LYNX1_HUMAN
Evidence for PS localization
Functions
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR . In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed). Prevents plasticity in the primary visual cortex late in life . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LYNX1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 70.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 70.0000 | 6 | no |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 70.0000 | 7 | no |
| GO:0005261 | monoatomic cation channel activity | 70.0000 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 70.0000 | 4 | no |
| GO:0015267 | channel activity | 70.0000 | 4 | no |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 70.0000 | 5 | no |
| GO:0015464 | acetylcholine receptor activity | 70.0000 | 4 | no |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 70.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 70.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 70.0000 | 4 | no |
| GO:0022836 | gated channel activity | 70.0000 | 5 | no |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 70.0000 | 7 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 70.0000 | 4 | no |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 70.0000 | 6 | no |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 70.0000 | 5 | no |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 70.0000 | 6 | no |
| GO:0042166 | acetylcholine binding | 40.0000 | 5 | no |
| GO:0043169 | cation binding | 40.0000 | 4 | no |
| GO:0099106 | ion channel regulator activity | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LYNX1_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 80.0000 | 7 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 80.0000 | 8 | yes |
| GO:0010646 | regulation of cell communication | 80.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 80.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 80.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 80.0000 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 70.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 70.0000 | 4 | no |
| GO:0035095 | behavioral response to nicotine | 50.0000 | 4 | no |
| GO:0051046 | regulation of secretion | 50.0000 | 5 | no |
| GO:0051049 | regulation of transport | 50.0000 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 50.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0006811 | monoatomic ion transport | 50.0000 | 4 | no |
| GO:0050890 | cognition | 40.0000 | 4 | no |
| GO:0051952 | regulation of amine transport | 40.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 40.0000 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 40.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 40.0000 | 6 | no |
| GO:0036293 | response to decreased oxygen levels | 30.0000 | 4 | no |
| GO:0050433 | regulation of catecholamine secretion | 30.0000 | 5 | no |
| GO:0051899 | membrane depolarization | 30.0000 | 4 | no |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0044057 | regulation of system process | 30.0000 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 30.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0095500 | acetylcholine receptor signaling pathway | 30.0000 | 4 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 30.0000 | 4 | no |
| GO:1905144 | response to acetylcholine | 30.0000 | 4 | no |
| GO:0007274 | neuromuscular synaptic transmission | 30.0000 | 8 | no |
| GO:0048814 | regulation of dendrite morphogenesis | 30.0000 | 5 | no |
| GO:0050773 | regulation of dendrite development | 30.0000 | 4 | no |
| GO:0060084 | synaptic transmission involved in micturition | 30.0000 | 9 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 30.0000 | 5 | no |
| GO:0006816 | calcium ion transport | 30.0000 | 7 | no |
| GO:0014059 | regulation of dopamine secretion | 30.0000 | 6 | no |
| GO:0030001 | metal ion transport | 30.0000 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRFM7_HUMAN | [view interactions] | Low throughput | no | no |
| ACHA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACHA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |