NEDD8_HUMAN
Evidence for PS localization
Functions
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (PubMed, PubMed, PubMed, PubMed, PubMed). Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity (PubMed). Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NEDD8_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 52.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 23.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.3333 | 5 | no |
| GO:0043168 | anion binding | 23.3333 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 22.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.3333 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NEDD8_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 42.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 41.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0009059 | macromolecule biosynthetic process | 38.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.3333 | 5 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.6667 | 4 | no |
| GO:0006412 | translation | 32.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.6667 | 5 | yes |
| GO:0002181 | cytoplasmic translation | 30.6667 | 5 | no |
| GO:0010646 | regulation of cell communication | 30.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.6667 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.6667 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 28.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 28.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.3333 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.3333 | 6 | no |
| GO:0090304 | nucleic acid metabolic process | 26.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.3333 | 5 | no |
| GO:0006996 | organelle organization | 25.3333 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.0000 | 7 | yes |
| GO:0008104 | protein localization | 24.0000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 24.0000 | 6 | yes |
| GO:0022607 | cellular component assembly | 24.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.0000 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 23.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 22.6667 | 4 | yes |
| GO:0016070 | RNA metabolic process | 22.6667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.6667 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.0000 | 6 | no |
| GO:0036211 | protein modification process | 21.3333 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 20.6667 | 6 | no |
| GO:0009057 | macromolecule catabolic process | 20.0000 | 4 | yes |
| GO:0043687 | post-translational protein modification | 16.0000 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 15.3333 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 14.6667 | 8 | yes |
| GO:0032446 | protein modification by small protein conjugation | 14.6667 | 7 | yes |
| GO:0006508 | proteolysis | 14.0000 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 13.3333 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 13.3333 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 13.3333 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 12.6667 | 6 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 10.6667 | 7 | yes |
| GO:0045116 | protein neddylation | 4.0000 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
| SKP2_HUMAN | [view interactions] | Low throughput | no | yes |
| CKS1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBX2_HUMAN | [view interactions] | Low throughput | no | yes |
| ERCC8_HUMAN | [view interactions] | Low throughput | no | no |
| KBTB2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | Low throughput | no | yes |
| SKP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ELOC_HUMAN | [view interactions] | Low throughput | no | no |
| ELOB_HUMAN | [view interactions] | Low throughput | no | no |
| KHNYN_HUMAN | [view interactions] | Low throughput | no | yes |
| NUB1_HUMAN | [view interactions] | Low throughput | no | no |
| CSN5_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN6_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBX11_HUMAN | [view interactions] | Low throughput | no | no |
| CUL1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | Low throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | Low throughput | no | yes |
| ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
| BRAP_HUMAN | [view interactions] | Low throughput | no | yes |
| AHR_HUMAN | [view interactions] | Low throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS20_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRAME_HUMAN | [view interactions] | Low throughput | no | no |
| CASP7_HUMAN | [view interactions] | Low throughput | no | no |
| NEDD8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | Low throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMUF2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
| ELOA1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| GARS_HUMAN | [view interactions] | Low throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
| STON2_HUMAN | [view interactions] | Low throughput | no | yes |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| UBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| ULA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SENP8_HUMAN | [view interactions] | Low throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL2_HUMAN | [view interactions] | Low throughput | no | yes |
| HYPK_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SAE2_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | Low throughput | no | no |
| DNM3B_HUMAN | [view interactions] | Low throughput | no | yes |
| ARI2_HUMAN | [view interactions] | Low throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCNL1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARI1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| KLDC2_HUMAN | [view interactions] | Low throughput | no | yes |
| CTRC_HUMAN | [view interactions] | Low throughput | no | no |
| G3BP1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN2_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSN4_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN7B_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN8_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN1_HUMAN | [view interactions] | Low throughput | no | no |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP77_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB6_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| KLD10_HUMAN | [view interactions] | High throughput | no | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| KLH15_HUMAN | [view interactions] | High throughput | no | yes |
| KLH22_HUMAN | [view interactions] | High throughput | no | no |
| KLHL9_HUMAN | [view interactions] | High throughput | no | no |
| K2C1_HUMAN | [view interactions] | High throughput | no | no |
| K1C10_HUMAN | [view interactions] | High throughput | no | no |
| K1C13_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| K1C24_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| K22O_HUMAN | [view interactions] | High throughput | no | no |
| K1C9_HUMAN | [view interactions] | High throughput | no | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| CSN9_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| TIRR_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PWP1_HUMAN | [view interactions] | High throughput | no | no |
| QPCT_HUMAN | [view interactions] | High throughput | no | no |
| RN187_HUMAN | [view interactions] | High throughput | no | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| STRBP_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP56_HUMAN | [view interactions] | High throughput | no | yes |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| POLI_HUMAN | [view interactions] | High throughput | no | yes |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBLB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| FBX21_HUMAN | [view interactions] | High throughput | no | yes |
| UBP13_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP25_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| KLDC3_HUMAN | [view interactions] | High throughput | no | yes |
| ASB6_HUMAN | [view interactions] | High throughput | no | yes |
| CRBN_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLD3_HUMAN | [view interactions] | High throughput | no | yes |
| INAVA_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEI1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| NEK10_HUMAN | [view interactions] | High throughput | no | no |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| DFFB_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| N4BP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| SMD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBL7_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| CSF1R_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1J_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| ASB8_HUMAN | [view interactions] | High throughput | no | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| BRWD3_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| FBX4_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA13_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| NEP1_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL15_HUMAN | [view interactions] | High throughput | no | no |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF2A_HUMAN | [view interactions] | High throughput | no | yes |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| HARS1_HUMAN | [view interactions] | High throughput | no | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| NXPH2_HUMAN | [view interactions] | High throughput | no | no |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG4_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| SCN1A_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| MKNK1_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD5_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS2_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPF_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB2_HUMAN | [view interactions] | High throughput | no | no |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD9_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GHR_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIRBP_HUMAN | [view interactions] | High throughput | no | no |
| OR4S2_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| ARLY_HUMAN | [view interactions] | High throughput | no | no |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| POP1_HUMAN | [view interactions] | High throughput | no | no |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| DCTP1_HUMAN | [view interactions] | High throughput | no | no |
| HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QNG1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2D3_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX3_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| NIT1_HUMAN | [view interactions] | High throughput | no | yes |
| FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| RNZ2_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| ROA0_HUMAN | [view interactions] | High throughput | no | yes |
| AL1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLE1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OFUT1_HUMAN | [view interactions] | High throughput | no | yes |
| ROAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| UAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| ANGE2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHID1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| QORL1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDHD5_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGM1_HUMAN | [view interactions] | High throughput | no | no |
| HS902_HUMAN | [view interactions] | High throughput | no | no |
| PTER_HUMAN | [view interactions] | High throughput | no | yes |