Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BIRC6_HUMAN

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in BIRC6_HUMAN
GO:0043169 cation binding 23.3333 4 no
GO:0043168 anion binding 21.6667 4 no
GO:0046872 metal ion binding 21.6667 5 no
GO:0004842 ubiquitin-protein transferase activity 6.6667 4 yes
GO:0016755 aminoacyltransferase activity 6.6667 4 yes
GO:0004866 endopeptidase inhibitor activity 5.0000 5 yes
GO:0004869 cysteine-type endopeptidase inhibitor activity 5.0000 6 yes
GO:0030414 peptidase inhibitor activity 5.0000 4 yes
GO:0061135 endopeptidase regulator activity 5.0000 4 yes
GO:0061631 ubiquitin conjugating enzyme activity 3.3333 5 yes
GO:0061650 ubiquitin-like protein conjugating enzyme activity 3.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BIRC6_HUMAN
GO:0048522 positive regulation of cellular process 60.0000 4 yes
GO:0010646 regulation of cell communication 55.0000 4 yes
GO:0009966 regulation of signal transduction 48.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.3333 4 no
GO:0080090 regulation of primary metabolic process 48.3333 4 no
GO:0031323 regulation of cellular metabolic process 43.3333 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 yes
GO:0006996 organelle organization 41.6667 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0008104 protein localization 36.6667 4 no
GO:0009893 positive regulation of metabolic process 35.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.0000 5 no
GO:1902531 regulation of intracellular signal transduction 31.6667 5 no
GO:0009889 regulation of biosynthetic process 30.0000 4 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0010468 regulation of gene expression 30.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0009892 negative regulation of metabolic process 28.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.3333 5 no
GO:0022607 cellular component assembly 28.3333 4 no
GO:0009967 positive regulation of signal transduction 26.6667 5 no
GO:0048584 positive regulation of response to stimulus 26.6667 4 no
GO:0051049 regulation of transport 26.6667 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 yes
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 23.3333 5 no
GO:0031399 regulation of protein modification process 23.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 23.3333 4 no
GO:0015031 protein transport 23.3333 4 no
GO:0051130 positive regulation of cellular component organization 23.3333 5 no
GO:0036211 protein modification process 21.6667 4 yes
GO:0042981 regulation of apoptotic process 21.6667 5 yes
GO:0043067 regulation of programmed cell death 21.6667 4 yes
GO:0043412 macromolecule modification 21.6667 4 yes
GO:0051726 regulation of cell cycle 21.6667 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.6667 5 no
GO:0007010 cytoskeleton organization 21.6667 5 no
GO:0009968 negative regulation of signal transduction 20.0000 5 yes
GO:0010564 regulation of cell cycle process 20.0000 5 yes
GO:0010648 negative regulation of cell communication 20.0000 5 yes
GO:0023057 negative regulation of signaling 20.0000 4 yes
GO:0048585 negative regulation of response to stimulus 20.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 18.3333 4 yes
GO:0006915 apoptotic process 18.3333 4 yes
GO:0008284 positive regulation of cell population proliferation 18.3333 5 yes
GO:0043066 negative regulation of apoptotic process 16.6667 6 yes
GO:0043069 negative regulation of programmed cell death 16.6667 5 yes
GO:0032465 regulation of cytokinesis 15.0000 5 yes
GO:0051302 regulation of cell division 15.0000 4 yes
GO:0016310 phosphorylation 11.6667 5 yes
GO:0043687 post-translational protein modification 10.0000 5 yes
GO:0070647 protein modification by small protein conjugation or removal 10.0000 6 yes
GO:0006468 protein phosphorylation 10.0000 5 yes
GO:0016567 protein ubiquitination 8.3333 8 yes
GO:0032446 protein modification by small protein conjugation 8.3333 7 yes
GO:2001233 regulation of apoptotic signaling pathway 8.3333 5 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 6.6667 6 yes
GO:2001234 negative regulation of apoptotic signaling pathway 5.0000 6 yes
GO:0060712 spongiotrophoblast layer development 3.3333 4 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 3.3333 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MP2K1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK1_HUMAN [view interactions] Low throughput no yes
EXOC4_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB8B_HUMAN [view entry] [view interactions] Low throughput yes no
KIF23_HUMAN [view interactions] Low throughput no yes
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
RNF41_HUMAN [view interactions] Low throughput no yes
AURKB_HUMAN [view interactions] Low throughput no yes
GOGA4_HUMAN [view interactions] Low throughput no yes
HTRA2_HUMAN [view interactions] Low throughput no yes
DBLOH_HUMAN [view interactions] Low throughput no no
CASP9_HUMAN [view interactions] Low throughput no yes
CASP3_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP7_HUMAN [view interactions] Low throughput no no
BIRC6_HUMAN [view entry] [view interactions] Low throughput yes yes
CCNA2_HUMAN [view interactions] Low throughput no no
CDC27_HUMAN [view interactions] Low throughput no yes
APC11_HUMAN [view interactions] Low throughput no yes
MCPH1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
AGO2_HUMAN [view entry] [view interactions] Low throughput yes yes
ESRP1_HUMAN [view interactions] Low throughput no yes
STX17_HUMAN [view interactions] Low throughput no yes
SNP29_HUMAN [view interactions] Low throughput no yes
MLP3B_HUMAN [view interactions] Low throughput no yes
UBA6_HUMAN [view interactions] Low throughput no no
MLP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
MLP3C_HUMAN [view interactions] Low throughput no no
UB2D1_HUMAN [view interactions] Low throughput no yes
GBRAP_HUMAN [view entry] [view interactions] Low throughput yes no
GBRL1_HUMAN [view interactions] Low throughput no yes
CASP8_HUMAN [view interactions] Low throughput no yes
GBRL2_HUMAN [view entry] [view interactions] Low throughput yes yes
CYBP_HUMAN [view entry] [view interactions] Low throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
