Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA3_HUMAN
GO:0005216 ion channel activity 64.7059 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 64.7059 6 yes
GO:0015267 channel activity 64.7059 4 yes
GO:0015276 ligand-gated ion channel activity 64.7059 5 yes
GO:0022824 transmitter-gated ion channel activity 64.7059 5 yes
GO:0022834 ligand-gated channel activity 64.7059 6 yes
GO:0022835 transmitter-gated channel activity 64.7059 4 yes
GO:0022836 gated channel activity 64.7059 5 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 58.8235 7 yes
GO:0005261 cation channel activity 58.8235 5 yes
GO:0008324 cation transmembrane transporter activity 58.8235 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 58.8235 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 58.8235 4 yes
GO:0099094 ligand-gated cation channel activity 58.8235 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 58.8235 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 58.8235 6 yes
GO:0022848 acetylcholine-gated cation-selective channel activity 52.9412 7 yes
GO:0015464 acetylcholine receptor activity 47.0588 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA3_HUMAN
GO:0098916 anterograde trans-synaptic signaling 64.7059 5 yes
GO:0099537 trans-synaptic signaling 64.7059 4 yes
GO:0006811 ion transport 64.7059 4 yes
GO:0007268 chemical synaptic transmission 64.7059 6 yes
GO:0010646 regulation of cell communication 58.8235 4 yes
GO:0051899 membrane depolarization 52.9412 4 yes
GO:0048522 positive regulation of cellular process 47.0588 4 yes
GO:0051049 regulation of transport 47.0588 4 yes
GO:0007271 synaptic transmission, cholinergic 47.0588 7 yes
GO:0050804 modulation of chemical synaptic transmission 41.1765 5 yes
GO:0051046 regulation of secretion 41.1765 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 41.1765 4 yes
GO:0099177 regulation of trans-synaptic signaling 41.1765 4 yes
GO:1903530 regulation of secretion by cell 41.1765 4 yes
GO:0051128 regulation of cellular component organization 35.2941 4 yes
GO:0080090 regulation of primary metabolic process 35.2941 4 yes
GO:0031323 regulation of cellular metabolic process 35.2941 4 yes
GO:0035095 behavioral response to nicotine 35.2941 4 yes
GO:0043085 positive regulation of catalytic activity 29.4118 4 yes
GO:0044057 regulation of system process 29.4118 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 yes
GO:0051246 regulation of protein metabolic process 29.4118 5 yes
GO:0051247 positive regulation of protein metabolic process 29.4118 6 yes
GO:0051338 regulation of transferase activity 29.4118 4 yes
GO:0051347 positive regulation of transferase activity 29.4118 5 yes
GO:0060255 regulation of macromolecule metabolic process 29.4118 4 yes
GO:0009966 regulation of signal transduction 29.4118 4 no
GO:0010243 response to organonitrogen compound 29.4118 4 no
GO:0048523 negative regulation of cellular process 29.4118 4 no
GO:0009893 positive regulation of metabolic process 29.4118 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 yes
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 yes
GO:0031399 regulation of protein modification process 29.4118 6 yes
GO:0031401 positive regulation of protein modification process 29.4118 7 yes
GO:0043269 regulation of ion transport 23.5294 5 yes
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 yes
GO:0046928 regulation of neurotransmitter secretion 23.5294 4 yes
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 yes
GO:0051588 regulation of neurotransmitter transport 23.5294 5 yes
GO:0051952 regulation of amine transport 23.5294 5 yes
GO:0060084 synaptic transmission involved in micturition 23.5294 8 yes
GO:0095500 acetylcholine receptor signaling pathway 23.5294 4 yes
GO:1905144 response to acetylcholine 23.5294 4 yes
GO:0006812 cation transport 23.5294 5 no
GO:0036293 response to decreased oxygen levels 23.5294 4 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 yes
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 yes
GO:0007274 neuromuscular synaptic transmission 23.5294 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 yes
GO:0019220 regulation of phosphate metabolic process 23.5294 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 23.5294 4 yes
