GLRB_HUMAN
Evidence for PS localization
Functions
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed). Plays an important role in the down-regulation of neuronal excitability (PubMed, PubMed). Contributes to the generation of inhibitory postsynaptic currents (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 251 | Gly | Asp | Hyperekplexia2(HKPX2) | - |
| 199 | Met | Arg | Hyperekplexia2(HKPX2) | - |
| 307 | Leu | Arg | Hyperekplexia2(HKPX2) | - |
| 332 | Trp | Cys | Hyperekplexia2(HKPX2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GLRB_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 45.4545 | 4 | yes |
| GO:0015267 | channel activity | 45.4545 | 4 | yes |
| GO:0022836 | gated channel activity | 45.4545 | 5 | yes |
| GO:0046872 | metal ion binding | 40.9091 | 4 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 36.3636 | 6 | yes |
| GO:0015276 | ligand-gated ion channel activity | 36.3636 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 36.3636 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 36.3636 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 36.3636 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 36.3636 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 36.3636 | 4 | no |
| GO:0008509 | anion transmembrane transporter activity | 27.2727 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 27.2727 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 27.2727 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 27.2727 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 27.2727 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 27.2727 | 6 | yes |
| GO:0005261 | cation channel activity | 27.2727 | 5 | no |
| GO:0017076 | purine nucleotide binding | 27.2727 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.2727 | 5 | no |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 22.7273 | 7 | yes |
| GO:0005253 | anion channel activity | 22.7273 | 5 | yes |
| GO:0005254 | chloride channel activity | 22.7273 | 6 | yes |
| GO:0099094 | ligand-gated cation channel activity | 22.7273 | 6 | no |
| GO:0005524 | ATP binding | 22.7273 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.7273 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | no |
| GO:0005237 | inhibitory extracellular ligand-gated ion channel activity | 13.6364 | 7 | yes |
| GO:0099095 | ligand-gated anion channel activity | 13.6364 | 6 | yes |
| GO:0016594 | glycine binding | 9.0909 | 4 | yes |
| GO:0016597 | amino acid binding | 9.0909 | 4 | yes |
| GO:0016933 | extracellularly glycine-gated ion channel activity | 9.0909 | 8 | yes |
| GO:0016934 | extracellularly glycine-gated chloride channel activity | 9.0909 | 7 | yes |
| GO:0031406 | carboxylic acid binding | 9.0909 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GLRB_HUMAN |
|---|---|---|---|---|
| GO:0006811 | ion transport | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0051049 | regulation of transport | 45.4545 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 36.3636 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 36.3636 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 36.3636 | 4 | yes |
| GO:0010646 | regulation of cell communication | 31.8182 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.8182 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 27.2727 | 4 | yes |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | no |
| GO:0051046 | regulation of secretion | 27.2727 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 27.2727 | 4 | no |
| GO:0006812 | cation transport | 27.2727 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.2727 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.2727 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 27.2727 | 4 | no |
| GO:0006820 | anion transport | 22.7273 | 5 | yes |
| GO:0006821 | chloride transport | 22.7273 | 7 | yes |
| GO:0015698 | inorganic anion transport | 22.7273 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.7273 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.7273 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.7273 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.7273 | 5 | no |
| GO:0036211 | protein modification process | 22.7273 | 4 | no |
| GO:0043412 | macromolecule modification | 22.7273 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.7273 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.7273 | 5 | no |
| GO:0030001 | metal ion transport | 22.7273 | 6 | no |
| GO:0043269 | regulation of ion transport | 22.7273 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.7273 | 4 | no |
| GO:0008104 | protein localization | 18.1818 | 4 | yes |
| GO:0098656 | anion transmembrane transport | 18.1818 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 18.1818 | 5 | yes |
| GO:1902476 | chloride transmembrane transport | 18.1818 | 6 | yes |
| GO:0007218 | neuropeptide signaling pathway | 9.0909 | 4 | yes |
| GO:0007399 | nervous system development | 9.0909 | 4 | yes |
| GO:0007600 | sensory perception | 9.0909 | 4 | yes |
| GO:0008344 | adult locomotory behavior | 9.0909 | 4 | yes |
| GO:0043113 | receptor clustering | 9.0909 | 5 | yes |
| GO:0043200 | response to amino acid | 9.0909 | 4 | yes |
| GO:0050905 | neuromuscular process | 9.0909 | 4 | yes |
| GO:0060012 | synaptic transmission, glycinergic | 9.0909 | 7 | yes |
| GO:0072578 | neurotransmitter-gated ion channel clustering | 9.0909 | 6 | yes |
| GO:0072657 | protein localization to membrane | 9.0909 | 4 | yes |
| GO:0097112 | gamma-aminobutyric acid receptor clustering | 9.0909 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BTNL8_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| NEMP1_HUMAN | [view interactions] | High throughput | no | no |
| GBRA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| NRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| SCN4A_HUMAN | [view interactions] | High throughput | no | no |
| GLRA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD3D_HUMAN | [view interactions] | High throughput | no | no |
| HFE_HUMAN | [view interactions] | High throughput | no | yes |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN16_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPM2_HUMAN | [view interactions] | High throughput | no | yes |
| MARH6_HUMAN | [view interactions] | High throughput | no | yes |
| RN133_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| OR4N2_HUMAN | [view interactions] | High throughput | no | no |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| GFRA3_HUMAN | [view interactions] | High throughput | no | yes |
| HEPS_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ANO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |