AT8A1_HUMAN
Evidence for PS localization
Functions
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane . Acts as aminophospholipid translocase at the plasma membrane in neuronal cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004264 | TRG_DiLeu_BaEn_1 | TRG | 1105 | 1110 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT8A1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 40.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | yes |
| GO:0005524 | ATP binding | 20.0000 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 20.0000 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 20.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT8A1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 40.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 40.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0006811 | ion transport | 20.0000 | 4 | yes |
| GO:0030334 | regulation of cell migration | 20.0000 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 20.0000 | 6 | yes |
| GO:0032368 | regulation of lipid transport | 20.0000 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 20.0000 | 4 | yes |
| GO:0061024 | membrane organization | 20.0000 | 4 | yes |
| GO:1905952 | regulation of lipid localization | 20.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 20.0000 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CC50A_HUMAN | [view interactions] | Low throughput | no | yes |
| CC50B_HUMAN | [view interactions] | Low throughput | no | yes |
| NPT3_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| S6A20_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| CANB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INO1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRCR1_HUMAN | [view interactions] | Computational | no | no |