AT8A1_HUMAN
Evidence for PS localization
Functions
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane . Acts as aminophospholipid translocase at the plasma membrane in neuronal cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004264 | TRG_DiLeu_BaEn_1 | TRG | 1105 | 1110 | - |
| ELMI004264 | TRG_DiLeu_BaEn_1 | TRG | 1105 | 1110 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT8A1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 53.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 53.3333 | 5 | yes |
| GO:0000166 | nucleotide binding | 40.0000 | 4 | yes |
| GO:0043168 | anion binding | 40.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 26.6667 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 26.6667 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.6667 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.6667 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.6667 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.6667 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | yes |
| GO:0005509 | calcium ion binding | 26.6667 | 6 | no |
| GO:0005524 | ATP binding | 20.0000 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 20.0000 | 7 | yes |
| GO:0000287 | magnesium ion binding | 13.3333 | 6 | yes |
| GO:0015247 | aminophospholipid flippase activity | 13.3333 | 4 | yes |
| GO:0090556 | phosphatidylserine floppase activity | 13.3333 | 4 | yes |
| GO:0140333 | glycerophospholipid flippase activity | 13.3333 | 4 | yes |
| GO:0140346 | phosphatidylserine flippase activity | 13.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT8A1_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | yes |
| GO:0051049 | regulation of transport | 46.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 46.6667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 46.6667 | 4 | yes |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0061024 | membrane organization | 33.3333 | 4 | yes |
| GO:0006886 | intracellular protein transport | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0016050 | vesicle organization | 26.6667 | 5 | no |
| GO:0006811 | monoatomic ion transport | 26.6667 | 4 | yes |
| GO:0051050 | positive regulation of transport | 26.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.0000 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 20.0000 | 6 | yes |
| GO:0032368 | regulation of lipid transport | 20.0000 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 20.0000 | 4 | yes |
| GO:1905952 | regulation of lipid localization | 20.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 20.0000 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 20.0000 | 5 | yes |
| GO:0006869 | lipid transport | 13.3333 | 5 | yes |
| GO:0015748 | organophosphate ester transport | 13.3333 | 5 | yes |
| GO:0015914 | phospholipid transport | 13.3333 | 6 | yes |
| GO:0015917 | aminophospholipid transport | 13.3333 | 5 | yes |
| GO:0032370 | positive regulation of lipid transport | 13.3333 | 5 | yes |
| GO:0034204 | lipid translocation | 13.3333 | 4 | yes |
| GO:0045332 | phospholipid translocation | 13.3333 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 13.3333 | 5 | yes |
| GO:0061091 | regulation of phospholipid translocation | 13.3333 | 4 | yes |
| GO:0061092 | positive regulation of phospholipid translocation | 13.3333 | 5 | yes |
| GO:0140331 | aminophospholipid translocation | 13.3333 | 6 | yes |
| GO:1905954 | positive regulation of lipid localization | 13.3333 | 4 | yes |
| GO:2001138 | regulation of phospholipid transport | 13.3333 | 6 | yes |
| GO:2001140 | positive regulation of phospholipid transport | 13.3333 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CC50A_HUMAN | [view interactions] | Low throughput | no | yes |
| CC50B_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPT3_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| S6A20_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT8B3_HUMAN | [view interactions] | High throughput | no | no |
| AT8A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| CANB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INO1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |