CANB1_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002320 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI002320 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CANB1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 46.4286 | 4 | yes |
| GO:0046872 | metal ion binding | 46.4286 | 5 | yes |
| GO:0005509 | calcium ion binding | 32.1429 | 6 | yes |
| GO:0019900 | kinase binding | 32.1429 | 4 | no |
| GO:0019901 | protein kinase binding | 32.1429 | 5 | no |
| GO:0019902 | phosphatase binding | 21.4286 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 17.8571 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 17.8571 | 4 | yes |
| GO:0004722 | protein serine/threonine phosphatase activity | 14.2857 | 4 | yes |
| GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | 14.2857 | 5 | yes |
| GO:0016791 | phosphatase activity | 14.2857 | 5 | yes |
| GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity | 7.1429 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CANB1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.4286 | 4 | yes |
| GO:0010646 | regulation of cell communication | 71.4286 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 64.2857 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 64.2857 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.7143 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.7143 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 60.7143 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | yes |
| GO:0051049 | regulation of transport | 57.1429 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 53.5714 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.5714 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 50.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 42.8571 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.2857 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 39.2857 | 4 | yes |
| GO:0051050 | positive regulation of transport | 39.2857 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 39.2857 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 39.2857 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 35.7143 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 35.7143 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 35.7143 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 35.7143 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 35.7143 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 35.7143 | 7 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 35.7143 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 35.7143 | 4 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 35.7143 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 35.7143 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 35.7143 | 6 | yes |
| GO:0036211 | protein modification process | 35.7143 | 4 | no |
| GO:0043412 | macromolecule modification | 35.7143 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 35.7143 | 7 | yes |
| GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.1429 | 6 | yes |
| GO:0050848 | regulation of calcium-mediated signaling | 32.1429 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.1429 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.1429 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 32.1429 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 32.1429 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.1429 | 6 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 28.5714 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 28.5714 | 6 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 28.5714 | 5 | yes |
| GO:0051051 | negative regulation of transport | 28.5714 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 28.5714 | 6 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.5714 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 28.5714 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 28.5714 | 7 | yes |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
| GO:0008104 | protein localization | 28.5714 | 4 | yes |
| GO:0019722 | calcium-mediated signaling | 25.0000 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 25.0000 | 5 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 25.0000 | 6 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 25.0000 | 5 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 25.0000 | 6 | yes |
| GO:0071702 | organic substance transport | 25.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 25.0000 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 25.0000 | 7 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.0000 | 8 | yes |
| GO:0015031 | protein transport | 21.4286 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.4286 | 8 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 21.4286 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.4286 | 7 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.4286 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.4286 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.4286 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.4286 | 7 | no |
| GO:0033674 | positive regulation of kinase activity | 21.4286 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | no |
| GO:0043549 | regulation of kinase activity | 21.4286 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.4286 | 7 | no |
| GO:0051338 | regulation of transferase activity | 21.4286 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 21.4286 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0051223 | regulation of protein transport | 21.4286 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 21.4286 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 21.4286 | 7 | no |
| GO:0042326 | negative regulation of phosphorylation | 21.4286 | 8 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 21.4286 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0006886 | intracellular protein transport | 21.4286 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 17.8571 | 5 | yes |
| GO:0033365 | protein localization to organelle | 17.8571 | 5 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 17.8571 | 9 | yes |
| GO:0050850 | positive regulation of calcium-mediated signaling | 17.8571 | 7 | yes |
| GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 17.8571 | 8 | yes |
| GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade | 17.8571 | 9 | yes |
| GO:0072594 | establishment of protein localization to organelle | 17.8571 | 4 | yes |
| GO:0090279 | regulation of calcium ion import | 17.8571 | 8 | yes |
| GO:0090280 | positive regulation of calcium ion import | 17.8571 | 7 | yes |
| GO:0106056 | regulation of calcineurin-mediated signaling | 17.8571 | 7 | yes |
| GO:0106058 | positive regulation of calcineurin-mediated signaling | 17.8571 | 8 | yes |
| GO:1905664 | regulation of calcium ion import across plasma membrane | 17.8571 | 8 | yes |
| GO:1905665 | positive regulation of calcium ion import across plasma membrane | 17.8571 | 8 | yes |
| GO:0033173 | calcineurin-NFAT signaling cascade | 14.2857 | 7 | yes |
| GO:0034504 | protein localization to nucleus | 14.2857 | 6 | yes |
| GO:0051169 | nuclear transport | 14.2857 | 4 | yes |
| GO:0051170 | import into nucleus | 14.2857 | 6 | yes |
| GO:0090281 | negative regulation of calcium ion import | 14.2857 | 7 | yes |
| GO:0097720 | calcineurin-mediated signaling | 14.2857 | 6 | yes |
| GO:1905949 | negative regulation of calcium ion import across plasma membrane | 14.2857 | 8 | yes |
| GO:0006606 | protein import into nucleus | 14.2857 | 5 | yes |
| GO:0006913 | nucleocytoplasmic transport | 14.2857 | 5 | yes |
| GO:0030855 | epithelial cell differentiation | 10.7143 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 10.7143 | 6 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 10.7143 | 6 | yes |
| GO:0002090 | regulation of receptor internalization | 10.7143 | 7 | yes |
| GO:0007507 | heart development | 10.7143 | 4 | yes |
| GO:0022011 | myelination in peripheral nervous system | 7.1429 | 5 | yes |
| GO:0032292 | peripheral nervous system axon ensheathment | 7.1429 | 4 | yes |
| GO:0042552 | myelination | 7.1429 | 4 | yes |
| GO:0048754 | branching morphogenesis of an epithelial tube | 7.1429 | 4 | yes |
| GO:0048762 | mesenchymal cell differentiation | 7.1429 | 4 | yes |
| GO:0060479 | lung cell differentiation | 7.1429 | 4 | yes |
| GO:0060487 | lung epithelial cell differentiation | 7.1429 | 5 | yes |
| GO:0098693 | regulation of synaptic vesicle cycle | 7.1429 | 5 | yes |
| GO:0001569 | branching involved in blood vessel morphogenesis | 7.1429 | 5 | yes |
| GO:0001837 | epithelial to mesenchymal transition | 7.1429 | 5 | yes |
| GO:0002009 | morphogenesis of an epithelium | 7.1429 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSA7_HUMAN | [view interactions] | Low throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NFAC1_HUMAN | [view interactions] | Low throughput | no | no |
| CABP2_HUMAN | [view interactions] | Low throughput | no | no |
| CABP5_HUMAN | [view interactions] | Low throughput | no | no |
| CABP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CANB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SL9A1_HUMAN | [view interactions] | Low throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| PP2BC_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| IBP6_HUMAN | [view interactions] | High throughput | no | yes |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| T200A_HUMAN | [view interactions] | High throughput | no | yes |
| CDR2_HUMAN | [view interactions] | High throughput | no | yes |
| RCAN3_HUMAN | [view interactions] | High throughput | no | no |
| NSMA2_HUMAN | [view interactions] | High throughput | no | yes |
| ESS2_HUMAN | [view interactions] | High throughput | no | yes |
| CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
| PBIR1_HUMAN | [view interactions] | High throughput | no | yes |
| SRBD1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCG8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NP1L2_HUMAN | [view interactions] | High throughput | no | no |
| CSAG1_HUMAN | [view interactions] | High throughput | no | no |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| RCAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAN2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7_HUMAN | [view interactions] | High throughput | no | no |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| KCNKI_HUMAN | [view interactions] | High throughput | no | no |
| CASB_HUMAN | [view interactions] | High throughput | no | no |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| PRR3_HUMAN | [view interactions] | High throughput | no | no |
| TENS4_HUMAN | [view interactions] | High throughput | no | no |
| TMCC3_HUMAN | [view interactions] | High throughput | no | yes |
| PMEPA_HUMAN | [view interactions] | High throughput | no | no |
| F163B_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| SPT33_HUMAN | [view interactions] | High throughput | no | no |
| SOX15_HUMAN | [view interactions] | High throughput | no | no |
| RASF2_HUMAN | [view interactions] | High throughput | no | yes |
| LIME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT8A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |