Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA3_HUMAN

GO
G2C
SynaptomeDB

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA3_HUMAN
GO:0005216 monoatomic ion channel activity 69.2308 4 yes
GO:0015267 channel activity 69.2308 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 69.2308 5 yes
GO:0022834 ligand-gated channel activity 69.2308 6 yes
GO:0022836 gated channel activity 69.2308 5 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 61.5385 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 61.5385 7 yes
GO:0005261 monoatomic cation channel activity 61.5385 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 61.5385 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 61.5385 6 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 53.8462 5 yes
GO:0022835 transmitter-gated channel activity 53.8462 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 53.8462 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 53.8462 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 53.8462 6 yes
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 46.1538 7 yes
GO:0043169 cation binding 46.1538 4 yes
GO:0015464 acetylcholine receptor activity 38.4615 4 yes
GO:0042166 acetylcholine binding 23.0769 5 yes
GO:0043168 anion binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA3_HUMAN
GO:0007268 chemical synaptic transmission 61.5385 7 yes
GO:0010646 regulation of cell communication 61.5385 4 yes
GO:0098916 anterograde trans-synaptic signaling 61.5385 6 yes
GO:0099536 synaptic signaling 61.5385 4 yes
GO:0099537 trans-synaptic signaling 61.5385 5 yes
GO:0006811 monoatomic ion transport 53.8462 4 yes
GO:0048522 positive regulation of cellular process 53.8462 4 yes
GO:0007271 synaptic transmission, cholinergic 46.1538 8 yes
GO:0051049 regulation of transport 46.1538 4 yes
GO:0007274 neuromuscular synaptic transmission 38.4615 8 yes
GO:0035095 behavioral response to nicotine 38.4615 4 yes
GO:0050804 modulation of chemical synaptic transmission 38.4615 5 yes
GO:0051128 regulation of cellular component organization 38.4615 4 yes
GO:0099177 regulation of trans-synaptic signaling 38.4615 4 yes
GO:0051046 regulation of secretion 30.7692 5 yes
GO:0060084 synaptic transmission involved in micturition 30.7692 9 yes
GO:0080090 regulation of primary metabolic process 30.7692 4 yes
GO:1903530 regulation of secretion by cell 30.7692 4 yes
GO:0006937 regulation of muscle contraction 23.0769 6 yes
GO:0006940 regulation of smooth muscle contraction 23.0769 7 yes
GO:0007399 nervous system development 23.0769 4 yes
GO:0009893 positive regulation of metabolic process 23.0769 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 23.0769 5 yes
GO:0010975 regulation of neuron projection development 23.0769 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 yes
GO:0022607 cellular component assembly 23.0769 4 yes
GO:0031323 regulation of cellular metabolic process 23.0769 4 yes
GO:0031344 regulation of cell projection organization 23.0769 5 yes
GO:0031399 regulation of protein modification process 23.0769 6 yes
GO:0031401 positive regulation of protein modification process 23.0769 7 yes
GO:0043933 protein-containing complex organization 23.0769 4 yes
GO:0044057 regulation of system process 23.0769 4 yes
GO:0046928 regulation of neurotransmitter secretion 23.0769 5 yes
GO:0048814 regulation of dendrite morphogenesis 23.0769 5 yes
GO:0050773 regulation of dendrite development 23.0769 4 yes
GO:0051246 regulation of protein metabolic process 23.0769 5 yes
GO:0051247 positive regulation of protein metabolic process 23.0769 6 yes
GO:0051588 regulation of neurotransmitter transport 23.0769 5 yes
GO:0051952 regulation of amine transport 23.0769 5 yes
GO:0060255 regulation of macromolecule metabolic process 23.0769 4 yes
GO:0065003 protein-containing complex assembly 23.0769 5 yes
GO:0090257 regulation of muscle system process 23.0769 5 yes
GO:0095500 acetylcholine receptor signaling pathway 23.0769 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 yes
GO:1905144 response to acetylcholine 23.0769 4 yes
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0006812 monoatomic cation transport 23.0769 5 no
GO:0006936 muscle contraction 23.0769 4 no
GO:0006939 smooth muscle contraction 23.0769 5 no
GO:0007600 sensory perception 23.0769 4 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0014070 response to organic cyclic compound 23.0769 4 no
GO:0030001 metal ion transport 23.0769 6 no
GO:0036293 response to decreased oxygen levels 23.0769 4 no
GO:0009966 regulation of signal transduction 23.0769 4 no
GO:0098662 inorganic cation transmembrane transport 23.0769 4 no
GO:0001932 regulation of protein phosphorylation 15.3846 7 yes
GO:0001934 positive regulation of protein phosphorylation 15.3846 8 yes
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 15.3846 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 15.3846 6 yes
GO:0014056 regulation of acetylcholine secretion, neurotransmission 15.3846 6 yes
GO:0019220 regulation of phosphate metabolic process 15.3846 6 yes
GO:0031325 positive regulation of cellular metabolic process 15.3846 5 yes
GO:0032147 activation of protein kinase activity 15.3846 8 yes
GO:0032222 regulation of synaptic transmission, cholinergic 15.3846 6 yes
GO:0033674 positive regulation of kinase activity 15.3846 6 yes
GO:0042325 regulation of phosphorylation 15.3846 7 yes
GO:0042327 positive regulation of phosphorylation 15.3846 8 yes
GO:0043085 positive regulation of catalytic activity 15.3846 4 yes
GO:0043549 regulation of kinase activity 15.3846 5 yes
GO:0045859 regulation of protein kinase activity 15.3846 6 yes
GO:0045860 positive regulation of protein kinase activity 15.3846 7 yes
GO:0045937 positive regulation of phosphate metabolic process 15.3846 7 yes
GO:0051174 regulation of phosphorus metabolic process 15.3846 5 yes
GO:0051338 regulation of transferase activity 15.3846 4 yes
GO:0051347 positive regulation of transferase activity 15.3846 5 yes
GO:0060078 regulation of postsynaptic membrane potential 15.3846 4 yes
GO:0060079 excitatory postsynaptic potential 15.3846 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHB4_HUMAN [view entry] [view interactions] Low throughput yes no
UBQL1_HUMAN [view interactions] Low throughput no yes
P2RX2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA3_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA5_HUMAN [view entry] [view interactions] Low throughput yes yes
TM219_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
C1QL4_HUMAN [view interactions] High throughput no no
LEMD2_HUMAN [view interactions] High throughput no yes
TM143_HUMAN [view interactions] High throughput no yes
FACR2_HUMAN [view interactions] High throughput no yes
APOL2_HUMAN [view entry] [view interactions] High throughput yes yes
GL8D2_HUMAN [view interactions] High throughput no yes
TM231_HUMAN [view interactions] High throughput no yes
ENTP7_HUMAN [view interactions] High throughput no no
EXTL2_HUMAN [view interactions] High throughput no yes
DSE_HUMAN [view interactions] High throughput no yes
SIA10_HUMAN [view interactions] High throughput no yes
LYPD6_HUMAN [view interactions] High throughput no no
LYNX1_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
EDA_HUMAN [view interactions] High throughput no no
CNNM1_HUMAN [view interactions] High throughput no yes
ASTRA_HUMAN [view interactions] High throughput no no
GHDC_HUMAN [view interactions] High throughput no yes
5HT3A_HUMAN [view entry] [view interactions] High throughput yes no
TMPPE_HUMAN [view interactions] High throughput no yes
CLRN2_HUMAN [view interactions] High throughput no no
PLD6_HUMAN [view interactions] High throughput no yes
KLC3_HUMAN [view interactions] High throughput no no
DOC2B_HUMAN [view interactions] High throughput no no
CLGN_HUMAN [view interactions] High throughput no no
TM223_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
XYLK_HUMAN [view interactions] High throughput no yes
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
MFAP3_HUMAN [view interactions] High throughput no yes
ITPR2_HUMAN [view interactions] High throughput no yes
ITPR3_HUMAN [view interactions] High throughput no yes
DIK1A_HUMAN [view interactions] High throughput no yes