DECR_HUMAN
Evidence for PS localization
Functions
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DECR_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.3333 | 4 | yes |
| GO:0000166 | nucleotide binding | 28.5714 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.1905 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.8095 | 6 | yes |
| GO:0043169 | cation binding | 21.4286 | 4 | no |
| GO:0046872 | metal ion binding | 21.4286 | 5 | no |
| GO:0003723 | RNA binding | 21.4286 | 4 | no |
| GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity | 4.7619 | 5 | yes |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 4.7619 | 4 | yes |
| GO:0050661 | NADP binding | 4.7619 | 7 | yes |
| GO:0070402 | NADPH binding | 4.7619 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DECR_HUMAN |
|---|---|---|---|---|
| GO:0009893 | positive regulation of metabolic process | 40.4762 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.4762 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.0952 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.7143 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.7143 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 30.9524 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 30.9524 | 4 | yes |
| GO:0008104 | protein localization | 30.9524 | 4 | no |
| GO:0022607 | cellular component assembly | 30.9524 | 4 | no |
| GO:0071702 | organic substance transport | 30.9524 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.9524 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.5714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0016054 | organic acid catabolic process | 26.1905 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 26.1905 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.1905 | 4 | no |
| GO:0006996 | organelle organization | 26.1905 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.1905 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.1905 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.1905 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.1905 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.1905 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.1905 | 4 | no |
| GO:0006631 | fatty acid metabolic process | 23.8095 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 23.8095 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.8095 | 4 | no |
| GO:0006635 | fatty acid beta-oxidation | 21.4286 | 6 | yes |
| GO:0009062 | fatty acid catabolic process | 21.4286 | 5 | yes |
| GO:0016042 | lipid catabolic process | 21.4286 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 21.4286 | 5 | yes |
| GO:0030258 | lipid modification | 21.4286 | 4 | yes |
| GO:0034440 | lipid oxidation | 21.4286 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 21.4286 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 21.4286 | 4 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 21.4286 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 21.4286 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0015031 | protein transport | 21.4286 | 4 | no |
| GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
| GO:0051049 | regulation of transport | 21.4286 | 4 | no |
| GO:0120161 | regulation of cold-induced thermogenesis | 11.9048 | 4 | yes |
| GO:0120162 | positive regulation of cold-induced thermogenesis | 11.9048 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DECR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| AF1L1_HUMAN | [view interactions] | High throughput | no | no |
| SAP30_HUMAN | [view interactions] | High throughput | no | yes |
| COMD5_HUMAN | [view interactions] | High throughput | no | no |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| FST_HUMAN | [view interactions] | High throughput | no | no |
| TISB_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| HEBP1_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX3_HUMAN | [view interactions] | High throughput | no | no |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ACADS_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| CLYBL_HUMAN | [view interactions] | High throughput | no | yes |
| CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| ACD11_HUMAN | [view interactions] | High throughput | no | yes |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UGDH_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC1_HUMAN | [view interactions] | High throughput | no | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| NOP56_HUMAN | [view interactions] | High throughput | no | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| NALP5_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F118B_HUMAN | [view interactions] | High throughput | no | yes |
| PTTG1_HUMAN | [view interactions] | High throughput | no | no |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |