Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NDEL1_HUMAN

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NDEL1_HUMAN
GO:0043168 anion binding 26.8657 4 no
GO:0000166 nucleotide binding 23.8806 4 no
GO:0017076 purine nucleotide binding 23.8806 5 no
GO:0032555 purine ribonucleotide binding 23.8806 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8806 4 no
GO:0019900 kinase binding 20.8955 4 no
GO:0015631 tubulin binding 19.4030 4 yes
GO:0008017 microtubule binding 16.4179 5 yes
GO:0043014 alpha-tubulin binding 2.9851 5 yes
GO:0048487 beta-tubulin binding 2.9851 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NDEL1_HUMAN
GO:0048522 positive regulation of cellular process 49.2537 4 yes
GO:0051128 regulation of cellular component organization 47.7612 4 yes
GO:0048523 negative regulation of cellular process 47.7612 4 no
GO:0006996 organelle organization 44.7761 4 yes
GO:0060255 regulation of macromolecule metabolic process 41.7910 4 no
GO:0008104 protein localization 41.7910 4 no
GO:0031323 regulation of cellular metabolic process 40.2985 4 no
GO:0051049 regulation of transport 35.8209 4 yes
GO:0010646 regulation of cell communication 35.8209 4 no
GO:0080090 regulation of primary metabolic process 34.3284 4 no
GO:0007010 cytoskeleton organization 32.8358 5 yes
GO:0030030 cell projection organization 32.8358 4 yes
GO:0060341 regulation of cellular localization 31.3433 4 yes
GO:0009889 regulation of biosynthetic process 31.3433 4 no
GO:0010556 regulation of macromolecule biosynthetic process 29.8507 5 no
GO:0031326 regulation of cellular biosynthetic process 29.8507 5 no
GO:0022607 cellular component assembly 29.8507 4 no
GO:0010468 regulation of gene expression 28.3582 6 no
GO:0032880 regulation of protein localization 26.8657 5 yes
GO:0009892 negative regulation of metabolic process 26.8657 4 no
GO:0009893 positive regulation of metabolic process 26.8657 4 no
GO:0051246 regulation of protein metabolic process 26.8657 5 no
GO:0044087 regulation of cellular component biogenesis 25.3731 4 yes
GO:0051130 positive regulation of cellular component organization 25.3731 5 yes
GO:0033043 regulation of organelle organization 25.3731 5 no
GO:0010604 positive regulation of macromolecule metabolic process 23.8806 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8806 5 no
GO:0031324 negative regulation of cellular metabolic process 23.8806 5 no
GO:0009966 regulation of signal transduction 23.8806 4 no
GO:0031325 positive regulation of cellular metabolic process 22.3881 5 no
GO:0120036 plasma membrane bounded cell projection organization 22.3881 5 no
GO:0015031 protein transport 20.8955 4 no
GO:0031399 regulation of protein modification process 20.8955 6 no
GO:0071702 organic substance transport 20.8955 4 no
GO:0071705 nitrogen compound transport 20.8955 4 no
GO:0051050 positive regulation of transport 20.8955 4 no
GO:0071310 cellular response to organic substance 20.8955 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 19.4030 4 yes
GO:0031344 regulation of cell projection organization 19.4030 5 yes
GO:0048812 neuron projection morphogenesis 19.4030 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.4030 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 19.4030 4 yes
GO:0070201 regulation of establishment of protein localization 17.9104 6 yes
GO:0010970 transport along microtubule 16.4179 4 yes
GO:0099111 microtubule-based transport 16.4179 4 yes
GO:0032386 regulation of intracellular transport 14.9254 5 yes
GO:0044089 positive regulation of cellular component biogenesis 14.9254 5 yes
GO:0051223 regulation of protein transport 14.9254 5 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 14.9254 4 yes
GO:0007409 axonogenesis 13.4328 6 yes
GO:0010975 regulation of neuron projection development 13.4328 7 yes
GO:0051650 establishment of vesicle localization 13.4328 4 yes
GO:0031346 positive regulation of cell projection organization 11.9403 6 yes
GO:0072384 organelle transport along microtubule 11.9403 4 yes
GO:0001764 neuron migration 10.4478 4 yes
GO:0008088 axo-dendritic transport 10.4478 5 yes
GO:0033157 regulation of intracellular protein transport 10.4478 6 yes
GO:0060491 regulation of cell projection assembly 10.4478 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 10.4478 6 yes
GO:0008090 retrograde axonal transport 8.9552 7 yes
GO:0051293 establishment of spindle localization 8.9552 4 yes
GO:0051336 regulation of hydrolase activity 8.9552 4 yes
GO:0098930 axonal transport 8.9552 6 yes
GO:0099518 vesicle cytoskeletal trafficking 8.9552 5 yes
GO:0000132 establishment of mitotic spindle orientation 7.4627 6 yes
GO:0007020 microtubule nucleation 7.4627 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 7.4627 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 7.4627 5 yes
GO:0040001 establishment of mitotic spindle localization 7.4627 5 yes
GO:0043085 positive regulation of catalytic activity 7.4627 4 yes
GO:0047496 vesicle transport along microtubule 7.4627 5 yes
GO:0051294 establishment of spindle orientation 7.4627 5 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7.4627 6 yes
GO:0021795 cerebral cortex cell migration 5.9701 6 yes
GO:0021799 cerebral cortex radially oriented cell migration 5.9701 7 yes
GO:0021885 forebrain cell migration 5.9701 4 yes
GO:0022029 telencephalon cell migration 5.9701 5 yes
GO:0043087 regulation of GTPase activity 5.9701 5 yes
GO:0051303 establishment of chromosome localization 5.9701 4 yes
GO:0051345 positive regulation of hydrolase activity 5.9701 5 yes
GO:0060052 neurofilament cytoskeleton organization 5.9701 4 yes
GO:0140650 radial glia-guided pyramidal neuron migration 5.9701 5 yes
GO:1900027 regulation of ruffle assembly 5.9701 7 yes
GO:1990138 neuron projection extension 5.9701 4 yes
GO:0008286 insulin receptor signaling pathway 4.4776 6 yes
GO:0021955 central nervous system neuron axonogenesis 4.4776 7 yes
GO:0043547 positive regulation of GTPase activity 4.4776 6 yes
GO:1900029 positive regulation of ruffle assembly 4.4776 7 yes
GO:0007100 mitotic centrosome separation 2.9851 4 yes
GO:0032418 lysosome localization 2.9851 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CENPF_HUMAN [view interactions] Low throughput no no
MIC60_HUMAN [view entry] [view interactions] Low throughput yes yes
ZN365_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
VINC_HUMAN [view entry] [view interactions] Low throughput yes no
NDE1_HUMAN [view interactions] Low throughput no yes
DC1I1_HUMAN [view entry] [view interactions] Low throughput yes yes
TACC3_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
ANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
BUB1_HUMAN [view interactions] Low throughput no no
KTNA1_HUMAN [view interactions] Low throughput no yes
KTNB1_HUMAN [view interactions] Low throughput no yes
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
LMNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
TBG1_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
NFH_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG01_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBB1_HUMAN [view interactions] Low throughput no yes
TARA_HUMAN [view interactions] Low throughput no yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
MS18A_HUMAN [view interactions] High throughput no yes
DIXC1_HUMAN [view entry] [view interactions] High throughput yes no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
CCSE2_HUMAN [view interactions] High throughput no yes
GRDN_HUMAN [view interactions] High throughput no no
LC7L2_HUMAN [view interactions] High throughput no yes
CCSE1_HUMAN [view interactions] High throughput no no
AF10_HUMAN [view interactions] High throughput no no
MRC2_HUMAN [view interactions] High throughput no yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
ZNF10_HUMAN [view interactions] High throughput no no
ZNF17_HUMAN [view interactions] High throughput no no
ZN197_HUMAN [view interactions] High throughput no no
ZN211_HUMAN [view interactions] High throughput no yes
ZN230_HUMAN [view interactions] High throughput no no
ZNF91_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
CTR9_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
PGM2L_HUMAN [view entry] [view interactions] High throughput yes yes
S12A9_HUMAN [view interactions] High throughput no yes
S43A3_HUMAN [view interactions] High throughput no yes
PCGF6_HUMAN [view interactions] High throughput no no
C1QT6_HUMAN [view interactions] High throughput no no
FAKD5_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
GGYF1_HUMAN [view interactions] High throughput no yes
CHD8_HUMAN [view interactions] High throughput no no
C19L2_HUMAN [view interactions] High throughput no yes
DTNB_HUMAN [view entry] [view interactions] High throughput yes no
UBP2_HUMAN [view interactions] High throughput no yes
XPA_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ZN844_HUMAN [view interactions] High throughput no no
AIMP2_HUMAN [view interactions] High throughput no yes
ZN260_HUMAN [view interactions] High throughput no yes
ZN544_HUMAN [view interactions] High throughput no yes
ZN572_HUMAN [view interactions] High throughput no yes
ZN417_HUMAN [view interactions] High throughput no yes
ZN599_HUMAN [view interactions] High throughput no no
PKP2_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
SNPC5_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS2_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
KIFC3_HUMAN [view interactions] High throughput no no
ZN180_HUMAN [view interactions] High throughput no no
ZN490_HUMAN [view interactions] High throughput no no
T3JAM_HUMAN [view interactions] High throughput no no
GO45_HUMAN [view interactions] High throughput no yes
DDT4L_HUMAN [view interactions] High throughput no no
ZNF57_HUMAN [view interactions] High throughput no no
CLVS2_HUMAN [view interactions] High throughput no no
BRK1_HUMAN [view interactions] High throughput no no
ZNF35_HUMAN [view interactions] High throughput no no
BORC6_HUMAN [view interactions] High throughput no yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
ZNF12_HUMAN [view interactions] High throughput no no
PARVG_HUMAN [view interactions] High throughput no yes
ZNF3_HUMAN [view interactions] High throughput no yes
ZN707_HUMAN [view interactions] High throughput no yes
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
MED11_HUMAN [view interactions] High throughput no no
CCHCR_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
UBQL1_HUMAN [view interactions] High throughput no yes
MBIP1_HUMAN [view interactions] High throughput no yes
MAGAB_HUMAN [view interactions] High throughput no no
STAG1_HUMAN [view interactions] High throughput no yes
ZN234_HUMAN [view interactions] High throughput no yes
ZN460_HUMAN [view interactions] High throughput no no
ZN548_HUMAN [view interactions] High throughput no yes
ZFP1_HUMAN [view interactions] High throughput no no
SMG1_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
VPS39_HUMAN [view entry] [view interactions] High throughput yes no
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
FRIL_HUMAN [view interactions] High throughput no yes
ZN285_HUMAN [view interactions] High throughput no yes
BL1S2_HUMAN [view interactions] High throughput no yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ZN445_HUMAN [view interactions] High throughput no no
ZN662_HUMAN [view interactions] High throughput no no
CD050_HUMAN [view interactions] High throughput no no
NUP54_HUMAN [view interactions] High throughput no yes
PSMD7_HUMAN [view interactions] High throughput no yes
ODF2L_HUMAN [view interactions] High throughput no yes
ZN624_HUMAN [view interactions] High throughput no yes
PDZD4_HUMAN [view interactions] High throughput no yes
RBAK_HUMAN [view interactions] High throughput no no
MICA1_HUMAN [view interactions] High throughput no yes
ZFP62_HUMAN [view interactions] High throughput no no
ZN175_HUMAN [view interactions] High throughput no no
ZN229_HUMAN [view interactions] High throughput no no
ZN112_HUMAN [view interactions] High throughput no no
ZN223_HUMAN [view interactions] High throughput no yes
CAAP1_HUMAN [view interactions] High throughput no yes
NU214_HUMAN [view interactions] High throughput no no
CEP63_HUMAN [view interactions] High throughput no yes
ZN607_HUMAN [view interactions] High throughput no no
ZN835_HUMAN [view interactions] High throughput no no
ZN439_HUMAN [view interactions] High throughput no no
ZN461_HUMAN [view interactions] High throughput no no
ZN254_HUMAN [view interactions] High throughput no no
ZN670_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
ZN432_HUMAN [view interactions] High throughput no no
CE170_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
DRC5_HUMAN [view interactions] High throughput no no
ADIP_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
PA1B2_HUMAN [view interactions] High throughput no yes
ZN264_HUMAN [view interactions] High throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
RBM14_HUMAN [view interactions] High throughput no yes
KIF19_HUMAN [view interactions] High throughput no yes
KLC4_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
RBM10_HUMAN [view interactions] High throughput no yes
SLAI1_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
CEP55_HUMAN [view interactions] High throughput no yes
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
RBM5_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
PAR6G_HUMAN [view interactions] High throughput no no
KIF2C_HUMAN [view entry] [view interactions] High throughput yes no
ZC21C_HUMAN [view interactions] High throughput no yes
ZN250_HUMAN [view interactions] High throughput no yes
H2AW_HUMAN [view interactions] High throughput no yes
SFSWA_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
CPEB2_HUMAN [view entry] [view interactions] High throughput yes no
ESS2_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
KRR1_HUMAN [view interactions] High throughput no yes
CC183_HUMAN [view interactions] High throughput no no
SNP29_HUMAN [view interactions] High throughput no yes
SCAR3_HUMAN [view interactions] High throughput no yes
NP1L5_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
VEZF1_HUMAN [view interactions] High throughput no yes
TRI29_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
LNX2_HUMAN [view interactions] High throughput no yes
PTN14_HUMAN [view interactions] High throughput no yes
KI20B_HUMAN [view entry] [view interactions] High throughput yes yes
GRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANR26_HUMAN [view interactions] High throughput no yes
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW5_HUMAN [view interactions] High throughput no no
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
MTCL1_HUMAN [view interactions] High throughput no yes
CLPX_HUMAN [view interactions] High throughput no yes
CCD18_HUMAN [view interactions] High throughput no yes
S2543_HUMAN [view interactions] High throughput no no
SHOT1_HUMAN [view interactions] High throughput no no
SPF27_HUMAN [view interactions] High throughput no yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
OFD1_HUMAN [view interactions] High throughput no yes
TRIM7_HUMAN [view interactions] High throughput no yes
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
EVI5_HUMAN [view interactions] High throughput no yes
PRP19_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
PKHM1_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
PTX3_HUMAN [view interactions] High throughput no no
NPTX2_HUMAN [view entry] [view interactions] High throughput yes yes
AP4E1_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
GATA4_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
FMC1_HUMAN [view interactions] High throughput no no
NUP85_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no