BIRC6_HUMAN
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in BIRC6_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 20.4082 | 4 | no |
GO:0004842 | ubiquitin-protein transferase activity | 6.1224 | 4 | yes |
GO:0004866 | endopeptidase inhibitor activity | 6.1224 | 5 | yes |
GO:0004869 | cysteine-type endopeptidase inhibitor activity | 6.1224 | 6 | yes |
GO:0030414 | peptidase inhibitor activity | 6.1224 | 4 | yes |
GO:0061135 | endopeptidase regulator activity | 6.1224 | 4 | yes |
GO:0061631 | ubiquitin conjugating enzyme activity | 4.0816 | 5 | yes |
GO:0061650 | ubiquitin-like protein conjugating enzyme activity | 4.0816 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in BIRC6_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 53.0612 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 48.9796 | 4 | no |
GO:0010646 | regulation of cell communication | 46.9388 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 46.9388 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 44.8980 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.8980 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.8571 | 4 | yes |
GO:0006996 | organelle organization | 38.7755 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 38.7755 | 5 | no |
GO:0048523 | negative regulation of cellular process | 34.6939 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 34.6939 | 4 | no |
GO:0008104 | protein localization | 32.6531 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 30.6122 | 4 | no |
GO:0071702 | organic substance transport | 28.5714 | 4 | no |
GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
GO:0051049 | regulation of transport | 26.5306 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 26.5306 | 6 | no |
GO:0009894 | regulation of catabolic process | 24.4898 | 4 | no |
GO:0015031 | protein transport | 24.4898 | 4 | no |
GO:0016192 | vesicle-mediated transport | 24.4898 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.4898 | 6 | no |
GO:0031399 | regulation of protein modification process | 24.4898 | 6 | no |
GO:0042325 | regulation of phosphorylation | 24.4898 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.4898 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 24.4898 | 4 | no |
GO:0036211 | protein modification process | 22.4490 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 22.4490 | 4 | yes |
GO:0043412 | macromolecule modification | 22.4490 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 22.4490 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 22.4490 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 22.4490 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.4490 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.4490 | 5 | no |
GO:0010647 | positive regulation of cell communication | 22.4490 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.4490 | 4 | no |
GO:0010564 | regulation of cell cycle process | 20.4082 | 5 | yes |
GO:0051726 | regulation of cell cycle | 20.4082 | 4 | yes |
GO:0022607 | cellular component assembly | 20.4082 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 20.4082 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 20.4082 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 20.4082 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 20.4082 | 4 | no |
GO:0043549 | regulation of kinase activity | 20.4082 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 20.4082 | 6 | no |
GO:0051338 | regulation of transferase activity | 20.4082 | 4 | no |
GO:0010468 | regulation of gene expression | 20.4082 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 20.4082 | 5 | no |
GO:0008284 | positive regulation of cell population proliferation | 18.3673 | 5 | yes |
GO:0009968 | negative regulation of signal transduction | 18.3673 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 18.3673 | 5 | yes |
GO:0010941 | regulation of cell death | 18.3673 | 4 | yes |
GO:0023057 | negative regulation of signaling | 18.3673 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 18.3673 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 18.3673 | 5 | yes |
GO:0048585 | negative regulation of response to stimulus | 18.3673 | 4 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 16.3265 | 4 | yes |
GO:0032465 | regulation of cytokinesis | 14.2857 | 5 | yes |
GO:0051302 | regulation of cell division | 14.2857 | 4 | yes |
GO:0006468 | protein phosphorylation | 12.2449 | 5 | yes |
GO:0006915 | apoptotic process | 12.2449 | 4 | yes |
GO:0016310 | phosphorylation | 12.2449 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 12.2449 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 12.2449 | 6 | yes |
GO:0060548 | negative regulation of cell death | 12.2449 | 5 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 12.2449 | 5 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 10.2041 | 5 | yes |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 10.2041 | 6 | yes |
