KIF2C_HUMAN
Evidence for PS localization
Functions
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001290 | LIG_SxIP_EBH_1 | LIG | 93 | 104 | - |
| ELMI001290 | LIG_SxIP_EBH_1 | LIG | 93 | 104 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF2C_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.3333 | 4 | yes |
| GO:0000166 | nucleotide binding | 31.1111 | 4 | yes |
| GO:0015631 | tubulin binding | 31.1111 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.1111 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 31.1111 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.1111 | 4 | yes |
| GO:0008017 | microtubule binding | 28.8889 | 5 | yes |
| GO:0003723 | RNA binding | 26.6667 | 4 | no |
| GO:0005524 | ATP binding | 24.4444 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.4444 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 24.4444 | 5 | yes |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 15.5556 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.5556 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.5556 | 6 | yes |
| GO:0003677 | DNA binding | 13.3333 | 4 | yes |
| GO:0051010 | microtubule plus-end binding | 13.3333 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 11.1111 | 7 | yes |
| GO:0003690 | double-stranded DNA binding | 6.6667 | 5 | yes |
| GO:0043565 | sequence-specific DNA binding | 6.6667 | 5 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 6.6667 | 6 | yes |
| GO:0019237 | centromeric DNA binding | 4.4444 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF2C_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.8889 | 4 | no |
| GO:0006996 | organelle organization | 48.8889 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 44.4444 | 5 | yes |
| GO:0010646 | regulation of cell communication | 42.2222 | 4 | no |
| GO:0022607 | cellular component assembly | 42.2222 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.5556 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.1111 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 31.1111 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.1111 | 5 | no |
| GO:0036211 | protein modification process | 28.8889 | 4 | no |
| GO:0043412 | macromolecule modification | 28.8889 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.8889 | 5 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.6667 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.6667 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.6667 | 6 | no |
| GO:0043933 | protein-containing complex organization | 26.6667 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 26.6667 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0030030 | cell projection organization | 24.4444 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.4444 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.4444 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.4444 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.4444 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.4444 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.4444 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0051049 | regulation of transport | 22.2222 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 22.2222 | 5 | yes |
| GO:0022411 | cellular component disassembly | 20.0000 | 4 | yes |
| GO:0031109 | microtubule polymerization or depolymerization | 15.5556 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 11.1111 | 5 | yes |
| GO:0051261 | protein depolymerization | 11.1111 | 6 | yes |
| GO:0051303 | establishment of chromosome localization | 11.1111 | 4 | yes |
| GO:0051983 | regulation of chromosome segregation | 11.1111 | 6 | yes |
| GO:0007019 | microtubule depolymerization | 8.8889 | 5 | yes |
| GO:0051310 | metaphase chromosome alignment | 8.8889 | 5 | yes |
| GO:0007080 | mitotic metaphase chromosome alignment | 6.6667 | 4 | yes |
| GO:0051315 | attachment of mitotic spindle microtubules to kinetochore | 6.6667 | 4 | yes |
| GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity | 4.4444 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AURKB_HUMAN | [view interactions] | Low throughput | no | yes |
| KPYM_HUMAN | [view interactions] | Low throughput | no | yes |
| CENPH_HUMAN | [view interactions] | Low throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTUS2_HUMAN | [view interactions] | Low throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SGO2_HUMAN | [view interactions] | Low throughput | no | no |
| KIF2C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APC4_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| UTP11_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| HORM2_HUMAN | [view interactions] | High throughput | no | no |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| RBMX2_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| RRP36_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| PR38B_HUMAN | [view interactions] | High throughput | no | no |
| DDHD1_HUMAN | [view interactions] | High throughput | no | no |
| RMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| ANKS3_HUMAN | [view interactions] | High throughput | no | yes |
| VATL_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| FBX5_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| SEMG2_HUMAN | [view interactions] | High throughput | no | no |
| SEMG1_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S6A15_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| RCBT2_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ETAA1_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| RNZ2_HUMAN | [view interactions] | High throughput | no | yes |
| MTREX_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| B3GLT_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| POP1_HUMAN | [view interactions] | High throughput | no | no |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| SMS2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPB_HUMAN | [view interactions] | High throughput | no | yes |
| ADAM9_HUMAN | [view interactions] | High throughput | no | no |
| RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBD1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| WDR62_HUMAN | [view interactions] | High throughput | no | no |
| WDR18_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCGF5_HUMAN | [view interactions] | High throughput | no | yes |
| RM52_HUMAN | [view interactions] | High throughput | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| ZN668_HUMAN | [view interactions] | High throughput | no | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | no |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| ZN273_HUMAN | [view interactions] | High throughput | no | no |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| EXT1_HUMAN | [view interactions] | High throughput | no | yes |
| B3A2_HUMAN | [view interactions] | High throughput | no | yes |
| K2C79_HUMAN | [view interactions] | High throughput | no | no |
| GRHL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN287_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN566_HUMAN | [view interactions] | High throughput | no | no |
| SUH_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI18B_HUMAN | [view interactions] | High throughput | no | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FADD_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC3_HUMAN | [view interactions] | High throughput | no | yes |
| NUSAP_HUMAN | [view interactions] | High throughput | no | no |
| ESS2_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF1_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD7_HUMAN | [view interactions] | High throughput | no | no |
| TEX10_HUMAN | [view interactions] | High throughput | no | no |
| NPIB3_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| PPN_HUMAN | [view interactions] | High throughput | no | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| KLH40_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |