Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP1B1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
144 Cys Arg Keratitis-ichthyosis-deafnesssyndrome,autosomalrecessive(KIDAR) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI000438 LIG_Clathr_ClatBox_1 LIG 632 636 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AP1B1_HUMAN
GO:0019900 kinase binding 25.9740 4 yes
GO:0017076 purine nucleotide binding 25.9740 4 no
GO:0032555 purine ribonucleotide binding 25.9740 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.9740 4 no
GO:0019901 protein kinase binding 23.3766 5 yes
GO:0046872 metal ion binding 22.0779 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP1B1_HUMAN
GO:0051128 regulation of cellular component organization 55.8442 4 no
GO:0048522 positive regulation of cellular process 55.8442 4 no
GO:0016192 vesicle-mediated transport 54.5455 4 yes
GO:0051049 regulation of transport 48.0519 4 no
GO:0071702 organic substance transport 45.4545 4 yes
GO:0071705 nitrogen compound transport 45.4545 4 yes
GO:0048523 negative regulation of cellular process 45.4545 4 no
GO:0060255 regulation of macromolecule metabolic process 44.1558 4 no
GO:0008104 protein localization 42.8571 4 yes
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0080090 regulation of primary metabolic process 41.5584 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.2597 4 no
GO:0009966 regulation of signal transduction 38.9610 4 no
GO:0031323 regulation of cellular metabolic process 38.9610 4 no
GO:0006897 endocytosis 38.9610 5 no
GO:0015031 protein transport 36.3636 4 yes
GO:0022607 cellular component assembly 35.0649 4 no
GO:0009893 positive regulation of metabolic process 33.7662 4 no
GO:0006996 organelle organization 33.7662 4 no
GO:0051130 positive regulation of cellular component organization 32.4675 5 no
GO:0010604 positive regulation of macromolecule metabolic process 31.1688 5 no
GO:0060627 regulation of vesicle-mediated transport 31.1688 4 no
GO:0009892 negative regulation of metabolic process 29.8701 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.8701 5 no
GO:0051246 regulation of protein metabolic process 29.8701 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0006898 receptor-mediated endocytosis 28.5714 6 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.9740 5 no
GO:0031399 regulation of protein modification process 25.9740 6 no
GO:0006886 intracellular protein transport 25.9740 4 yes
GO:0030100 regulation of endocytosis 24.6753 5 no
GO:0019220 regulation of phosphate metabolic process 24.6753 6 no
GO:0051174 regulation of phosphorus metabolic process 24.6753 5 no
GO:0048584 positive regulation of response to stimulus 24.6753 4 no
GO:0051050 positive regulation of transport 24.6753 4 no
GO:0010468 regulation of gene expression 23.3766 5 no
GO:0009889 regulation of biosynthetic process 22.0779 4 no
GO:0010647 positive regulation of cell communication 22.0779 5 no
GO:0023056 positive regulation of signaling 22.0779 4 no
GO:0051247 positive regulation of protein metabolic process 22.0779 6 no
GO:0001932 regulation of protein phosphorylation 22.0779 7 no
GO:0042325 regulation of phosphorylation 22.0779 7 no
GO:0060341 regulation of cellular localization 20.7792 4 no
GO:0065003 protein-containing complex assembly 20.7792 5 no
GO:0044087 regulation of cellular component biogenesis 20.7792 4 no
GO:0071310 cellular response to organic substance 20.7792 4 no
GO:0031324 negative regulation of cellular metabolic process 20.7792 5 no
GO:0007507 heart development 5.1948 4 yes
GO:0001822 kidney development 2.5974 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in AP1B1_HUMAN
DOID:331 central nervous system disease 5.1948 3 no
DOID:936 brain disease 3.8961 4 no
DOID:0050700 cardiomyopathy 2.5974 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5974 5 no
DOID:114 heart disease 2.5974 3 no
DOID:2843 long QT syndrome 2.5974 6 no
DOID:1289 neurodegenerative disease 2.5974 4 no
DOID:0050701 electroclinical syndrome 2.5974 6 no
DOID:0112202 developmental and epileptic encephalopathy 2.5974 7 no
DOID:1826 epilepsy 2.5974 5 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
BST2_HUMAN [view interactions] Low throughput no yes
AP1M1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
AFTIN_HUMAN [view interactions] Low throughput no yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1S1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1S3_HUMAN [view interactions] Low throughput no yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATM_HUMAN [view interactions] Low throughput no yes
KI13A_HUMAN [view interactions] Low throughput no yes
GTR8_HUMAN [view interactions] Low throughput no yes
CABIN_HUMAN [view interactions] Low throughput no yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP180_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN4_HUMAN [view interactions] Low throughput no yes
NECP2_HUMAN [view interactions] High throughput no yes
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
AP1M2_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
AP1S2_HUMAN [view interactions] High throughput no no
GTSE1_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view interactions] High throughput no yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
ARFG1_HUMAN [view interactions] High throughput no no
RUN3A_HUMAN [view interactions] High throughput no yes
GP156_HUMAN [view interactions] High throughput no no
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R2_HUMAN [view interactions] High throughput no no
LSR_HUMAN [view interactions] High throughput no yes
GPBL1_HUMAN [view interactions] High throughput no yes
FBX4_HUMAN [view interactions] High throughput no no
FCHO1_HUMAN [view interactions] High throughput no yes
STALP_HUMAN [view interactions] High throughput no yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
SIGL1_HUMAN [view interactions] High throughput no no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS2_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
RMD5A_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
NPC1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
IF16_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
H2B1C_HUMAN [view interactions] High throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
BMP2K_HUMAN [view interactions] High throughput no yes
SYNRG_HUMAN [view interactions] High throughput no yes
HTR5B_HUMAN [view interactions] High throughput no yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
STON2_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
COMT_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
RNPS1_HUMAN [view interactions] High throughput no yes
VKORL_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
MMTA2_HUMAN [view interactions] High throughput no yes
SPT33_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
MEA1_HUMAN [view interactions] High throughput no no
REPS1_HUMAN [view interactions] High throughput no yes
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
PAAT_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHG18_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
ATR_HUMAN [view interactions] High throughput no no
ABCE1_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
INT9_HUMAN [view interactions] High throughput no no
TBD2A_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
TRM61_HUMAN [view interactions] High throughput no no
CBS_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
TTC37_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
AT8A1_HUMAN [view entry] [view interactions] High throughput yes yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
ARRC_HUMAN [view interactions] High throughput no no
PI51C_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
SMAP2_HUMAN [view interactions] High throughput no yes
TTP_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
COX8A_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MTR1B_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
VAMP4_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
WNK3_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CHK2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
SHBG_HUMAN [view interactions] High throughput no no
BARD1_HUMAN [view interactions] High throughput no yes
TB22B_HUMAN [view interactions] High throughput no no
MLH1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
CRBB1_HUMAN [view interactions] High throughput no no
FND11_HUMAN [view interactions] High throughput no no
NUP54_HUMAN [view interactions] High throughput no yes
SYFM_HUMAN [view interactions] High throughput no yes
MSGN1_HUMAN [view interactions] High throughput no no
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
ARH_HUMAN [view interactions] High throughput no yes
U2AF1_HUMAN [view interactions] High throughput no yes
AGR3_HUMAN [view interactions] High throughput no no
T10IP_HUMAN [view interactions] High throughput no no
P121A_HUMAN [view interactions] High throughput no yes
GPAN1_HUMAN [view interactions] High throughput no yes
PS1C2_HUMAN [view interactions] High throughput no no
RNF39_HUMAN [view interactions] High throughput no no
AP1G2_HUMAN [view interactions] High throughput no yes
GTF2I_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CC183_HUMAN [view interactions] High throughput no no
RSLAA_HUMAN [view interactions] Computational no yes
AP4E1_HUMAN [view interactions] Computational no no
AUXI_HUMAN [view entry] [view interactions] Computational yes yes
DYN2_HUMAN [view entry] [view interactions] Computational yes yes
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
AP4M1_HUMAN [view interactions] Computational no yes