GO:0042325 regulation of phosphorylation 23.5294 7 yes
GO:0042327 positive regulation of phosphorylation 23.5294 8 yes
GO:0043549 regulation of kinase activity 17.6471 5 yes
GO:0043933 protein-containing complex organization 17.6471 4 yes
GO:0045859 regulation of protein kinase activity 17.6471 6 yes
GO:0045860 positive regulation of protein kinase activity 17.6471 7 yes
GO:0048814 regulation of dendrite morphogenesis 17.6471 5 yes
GO:0050773 regulation of dendrite development 17.6471 4 yes
GO:0060078 regulation of postsynaptic membrane potential 17.6471 4 yes
GO:0065003 protein-containing complex assembly 17.6471 5 yes
GO:0090257 regulation of muscle system process 17.6471 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 17.6471 6 yes
GO:0006937 regulation of muscle contraction 17.6471 6 yes
GO:0006940 regulation of smooth muscle contraction 17.6471 7 yes
GO:0007399 nervous system development 17.6471 4 yes
GO:0010975 regulation of neuron projection development 17.6471 7 yes
GO:0022607 cellular component assembly 17.6471 4 yes
GO:0031344 regulation of cell projection organization 17.6471 5 yes
GO:0032147 activation of protein kinase activity 17.6471 8 yes
GO:0033674 positive regulation of kinase activity 17.6471 6 yes
GO:0060079 excitatory postsynaptic potential 11.7647 5 yes
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 11.7647 6 yes
GO:0014056 regulation of acetylcholine secretion, neurotransmission 11.7647 5 yes
GO:0032222 regulation of synaptic transmission, cholinergic 11.7647 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA5_HUMAN [view entry] [view interactions] Low throughput yes yes
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHB4_HUMAN [view entry] [view interactions] Low throughput yes no
UBQL1_HUMAN [view interactions] Low throughput no yes
P2RX2_HUMAN [view interactions] Low throughput no no
ACHA3_HUMAN [view entry] [view interactions] Low throughput yes no
DIK1A_HUMAN [view interactions] High throughput no yes
SIA10_HUMAN [view interactions] High throughput no yes
DSE_HUMAN [view interactions] High throughput no yes
EXTL2_HUMAN [view interactions] High throughput no yes
ENTP7_HUMAN [view interactions] High throughput no no
TM231_HUMAN [view interactions] High throughput no yes
GL8D2_HUMAN [view interactions] High throughput no yes
APOL2_HUMAN [view entry] [view interactions] High throughput yes yes
FACR2_HUMAN [view interactions] High throughput no yes
TM143_HUMAN [view interactions] High throughput no yes
LEMD2_HUMAN [view interactions] High throughput no yes
C1QL4_HUMAN [view interactions] High throughput no no
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
TM219_HUMAN [view interactions] High throughput no yes
ITPR3_HUMAN [view interactions] High throughput no yes
ITPR2_HUMAN [view interactions] High throughput no yes
MFAP3_HUMAN [view interactions] High throughput no yes
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
XYLK_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
TM223_HUMAN [view interactions] High throughput no yes
LYPD6_HUMAN [view interactions] High throughput no no
LYNX1_HUMAN [view entry] [view interactions] High throughput yes no
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
EDA_HUMAN [view interactions] High throughput no no
CNNM1_HUMAN [view interactions] High throughput no yes
ASTRA_HUMAN [view interactions] High throughput no no
GHDC_HUMAN [view interactions] High throughput no yes
5HT3A_HUMAN [view entry] [view interactions] High throughput yes no
TMPPE_HUMAN [view interactions] High throughput no yes
CLRN2_HUMAN [view interactions] High throughput no no
PLD6_HUMAN [view interactions] High throughput no yes
KLC3_HUMAN [view interactions] High throughput no no
DOC2B_HUMAN [view interactions] High throughput no no
CLGN_HUMAN [view interactions] High throughput no no
HYKK_HUMAN [view interactions] Computational no yes
ACHA2_HUMAN [view entry] [view interactions] Computational yes no
PSA4_HUMAN [view entry] [view interactions] Computational yes yes
ACHA9_HUMAN [view entry] [view interactions] Computational yes no
ACHA7_HUMAN [view entry] [view interactions] Computational yes yes
ACHA4_HUMAN [view entry] [view interactions] Computational yes no
JAK2_HUMAN [view entry] [view interactions] Computational yes yes