interactions] | High throughput | no | yes |
MRM3_HUMAN | [view interactions] | High throughput | no | yes |
MCUR1_HUMAN | [view interactions] | High throughput | no | no |
ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
EPHB6_HUMAN | [view interactions] | High throughput | no | no |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
TX101_HUMAN | [view interactions] | High throughput | no | no |
CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
OTX1_HUMAN | [view interactions] | High throughput | no | no |
FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
ARGI2_HUMAN | [view interactions] | High throughput | no | yes |
OXLD1_HUMAN | [view interactions] | High throughput | no | no |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COQ8A_HUMAN | [view interactions] | High throughput | no | no |
NDUF8_HUMAN | [view interactions] | High throughput | no | no |
TMM70_HUMAN | [view interactions] | High throughput | no | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BACD3_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
S2535_HUMAN | [view interactions] | High throughput | no | no |
ALAT2_HUMAN | [view interactions] | High throughput | no | yes |
ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
NUD13_HUMAN | [view interactions] | High throughput | no | no |
SPRE2_HUMAN | [view interactions] | High throughput | no | yes |
KBL_HUMAN | [view interactions] | High throughput | no | yes |
DIC_HUMAN | [view interactions] | High throughput | no | yes |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
GATA_HUMAN | [view interactions] | High throughput | no | yes |
AMACR_HUMAN | [view interactions] | High throughput | no | yes |
KAD4_HUMAN | [view interactions] | High throughput | no | yes |
SSH3_HUMAN | [view interactions] | High throughput | no | yes |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
QCR8_HUMAN | [view interactions] | High throughput | no | yes |
CCHL_HUMAN | [view interactions] | High throughput | no | yes |
RAB32_HUMAN | [view interactions] | High throughput | no | yes |
SQOR_HUMAN | [view interactions] | High throughput | no | yes |
ACADS_HUMAN | [view interactions] | High throughput | no | yes |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CACP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECI1_HUMAN | [view interactions] | High throughput | no | yes |
ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACD11_HUMAN | [view interactions] | High throughput | no | yes |
ACADL_HUMAN | [view interactions] | High throughput | no | no |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
ACADV_HUMAN | [view interactions] | High throughput | no | yes |
ECH1_HUMAN | [view interactions] | High throughput | no | yes |
DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SKP1_HUMAN | [view interactions] | High throughput | no | yes |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
S10AB_HUMAN | [view interactions] | High throughput | no | no |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS10_HUMAN | [view interactions] | High throughput | no | yes |
GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TF3C3_HUMAN | [view interactions] | High throughput | no | no |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | no |
COX15_HUMAN | [view interactions] | High throughput | no | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |