ACHA6_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA6_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 50.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 50.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 50.0000 | 7 | yes |
| GO:0005261 | cation channel activity | 50.0000 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015267 | channel activity | 50.0000 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 50.0000 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 50.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | 50.0000 | 7 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
| GO:0099094 | ligand-gated cation channel activity | 50.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
| GO:0015464 | acetylcholine receptor activity | 37.5000 | 4 | yes |
| GO:0033130 | acetylcholine receptor binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0016791 | phosphatase activity | 25.0000 | 5 | no |
| GO:0042578 | phosphoric ester hydrolase activity | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA6_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 75.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 62.5000 | 4 | yes |
| GO:0051046 | regulation of secretion | 62.5000 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 62.5000 | 4 | yes |
| GO:0006811 | ion transport | 50.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 37.5000 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 37.5000 | 5 | yes |
| GO:0051899 | membrane depolarization | 37.5000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 37.5000 | 4 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 37.5000 | 7 | no |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0014059 | regulation of dopamine secretion | 25.0000 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 25.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | yes |
| GO:0050433 | regulation of catecholamine secretion | 25.0000 | 5 | yes |
| GO:0051952 | regulation of amine transport | 25.0000 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 25.0000 | 6 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 25.0000 | 5 | yes |
| GO:0001508 | action potential | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0035095 | behavioral response to nicotine | 25.0000 | 4 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.0000 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 25.0000 | 8 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 25.0000 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 25.0000 | 8 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LYPD6_HUMAN | [view interactions] | High throughput | no | no |
| LYNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CANB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACHB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACHB4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |