CANB1_HUMAN
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI002320 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CANB1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 40.0000 | 4 | yes |
GO:0019900 | kinase binding | 40.0000 | 4 | no |
GO:0019901 | protein kinase binding | 37.7778 | 5 | no |
GO:0019902 | phosphatase binding | 24.4444 | 4 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 22.2222 | 4 | yes |
GO:0004722 | protein serine/threonine phosphatase activity | 20.0000 | 4 | yes |
GO:0005509 | calcium ion binding | 20.0000 | 5 | yes |
GO:0016791 | phosphatase activity | 20.0000 | 5 | yes |
GO:0019888 | protein phosphatase regulator activity | 17.7778 | 4 | yes |
GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | 8.8889 | 5 | yes |
GO:0016018 | cyclosporin A binding | 8.8889 | 4 | yes |
GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity | 4.4444 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CANB1_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 77.7778 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 75.5556 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 73.3333 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 73.3333 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 60.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 57.7778 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 55.5556 | 5 | no |
GO:0010468 | regulation of gene expression | 51.1111 | 5 | yes |
GO:0009966 | regulation of signal transduction | 48.8889 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 46.6667 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 46.6667 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 46.6667 | 5 | no |
GO:0051049 | regulation of transport | 46.6667 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 46.6667 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 44.4444 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 44.4444 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 44.4444 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 44.4444 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.2222 | 5 | yes |
GO:0036211 | protein modification process | 42.2222 | 4 | no |
GO:0043412 | macromolecule modification | 42.2222 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 42.2222 | 6 | no |
GO:0031399 | regulation of protein modification process | 42.2222 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 42.2222 | 5 | no |
GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 37.7778 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 37.7778 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.7778 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 37.7778 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 35.5556 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 35.5556 | 6 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 35.5556 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 35.5556 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 35.5556 | 6 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 33.3333 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 33.3333 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 33.3333 | 7 | no |
GO:0008104 | protein localization | 31.1111 | 4 | no |
GO:0060341 | regulation of cellular localization | 31.1111 | 4 | no |
GO:0042325 | regulation of phosphorylation | 31.1111 | 7 | no |
GO:0051050 | positive regulation of transport | 28.8889 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 28.8889 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 28.8889 | 4 | no |
GO:0032880 | regulation of protein localization | 26.6667 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 26.6667 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 26.6667 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 26.6667 | 7 | no |
GO:0051338 | regulation of transferase activity | 26.6667 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 24.4444 | 6 | no |
GO:0071702 | organic substance transport | 24.4444 | 4 | no |
GO:0071705 | nitrogen compound transport | 24.4444 | 4 | no |
GO:0043549 | regulation of kinase activity | 24.4444 | 5 | no |
GO:0010941 | regulation of cell death | 24.4444 | 4 | no |
GO:0019932 | second-messenger-mediated signaling | 24.4444 | 4 | yes |
GO:0006886 | intracellular protein transport | 22.2222 | 4 | no |
GO:0015031 | protein transport | 22.2222 | 4 | no |
GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
GO:0051223 | regulation of protein transport | 22.2222 | 5 | no |
GO:0042326 | negative regulation of phosphorylation | 22.2222 | 8 | no |
GO:0051345 | positive regulation of hydrolase activity | 22.2222 | 5 | no |
GO:0035303 | regulation of dephosphorylation | 22.2222 | 7 | no |
GO:0035304 | regulation of protein dephosphorylation | 22.2222 | 7 | no |
GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 20.0000 | 7 | yes |
GO:0009891 | positive regulation of biosynthetic process | 20.0000 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 17.7778 | 7 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 17.7778 | 6 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 17.7778 | 6 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 17.7778 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 17.7778 | 8 | yes |
GO:0019722 | calcium-mediated signaling | 17.7778 | 5 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 13.3333 | 8 | yes |
GO:0048016 | inositol phosphate-mediated signaling | 8.8889 | 5 | yes |
GO:0097720 | calcineurin-mediated signaling | 8.8889 | 6 | yes |
GO:0033173 | calcineurin-NFAT signaling cascade | 8.8889 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in CANB1_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 4.4444 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 4.4444 | 5 | no |
DOID:114 | heart disease | 4.4444 | 3 | no |
DOID:2843 | long QT syndrome | 4.4444 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NFAC1_HUMAN | [view interactions] | Low throughput | no | no |
CABP2_HUMAN | [view interactions] | Low throughput | no | no |
CABP5_HUMAN | [view interactions] | Low throughput | no | no |
CABP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PPIA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SL9A1_HUMAN | [view interactions] | Low throughput | no | no |
CANB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PP2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
BCL2_HUMAN | [view interactions] | Low throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PSA7_HUMAN | [view interactions] | Low throughput | no | yes |
PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCAN1_HUMAN | [view interactions] | High throughput | no | yes |
RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HYPM_HUMAN | [view interactions] | High throughput | no | no |
KCNKI_HUMAN | [view interactions] | High throughput | no | no |
CASB_HUMAN | [view interactions] | High throughput | no | no |
IF2B3_HUMAN | [view interactions] | High throughput | no | no |
HXC5_HUMAN | [view interactions] | High throughput | no | no |
DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
PRR3_HUMAN | [view interactions] | High throughput | no | no |
TENS4_HUMAN | [view interactions] | High throughput | no | no |
TMCC3_HUMAN | [view interactions] | High throughput | no | yes |
PMEPA_HUMAN | [view interactions] | High throughput | no | no |
F163B_HUMAN | [view interactions] | High throughput | no | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
SPT33_HUMAN | [view interactions] | High throughput | no | no |
SOX15_HUMAN | [view interactions] | High throughput | no | no |
RASF2_HUMAN | [view interactions] | High throughput | no | yes |
LIME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI41_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT8A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
KLRG2_HUMAN | [view interactions] | High throughput | no | no |
PP2BC_HUMAN | [view interactions] | High throughput | no | yes |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
IBP6_HUMAN | [view interactions] | High throughput | no | yes |
DEF1_HUMAN | [view interactions] | High throughput | no | no |
T200A_HUMAN | [view interactions] | High throughput | no | yes |
CDR2_HUMAN | [view interactions] | High throughput | no | yes |
RCAN3_HUMAN | [view interactions] | High throughput | no | no |
NSMA2_HUMAN | [view interactions] | High throughput | no | yes |
ESS2_HUMAN | [view interactions] | High throughput | no | yes |
CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
PBIR1_HUMAN | [view interactions] | High throughput | no | yes |
SRBD1_HUMAN | [view interactions] | High throughput | no | yes |
M3K12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCG8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NP1L2_HUMAN | [view interactions] | High throughput | no | no |
CSAG1_HUMAN | [view interactions] | High throughput | no | no |
CSAG2_HUMAN | [view interactions] | High throughput | no | no |
ACHA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
FCG2A_HUMAN | [view interactions] | High throughput | no | no |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCAN2_HUMAN | [view interactions] | High throughput | no | yes |
MYH7_HUMAN | [view interactions] | High throughput | no | no |
TINF2_HUMAN | [view interactions] | High throughput | no | no |
PP2AA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
2A5G_HUMAN | [view interactions] | Computational | no | yes |
2AAA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NEB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NFAC4_HUMAN | [view interactions] | Computational | no | yes |
1433S_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PP1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PR15B_HUMAN | [view interactions] | Computational | no | no |
PP1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PPR1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
WDR82_HUMAN | [view interactions] | Computational | no | no |
SODC_HUMAN | [view interactions] | Computational | no | yes |
NFAC3_HUMAN | [view interactions] | Computational | no | no |
CYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CANB2_HUMAN | [view interactions] | Computational | no | no |
PP2AB_HUMAN | [view interactions] | Computational | no | yes |
PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NFAC2_HUMAN | [view interactions] | Computational | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PPR1A_HUMAN | [view interactions] | Computational | no | yes |
CNEP1_HUMAN | [view interactions] | Computational | no | yes |
PP4R4_HUMAN | [view interactions] | Computational | no | yes |
2ABA_HUMAN | [view interactions] | Computational | no | yes |
PLCG2_HUMAN | [view interactions] | Computational | no | yes |
MYPT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TADBP_HUMAN | [view interactions] | Computational | no | yes |
1433E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NEPR1_HUMAN | [view interactions] | Computational | no | yes |
PP4R2_HUMAN | [view interactions] | Computational | no | yes |
SHOC2_HUMAN | [view interactions] | Computational | no | yes |
FKB1A_HUMAN | [view interactions] | Computational | no | yes |
TOX4_HUMAN | [view interactions] | Computational | no | yes |
2A5A_HUMAN | [view interactions] | Computational | no | yes |
1433G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |