HIBCH_HUMAN
Evidence for PS localization
Functions
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 122 | Tyr | Cys | 3-hydroxyisobutryl-CoAhydrolasedeficiency(HIBCHD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HIBCH_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 47.6190 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.8095 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.8095 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HIBCH_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.3810 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.8571 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 38.0952 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 38.0952 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 33.3333 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 28.5714 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 28.5714 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 28.5714 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 7 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.8095 | 8 | no |
| GO:0008104 | protein localization | 23.8095 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.8095 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
| GO:0010646 | regulation of cell communication | 23.8095 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.8095 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.8095 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.8095 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.8095 | 6 | no |
| GO:0006396 | RNA processing | 23.8095 | 6 | no |
| GO:0016070 | RNA metabolic process | 23.8095 | 5 | no |
| GO:0016054 | organic acid catabolic process | 19.0476 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 19.0476 | 5 | yes |
| GO:0009063 | amino acid catabolic process | 14.2857 | 4 | yes |
| GO:0006573 | valine metabolic process | 9.5238 | 5 | yes |
| GO:0006574 | valine catabolic process | 9.5238 | 6 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 9.5238 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 9.5238 | 5 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 9.5238 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 9.5238 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAB39_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| CLIC5_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCP_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| HOT_HUMAN | [view interactions] | High throughput | no | no |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUTA_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| OXLD1_HUMAN | [view interactions] | High throughput | no | no |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| GATC_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| SCRT2_HUMAN | [view interactions] | High throughput | no | no |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| RPP29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| PRR19_HUMAN | [view interactions] | High throughput | no | no |
| NP1L2_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| ETFR1_HUMAN | [view interactions] | High throughput | no | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| CIART_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| I2BPL_HUMAN | [view interactions] | High throughput | no | yes |