MSH6_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
CNOT9_HUMAN [view interactions] High throughput no yes
LSM2_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
IPO11_HUMAN [view interactions] High throughput no yes
CLPB_HUMAN [view interactions] High throughput no yes
TIM29_HUMAN [view interactions] High throughput no no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
ANC2_HUMAN [view interactions] High throughput no no
CALR3_HUMAN [view interactions] High throughput no no
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR2_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
GOGA1_HUMAN [view interactions] High throughput no yes
K1C18_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
NDC80_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
PEX3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
RPB3_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
TMPS2_HUMAN [view interactions] High throughput no no
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
ARL8B_HUMAN [view interactions] High throughput no yes
ARL10_HUMAN [view interactions] High throughput no yes
ARL16_HUMAN [view interactions] High throughput no no
DHCR7_HUMAN [view interactions] High throughput no yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
RBBP7_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
BIRC5_HUMAN [view interactions] High throughput no no
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
L2GL2_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
KIF22_HUMAN [view interactions] High throughput no no
MYH13_HUMAN [view interactions] High throughput no no
ATS4_HUMAN [view interactions] High throughput no yes
PRS8_HUMAN [view interactions] High throughput no yes
DCA12_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
MOS_HUMAN [view interactions] High throughput no no
HERC2_HUMAN [view interactions] High throughput no yes
CCD22_HUMAN [view entry] [view interactions] High throughput yes no
AGRP_HUMAN [view interactions] High throughput no no
UGGG2_HUMAN [view interactions] High throughput no no
VEGFD_HUMAN [view interactions] High throughput no no
ANGL3_HUMAN [view interactions] High throughput no no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGB1_HUMAN [view entry] [view interactions] High throughput yes yes
NUMA1_HUMAN [view interactions] High throughput no yes
H2A1H_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CCD61_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
RASF2_HUMAN [view interactions] High throughput no yes
RPGR_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
SSH3_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
TEX35_HUMAN [view interactions] High throughput no no
PRS45_HUMAN [view interactions] High throughput no no
RTBDN_HUMAN [view interactions] High throughput no no
CC020_HUMAN [view interactions] High throughput no no
WDR4_HUMAN [view interactions] High throughput no no
GSDME_HUMAN [view interactions] High throughput no yes
ABRX2_HUMAN [view interactions] High throughput no yes
CAH11_HUMAN [view interactions] High throughput no no
CHIA_HUMAN [view interactions] High throughput no yes
CLC11_HUMAN [view interactions] High throughput no no
TB22A_HUMAN [view interactions] High throughput no yes
CCNQ_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
FERM2_HUMAN [view interactions] High throughput no yes
OSBL2_HUMAN [view interactions] High throughput no yes
HEY1_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RMD5A_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
PSB2_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
RUN3A_HUMAN [view interactions] High throughput no yes
MF2L2_HUMAN [view interactions] High throughput no no
PLPL1_HUMAN [view interactions] High throughput no no
SOSB1_HUMAN [view interactions] High throughput no yes
CD79B_HUMAN [view interactions] High throughput no no
MCH_HUMAN [view entry] [view interactions] High throughput yes no
CCL17_HUMAN [view interactions] High throughput no yes
TAFA3_HUMAN [view interactions] High throughput no no
TTLL5_HUMAN [view interactions] High throughput no yes
CAPSL_HUMAN [view interactions] High throughput no no
SPSB3_HUMAN [view interactions] High throughput no yes
FSD2_HUMAN [view interactions] High throughput no no
ISK14_HUMAN [view interactions] High throughput no no
LDOC1_HUMAN [view interactions] High throughput no no
STRAA_HUMAN [view interactions] High throughput no yes
DEN5A_HUMAN [view interactions] High throughput no yes
TM266_HUMAN [view interactions] High throughput no no
CCL18_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
PATE1_HUMAN [view interactions] High throughput no no
RAMP1_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
ABTB2_HUMAN [view interactions] High throughput no yes
TM135_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
BFSP1_HUMAN [view interactions] High throughput no no
CXCL3_HUMAN [view interactions] High throughput no no
TOR2A_HUMAN [view interactions] High throughput no no
PP4P1_HUMAN [view interactions] High throughput no yes
IQCF2_HUMAN [view interactions] High throughput no no
PPR21_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
GROA_HUMAN [view interactions] High throughput no no
DIK1A_HUMAN [view interactions] High throughput no yes
LPIN3_HUMAN [view interactions] High throughput no yes
KLH33_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
S22A9_HUMAN [view interactions] High throughput no no
CUED1_HUMAN [view interactions] High throughput no yes
CYTC_HUMAN [view entry] [view interactions] High throughput yes yes
DNPEP_HUMAN [view interactions] High throughput no yes
PRTN3_HUMAN [view interactions] High throughput no no
PTH_HUMAN [view interactions] High throughput no yes
ITLN2_HUMAN [view interactions] High throughput no no
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
STK11_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
ITB2_HUMAN [view interactions] High throughput no no
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
BLTP1_HUMAN [view interactions] High throughput no yes
NF1_HUMAN [view entry] [view interactions] High throughput yes no
SON_HUMAN [view interactions] High throughput no yes
VP13B_HUMAN [view interactions] High throughput no no
MBD3_HUMAN [view interactions] High throughput no yes