LYNX1_HUMAN
Evidence for PS localization
Functions
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR . In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed). Prevents plasticity in the primary visual cortex late in life . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LYNX1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 80.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 80.0000 | 6 | no |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 80.0000 | 7 | no |
| GO:0005261 | cation channel activity | 80.0000 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 80.0000 | 4 | no |
| GO:0015267 | channel activity | 80.0000 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 80.0000 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 80.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 80.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 80.0000 | 4 | no |
| GO:0022836 | gated channel activity | 80.0000 | 5 | no |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | 80.0000 | 7 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 80.0000 | 4 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 80.0000 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 80.0000 | 6 | no |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 80.0000 | 5 | no |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 80.0000 | 6 | no |
| GO:0015464 | acetylcholine receptor activity | 70.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LYNX1_HUMAN |
|---|---|---|---|---|
| GO:0006811 | ion transport | 80.0000 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 80.0000 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 80.0000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 80.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 70.0000 | 4 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 70.0000 | 7 | no |
| GO:0051049 | regulation of transport | 70.0000 | 4 | no |
| GO:0051899 | membrane depolarization | 70.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 60.0000 | 5 | no |
| GO:0051046 | regulation of secretion | 60.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 60.0000 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 60.0000 | 4 | no |
| GO:0035095 | behavioral response to nicotine | 50.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 50.0000 | 5 | no |
| GO:0046928 | regulation of neurotransmitter secretion | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0051588 | regulation of neurotransmitter transport | 40.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0051952 | regulation of amine transport | 40.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0007274 | neuromuscular synaptic transmission | 30.0000 | 7 | no |
| GO:0044057 | regulation of system process | 30.0000 | 4 | no |
| GO:0060084 | synaptic transmission involved in micturition | 30.0000 | 8 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 30.0000 | 7 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | no |
| GO:0048814 | regulation of dendrite morphogenesis | 30.0000 | 5 | no |
| GO:0050773 | regulation of dendrite development | 30.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0095500 | acetylcholine receptor signaling pathway | 30.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | no |
| GO:1905144 | response to acetylcholine | 30.0000 | 4 | no |
| GO:0006812 | cation transport | 30.0000 | 5 | no |
| GO:0006816 | calcium ion transport | 30.0000 | 7 | no |
| GO:0030001 | metal ion transport | 30.0000 | 6 | no |
| GO:0036293 | response to decreased oxygen levels | 30.0000 | 4 | no |
| GO:0050890 | cognition | 30.0000 | 4 | no |
| GO:0014059 | regulation of dopamine secretion | 30.0000 | 6 | no |
| GO:0050433 | regulation of catecholamine secretion | 30.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 20.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A0A1W2PN81_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CRFM7_HUMAN | [view interactions] | Low throughput | no | no |
| ACHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |