SYNJ1_HUMAN
Evidence for PS localization
Functions
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed). Has a role in clathrin-mediated endocytosis . Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 219 | Arg | Gln | Parkinsondisease20,early-onset(PARK20) | - |
| 420 | Arg | Pro | Parkinsondisease20,early-onset(PARK20) | - |
| 849 | Tyr | Cys | Developmentalandepilepticencephalopathy53(DEE53) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002576 | LIG_AP2alpha_2 | LIG | 1323 | 1325 | - |
| ELMI002577 | LIG_AP2alpha_2 | LIG | 1555 | 1557 | - |
| ELMI002578 | LIG_EH_1 | LIG | 1393 | 1397 | - |
| ELMI002579 | LIG_EH_1 | LIG | 1403 | 1407 | - |
| ELMI002580 | LIG_EH_1 | LIG | 1414 | 1418 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYNJ1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 22.6415 | 4 | yes |
| GO:0019900 | kinase binding | 20.7547 | 4 | no |
| GO:0019901 | protein kinase binding | 20.7547 | 5 | no |
| GO:0045296 | cadherin binding | 20.7547 | 4 | no |
| GO:0017124 | SH3 domain binding | 15.0943 | 4 | yes |
| GO:0016791 | phosphatase activity | 7.5472 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 7.5472 | 4 | yes |
| GO:0004438 | phosphatidylinositol-3-phosphatase activity | 3.7736 | 8 | yes |
| GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | 3.7736 | 8 | yes |
| GO:0034593 | phosphatidylinositol bisphosphate phosphatase activity | 3.7736 | 7 | yes |
| GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity | 3.7736 | 7 | yes |
| GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity | 3.7736 | 7 | yes |
| GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity | 3.7736 | 8 | yes |
| GO:0043813 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | 3.7736 | 8 | yes |
| GO:0046030 | inositol trisphosphate phosphatase activity | 3.7736 | 7 | yes |
| GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | 3.7736 | 9 | yes |
| GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity | 3.7736 | 8 | yes |
| GO:0052744 | phosphatidylinositol monophosphate phosphatase activity | 3.7736 | 7 | yes |
| GO:0052745 | inositol phosphate phosphatase activity | 3.7736 | 6 | yes |
| GO:0052866 | phosphatidylinositol phosphate phosphatase activity | 3.7736 | 6 | yes |
| GO:0106018 | phosphatidylinositol-3,5-bisphosphate phosphatase activity | 3.7736 | 8 | yes |
| GO:0106019 | phosphatidylinositol-4,5-bisphosphate phosphatase activity | 3.7736 | 8 | yes |
| GO:1990175 | EH domain binding | 3.7736 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYNJ1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.7170 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 52.8302 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.8302 | 4 | yes |
| GO:0008104 | protein localization | 47.1698 | 4 | no |
| GO:0006897 | endocytosis | 47.1698 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 45.2830 | 4 | no |
| GO:0006996 | organelle organization | 43.3962 | 4 | no |
| GO:0022607 | cellular component assembly | 41.5094 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 37.7358 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.7358 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.8491 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.8491 | 4 | no |
| GO:0071702 | organic substance transport | 33.9623 | 4 | no |
| GO:0051049 | regulation of transport | 33.9623 | 4 | yes |
| GO:0010646 | regulation of cell communication | 32.0755 | 4 | no |
| GO:0015031 | protein transport | 32.0755 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.0755 | 4 | no |
| GO:0043933 | protein-containing complex organization | 32.0755 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.0755 | 5 | yes |
| GO:0006886 | intracellular protein transport | 28.3019 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.3019 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 26.4151 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.4151 | 5 | no |
| GO:0030030 | cell projection organization | 26.4151 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 26.4151 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 26.4151 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 24.5283 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.5283 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.5283 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.5283 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.5283 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 24.5283 | 6 | no |
| GO:0009966 | regulation of signal transduction | 24.5283 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 24.5283 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.5283 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 22.6415 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.6415 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.6415 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.6415 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.6415 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.6415 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.7547 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.7547 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.7547 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.7547 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.7547 | 6 | no |
| GO:0030100 | regulation of endocytosis | 20.7547 | 5 | yes |
| GO:0051050 | positive regulation of transport | 20.7547 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.9811 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 16.9811 | 6 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 16.9811 | 5 | yes |
| GO:0050890 | cognition | 16.9811 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 16.9811 | 4 | yes |
| GO:0060284 | regulation of cell development | 16.9811 | 5 | yes |
| GO:0061024 | membrane organization | 16.9811 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 16.9811 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 16.9811 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 15.0943 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 15.0943 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 15.0943 | 5 | yes |
| GO:0045807 | positive regulation of endocytosis | 13.2075 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 13.2075 | 4 | yes |
| GO:0007612 | learning | 11.3208 | 4 | yes |
| GO:0022411 | cellular component disassembly | 11.3208 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 11.3208 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 11.3208 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 9.4340 | 6 | yes |
| GO:0016191 | synaptic vesicle uncoating | 9.4340 | 9 | yes |
| GO:0032984 | protein-containing complex disassembly | 9.4340 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 9.4340 | 6 | yes |
| GO:0050769 | positive regulation of neurogenesis | 9.4340 | 6 | yes |
| GO:0051261 | protein depolymerization | 9.4340 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 9.4340 | 5 | yes |
| GO:0072318 | clathrin coat disassembly | 9.4340 | 8 | yes |
| GO:0072319 | vesicle uncoating | 9.4340 | 7 | yes |
| GO:0034097 | response to cytokine | 7.5472 | 4 | yes |
| GO:0007420 | brain development | 5.6604 | 4 | yes |
| GO:0014013 | regulation of gliogenesis | 5.6604 | 7 | yes |
| GO:0014015 | positive regulation of gliogenesis | 5.6604 | 7 | yes |
| GO:0016311 | dephosphorylation | 5.6604 | 5 | yes |
| GO:0033993 | response to lipid | 5.6604 | 4 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 5.6604 | 6 | yes |
| GO:0048489 | synaptic vesicle transport | 5.6604 | 4 | yes |
| GO:0097479 | synaptic vesicle localization | 5.6604 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 3.7736 | 4 | yes |
| GO:1904978 | regulation of endosome organization | 3.7736 | 6 | yes |
| GO:1904980 | positive regulation of endosome organization | 3.7736 | 7 | yes |
| GO:0006644 | phospholipid metabolic process | 3.7736 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 3.7736 | 5 | yes |
| GO:0006661 | phosphatidylinositol biosynthetic process | 3.7736 | 6 | yes |
| GO:0006836 | neurotransmitter transport | 3.7736 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 3.7736 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 3.7736 | 4 | yes |
| GO:0019751 | polyol metabolic process | 3.7736 | 4 | yes |
| GO:0030258 | lipid modification | 3.7736 | 4 | yes |
| GO:0032526 | response to retinoic acid | 3.7736 | 4 | yes |
| GO:0043647 | inositol phosphate metabolic process | 3.7736 | 4 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 3.7736 | 4 | yes |
| GO:0046164 | alcohol catabolic process | 3.7736 | 4 | yes |
| GO:0046174 | polyol catabolic process | 3.7736 | 5 | yes |
| GO:0046434 | organophosphate catabolic process | 3.7736 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 3.7736 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 3.7736 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 3.7736 | 6 | yes |
| GO:0046838 | phosphorylated carbohydrate dephosphorylation | 3.7736 | 4 | yes |
| GO:0046839 | phospholipid dephosphorylation | 3.7736 | 5 | yes |
| GO:0046855 | inositol phosphate dephosphorylation | 3.7736 | 5 | yes |
| GO:0046856 | phosphatidylinositol dephosphorylation | 3.7736 | 6 | yes |
| GO:0071545 | inositol phosphate catabolic process | 3.7736 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 3.7736 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYNJ1_HUMAN |
|---|---|---|---|---|
| DOID:0050701 | electroclinical syndrome | 3.7736 | 6 | yes |
| DOID:0050890 | synucleinopathy | 3.7736 | 5 | yes |
| DOID:0060894 | early-onset Parkinsons disease | 3.7736 | 7 | yes |
| DOID:0060898 | Parkinsons disease 20 | 3.7736 | 8 | yes |
| DOID:0080464 | developmental and epileptic encephalopathy 53 | 3.7736 | 8 | yes |
| DOID:0112202 | developmental and epileptic encephalopathy | 3.7736 | 7 | yes |
| DOID:1289 | neurodegenerative disease | 3.7736 | 4 | yes |
| DOID:14330 | Parkinsons disease | 3.7736 | 6 | yes |
| DOID:1826 | epilepsy | 3.7736 | 5 | yes |
| DOID:331 | central nervous system disease | 3.7736 | 3 | yes |
| DOID:936 | brain disease | 3.7736 | 4 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SRBS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FNBP4_HUMAN | [view interactions] | Low throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNX9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYO1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DBNL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| ALKB2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| HXA2_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| REST_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |