Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP1B1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
144 Cys Arg Keratitis-ichthyosis-deafnesssyndrome,autosomalrecessive(KIDAR) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI000438 LIG_Clathr_ClatBox_1 LIG 632 636 -
ELMI000438 LIG_Clathr_ClatBox_1 LIG 632 636 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AP1B1_HUMAN
GO:0043168 anion binding 27.5862 4 no
GO:0019900 kinase binding 26.4368 4 yes
GO:0000166 nucleotide binding 26.4368 4 no
GO:0017076 purine nucleotide binding 25.2874 5 no
GO:0019901 protein kinase binding 24.1379 5 yes
GO:0032555 purine ribonucleotide binding 24.1379 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.1379 4 no
GO:0043169 cation binding 24.1379 4 no
GO:0046872 metal ion binding 24.1379 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP1B1_HUMAN
GO:0048522 positive regulation of cellular process 52.8736 4 no
GO:0051128 regulation of cellular component organization 52.8736 4 no
GO:0071702 organic substance transport 44.8276 4 yes
GO:0048523 negative regulation of cellular process 44.8276 4 no
GO:0051049 regulation of transport 44.8276 4 no
GO:0071705 nitrogen compound transport 43.6782 4 yes
GO:0060255 regulation of macromolecule metabolic process 43.6782 4 no
GO:0006996 organelle organization 42.5287 4 yes
GO:0008104 protein localization 42.5287 4 yes
GO:0010646 regulation of cell communication 41.3793 4 no
GO:0022607 cellular component assembly 40.2299 4 yes
GO:0031323 regulation of cellular metabolic process 40.2299 4 no
GO:0080090 regulation of primary metabolic process 40.2299 4 no
GO:0009966 regulation of signal transduction 37.9310 4 no
GO:0098657 import into cell 37.9310 4 no
GO:0015031 protein transport 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 32.1839 4 no
GO:0009892 negative regulation of metabolic process 29.8851 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.8851 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.8851 5 no
GO:0051246 regulation of protein metabolic process 29.8851 5 no
GO:0048584 positive regulation of response to stimulus 28.7356 4 no
GO:0051130 positive regulation of cellular component organization 28.7356 5 no
GO:0009889 regulation of biosynthetic process 27.5862 4 no
GO:0031325 positive regulation of cellular metabolic process 27.5862 5 no
GO:1902531 regulation of intracellular signal transduction 27.5862 5 no
GO:0033043 regulation of organelle organization 27.5862 5 no
GO:0010556 regulation of macromolecule biosynthetic process 26.4368 5 no
GO:0023056 positive regulation of signaling 26.4368 4 no
GO:0031326 regulation of cellular biosynthetic process 26.4368 5 no
GO:0031399 regulation of protein modification process 26.4368 6 no
GO:0043933 protein-containing complex organization 26.4368 4 no
GO:0060627 regulation of vesicle-mediated transport 26.4368 4 no
GO:0010647 positive regulation of cell communication 25.2874 5 no
GO:0031324 negative regulation of cellular metabolic process 24.1379 5 no
GO:0009967 positive regulation of signal transduction 22.9885 5 no
GO:0019220 regulation of phosphate metabolic process 22.9885 6 no
GO:0044087 regulation of cellular component biogenesis 22.9885 4 no
GO:0051174 regulation of phosphorus metabolic process 22.9885 5 no
GO:0051050 positive regulation of transport 22.9885 4 no
GO:0060341 regulation of cellular localization 22.9885 4 no
GO:0006898 receptor-mediated endocytosis 22.9885 4 no
GO:0006886 intracellular protein transport 22.9885 4 yes
GO:0010468 regulation of gene expression 21.8391 6 no
GO:0051247 positive regulation of protein metabolic process 21.8391 6 no
GO:0030100 regulation of endocytosis 21.8391 5 no
GO:0001932 regulation of protein phosphorylation 20.6897 7 no
GO:0036211 protein modification process 20.6897 4 no
GO:0042325 regulation of phosphorylation 20.6897 7 no
GO:0043412 macromolecule modification 20.6897 4 no
GO:0032880 regulation of protein localization 20.6897 5 no
GO:0046903 secretion 16.0920 4 yes
GO:0016050 vesicle organization 13.7931 5 yes
GO:0070925 organelle assembly 10.3448 5 yes
GO:0035592 establishment of protein localization to extracellular region 6.8966 4 yes
GO:0071692 protein localization to extracellular region 6.8966 5 yes
GO:0009306 protein secretion 6.8966 4 yes
GO:0032438 melanosome organization 5.7471 7 yes
GO:0033363 secretory granule organization 5.7471 6 yes
GO:0048753 pigment granule organization 5.7471 6 yes
GO:0060155 platelet dense granule organization 5.7471 7 yes
GO:1903232 melanosome assembly 5.7471 6 yes
GO:0007507 heart development 5.7471 4 yes
GO:0110010 basolateral protein secretion 4.5977 5 yes
GO:0001822 kidney development 3.4483 4 yes
GO:0007368 determination of left/right symmetry 2.2989 5 yes
GO:0009855 determination of bilateral symmetry 2.2989 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BST2_HUMAN [view interactions] Low throughput no yes
HLAA_HUMAN [view interactions] Low throughput no no
AP1B1_HUMAN [view entry] [view interactions] Low throughput yes yes
STING_HUMAN [view interactions] Low throughput no yes
AP1M1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
AFTIN_HUMAN [view interactions] Low throughput no yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1S1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1S3_HUMAN [view interactions] Low throughput no yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATM_HUMAN [view interactions] Low throughput no yes
KI13A_HUMAN [view interactions] Low throughput no yes
SL2A8_HUMAN [view interactions] Low throughput no yes
