Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GLRB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed). Plays an important role in the down-regulation of neuronal excitability (PubMed, PubMed). Contributes to the generation of inhibitory postsynaptic currents (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
251 Gly Asp Hyperekplexia2(HKPX2) -
199 Met Arg Hyperekplexia2(HKPX2) -
307 Leu Arg Hyperekplexia2(HKPX2) -
332 Trp Cys Hyperekplexia2(HKPX2) -
477 Ala Pro Hyperekplexia2(HKPX2) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GLRB_HUMAN
GO:0043169 cation binding 57.1429 4 yes
GO:0005216 monoatomic ion channel activity 52.3810 4 yes
GO:0015267 channel activity 52.3810 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 47.6190 5 yes
GO:0022834 ligand-gated channel activity 47.6190 6 yes
GO:0022836 gated channel activity 47.6190 5 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 42.8571 6 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 42.8571 5 yes
GO:0022835 transmitter-gated channel activity 42.8571 4 yes
GO:0043168 anion binding 42.8571 4 yes
GO:0046872 metal ion binding 42.8571 5 no
GO:0098960 postsynaptic neurotransmitter receptor activity 38.0952 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 38.0952 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 38.0952 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 33.3333 7 yes
GO:0008509 monoatomic anion transmembrane transporter activity 28.5714 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 28.5714 4 yes
GO:0015108 chloride transmembrane transporter activity 28.5714 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 28.5714 4 no
GO:0005253 monoatomic anion channel activity 23.8095 5 yes
GO:0005254 chloride channel activity 23.8095 6 yes
GO:0099095 ligand-gated monoatomic anion channel activity 23.8095 6 yes
GO:0005261 monoatomic cation channel activity 23.8095 5 no
GO:0000166 nucleotide binding 23.8095 4 no
GO:0005524 ATP binding 23.8095 5 no
GO:0017076 purine nucleotide binding 23.8095 5 no
GO:0030554 adenyl nucleotide binding 23.8095 6 no
GO:0032555 purine ribonucleotide binding 23.8095 4 no
GO:0032559 adenyl ribonucleotide binding 23.8095 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8095 4 no
GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity 19.0476 7 yes
GO:0016933 extracellularly glycine-gated ion channel activity 14.2857 8 yes
GO:0016934 extracellularly glycine-gated chloride channel activity 14.2857 7 yes
GO:0031406 carboxylic acid binding 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GLRB_HUMAN
GO:0010646 regulation of cell communication 47.6190 4 no
GO:0006811 monoatomic ion transport 47.6190 4 yes
GO:0051049 regulation of transport 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0098916 anterograde trans-synaptic signaling 38.0952 6 yes
GO:0099536 synaptic signaling 38.0952 4 yes
GO:0099537 trans-synaptic signaling 38.0952 5 yes
GO:0050804 modulation of chemical synaptic transmission 38.0952 5 no
GO:0099177 regulation of trans-synaptic signaling 38.0952 4 no
GO:0007268 chemical synaptic transmission 38.0952 7 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0051046 regulation of secretion 28.5714 5 no
GO:1903530 regulation of secretion by cell 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.8095 5 no
GO:0010647 positive regulation of cell communication 23.8095 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.8095 5 no
GO:0009889 regulation of biosynthetic process 23.8095 4 no
GO:0010468 regulation of gene expression 23.8095 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.8095 5 no
GO:0031326 regulation of cellular biosynthetic process 23.8095 5 no
GO:0022607 cellular component assembly 23.8095 4 no
GO:0006820 monoatomic anion transport 23.8095 5 yes
GO:0006821 chloride transport 23.8095 5 yes
GO:0015698 inorganic anion transport 23.8095 4 yes
GO:0098656 monoatomic anion transmembrane transport 19.0476 4 yes
GO:0098661 inorganic anion transmembrane transport 19.0476 4 yes
GO:1902476 chloride transmembrane transport 19.0476 5 yes
GO:0007600 sensory perception 14.2857 4 yes
GO:0008104 protein localization 14.2857 4 yes
GO:0008344 adult locomotory behavior 14.2857 4 yes
GO:0050905 neuromuscular process 14.2857 4 yes
GO:0072578 neurotransmitter-gated ion channel clustering 9.5238 6 yes
GO:0072657 protein localization to membrane 9.5238 4 yes
GO:0090659 walking behavior 9.5238 4 yes
GO:0097112 gamma-aminobutyric acid receptor clustering 9.5238 7 yes
GO:0007218 neuropeptide signaling pathway 9.5238 4 yes
GO:0007399 nervous system development 9.5238 4 yes
GO:0007601 visual perception 9.5238 6 yes
GO:0007628 adult walking behavior 9.5238 5 yes
GO:0043113 receptor clustering 9.5238 5 yes
GO:0050953 sensory perception of light stimulus 9.5238 5 yes
GO:0060012 synaptic transmission, glycinergic 9.5238 8 yes
GO:0060013 righting reflex 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GLRA1_HUMAN [view entry] [view interactions] Low throughput yes no
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
PROF1_HUMAN [view entry] [view interactions] Low throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACHA3_HUMAN [view entry] [view interactions] High throughput yes no
BTNL8_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
NEMP1_HUMAN [view interactions] High throughput no no
GBRA3_HUMAN [view entry] [view interactions] High throughput yes yes
TECT2_HUMAN [view interactions] High throughput no yes
NRN1_HUMAN [view entry] [view interactions] High throughput yes no
GRIA3_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
CLC2D_HUMAN [view interactions] High throughput no yes
ASIC4_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
G3PT_HUMAN [view interactions] High throughput no no
SCN4A_HUMAN [view interactions] High throughput no no
GLRA3_HUMAN [view entry] [view interactions] High throughput yes no
5HT3B_HUMAN [view entry] [view interactions] High throughput yes yes
GPIX_HUMAN [view interactions] High throughput no no
NKG2A_HUMAN [view interactions] High throughput no no
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
CD3D_HUMAN [view interactions] High throughput no no
HFE_HUMAN [view interactions] High throughput no yes
S22A2_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
TSN16_HUMAN [view interactions] High throughput no no
HYOU1_HUMAN [view interactions] High throughput no yes
ACHB4_HUMAN [view entry] [view interactions] High throughput yes no
DPM2_HUMAN [view interactions] High throughput no yes
MARH6_HUMAN [view interactions] High throughput no yes
RN133_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
OR4N2_HUMAN [view interactions] High throughput no no
CLRN2_HUMAN [view interactions] High throughput no no
DOXA2_HUMAN [view interactions] High throughput no no
VMA21_HUMAN [view interactions] High throughput no no
GFRA3_HUMAN [view interactions] High throughput no yes
HEPS_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes