DECR_HUMAN
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DECR_HUMAN |
---|---|---|---|---|
GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity | 5.0000 | 5 | yes |
GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 5.0000 | 4 | yes |
GO:0050661 | NADP binding | 5.0000 | 4 | yes |
GO:0070402 | NADPH binding | 5.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DECR_HUMAN |
---|---|---|---|---|
GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 35.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
GO:0019752 | carboxylic acid metabolic process | 32.5000 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 32.5000 | 4 | yes |
GO:0022607 | cellular component assembly | 32.5000 | 4 | no |
GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
GO:0016054 | organic acid catabolic process | 27.5000 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 27.5000 | 5 | yes |
GO:0010468 | regulation of gene expression | 27.5000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
GO:0006631 | fatty acid metabolic process | 22.5000 | 4 | yes |
GO:0006635 | fatty acid beta-oxidation | 22.5000 | 6 | yes |
GO:0009062 | fatty acid catabolic process | 22.5000 | 5 | yes |
GO:0016042 | lipid catabolic process | 22.5000 | 4 | yes |
GO:0019395 | fatty acid oxidation | 22.5000 | 5 | yes |
GO:0030258 | lipid modification | 22.5000 | 4 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 22.5000 | 6 | yes |
GO:0034440 | lipid oxidation | 22.5000 | 5 | yes |
GO:0044242 | cellular lipid catabolic process | 22.5000 | 4 | yes |
GO:0072329 | monocarboxylic acid catabolic process | 22.5000 | 6 | yes |
GO:0006996 | organelle organization | 22.5000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 22.5000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 22.5000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 22.5000 | 5 | no |
GO:0051049 | regulation of transport | 22.5000 | 4 | no |
GO:0120162 | positive regulation of cold-induced thermogenesis | 12.5000 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DECR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCC1_HUMAN | [view interactions] | High throughput | no | yes |
MSH6_HUMAN | [view interactions] | High throughput | no | yes |
NOP56_HUMAN | [view interactions] | High throughput | no | yes |
CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
LCOR_HUMAN | [view interactions] | High throughput | no | yes |
JAK3_HUMAN | [view interactions] | High throughput | no | no |
BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
NALP5_HUMAN | [view interactions] | High throughput | no | no |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F118B_HUMAN | [view interactions] | High throughput | no | yes |
PTTG1_HUMAN | [view interactions] | High throughput | no | no |
CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
CHC10_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
PAK4_HUMAN | [view interactions] | High throughput | no | yes |
SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
MB212_HUMAN | [view interactions] | High throughput | no | no |
VGFR2_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ITA4_HUMAN | [view interactions] | High throughput | no | no |
GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CREB3_HUMAN | [view interactions] | High throughput | no | no |
ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MERL_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX32_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
F16P1_HUMAN | [view interactions] | High throughput | no | no |
AF1L1_HUMAN | [view interactions] | High throughput | no | no |
SAP30_HUMAN | [view interactions] | High throughput | no | yes |
COMD5_HUMAN | [view interactions] | High throughput | no | no |
MASU1_HUMAN | [view interactions] | High throughput | no | yes |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
CRYAA_HUMAN | [view interactions] | High throughput | no | no |
FST_HUMAN | [view interactions] | High throughput | no | no |
TISB_HUMAN | [view interactions] | High throughput | no | no |
TRI26_HUMAN | [view interactions] | High throughput | no | yes |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CATD_HUMAN | [view interactions] | High throughput | no | yes |
PLGT3_HUMAN | [view interactions] | High throughput | no | no |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
HEBP1_HUMAN | [view interactions] | High throughput | no | yes |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
CK054_HUMAN | [view interactions] | High throughput | no | no |
ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
FBX3_HUMAN | [view interactions] | High throughput | no | no |
ACADL_HUMAN | [view interactions] | High throughput | no | no |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
ACADS_HUMAN | [view interactions] | High throughput | no | yes |
ACADV_HUMAN | [view interactions] | High throughput | no | yes |
CLYBL_HUMAN | [view interactions] | High throughput | no | yes |
CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECH1_HUMAN | [view interactions] | High throughput | no | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
ACD11_HUMAN | [view interactions] | High throughput | no | yes |
ECI1_HUMAN | [view interactions] | High throughput | no | yes |
ETFA_HUMAN | [view interactions] | High throughput | no | yes |
HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEFM_HUMAN | [view interactions] | High throughput | no | no |
MK11_HUMAN | [view interactions] | High throughput | no | yes |
CALB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
OSGI2_HUMAN | [view interactions] | Computational | no | yes |