CABIN_HUMAN [view interactions] Low throughput no yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP180_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN4_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
IF16_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
H2B1C_HUMAN [view interactions] High throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
BMP2K_HUMAN [view interactions] High throughput no yes
SYNRG_HUMAN [view interactions] High throughput no yes
HTR5B_HUMAN [view interactions] High throughput no yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
STON2_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
COMT_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
RNPS1_HUMAN [view interactions] High throughput no yes
VKORL_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
MMTA2_HUMAN [view interactions] High throughput no yes
SPT33_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
MEA1_HUMAN [view interactions] High throughput no no
REPS1_HUMAN [view interactions] High throughput no yes
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
PAAT_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHG18_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CLD4_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
ATR_HUMAN [view entry] [view interactions] High throughput yes no
ABCE1_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
INT9_HUMAN [view interactions] High throughput no no
TBD2A_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
TRM61_HUMAN [view interactions] High throughput no no
CBS_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
SKI3_HUMAN [view interactions] High throughput no yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
AT8A1_HUMAN [view entry] [view interactions] High throughput yes yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
ARRC_HUMAN [view interactions] High throughput no no
PI51C_HUMAN [view entry] [view interactions] High throughput yes yes
INP4B_HUMAN [view interactions] High throughput no no
SYEP_HUMAN [view interactions] High throughput no yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
SYDC_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
GARS_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
MSH2_HUMAN [view interactions] High throughput no yes
RANG_HUMAN [view interactions] High throughput no no
TADBP_HUMAN [view interactions] High throughput no yes
AIMP2_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
CPIN1_HUMAN [view interactions] High throughput no no
NT5D3_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
MAT2B_HUMAN [view interactions] High throughput no yes
COHA1_HUMAN [view interactions] High throughput no no
HYOU1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
SMAP2_HUMAN [view interactions] High throughput no yes
TTP_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
COX8A_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MTR1B_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
NPC1_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
VAMP4_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
WNK3_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CHK2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK1_HUMAN [view interactions] High throughput no yes
SHBG_HUMAN [view interactions] High throughput no no
BARD1_HUMAN [view interactions] High throughput no yes
TB22B_HUMAN [view interactions] High throughput no no
MLH1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
CRBB1_HUMAN [view interactions] High throughput no no
FND11_HUMAN [view interactions] High throughput no no
NUP54_HUMAN [view interactions] High throughput no yes
SYFM_HUMAN [view interactions] High throughput no yes
MSGN1_HUMAN [view interactions] High throughput no no
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
ARH_HUMAN [view interactions] High throughput no yes
U2AF1_HUMAN [view interactions] High throughput no yes
AGR3_HUMAN [view interactions] High throughput no no
T10IP_HUMAN [view interactions] High throughput no no
P121A_HUMAN [view interactions] High throughput no yes
GPAN1_HUMAN [view interactions] High throughput no yes
PS1C2_HUMAN [view interactions] High throughput no no
RNF39_HUMAN [view interactions] High throughput no no
AP1G2_HUMAN [view interactions] High throughput no yes
GTF2I_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CC183_HUMAN [view interactions] High throughput no no
NECP2_HUMAN [view interactions] High throughput no yes
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
AP1M2_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
AP1S2_HUMAN [view interactions] High throughput no no
GTSE1_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
ARFG1_HUMAN [view interactions] High throughput no no
RUN3A_HUMAN [view interactions] High throughput no yes
GP156_HUMAN [view interactions] High throughput no no
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R2_HUMAN [view interactions] High throughput no no
LSR_HUMAN [view interactions] High throughput no yes
GPBL1_HUMAN [view interactions] High throughput no yes
FBX4_HUMAN [view interactions] High throughput no no
FCHO1_HUMAN [view entry] [view interactions] High throughput yes yes
STALP_HUMAN [view interactions] High throughput no yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
SIGL1_HUMAN [view interactions] High throughput no no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS2_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
RMD5A_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes