RAB8B_HUMAN
Evidence for PS localization
Functions
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB8B_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 39.5833 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 39.5833 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.5833 | 4 | yes |
| GO:0003924 | GTPase activity | 37.5000 | 7 | yes |
| GO:0005525 | GTP binding | 37.5000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 37.5000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 37.5000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 37.5000 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 37.5000 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 37.5000 | 5 | yes |
| GO:0019900 | kinase binding | 29.1667 | 4 | no |
| GO:0019901 | protein kinase binding | 27.0833 | 5 | no |
| GO:0019003 | GDP binding | 25.0000 | 4 | yes |
| GO:0045296 | cadherin binding | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB8B_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 62.5000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 60.4167 | 4 | yes |
| GO:0006996 | organelle organization | 52.0833 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.9167 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.9167 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.9167 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 47.9167 | 4 | no |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0015031 | protein transport | 39.5833 | 4 | yes |
| GO:0071702 | organic substance transport | 39.5833 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 39.5833 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.4167 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.4167 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.4167 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 33.3333 | 4 | yes |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 31.2500 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | no |
| GO:0007010 | cytoskeleton organization | 31.2500 | 5 | no |
| GO:0032880 | regulation of protein localization | 31.2500 | 5 | no |
| GO:0060341 | regulation of cellular localization | 31.2500 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 29.1667 | 4 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 29.1667 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 29.1667 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.1667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.1667 | 5 | no |
| GO:0033043 | regulation of organelle organization | 29.1667 | 5 | no |
| GO:0072657 | protein localization to membrane | 27.0833 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 27.0833 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 25.0000 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 22.9167 | 4 | yes |
| GO:0034330 | cell junction organization | 22.9167 | 4 | yes |
| GO:0051046 | regulation of secretion | 22.9167 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.9167 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 22.9167 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 22.9167 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 22.9167 | 6 | no |
| GO:0006897 | endocytosis | 22.9167 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.9167 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.9167 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.8333 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 20.8333 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 20.8333 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 20.8333 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.8333 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.8333 | 4 | no |
| GO:0043269 | regulation of ion transport | 20.8333 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.8333 | 4 | no |
| GO:0033365 | protein localization to organelle | 18.7500 | 5 | yes |
| GO:0046903 | secretion | 16.6667 | 4 | yes |
| GO:1901652 | response to peptide | 16.6667 | 4 | yes |
| GO:1901653 | cellular response to peptide | 16.6667 | 5 | yes |
| GO:0044057 | regulation of system process | 14.5833 | 4 | yes |
| GO:0061024 | membrane organization | 14.5833 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 14.5833 | 4 | yes |
| GO:0016050 | vesicle organization | 12.5000 | 5 | yes |
| GO:0006906 | vesicle fusion | 10.4167 | 6 | yes |
| GO:0032868 | response to insulin | 10.4167 | 5 | yes |
| GO:0032869 | cellular response to insulin stimulus | 10.4167 | 6 | yes |
| GO:0032870 | cellular response to hormone stimulus | 10.4167 | 4 | yes |
| GO:0043434 | response to peptide hormone | 10.4167 | 4 | yes |
| GO:0048284 | organelle fusion | 10.4167 | 5 | yes |
| GO:0061025 | membrane fusion | 10.4167 | 5 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 10.4167 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 10.4167 | 4 | yes |
| GO:0090174 | organelle membrane fusion | 10.4167 | 6 | yes |
| GO:0009306 | protein secretion | 8.3333 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 8.3333 | 6 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 8.3333 | 4 | yes |
| GO:0048278 | vesicle docking | 8.3333 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 8.3333 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 8.3333 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 8.3333 | 5 | yes |
| GO:0006605 | protein targeting | 6.2500 | 5 | yes |
| GO:0048210 | Golgi vesicle fusion to target membrane | 6.2500 | 7 | yes |
| GO:0006612 | protein targeting to membrane | 4.1667 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RAB8B_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 8.3333 | 3 | no |
| DOID:0050700 | cardiomyopathy | 6.2500 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.2500 | 5 | no |
| DOID:2843 | long QT syndrome | 4.1667 | 6 | no |
| DOID:0080000 | muscular disease | 4.1667 | 3 | no |
| DOID:423 | myopathy | 4.1667 | 5 | no |
| DOID:66 | muscle tissue disease | 4.1667 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BIRC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EH1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| SYNM_HUMAN | [view interactions] | High throughput | no | yes |
| SYTL4_HUMAN | [view interactions] | High throughput | no | yes |
| MILK1_HUMAN | [view interactions] | High throughput | no | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| CTU2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE2_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| UH1BL_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| I5P2_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| SHIP1_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| EVPL_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F184B_HUMAN | [view interactions] | High throughput | no | no |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MILK2_HUMAN | [view interactions] | High throughput | no | no |
| RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CI072_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| RED_HUMAN | [view interactions] | High throughput | no | yes |
| Z280C_HUMAN | [view interactions] | High throughput | no | yes |
| RADX_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP1_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX5R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| R3GEF_HUMAN | [view interactions] | Computational | no | yes |
| DEN1C_HUMAN | [view interactions] | Computational | no | no |
| OTOF_HUMAN | [view interactions] | Computational | no | yes |
| RAB3I_HUMAN | [view interactions] | Computational | no | no |