GLRA1_HUMAN
Glycine receptors are ligand-gated chloride channels (PubMed, PubMed). Channel opening is triggered by extracellular glycine (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Channel opening is also triggered by taurine and beta-alanine (PubMed, PubMed). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed). Plays an important role in the down-regulation of neuronal excitability (PubMed, PubMed). Contributes to the generation of inhibitory postsynaptic currents (PubMed). Channel activity is potentiated by ethanol (PubMed). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
272 | Ile | Asn | Hyperekplexia1(HKPX1) | - |
294 | Gln | His | Hyperekplexia1(HKPX1) | - |
299 | Arg | Leu | Hyperekplexia1(HKPX1) | - |
299 | Arg | Gln | Hyperekplexia1(HKPX1) | - |
304 | Lys | Glu | Hyperekplexia1(HKPX1) | - |
307 | Tyr | Cys | Hyperekplexia1(HKPX1) | - |
278 | Pro | Thr | Hyperekplexia1(HKPX1) | - |
280 | Arg | His | Hyperekplexia1(HKPX1) | - |
428 | Arg | His | Hyperekplexia1(HKPX1) | - |
93 | Arg | Trp | Hyperekplexia1(HKPX1) | - |
100 | Arg | Cys | Hyperekplexia1(HKPX1) | - |
246 | Arg | Trp | Hyperekplexia1(HKPX1) | - |
254 | Gln | Glu | Hyperekplexia1(HKPX1) | - |
258 | Pro | Ser | Hyperekplexia1(HKPX1) | - |
308 | Val | Met | Hyperekplexia1(HKPX1) | - |
319 | Leu | Pro | Hyperekplexia1(HKPX1) | - |
424 | Asp | Ala | Hyperekplexia1(HKPX1) | - |
450 | Arg | His | Hyperekplexia1(HKPX1) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GLRA1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 75.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
GO:0005216 | ion channel activity | 50.0000 | 4 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 50.0000 | 6 | yes |
GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 50.0000 | 7 | yes |
GO:0005237 | inhibitory extracellular ligand-gated ion channel activity | 50.0000 | 7 | yes |
GO:0005253 | anion channel activity | 50.0000 | 5 | yes |
GO:0005254 | chloride channel activity | 50.0000 | 6 | yes |
GO:0008270 | zinc ion binding | 50.0000 | 6 | yes |
GO:0008509 | anion transmembrane transporter activity | 50.0000 | 4 | yes |
GO:0015103 | inorganic anion transmembrane transporter activity | 50.0000 | 4 | yes |
GO:0015108 | chloride transmembrane transporter activity | 50.0000 | 5 | yes |
GO:0015267 | channel activity | 50.0000 | 4 | yes |
GO:0015276 | ligand-gated ion channel activity | 50.0000 | 5 | yes |
GO:0016594 | glycine binding | 50.0000 | 4 | yes |
GO:0016597 | amino acid binding | 50.0000 | 4 | yes |
GO:0016933 | extracellularly glycine-gated ion channel activity | 50.0000 | 8 | yes |
GO:0016934 | extracellularly glycine-gated chloride channel activity | 50.0000 | 7 | yes |
GO:0022824 | transmitter-gated ion channel activity | 50.0000 | 5 | yes |
GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
GO:0031406 | carboxylic acid binding | 50.0000 | 4 | yes |
GO:0043210 | alkanesulfonate binding | 50.0000 | 4 | yes |
GO:0046914 | transition metal ion binding | 50.0000 | 5 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
GO:0099095 | ligand-gated anion channel activity | 50.0000 | 6 | yes |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
GO:0005524 | ATP binding | 50.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 50.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 50.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 50.0000 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GLRA1_HUMAN |
---|---|---|---|---|
GO:0007268 | chemical synaptic transmission | 75.0000 | 6 | yes |
GO:0010038 | response to metal ion | 75.0000 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 75.0000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 75.0000 | 4 | yes |
GO:0001508 | action potential | 50.0000 | 4 | yes |
GO:0002087 | regulation of respiratory gaseous exchange by nervous system process | 50.0000 | 4 | yes |
GO:0006811 | ion transport | 50.0000 | 4 | yes |
GO:0006820 | anion transport | 50.0000 | 5 | yes |
GO:0006821 | chloride transport | 50.0000 | 7 | yes |
GO:0006936 | muscle contraction | 50.0000 | 4 | yes |
GO:0007218 | neuropeptide signaling pathway | 50.0000 | 4 | yes |
GO:0007600 | sensory perception | 50.0000 | 4 | yes |
GO:0007601 | visual perception | 50.0000 | 6 | yes |
GO:0007628 | adult walking behavior | 50.0000 | 5 | yes |
GO:0008344 | adult locomotory behavior | 50.0000 | 4 | yes |
GO:0010043 | response to zinc ion | 50.0000 | 5 | yes |
GO:0010243 | response to organonitrogen compound | 50.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
GO:0010648 | negative regulation of cell communication | 50.0000 | 5 | yes |
GO:0015698 | inorganic anion transport | 50.0000 | 6 | yes |
GO:0023057 | negative regulation of signaling | 50.0000 | 4 | yes |
GO:0031644 | regulation of nervous system process | 50.0000 | 5 | yes |
GO:0031645 | negative regulation of nervous system process | 50.0000 | 5 | yes |
GO:0043200 | response to amino acid | 50.0000 | 4 | yes |
GO:0043576 | regulation of respiratory gaseous exchange | 50.0000 | 4 | yes |
GO:0044057 | regulation of system process | 50.0000 | 4 | yes |
GO:0044065 | regulation of respiratory system process | 50.0000 | 5 | yes |
GO:0045471 | response to ethanol | 50.0000 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
GO:0050884 | neuromuscular process controlling posture | 50.0000 | 5 | yes |
GO:0050905 | neuromuscular process | 50.0000 | 4 | yes |
GO:0050953 | sensory perception of light stimulus | 50.0000 | 5 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 50.0000 | 4 | yes |
GO:0051969 | regulation of transmission of nerve impulse | 50.0000 | 4 | yes |
GO:0051970 | negative regulation of transmission of nerve impulse | 50.0000 | 5 | yes |
GO:0060012 | synaptic transmission, glycinergic | 50.0000 | 7 | yes |
GO:0060013 | righting reflex | 50.0000 | 4 | yes |
GO:0060046 | regulation of acrosome reaction | 50.0000 | 4 | yes |
GO:0060078 | regulation of postsynaptic membrane potential | 50.0000 | 4 | yes |
GO:0060080 | inhibitory postsynaptic potential | 50.0000 | 5 | yes |
GO:0071229 | cellular response to acid chemical | 50.0000 | 4 | yes |
GO:0071230 | cellular response to amino acid stimulus | 50.0000 | 5 | yes |
GO:0071241 | cellular response to inorganic substance | 50.0000 | 4 | yes |
GO:0071248 | cellular response to metal ion | 50.0000 | 5 | yes |
GO:0071294 | cellular response to zinc ion | 50.0000 | 6 | yes |
GO:0071310 | cellular response to organic substance | 50.0000 | 4 | yes |
GO:0071361 | cellular response to ethanol | 50.0000 | 6 | yes |
GO:0071417 | cellular response to organonitrogen compound | 50.0000 | 4 | yes |
GO:0090659 | walking behavior | 50.0000 | 4 | yes |
GO:0097305 | response to alcohol | 50.0000 | 4 | yes |
GO:0097306 | cellular response to alcohol | 50.0000 | 5 | yes |
GO:0098656 | anion transmembrane transport | 50.0000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 50.0000 | 4 | yes |
GO:0098661 | inorganic anion transmembrane transport | 50.0000 | 5 | yes |
GO:1901699 | cellular response to nitrogen compound | 50.0000 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 50.0000 | 4 | yes |
GO:1902476 | chloride transmembrane transport | 50.0000 | 6 | yes |
GO:2000243 | positive regulation of reproductive process | 50.0000 | 4 | yes |
GO:2000344 | positive regulation of acrosome reaction | 50.0000 | 5 | yes |
GO:0008104 | protein localization | 50.0000 | 4 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in GLRA1_HUMAN |
---|---|---|---|---|
DOID:0060695 | hyperekplexia | 50.0000 | 3 | yes |
DOID:0060696 | hyperekplexia 1 | 50.0000 | 4 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
MAGD1_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
SC6A5_HUMAN | [view interactions] | Computational | no | no |
GARS_HUMAN | [view interactions] | Computational | no | yes |