HIBCH_HUMAN
Evidence for PS localization
Functions
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 122 | Tyr | Cys | 3-hydroxyisobutryl-CoAhydrolasedeficiency(HIBCHD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HIBCH_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 52.1739 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HIBCH_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.4783 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.4783 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.4783 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.1304 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.1304 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.1304 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 34.7826 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.7826 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 30.4348 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 30.4348 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 30.4348 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 30.4348 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 26.0870 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0870 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010646 | regulation of cell communication | 26.0870 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
| GO:0043603 | cellular amide metabolic process | 26.0870 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.0870 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.0870 | 4 | no |
| GO:0016054 | organic acid catabolic process | 21.7391 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 21.7391 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 21.7391 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.7391 | 7 | no |
| GO:0006518 | peptide metabolic process | 21.7391 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0043604 | amide biosynthetic process | 21.7391 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.7391 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.7391 | 5 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0009063 | cellular amino acid catabolic process | 13.0435 | 4 | yes |
| GO:0006573 | valine metabolic process | 8.6957 | 5 | yes |
| GO:0006574 | valine catabolic process | 8.6957 | 6 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 8.6957 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 8.6957 | 5 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 8.6957 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| OXLD1_HUMAN | [view interactions] | High throughput | no | no |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| GATC_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| SCRT2_HUMAN | [view interactions] | High throughput | no | no |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| RPP29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| PRR19_HUMAN | [view interactions] | High throughput | no | no |
| NP1L2_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| ETFR1_HUMAN | [view interactions] | High throughput | no | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| CIART_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| I2BPL_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAB39_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| CLIC5_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCP_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| HOT_HUMAN | [view interactions] | High throughput | no | no |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUTA_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RT15_HUMAN | [view interactions] | Computational | no | yes |
| RM02_HUMAN | [view interactions] | Computational | no | yes |
| RM44_HUMAN | [view interactions] | Computational | no | yes |
| RT16_HUMAN | [view interactions] | Computational | no | yes |
| RM36_HUMAN | [view interactions] | Computational | no | yes |
| RM27_HUMAN | [view interactions] | Computational | no | yes |
| ACDSB_HUMAN | [view interactions] | Computational | no | yes |
| RM40_HUMAN | [view interactions] | Computational | no | yes |
| RT35_HUMAN | [view interactions] | Computational | no | yes |
| RM03_HUMAN | [view interactions] | Computational | no | yes |
| RT07_HUMAN | [view interactions] | Computational | no | yes |
| RT10_HUMAN | [view interactions] | Computational | no | yes |
| RM32_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| RM04_HUMAN | [view interactions] | Computational | no | yes |
| RT02_HUMAN | [view interactions] | Computational | no | no |
| RM16_HUMAN | [view interactions] | Computational | no | yes |
| RT09_HUMAN | [view interactions] | Computational | no | yes |
| RM22_HUMAN | [view interactions] | Computational | no | yes |
| RT12_HUMAN | [view interactions] | Computational | no | yes |
| RM47_HUMAN | [view interactions] | Computational | no | yes |
| RS18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RM17_HUMAN | [view interactions] | Computational | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RT06_HUMAN | [view interactions] | Computational | no | yes |
| RM46_HUMAN | [view interactions] | Computational | no | yes |
| RM43_HUMAN | [view interactions] | Computational | no | no |
| RM13_HUMAN | [view interactions] | Computational | no | yes |
| RT05_HUMAN | [view interactions] | Computational | no | yes |
| RS5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RM41_HUMAN | [view interactions] | Computational | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RT14_HUMAN | [view interactions] | Computational | no | yes |
| RM33_HUMAN | [view interactions] | Computational | no | yes |
| RM19_HUMAN | [view interactions] | Computational | no | yes |
| RT29_HUMAN | [view interactions] | Computational | no | yes |
| RM15_HUMAN | [view interactions] | Computational | no | yes |