Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAK3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
67 Arg Cys Intellectualdevelopmentaldisorder,X-linked30(XLID30) -
380 Ala Glu Intellectualdevelopmentaldisorder,X-linked30(XLID30) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAK3_HUMAN
GO:0017076 purine nucleotide binding 43.1818 4 yes
GO:0032555 purine ribonucleotide binding 43.1818 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.9091 4 yes
GO:0019900 kinase binding 36.3636 4 no
GO:0019901 protein kinase binding 36.3636 5 no
GO:0030554 adenyl nucleotide binding 27.2727 5 yes
GO:0032559 adenyl ribonucleotide binding 27.2727 5 yes
GO:0046872 metal ion binding 27.2727 4 yes
GO:0005524 ATP binding 25.0000 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 20.4545 4 yes
GO:0016301 kinase activity 20.4545 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.4545 4 yes
GO:0003779 actin binding 20.4545 4 no
GO:0045296 cadherin binding 20.4545 4 no
GO:0004674 protein serine/threonine kinase activity 13.6364 4 yes
GO:0106310 protein serine kinase activity 13.6364 4 yes
GO:0031267 small GTPase binding 11.3636 5 yes
GO:0051020 GTPase binding 11.3636 4 yes
GO:0004708 MAP kinase kinase activity 6.8182 5 yes
GO:0017124 SH3 domain binding 6.8182 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAK3_HUMAN
GO:0048522 positive regulation of cellular process 77.2727 4 yes
GO:0010646 regulation of cell communication 65.9091 4 yes
GO:0048523 negative regulation of cellular process 61.3636 4 no
GO:0009966 regulation of signal transduction 59.0909 4 yes
GO:0031323 regulation of cellular metabolic process 59.0909 4 yes
GO:0051128 regulation of cellular component organization 56.8182 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 54.5455 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 yes
GO:0080090 regulation of primary metabolic process 54.5455 4 yes
GO:0009893 positive regulation of metabolic process 52.2727 4 yes
GO:0031325 positive regulation of cellular metabolic process 52.2727 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 yes
GO:0022607 cellular component assembly 45.4545 4 no
GO:0044087 regulation of cellular component biogenesis 45.4545 4 yes
GO:0051049 regulation of transport 43.1818 4 no
GO:0010647 positive regulation of cell communication 43.1818 5 no
GO:0023056 positive regulation of signaling 43.1818 4 no
GO:0010941 regulation of cell death 40.9091 4 yes
GO:0033043 regulation of organelle organization 40.9091 5 yes
GO:0042981 regulation of apoptotic process 40.9091 6 yes
GO:0043067 regulation of programmed cell death 40.9091 5 yes
GO:0051130 positive regulation of cellular component organization 40.9091 5 yes
GO:1902531 regulation of intracellular signal transduction 40.9091 5 yes
GO:0019220 regulation of phosphate metabolic process 38.6364 6 no
GO:0042325 regulation of phosphorylation 38.6364 7 no
GO:0051174 regulation of phosphorus metabolic process 38.6364 5 no
GO:0051246 regulation of protein metabolic process 38.6364 5 no
GO:0009967 positive regulation of signal transduction 38.6364 5 no
GO:0042127 regulation of cell population proliferation 38.6364 4 no
GO:0009889 regulation of biosynthetic process 38.6364 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 38.6364 4 yes
GO:0031326 regulation of cellular biosynthetic process 38.6364 5 yes
GO:0034330 cell junction organization 38.6364 4 yes
GO:0008104 protein localization 36.3636 4 no
GO:0010468 regulation of gene expression 36.3636 5 no
GO:0006996 organelle organization 36.3636 4 no
GO:0031399 regulation of protein modification process 36.3636 6 no
GO:0043085 positive regulation of catalytic activity 36.3636 4 no
GO:0051247 positive regulation of protein metabolic process 36.3636 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.3636 5 yes
GO:0030030 cell projection organization 36.3636 4 yes
GO:2000145 regulation of cell motility 34.0909 4 yes
GO:0001932 regulation of protein phosphorylation 34.0909 7 no
GO:0010562 positive regulation of phosphorus metabolic process 34.0909 6 no
GO:0031401 positive regulation of protein modification process 34.0909 7 no
GO:0042327 positive regulation of phosphorylation 34.0909 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.0909 7 no
