ITSN1_HUMAN
Plays a role in synaptic vesicle endocytosis in brain neurons. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ITSN1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 24.7312 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 23.6559 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.5806 | 4 | no |
GO:0046872 | metal ion binding | 15.0538 | 4 | yes |
GO:0030695 | GTPase regulator activity | 8.6022 | 4 | yes |
GO:0005509 | calcium ion binding | 7.5269 | 5 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 6.4516 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ITSN1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 53.7634 | 4 | no |
GO:0016192 | vesicle-mediated transport | 51.6129 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 44.0860 | 4 | no |
GO:0008104 | protein localization | 40.8602 | 4 | yes |
GO:0006897 | endocytosis | 38.7097 | 5 | yes |
GO:0071702 | organic substance transport | 36.5591 | 4 | yes |
GO:0022607 | cellular component assembly | 36.5591 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 36.5591 | 4 | no |
GO:0071705 | nitrogen compound transport | 35.4839 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 35.4839 | 4 | no |
GO:0010646 | regulation of cell communication | 34.4086 | 4 | yes |
GO:0051049 | regulation of transport | 34.4086 | 4 | no |
GO:0015031 | protein transport | 32.2581 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 32.2581 | 4 | no |
GO:0009966 | regulation of signal transduction | 31.1828 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 31.1828 | 4 | no |
GO:0006996 | organelle organization | 31.1828 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.0323 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 26.8817 | 5 | no |
GO:0010468 | regulation of gene expression | 26.8817 | 5 | no |
GO:0043933 | protein-containing complex organization | 25.8065 | 4 | no |
GO:0030030 | cell projection organization | 25.8065 | 4 | no |
GO:0006898 | receptor-mediated endocytosis | 23.6559 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 23.6559 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.6559 | 5 | no |
GO:0065003 | protein-containing complex assembly | 22.5806 | 5 | no |
GO:0031344 | regulation of cell projection organization | 22.5806 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.5806 | 6 | no |
GO:0051050 | positive regulation of transport | 22.5806 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 22.5806 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.5806 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.5054 | 5 | yes |
GO:0023056 | positive regulation of signaling | 21.5054 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.5054 | 4 | no |
GO:0010647 | positive regulation of cell communication | 20.4301 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 20.4301 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.4301 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 20.4301 | 5 | no |
GO:0072583 | clathrin-dependent endocytosis | 16.1290 | 7 | yes |
GO:0099003 | vesicle-mediated transport in synapse | 13.9785 | 5 | yes |
GO:0016197 | endosomal transport | 12.9032 | 4 | yes |
GO:0048488 | synaptic vesicle endocytosis | 12.9032 | 5 | yes |
GO:0140238 | presynaptic endocytosis | 12.9032 | 4 | yes |
GO:0046903 | secretion | 10.7527 | 4 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 9.6774 | 6 | yes |
GO:0006887 | exocytosis | 8.6022 | 4 | yes |
GO:0150007 | clathrin-dependent synaptic vesicle endocytosis | 3.2258 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in ITSN1_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 2.1505 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHIP2_HUMAN | [view interactions] | Low throughput | no | yes |
DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SNP23_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DEN1A_HUMAN | [view interactions] | Low throughput | no | no |
RHG31_HUMAN | [view interactions] | Low throughput | no | yes |
SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CBLB_HUMAN | [view interactions] | Low throughput | no | yes |
RHG30_HUMAN | [view interactions] | Low throughput | no | no |
FCHO2_HUMAN | [view interactions] | Low throughput | no | yes |
ANXA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DOPO_HUMAN | [view interactions] | Low throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCAM1_HUMAN | [view interactions] | Low throughput | no | no |
TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STON2_HUMAN | [view interactions] | Low throughput | no | yes |
ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARFP2_HUMAN | [view interactions] | Low throughput | no | no |
SPY2_HUMAN | [view interactions] | Low throughput | no | yes |
FCSD2_HUMAN | [view interactions] | Low throughput | no | no |
EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SGIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
WASP_HUMAN | [view interactions] | Low throughput | no | yes |
PAK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
WIPF3_HUMAN | [view interactions] | Low throughput | no | yes |
MAP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SMO_HUMAN | [view interactions] | Low throughput | no | yes |
VLDLR_HUMAN | [view interactions] | Low throughput | no | yes |
DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
GRAB_HUMAN | [view interactions] | Low throughput | no | no |
ITSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GPVI_HUMAN | [view interactions] | Low throughput | no | no |
AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EP15R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ASAP2_HUMAN | [view interactions] | High throughput | no | yes |
SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
CCNO_HUMAN | [view interactions] | High throughput | no | no |
PFD5_HUMAN | [view interactions] | High throughput | no | yes |
WBP11_HUMAN | [view interactions] | High throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PLK1_HUMAN | [view interactions] | High throughput | no | yes |
KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KITH_HUMAN | [view interactions] | High throughput | no | yes |
UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
M3K20_HUMAN | [view interactions] | High throughput | no | yes |
SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFG_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
ADIP_HUMAN | [view interactions] | High throughput | no | yes |
NU214_HUMAN | [view interactions] | High throughput | no | no |
NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCP2_HUMAN | [view interactions] | High throughput | no | no |
HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECH1_HUMAN | [view interactions] | High throughput | no | yes |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UTP4_HUMAN | [view interactions] | High throughput | no | yes |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPF30_HUMAN | [view interactions] | High throughput | no | no |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
U119A_HUMAN | [view interactions] | High throughput | no | no |
RM20_HUMAN | [view interactions] | High throughput | no | yes |
SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FNBP4_HUMAN | [view interactions] | High throughput | no | yes |
FOG2_HUMAN | [view interactions] | High throughput | no | yes |
AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGFG2_HUMAN | [view interactions] | High throughput | no | yes |
CLIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
PEPL_HUMAN | [view interactions] | High throughput | no | yes |
P85A_HUMAN | [view interactions] | High throughput | no | yes |
LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYH1_HUMAN | [view interactions] | High throughput | no | no |
BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI16B_HUMAN | [view interactions] | High throughput | no | yes |
DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
GCC1_HUMAN | [view interactions] | High throughput | no | yes |
HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
CE85L_HUMAN | [view interactions] | High throughput | no | yes |
PACN3_HUMAN | [view interactions] | High throughput | no | yes |
PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PREX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAI14_HUMAN | [view interactions] | High throughput | no | yes |
SCOC_HUMAN | [view interactions] | High throughput | no | yes |
TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
P3C2B_HUMAN | [view interactions] | High throughput | no | no |
GARE2_HUMAN | [view interactions] | High throughput | no | no |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMOL1_HUMAN | [view interactions] | High throughput | no | no |
BECN1_HUMAN | [view interactions] | High throughput | no | yes |
HM20A_HUMAN | [view interactions] | High throughput | no | yes |
K2C1_HUMAN | [view interactions] | High throughput | no | no |
K2C71_HUMAN | [view interactions] | High throughput | no | no |
K2C79_HUMAN | [view interactions] | High throughput | no | no |
SWP70_HUMAN | [view interactions] | High throughput | no | no |
SYNCI_HUMAN | [view interactions] | High throughput | no | no |
DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PLVAP_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
NECP2_HUMAN | [view interactions] | High throughput | no | yes |
DTX3_HUMAN | [view interactions] | High throughput | no | yes |
AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
LSR_HUMAN | [view interactions] | High throughput | no | yes |
GALD1_HUMAN | [view interactions] | High throughput | no | yes |
LOX5_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJB11_HUMAN | [view interactions] | High throughput | no | yes |
DOCK4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HDX_HUMAN | [view interactions] | High throughput | no | yes |
CH10_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
NUP93_HUMAN | [view interactions] | High throughput | no | yes |
PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
LA_HUMAN | [view interactions] | High throughput | no | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
PATL1_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FCHO1_HUMAN | [view interactions] | High throughput | no | yes |
KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TTC37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SKIV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SETD3_HUMAN | [view interactions] | High throughput | no | yes |
IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
RNH2A_HUMAN | [view interactions] | High throughput | no | no |
DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNR6C_HUMAN | [view interactions] | High throughput | no | no |
SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
ADA15_HUMAN | [view interactions] | High throughput | no | yes |
ADA12_HUMAN | [view interactions] | High throughput | no | no |
TMG4_HUMAN | [view interactions] | High throughput | no | yes |
LMO4_HUMAN | [view interactions] | High throughput | no | yes |
BCAP_HUMAN | [view interactions] | High throughput | no | no |
SYNRG_HUMAN | [view interactions] | Computational | no | yes |
DYN3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
EFNB1_HUMAN | [view interactions] | Computational | no | yes |
CLH2_HUMAN | [view interactions] | Computational | no | no |
WNK4_HUMAN | [view interactions] | Computational | no | yes |
EFNB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP180_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARFG1_HUMAN | [view interactions] | Computational | no | no |