GO:0016567 | protein ubiquitination | 6.1224 | 7 | yes |
GO:0032446 | protein modification by small protein conjugation | 6.1224 | 6 | yes |
GO:2001234 | negative regulation of apoptotic signaling pathway | 6.1224 | 6 | yes |
GO:0060712 | spongiotrophoblast layer development | 4.0816 | 4 | yes |
GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 4.0816 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in BIRC6_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 6.1224 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 6.1224 | 5 | no |
DOID:114 | heart disease | 6.1224 | 3 | no |
DOID:2843 | long QT syndrome | 6.1224 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
GBRL1_HUMAN | [view interactions] | Low throughput | no | yes |
CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
GBRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB8B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KIF23_HUMAN | [view interactions] | Low throughput | no | yes |
UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
AURKB_HUMAN | [view interactions] | Low throughput | no | yes |
GOGA4_HUMAN | [view interactions] | Low throughput | no | yes |
HTRA2_HUMAN | [view interactions] | Low throughput | no | yes |
DBLOH_HUMAN | [view interactions] | Low throughput | no | no |
CASP9_HUMAN | [view interactions] | Low throughput | no | yes |
CASP3_HUMAN | [view interactions] | Low throughput | no | yes |
CASP7_HUMAN | [view interactions] | Low throughput | no | no |
BIRC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
CDC27_HUMAN | [view interactions] | Low throughput | no | yes |
APC11_HUMAN | [view interactions] | Low throughput | no | yes |
MCPH1_HUMAN | [view interactions] | Low throughput | no | yes |
P53_HUMAN | [view interactions] | Low throughput | no | no |
AGO2_HUMAN | [view interactions] | Low throughput | no | yes |
ESRP1_HUMAN | [view interactions] | Low throughput | no | yes |
STX17_HUMAN | [view interactions] | Low throughput | no | yes |
SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
UBA6_HUMAN | [view interactions] | Low throughput | no | no |
MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MLP3C_HUMAN | [view interactions] | Low throughput | no | no |
ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITB2_HUMAN | [view interactions] | High throughput | no | no |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
K1109_HUMAN | [view interactions] | High throughput | no | yes |
NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SON_HUMAN | [view interactions] | High throughput | no | yes |
VP13B_HUMAN | [view interactions] | High throughput | no | no |
CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
LSM2_HUMAN | [view interactions] | High throughput | no | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
IPO11_HUMAN | [view interactions] | High throughput | no | yes |
CLPB_HUMAN | [view interactions] | High throughput | no | yes |
TIM29_HUMAN | [view interactions] | High throughput | no | no |
ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMOT_HUMAN | [view interactions] | High throughput | no | no |
ANC2_HUMAN | [view interactions] | High throughput | no | no |
CALR3_HUMAN | [view interactions] | High throughput | no | no |
CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR2_HUMAN | [view interactions] | High throughput | no | yes |
IF6_HUMAN | [view interactions] | High throughput | no | yes |
ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
K1C18_HUMAN | [view interactions] | High throughput | no | no |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
K2C8_HUMAN | [view interactions] | High throughput | no | no |
NDC80_HUMAN | [view interactions] | High throughput | no | no |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
PEX3_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPB3_HUMAN | [view interactions] | High throughput | no | yes |
PAXI_HUMAN | [view interactions] | High throughput | no | yes |
VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
BIRC5_HUMAN | [view interactions] | High throughput | no | no |
EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
L2GL2_HUMAN | [view interactions] | High throughput | no | yes |
WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF22_HUMAN | [view interactions] | High throughput | no | no |
MYH13_HUMAN | [view interactions] | High throughput | no | no |
ATS4_HUMAN | [view interactions] | High throughput | no | yes |
PRS8_HUMAN | [view interactions] | High throughput | no | yes |
DCA12_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOS_HUMAN | [view interactions] | High throughput | no | no |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGRP_HUMAN | [view interactions] | High throughput | no | no |
UGGG2_HUMAN | [view interactions] | High throughput | no | no |
VEGFD_HUMAN | [view interactions] | High throughput | no | no |
ANGL3_HUMAN | [view interactions] | High throughput | no | no |
RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
H2A1H_HUMAN | [view interactions] | High throughput | no | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD61_HUMAN | [view interactions] | High throughput | no | yes |
RACK1_HUMAN | [view interactions] | High throughput | no | yes |
VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASF2_HUMAN | [view interactions] | High throughput | no | yes |
RPGR_HUMAN | [view interactions] | High throughput | no | yes |
SCO1_HUMAN | [view interactions] | High throughput | no | yes |
IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
SSH3_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
TEX35_HUMAN | [view interactions] | High throughput | no | no |
PRS45_HUMAN | [view interactions] | High throughput | no | no |
RTBDN_HUMAN | [view interactions] | High throughput | no | no |
CC020_HUMAN | [view interactions] | High throughput | no | no |
WDR4_HUMAN | [view interactions] | High throughput | no | no |
GSDME_HUMAN | [view interactions] | High throughput | no | yes |
ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
CAH11_HUMAN | [view interactions] | High throughput | no | no |
CHIA_HUMAN | [view interactions] | High throughput | no | yes |
CLC11_HUMAN | [view interactions] | High throughput | no | no |
TB22A_HUMAN | [view interactions] | High throughput | no | yes |
CCNQ_HUMAN | [view interactions] | High throughput | no | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FERM2_HUMAN | [view interactions] | High throughput | no | yes |
OSBL2_HUMAN | [view interactions] | High throughput | no | yes |
HEY1_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
SUZ12_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB2_HUMAN | [view interactions] | High throughput | no | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
MF2L2_HUMAN | [view interactions] | High throughput | no | no |
PLPL1_HUMAN | [view interactions] | High throughput | no | no |
SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
CD79B_HUMAN | [view interactions] | High throughput | no | no |
MCH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCL17_HUMAN | [view interactions] | High throughput | no | yes |
TAFA3_HUMAN | [view interactions] | High throughput | no | no |
TTLL5_HUMAN | [view interactions] | High throughput | no | yes |
CAPSL_HUMAN | [view interactions] | High throughput | no | no |
SPSB3_HUMAN | [view interactions] | High throughput | no | yes |
FSD2_HUMAN | [view interactions] | High throughput | no | no |
ISK14_HUMAN | [view interactions] | High throughput | no | no |
LDOC1_HUMAN | [view interactions] | High throughput | no | no |
STRAA_HUMAN | [view interactions] | High throughput | no | yes |
DEN5A_HUMAN | [view interactions] | High throughput | no | yes |
TM266_HUMAN | [view interactions] | High throughput | no | no |
CCL18_HUMAN | [view interactions] | High throughput | no | no |
PPP6_HUMAN | [view interactions] | High throughput | no | yes |
CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PATE1_HUMAN | [view interactions] | High throughput | no | no |
RAMP1_HUMAN | [view interactions] | High throughput | no | no |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CS048_HUMAN | [view interactions] | High throughput | no | no |
ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
TM135_HUMAN | [view interactions] | High throughput | no | yes |
K1H1_HUMAN | [view interactions] | High throughput | no | no |
BFSP1_HUMAN | [view interactions] | High throughput | no | no |
CXCL3_HUMAN | [view interactions] | High throughput | no | no |
TOR2A_HUMAN | [view interactions] | High throughput | no | no |
PP4P1_HUMAN | [view interactions] | High throughput | no | yes |
IQCF2_HUMAN | [view interactions] | High throughput | no | no |
PPR21_HUMAN | [view interactions] | High throughput | no | yes |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GROA_HUMAN | [view interactions] | High throughput | no | no |
DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
KLH33_HUMAN | [view interactions] | High throughput | no | yes |
SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
S22A9_HUMAN | [view interactions] | High throughput | no | no |
CUED1_HUMAN | [view interactions] | High throughput | no | yes |
CYTC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
PRTN3_HUMAN | [view interactions] | High throughput | no | no |
PTH_HUMAN | [view interactions] | High throughput | no | yes |
ITLN2_HUMAN | [view interactions] | High throughput | no | no |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
UBR4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BIRC7_HUMAN | [view interactions] | Computational | no | no |
UBP34_HUMAN | [view interactions] | Computational | no | yes |