GO:0009891 positive regulation of biosynthetic process 34.0909 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.0909 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 34.0909 6 yes
GO:0045595 regulation of cell differentiation 34.0909 4 yes
GO:0051094 positive regulation of developmental process 34.0909 4 yes
GO:0051493 regulation of cytoskeleton organization 34.0909 6 yes
GO:0080134 regulation of response to stress 34.0909 4 yes
GO:0120036 plasma membrane bounded cell projection organization 34.0909 5 yes
GO:0001934 positive regulation of protein phosphorylation 31.8182 8 no
GO:0031344 regulation of cell projection organization 31.8182 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.8182 6 yes
GO:0007010 cytoskeleton organization 29.5455 5 no
GO:0051338 regulation of transferase activity 29.5455 4 no
GO:0060341 regulation of cellular localization 29.5455 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 29.5455 6 yes
GO:0030334 regulation of cell migration 29.5455 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 29.5455 6 yes
GO:0071310 cellular response to organic substance 29.5455 4 yes
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0030155 regulation of cell adhesion 27.2727 4 no
GO:0043549 regulation of kinase activity 27.2727 5 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0048585 negative regulation of response to stimulus 27.2727 4 no
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.2727 5 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:0043066 negative regulation of apoptotic process 27.2727 7 no
GO:0043069 negative regulation of programmed cell death 27.2727 6 no
GO:0060548 negative regulation of cell death 27.2727 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 27.2727 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 27.2727 5 yes
GO:0010942 positive regulation of cell death 27.2727 5 yes
GO:0032101 regulation of response to external stimulus 27.2727 4 yes
GO:0032970 regulation of actin filament-based process 27.2727 4 yes
GO:0036211 protein modification process 27.2727 4 yes
GO:0043065 positive regulation of apoptotic process 27.2727 7 yes
GO:0043068 positive regulation of programmed cell death 27.2727 6 yes
GO:0043254 regulation of protein-containing complex assembly 27.2727 5 yes
GO:0043412 macromolecule modification 27.2727 4 yes
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 yes
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 yes
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0022604 regulation of cell morphogenesis 25.0000 5 yes
GO:0031175 neuron projection development 25.0000 6 yes
GO:0031346 positive regulation of cell projection organization 25.0000 6 yes
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 yes
GO:0043408 regulation of MAPK cascade 25.0000 6 yes
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:2000147 positive regulation of cell motility 22.7273 5 yes
GO:0016192 vesicle-mediated transport 22.7273 4 no
GO:0045893 positive regulation of DNA-templated transcription 22.7273 7 no
GO:0051254 positive regulation of RNA metabolic process 22.7273 6 no
GO:1902680 positive regulation of RNA biosynthetic process 22.7273 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.7273 8 no
GO:0009968 negative regulation of signal transduction 22.7273 5 no
GO:0010810 regulation of cell-substrate adhesion 22.7273 5 no
GO:0045859 regulation of protein kinase activity 22.7273 6 no
GO:0051347 positive regulation of transferase activity 22.7273 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.7273 5 no
GO:0050804 modulation of chemical synaptic transmission 22.7273 5 no
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 no
GO:0099177 regulation of trans-synaptic signaling 22.7273 4 no
GO:0008284 positive regulation of cell population proliferation 22.7273 5 no
GO:0010638 positive regulation of organelle organization 22.7273 6 no
GO:0002684 positive regulation of immune system process 22.7273 4 yes
GO:0006468 protein phosphorylation 22.7273 5 yes
GO:0016310 phosphorylation 22.7273 5 yes
GO:0030335 positive regulation of cell migration 22.7273 6 yes
GO:0040017 positive regulation of locomotion 22.7273 4 yes
GO:0045597 positive regulation of cell differentiation 22.7273 5 yes
GO:0050808 synapse organization 22.7273 5 yes
GO:0060284 regulation of cell development 22.7273 5 yes
GO:0071407 cellular response to organic cyclic compound 22.7273 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 20.4545 7 no
GO:0007015 actin filament organization 20.4545 5 no
GO:0010243 response to organonitrogen compound 20.4545 4 no
GO:0033674 positive regulation of kinase activity 20.4545 6 no
GO:0045785 positive regulation of cell adhesion 20.4545 5 no
GO:1901701 cellular response to oxygen-containing compound 20.4545 4 no
GO:0051248 negative regulation of protein metabolic process 20.4545 6 no
GO:0034329 cell junction assembly 20.4545 5 no
GO:0030031 cell projection assembly 20.4545 5 no
GO:0010720 positive regulation of cell development 20.4545 6 yes
GO:0032103 positive regulation of response to external stimulus 20.4545 5 yes
GO:0032271 regulation of protein polymerization 20.4545 6 yes
GO:0043523 regulation of neuron apoptotic process 18.1818 6 yes
GO:0048013 ephrin receptor signaling pathway 18.1818 6 yes
GO:0050776 regulation of immune response 18.1818 4 yes
GO:0110053 regulation of actin filament organization 18.1818 6 yes
GO:1901214 regulation of neuron death 18.1818 5 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 15.9091 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 15.9091 4 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 15.9091 6 yes
GO:0031347 regulation of defense response 15.9091 5 yes
GO:0032990 cell part morphogenesis 15.9091 4 yes
GO:0048812 neuron projection morphogenesis 15.9091 7 yes
GO:0048858 cell projection morphogenesis 15.9091 5 yes
GO:0050778 positive regulation of immune response 15.9091 5 yes
GO:0050807 regulation of synapse organization 15.9091 5 yes
GO:0051960 regulation of nervous system development 15.9091 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 15.9091 6 yes
GO:0010762 regulation of fibroblast migration 13.6364 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 13.6364 7 yes
GO:0010975 regulation of neuron projection development 13.6364 7 yes
GO:0031349 positive regulation of defense response 13.6364 5 yes
GO:0050767 regulation of neurogenesis 13.6364 6 yes
GO:0051962 positive regulation of nervous system development 13.6364 5 yes
GO:1901216 positive regulation of neuron death 13.6364 6 yes
GO:0002220 innate immune response activating cell surface receptor signaling pathway 11.3636 5 yes
GO:0002223 stimulatory C-type lectin receptor signaling pathway 11.3636 5 yes
GO:0002758 innate immune response-activating signal transduction 11.3636 4 yes
GO:0002831 regulation of response to biotic stimulus 11.3636 4 yes
GO:0002833 positive regulation of response to biotic stimulus 11.3636 5 yes
GO:0010763 positive regulation of fibroblast migration 11.3636 7 yes
GO:0032535 regulation of cellular component size 11.3636 4 yes
GO:0043525 positive regulation of neuron apoptotic process 11.3636 7 yes
GO:0045088 regulation of innate immune response 11.3636 5 yes
GO:0045089 positive regulation of innate immune response 11.3636 6 yes
GO:0050769 positive regulation of neurogenesis 11.3636 6 yes
GO:0050770 regulation of axonogenesis 11.3636 5 yes
GO:0051052 regulation of DNA metabolic process 11.3636 5 yes
GO:0051054 positive regulation of DNA metabolic process 11.3636 6 yes
GO:0097061 dendritic spine organization 11.3636 5 yes
GO:0099173 postsynapse organization 11.3636 4 yes
GO:0106027 neuron projection organization 11.3636 6 yes
GO:1990858 cellular response to lectin 11.3636 4 yes
GO:2000278 regulation of DNA biosynthetic process 9.0909 6 yes
GO:2000573 positive regulation of DNA biosynthetic process 9.0909 7 yes
GO:0008064 regulation of actin polymerization or depolymerization 9.0909 6 yes
GO:0030832 regulation of actin filament length 9.0909 5 yes
GO:0030833 regulation of actin filament polymerization 9.0909 7 yes
GO:0060997 dendritic spine morphogenesis 9.0909 6 yes
GO:0010976 positive regulation of neuron projection development 6.8182 7 yes
GO:0007409 axonogenesis 4.5455 8 yes
GO:0048814 regulation of dendrite morphogenesis 4.5455 5 yes
GO:0050773 regulation of dendrite development 4.5455 4 yes
GO:0050775 positive regulation of dendrite morphogenesis 4.5455 6 yes
GO:0060998 regulation of dendritic spine development 4.5455 4 yes
GO:0060999 positive regulation of dendritic spine development 4.5455 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 4.5455 5 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 4.5455 6 yes
GO:0099175 regulation of postsynapse organization 4.5455 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PAK3_HUMAN
DOID:0060038 specific developmental disorder 6.8182 3 yes
DOID:1059 intellectual disability 6.8182 4 yes
DOID:0050776 non-syndromic X-linked intellectual disability 4.5455 6 yes
DOID:0050889 non-syndromic intellectual disability 4.5455 5 yes
DOID:0112051 non-syndromic X-linked intellectual disability 30 4.5455 7 yes
DOID:3635 congenital myasthenic syndrome 4.5455 7 no
DOID:439 neuromuscular junction disease 4.5455 6 no
DOID:440 neuromuscular disease 4.5455 5 no
DOID:574 peripheral nervous system disease 4.5455 3 no
DOID:870 neuropathy 4.5455 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
PLK1_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
RHOQ_HUMAN [view interactions] Low throughput no no
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
MSRB2_HUMAN [view interactions] High throughput no no
RASF8_HUMAN [view interactions] High throughput no yes
EFMT2_HUMAN [view interactions] High throughput no yes
ITB8_HUMAN [view interactions] High throughput no no
RAMAC_HUMAN [view interactions] High throughput no yes
RT18C_HUMAN [view interactions] High throughput no yes
PTPR2_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
RM52_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
COMD2_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PAK3_HUMAN [view entry] [view interactions] High throughput yes no
RHG18_HUMAN [view interactions] High throughput no yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
GNB5_HUMAN [view entry] [view interactions] High throughput yes yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K4_HUMAN [view interactions] High throughput no yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
PAK2_HUMAN [view entry] [view interactions] Computational yes no
PAXI_HUMAN [view interactions] Computational no yes
ITA1_HUMAN [view interactions] Computational no yes
ML12A_HUMAN [view interactions] Computational no no
LAMB1_HUMAN [view interactions] Computational no yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
PLAK_HUMAN [view entry] [view interactions] Computational yes yes
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
MK04_HUMAN [view interactions] Computational no no
ARHG6_HUMAN [view interactions] Computational no no
LAMC2_HUMAN [view interactions] Computational no no
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
PAK5_HUMAN [view interactions] Computational no yes
LAMB2_HUMAN [view interactions] Computational no yes
LAMC3_HUMAN [view interactions] Computational no no
MK06_HUMAN [view interactions] Computational no yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
LIMK1_HUMAN [view interactions] Computational no yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
RAPSN_HUMAN [view entry] [view interactions] Computational yes no
DAG1_HUMAN [view entry] [view interactions] Computational yes no
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
RAC3_HUMAN [view entry] [view interactions] Computational yes no
NCK2_HUMAN [view entry] [view interactions] Computational yes yes
ROBO1_HUMAN [view interactions] Computational no yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
CTND1_HUMAN [view entry] [view interactions] Computational yes no
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
ACTS_HUMAN [view interactions] Computational no no
RAF1_HUMAN [view entry] [view interactions] Computational yes no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
MUSK_HUMAN [view entry] [view interactions] Computational yes no
LAMA1_HUMAN [view interactions] Computational no no
MK11_HUMAN [view interactions] Computational no yes
GIT2_HUMAN [view interactions] Computational no yes
PAK4_HUMAN [view interactions] Computational no yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
LAMA2_HUMAN [view interactions] Computational no no
LAMA3_HUMAN [view interactions] Computational no no
ROBO2_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LAMB3_HUMAN [view interactions] Computational no yes
ACHA_HUMAN [view entry] [view interactions] Computational yes no
CADH5_HUMAN [view interactions] Computational no yes
LAMC1_HUMAN [view interactions] Computational no yes
MYO6_HUMAN [view entry] [view interactions] Computational yes no
ITB1_HUMAN [view entry] [view interactions] Computational yes no