GLRA1_HUMAN
Evidence for PS localization
Functions
Glycine receptors are ligand-gated chloride channels (PubMed, PubMed). Channel opening is triggered by extracellular glycine (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Channel opening is also triggered by taurine and beta-alanine (PubMed, PubMed). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed). Plays an important role in the down-regulation of neuronal excitability (PubMed, PubMed). Contributes to the generation of inhibitory postsynaptic currents (PubMed). Channel activity is potentiated by ethanol (PubMed). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 272 | Ile | Asn | Hyperekplexia1(HKPX1) | - |
| 294 | Gln | His | Hyperekplexia1(HKPX1) | - |
| 299 | Arg | Leu | Hyperekplexia1(HKPX1) | - |
| 299 | Arg | Gln | Hyperekplexia1(HKPX1) | - |
| 304 | Lys | Glu | Hyperekplexia1(HKPX1) | - |
| 307 | Tyr | Cys | Hyperekplexia1(HKPX1) | - |
| 278 | Pro | Thr | Hyperekplexia1(HKPX1) | - |
| 280 | Arg | His | Hyperekplexia1(HKPX1) | - |
| 428 | Arg | His | Hyperekplexia1(HKPX1) | - |
| 93 | Arg | Trp | Hyperekplexia1(HKPX1) | - |
| 100 | Arg | Cys | Hyperekplexia1(HKPX1) | - |
| 246 | Arg | Trp | Hyperekplexia1(HKPX1) | - |
| 254 | Gln | Glu | Hyperekplexia1(HKPX1) | - |
| 258 | Pro | Ser | Hyperekplexia1(HKPX1) | - |
| 308 | Val | Met | Hyperekplexia1(HKPX1) | - |
| 319 | Leu | Pro | Hyperekplexia1(HKPX1) | - |
| 424 | Asp | Ala | Hyperekplexia1(HKPX1) | - |
| 450 | Arg | His | Hyperekplexia1(HKPX1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GLRA1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 100.0000 | 4 | yes |
| GO:0043169 | cation binding | 80.0000 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 60.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 60.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 60.0000 | 7 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated monoatomic ion channel activity | 60.0000 | 7 | yes |
| GO:0005253 | monoatomic anion channel activity | 60.0000 | 5 | yes |
| GO:0005254 | chloride channel activity | 60.0000 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 60.0000 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 60.0000 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 60.0000 | 5 | yes |
| GO:0015267 | channel activity | 60.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 60.0000 | 5 | yes |
| GO:0016933 | extracellularly glycine-gated ion channel activity | 60.0000 | 8 | yes |
| GO:0016934 | extracellularly glycine-gated chloride channel activity | 60.0000 | 7 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 60.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 60.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 60.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 60.0000 | 5 | yes |
| GO:0031406 | carboxylic acid binding | 60.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 60.0000 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 60.0000 | 4 | yes |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 60.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 60.0000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 60.0000 | 6 | yes |
| GO:0008270 | zinc ion binding | 40.0000 | 7 | yes |
| GO:0030977 | taurine binding | 40.0000 | 4 | yes |
| GO:0046914 | transition metal ion binding | 40.0000 | 6 | yes |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 40.0000 | 6 | yes |
| GO:0000166 | nucleotide binding | 40.0000 | 4 | no |
| GO:0005524 | ATP binding | 40.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 40.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 40.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GLRA1_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 80.0000 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 80.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 80.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 80.0000 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 60.0000 | 4 | yes |
| GO:0006820 | monoatomic anion transport | 60.0000 | 5 | yes |
| GO:0006821 | chloride transport | 60.0000 | 5 | yes |
| GO:0007218 | neuropeptide signaling pathway | 60.0000 | 4 | yes |
| GO:0007600 | sensory perception | 60.0000 | 4 | yes |
| GO:0007601 | visual perception | 60.0000 | 6 | yes |
| GO:0007628 | adult walking behavior | 60.0000 | 5 | yes |
| GO:0008344 | adult locomotory behavior | 60.0000 | 4 | yes |
| GO:0010038 | response to metal ion | 60.0000 | 4 | yes |
| GO:0015698 | inorganic anion transport | 60.0000 | 4 | yes |
| GO:0050905 | neuromuscular process | 60.0000 | 4 | yes |
| GO:0050953 | sensory perception of light stimulus | 60.0000 | 5 | yes |
| GO:0060012 | synaptic transmission, glycinergic | 60.0000 | 8 | yes |
| GO:0060013 | righting reflex | 60.0000 | 4 | yes |
| GO:0090659 | walking behavior | 60.0000 | 4 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 60.0000 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 60.0000 | 4 | yes |
| GO:1902476 | chloride transmembrane transport | 60.0000 | 5 | yes |
| GO:0008104 | protein localization | 60.0000 | 4 | no |
| GO:0001508 | action potential | 40.0000 | 4 | yes |
| GO:0002087 | regulation of respiratory gaseous exchange by nervous system process | 40.0000 | 4 | yes |
| GO:0006936 | muscle contraction | 40.0000 | 4 | yes |
| GO:0010043 | response to zinc ion | 40.0000 | 5 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | yes |
| GO:0019228 | neuronal action potential | 40.0000 | 5 | yes |
| GO:0031644 | regulation of nervous system process | 40.0000 | 5 | yes |
| GO:0031645 | negative regulation of nervous system process | 40.0000 | 5 | yes |
| GO:0043200 | response to amino acid | 40.0000 | 4 | yes |
| GO:0043576 | regulation of respiratory gaseous exchange | 40.0000 | 4 | yes |
| GO:0044057 | regulation of system process | 40.0000 | 4 | yes |
| GO:0044065 | regulation of respiratory system process | 40.0000 | 5 | yes |
| GO:0045471 | response to ethanol | 40.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:0050884 | neuromuscular process controlling posture | 40.0000 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 40.0000 | 4 | yes |
| GO:0051969 | regulation of transmission of nerve impulse | 40.0000 | 5 | yes |
| GO:0051970 | negative regulation of transmission of nerve impulse | 40.0000 | 6 | yes |
| GO:0060046 | regulation of acrosome reaction | 40.0000 | 4 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 40.0000 | 4 | yes |
| GO:0060080 | inhibitory postsynaptic potential | 40.0000 | 5 | yes |
| GO:0071229 | cellular response to acid chemical | 40.0000 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 40.0000 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 40.0000 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 40.0000 | 5 | yes |
| GO:0071294 | cellular response to zinc ion | 40.0000 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | yes |
| GO:0071361 | cellular response to ethanol | 40.0000 | 6 | yes |
| GO:0097305 | response to alcohol | 40.0000 | 4 | yes |
| GO:0097306 | cellular response to alcohol | 40.0000 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 40.0000 | 4 | yes |
| GO:2000243 | positive regulation of reproductive process | 40.0000 | 4 | yes |
| GO:2000344 | positive regulation of acrosome reaction | 40.0000 | 5 | yes |
| GO:0043113 | receptor clustering | 40.0000 | 5 | no |
| GO:0072578 | neurotransmitter-gated ion channel clustering | 40.0000 | 6 | no |
| GO:0072657 | protein localization to membrane | 40.0000 | 4 | no |
| GO:0097112 | gamma-aminobutyric acid receptor clustering | 40.0000 | 7 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |