Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ITSN1_HUMAN

Plays a role in synaptic vesicle endocytosis in brain neurons. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ITSN1_HUMAN
GO:0043168 anion binding 29.3103 4 no
GO:0000166 nucleotide binding 25.8621 4 no
GO:0017076 purine nucleotide binding 25.8621 5 no
GO:0032555 purine ribonucleotide binding 24.1379 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.4138 4 no
GO:0043169 cation binding 18.1034 4 yes
GO:0046872 metal ion binding 18.1034 5 yes
GO:0005509 calcium ion binding 10.3448 6 yes
GO:0030695 GTPase regulator activity 10.3448 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 7.7586 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ITSN1_HUMAN
GO:0048522 positive regulation of cellular process 55.1724 4 no
GO:0051128 regulation of cellular component organization 43.9655 4 no
GO:0010646 regulation of cell communication 40.5172 4 yes
GO:0008104 protein localization 38.7931 4 yes
GO:0048523 negative regulation of cellular process 37.9310 4 no
GO:0071702 organic substance transport 36.2069 4 yes
GO:0071705 nitrogen compound transport 36.2069 4 yes
GO:0006996 organelle organization 35.3448 4 no
GO:0022607 cellular component assembly 35.3448 4 no
GO:0098657 import into cell 34.4828 4 yes
GO:0060255 regulation of macromolecule metabolic process 33.6207 4 no
GO:0009966 regulation of signal transduction 32.7586 4 yes
GO:0015031 protein transport 32.7586 4 yes
GO:0051049 regulation of transport 30.1724 4 no
GO:0031323 regulation of cellular metabolic process 30.1724 4 no
GO:0080090 regulation of primary metabolic process 29.3103 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 24.1379 5 yes
GO:0009893 positive regulation of metabolic process 24.1379 4 no
GO:0048584 positive regulation of response to stimulus 23.2759 4 no
GO:0010468 regulation of gene expression 23.2759 6 no
GO:0010604 positive regulation of macromolecule metabolic process 23.2759 5 no
GO:0006886 intracellular protein transport 21.5517 4 no
GO:0023056 positive regulation of signaling 21.5517 4 no
GO:0007010 cytoskeleton organization 20.6897 5 no
GO:0051240 positive regulation of multicellular organismal process 20.6897 4 no
GO:0051050 positive regulation of transport 20.6897 4 no
GO:0043933 protein-containing complex organization 20.6897 4 no
GO:0033043 regulation of organelle organization 20.6897 5 no
GO:0006898 receptor-mediated endocytosis 17.2414 4 yes
GO:0072583 clathrin-dependent endocytosis 12.0690 5 yes
GO:0046903 secretion 10.3448 4 yes
GO:0048488 synaptic vesicle endocytosis 10.3448 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 10.3448 6 yes
GO:0140238 presynaptic endocytosis 10.3448 4 yes
GO:0150007 clathrin-dependent synaptic vesicle endocytosis 2.5862 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DOPO_HUMAN [view interactions] Low throughput no no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
TS101_HUMAN [view entry] [view interactions] Low throughput yes yes
REPS1_HUMAN [view interactions] Low throughput no yes
SCAM1_HUMAN [view interactions] Low throughput no no
STON2_HUMAN [view interactions] Low throughput no yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARFP2_HUMAN [view interactions] Low throughput no no
SPY2_HUMAN [view interactions] Low throughput no yes
FCSD2_HUMAN [view interactions] Low throughput no no
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SGIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
WASP_HUMAN [view interactions] Low throughput no yes
PAK3_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
ITCH_HUMAN [view interactions] Low throughput no yes
WIPF3_HUMAN [view interactions] Low throughput no yes
MAP6_HUMAN [view entry] [view interactions] Low throughput yes yes
SMO_HUMAN [view entry] [view interactions] Low throughput yes yes
VLDLR_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
GRAB_HUMAN [view interactions] Low throughput no no
ITSN2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
GPVI_HUMAN [view interactions] Low throughput no no
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
EP15R_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
WASL_HUMAN [view entry] [view interactions] Low throughput yes yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHIP2_HUMAN [view interactions] Low throughput no yes
DAB2_HUMAN [view interactions] Low throughput no yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
DEN1A_HUMAN [view interactions] Low throughput no no
RHG31_HUMAN [view interactions] Low throughput no yes
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBLB_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG30_HUMAN [view interactions] Low throughput no no
FCHO2_HUMAN [view interactions] Low throughput no yes
ANXA5_HUMAN [view entry] [view interactions] Low throughput yes no
SPF30_HUMAN [view interactions] High throughput no no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
U119A_HUMAN [view interactions] High throughput no no
RM20_HUMAN [view interactions] High throughput no yes
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
SMRC2_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
WHAMM_HUMAN [view interactions] High throughput no yes
IFT74_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
SIAH1_HUMAN [view interactions] High throughput no yes
SOS2_HUMAN [view interactions] High throughput no yes
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
CYH3_HUMAN [view entry] [view interactions] High throughput yes yes
ZMYM5_HUMAN [view interactions] High throughput no yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD24_HUMAN [view interactions] High throughput no no
CLIP2_HUMAN [view entry] [view interactions] High throughput yes yes
BRWD3_HUMAN [view interactions] High throughput no yes
COG4_HUMAN [view interactions] High throughput no no
TRIM5_HUMAN [view interactions] High throughput no yes
NASP_HUMAN [view interactions] High throughput no yes
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
ANR54_HUMAN [view interactions] High throughput no yes
SMC1A_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
SYNCI_HUMAN [view interactions] High throughput no no
TTC27_HUMAN [view interactions] High throughput no yes
GNPTG_HUMAN [view interactions] High throughput no yes
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
PDZD8_HUMAN [view interactions] High throughput no yes
ZC3H1_HUMAN [view interactions] High throughput no yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LMO3_HUMAN [view interactions] High throughput no no
BRCC3_HUMAN [view interactions] High throughput no no
AN36A_HUMAN [view interactions] High throughput no no
DNAI7_HUMAN [view interactions] High throughput no no
BECN1_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
MIPT3_HUMAN [view interactions] High throughput no yes
BFSP1_HUMAN [view interactions] High throughput no no
CYH1_HUMAN [view interactions] High throughput no no
RU17_HUMAN [view interactions] High throughput no yes
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPM7_HUMAN [view interactions] High throughput no no
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
P85A_HUMAN [view interactions] High throughput no yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
REPS2_HUMAN [view entry] [view interactions] High throughput yes no
SCAI_HUMAN [view entry] [view interactions] High throughput yes yes
NEMF_HUMAN [view interactions] High throughput no yes
KT222_HUMAN [view interactions] High throughput no no
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
FNBP4_HUMAN [view interactions] High throughput no yes
FOG2_HUMAN [view interactions] High throughput no yes
AGFG1_HUMAN [view interactions] High throughput no yes
RFIP2_HUMAN [view entry] [view interactions] High throughput yes yes
AGFG2_HUMAN [view interactions] High throughput no yes
GOGA5_HUMAN [view interactions] High throughput no yes
PEPL_HUMAN [view interactions] High throughput no yes
LIPA2_HUMAN [view entry] [view interactions] High throughput yes no
BRE1B_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
KI16B_HUMAN [view interactions] High throughput no yes
DESM_HUMAN [view entry] [view interactions] High throughput yes no
FNBP1_HUMAN [view interactions] High throughput no yes
GCC1_HUMAN [view interactions] High throughput no yes
HIP1_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS2_HUMAN [view interactions] High throughput no yes
CE85L_HUMAN [view interactions] High throughput no yes
PACN3_HUMAN [view interactions] High throughput no yes
PDC6I_HUMAN [view entry] [view interactions] High throughput yes yes
PREX1_HUMAN [view entry] [view interactions] High throughput yes no
RABE1_HUMAN [view entry] [view interactions] High throughput yes yes
RAI14_HUMAN [view interactions] High throughput no yes
SCOC_HUMAN [view interactions] High throughput no yes
TRIM8_HUMAN [view interactions] High throughput no yes
P3C2B_HUMAN [view interactions] High throughput no no
GARE2_HUMAN [view interactions] High throughput no no
SYNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
AMOL1_HUMAN [view interactions] High throughput no no
HM20A_HUMAN [view interactions] High throughput no yes
K2C1_HUMAN [view interactions] High throughput no no
K2C71_HUMAN [view interactions] High throughput no no
K2C79_HUMAN [view interactions] High throughput no no
SWP70_HUMAN [view entry] [view interactions] High throughput yes no
DLGP2_HUMAN [view entry] [view interactions] High throughput yes no
PLVAP_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
NECP2_HUMAN [view interactions] High throughput no yes
DTX3_HUMAN [view interactions] High throughput no yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
RUN3A_HUMAN [view interactions] High throughput no yes
LSR_HUMAN [view interactions] High throughput no yes
GALD1_HUMAN [view interactions] High throughput no yes
LOX5_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
DJB11_HUMAN [view interactions] High throughput no yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
HDX_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
NUP93_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
RBBP4_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
GLU2B_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
PATL1_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
OTU7A_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO1_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR1_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
AJUBA_HUMAN [view interactions] High throughput no yes
RIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SKI3_HUMAN [view interactions] High throughput no yes
SKI2_HUMAN [view interactions] High throughput no yes
SETD3_HUMAN [view interactions] High throughput no yes
IGBP1_HUMAN [view interactions] High throughput no yes
RNH2A_HUMAN [view interactions] High throughput no no
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
DCA15_HUMAN [view interactions] High throughput no no
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
BICD2_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
TNR6C_HUMAN [view interactions] High throughput no no
SMAP2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
ADA15_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
ADA12_HUMAN [view interactions] High throughput no no
CXD3_HUMAN [view interactions] High throughput no no
TMG4_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
LMO4_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
BCAP_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
ASAP2_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
PFD5_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
CCNO_HUMAN [view interactions] High throughput no no
ATG9A_HUMAN [view interactions] High throughput no yes
WBP11_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
KTI12_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
PLK1_HUMAN [view interactions] High throughput no yes
KS6A5_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
KITH_HUMAN [view interactions] High throughput no yes
UBE2K_HUMAN [view interactions] High throughput no yes
M3K20_HUMAN [view interactions] High throughput no yes
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
TFG_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
ADIP_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
UTP4_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
ECH1_HUMAN [view interactions] High throughput no yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
SCP2_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view interactions] High throughput no no
NU214_HUMAN [view interactions] High throughput no no