INSY1_HUMAN
Evidence for PS localization
Functions
Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in INSY1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 47.9167 | 4 | no |
| GO:0071702 | organic substance transport | 43.7500 | 4 | no |
| GO:0071705 | nitrogen compound transport | 41.6667 | 4 | no |
| GO:0015031 | protein transport | 39.5833 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 31.2500 | 4 | no |
| GO:0051049 | regulation of transport | 31.2500 | 4 | no |
| GO:0022607 | cellular component assembly | 27.0833 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 22.9167 | 4 | no |
| GO:0010646 | regulation of cell communication | 22.9167 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 22.9167 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.9167 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 22.9167 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCRS1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PBX3_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| REXO5_HUMAN | [view interactions] | High throughput | no | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| COMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PKD2_HUMAN | [view interactions] | High throughput | no | yes |
| CC85C_HUMAN | [view interactions] | High throughput | no | yes |
| VPS50_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPG_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| COMD9_HUMAN | [view interactions] | High throughput | no | yes |
| ANM3_HUMAN | [view interactions] | High throughput | no | yes |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| PHLB3_HUMAN | [view interactions] | High throughput | no | yes |
| EMAL4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| EMAL3_HUMAN | [view interactions] | High throughput | no | no |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| BORC5_HUMAN | [view interactions] | High throughput | no | yes |
| SLAF9_HUMAN | [view interactions] | High throughput | no | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| HMMR_HUMAN | [view interactions] | High throughput | no | yes |
| COG4_HUMAN | [view interactions] | High throughput | no | no |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| BEND3_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| CA122_HUMAN | [view interactions] | High throughput | no | no |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| BORC7_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL1_HUMAN | [view interactions] | High throughput | no | yes |
| ODF2L_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| IFT74_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| NADAP_HUMAN | [view interactions] | High throughput | no | yes |
| POC1B_HUMAN | [view interactions] | High throughput | no | no |
| COMD8_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMD2_HUMAN | [view interactions] | High throughput | no | yes |
| CTNL1_HUMAN | [view interactions] | High throughput | no | no |
| HOME2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDE1_HUMAN | [view interactions] | High throughput | no | yes |
| COMDA_HUMAN | [view interactions] | High throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| COMD5_HUMAN | [view interactions] | High throughput | no | no |
| CS044_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| PKN2_HUMAN | [view interactions] | High throughput | no | yes |
| PKN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GID4_HUMAN | [view interactions] | High throughput | no | yes |
| COMD1_HUMAN | [view interactions] | High throughput | no | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| KANL2_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC3_HUMAN | [view interactions] | High throughput | no | yes |
| CREB5_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TSSC4_HUMAN | [view interactions] | High throughput | no | yes |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFT81_HUMAN | [view interactions] | High throughput | no | yes |
| UACA_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSYL4_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAUS3_HUMAN | [view interactions] | High throughput | no | yes |
| PLD1_HUMAN | [view interactions] | High throughput | no | no |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMD7_HUMAN | [view interactions] | High throughput | no | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK9_HUMAN | [view interactions] | High throughput | no | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPH_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| DEN10_HUMAN | [view interactions] | High throughput | no | no |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED30_HUMAN | [view interactions] | High throughput | no | no |
| ATF7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGPD8_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| ARC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| ZNHI2_HUMAN | [view interactions] | High throughput | no | no |
| GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| COG2_HUMAN | [view interactions] | High throughput | no | no |
| WDR26_HUMAN | [view interactions] | High throughput | no | yes |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BL1S2_HUMAN | [view interactions] | High throughput | no | yes |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR2_HUMAN | [view interactions] | High throughput | no | yes |
| MKLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAPP_HUMAN | [view interactions] | High throughput | no | yes |