KIF5A_HUMAN
Evidence for PS localization
Functions
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 256 | Asn | Ser | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 280 | Arg | Cys | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 361 | Ala | Val | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 276 | Tyr | Cys | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 253 | Lys | Asn | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 63 | Tyr | Cys | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 198 | Met | Thr | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 204 | Arg | Gln | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 251 | Glu | Lys | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 257 | Lys | Asn | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 280 | Arg | His | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 280 | Arg | Leu | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 203 | Ser | Cys | Spasticparaplegia10,autosomaldominant(SPG10) | - |
| 1007 | Arg | Gly | Amyotrophiclateralsclerosis25(ALS25) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF5A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 24.1379 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 24.1379 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.4138 | 4 | yes |
| GO:0015631 | tubulin binding | 18.9655 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 18.9655 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 18.9655 | 5 | yes |
| GO:0005524 | ATP binding | 17.2414 | 5 | yes |
| GO:0008017 | microtubule binding | 17.2414 | 5 | yes |
| GO:0019894 | kinesin binding | 15.5172 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 12.0690 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 12.0690 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 12.0690 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 6.8966 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF5A_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 48.2759 | 4 | no |
| GO:0006996 | organelle organization | 44.8276 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.1034 | 4 | no |
| GO:0008104 | protein localization | 41.3793 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.6552 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.2069 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.2069 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.4828 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.4828 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.4828 | 4 | no |
| GO:0030030 | cell projection organization | 32.7586 | 4 | yes |
| GO:0071702 | organic substance transport | 32.7586 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 32.7586 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 31.0345 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 31.0345 | 4 | no |
| GO:0051049 | regulation of transport | 29.3103 | 4 | no |
| GO:0022607 | cellular component assembly | 29.3103 | 4 | no |
| GO:0015031 | protein transport | 27.5862 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.5862 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.8621 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.8621 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.8621 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.8621 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.1379 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.1379 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.1379 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.4138 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.4138 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.4138 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.4138 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.4138 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.4138 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.4138 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.4138 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.6897 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.6897 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6897 | 6 | no |
| GO:0006886 | intracellular protein transport | 20.6897 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 18.9655 | 4 | yes |
| GO:0031175 | neuron projection development | 18.9655 | 6 | yes |
| GO:0051650 | establishment of vesicle localization | 18.9655 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 17.2414 | 6 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 17.2414 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 17.2414 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 17.2414 | 4 | yes |
| GO:0010970 | transport along microtubule | 15.5172 | 4 | yes |
| GO:0099111 | microtubule-based transport | 15.5172 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 13.7931 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 13.7931 | 4 | yes |
| GO:0098930 | axonal transport | 13.7931 | 6 | yes |
| GO:0008089 | anterograde axonal transport | 12.0690 | 7 | yes |
| GO:0047496 | vesicle transport along microtubule | 12.0690 | 5 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 12.0690 | 5 | yes |
| GO:0008090 | retrograde axonal transport | 10.3448 | 7 | yes |
| GO:0035418 | protein localization to synapse | 10.3448 | 6 | yes |
| GO:0048489 | synaptic vesicle transport | 10.3448 | 4 | yes |
| GO:0097479 | synaptic vesicle localization | 10.3448 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 10.3448 | 5 | yes |
| GO:0007411 | axon guidance | 6.8966 | 8 | yes |
| GO:0016482 | cytosolic transport | 6.8966 | 4 | yes |
| GO:0097485 | neuron projection guidance | 6.8966 | 7 | yes |
| GO:0098840 | protein transport along microtubule | 6.8966 | 4 | yes |
| GO:0098935 | dendritic transport | 6.8966 | 6 | yes |
| GO:0098937 | anterograde dendritic transport | 6.8966 | 7 | yes |
| GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex | 6.8966 | 4 | yes |
| GO:0099640 | axo-dendritic protein transport | 6.8966 | 5 | yes |
| GO:0099641 | anterograde axonal protein transport | 6.8966 | 6 | yes |
| GO:1905383 | protein localization to presynapse | 6.8966 | 7 | yes |
| GO:0032252 | secretory granule localization | 5.1724 | 4 | yes |
| GO:0032253 | dense core granule localization | 5.1724 | 5 | yes |
| GO:0099519 | dense core granule cytoskeletal transport | 5.1724 | 6 | yes |
| GO:1901950 | dense core granule transport | 5.1724 | 5 | yes |
| GO:1990049 | retrograde neuronal dense core vesicle transport | 5.1724 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KIF5A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 8.6207 | 3 | yes |
| DOID:0110763 | hereditary spastic paraplegia 10 | 3.4483 | 6 | yes |
| DOID:2476 | hereditary spastic paraplegia | 3.4483 | 5 | yes |
| DOID:607 | paraplegia | 3.4483 | 4 | yes |
| DOID:936 | brain disease | 3.4483 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
| DTNB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | Low throughput | no | yes |
| ANR27_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAK2_HUMAN | [view interactions] | Low throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| VP26B_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| RXRB_HUMAN | [view interactions] | High throughput | no | yes |
| PHS_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| SALL4_HUMAN | [view interactions] | High throughput | no | no |
| TF2L1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE4_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCL_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| N62CL_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEBPG_HUMAN | [view interactions] | High throughput | no | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NFH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| INS_HUMAN | [view interactions] | Computational | no | no |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |