Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAK3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
67 Arg Cys Intellectualdevelopmentaldisorder,X-linked30(XLID30) -
380 Ala Glu Intellectualdevelopmentaldisorder,X-linked30(XLID30) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAK3_HUMAN
GO:0000166 nucleotide binding 52.9412 4 yes
GO:0043168 anion binding 52.9412 4 yes
GO:0017076 purine nucleotide binding 47.0588 5 yes
GO:0032555 purine ribonucleotide binding 41.1765 4 yes
GO:0030554 adenyl nucleotide binding 35.2941 6 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.2941 4 yes
GO:0032559 adenyl ribonucleotide binding 29.4118 5 yes
GO:0043169 cation binding 29.4118 4 yes
GO:0046872 metal ion binding 29.4118 5 yes
GO:0030695 GTPase regulator activity 29.4118 4 no
GO:0005524 ATP binding 23.5294 5 yes
GO:0031267 small GTPase binding 23.5294 5 yes
GO:0051020 GTPase binding 23.5294 4 yes
GO:0015631 tubulin binding 23.5294 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no
GO:0004674 protein serine/threonine kinase activity 17.6471 4 yes
GO:0016301 kinase activity 17.6471 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.6471 4 yes
GO:0017124 SH3 domain binding 17.6471 4 yes
GO:0106310 protein serine kinase activity 17.6471 4 yes
GO:0004708 MAP kinase kinase activity 11.7647 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAK3_HUMAN
GO:0010646 regulation of cell communication 64.7059 4 yes
GO:0044087 regulation of cellular component biogenesis 58.8235 4 yes
GO:0051128 regulation of cellular component organization 58.8235 4 yes
GO:0009966 regulation of signal transduction 52.9412 4 yes
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0032101 regulation of response to external stimulus 47.0588 4 yes
GO:0033043 regulation of organelle organization 47.0588 5 yes
GO:0043254 regulation of protein-containing complex assembly 47.0588 5 yes
GO:0051493 regulation of cytoskeleton organization 47.0588 6 yes
GO:1902531 regulation of intracellular signal transduction 47.0588 5 yes
GO:1902903 regulation of supramolecular fiber organization 47.0588 5 yes
GO:0048522 positive regulation of cellular process 47.0588 4 no
GO:0030030 cell projection organization 41.1765 4 yes
GO:0031344 regulation of cell projection organization 41.1765 5 yes
GO:0032271 regulation of protein polymerization 41.1765 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 41.1765 6 yes
GO:0051130 positive regulation of cellular component organization 41.1765 5 no
GO:0051049 regulation of transport 41.1765 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 35.2941 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 35.2941 5 yes
GO:0031347 regulation of defense response 35.2941 5 yes
GO:0034330 cell junction organization 35.2941 4 yes
GO:0048584 positive regulation of response to stimulus 35.2941 4 yes
GO:0080134 regulation of response to stress 35.2941 4 yes
GO:0120036 plasma membrane bounded cell projection organization 35.2941 5 yes
GO:0006996 organelle organization 35.2941 4 no
GO:0008104 protein localization 35.2941 4 no
GO:0044089 positive regulation of cellular component biogenesis 35.2941 5 no
GO:0060255 regulation of macromolecule metabolic process 35.2941 4 no
GO:0080090 regulation of primary metabolic process 35.2941 4 no
GO:0022607 cellular component assembly 35.2941 4 no
GO:0060627 regulation of vesicle-mediated transport 35.2941 4 no
GO:0022603 regulation of anatomical structure morphogenesis 29.4118 4 yes
GO:0031175 neuron projection development 29.4118 6 yes
GO:0032103 positive regulation of response to external stimulus 29.4118 5 yes
GO:0032956 regulation of actin cytoskeleton organization 29.4118 5 yes
GO:0032970 regulation of actin filament-based process 29.4118 4 yes
GO:0048013 ephrin receptor signaling pathway 29.4118 6 yes
GO:0048812 neuron projection morphogenesis 29.4118 5 yes
GO:0050808 synapse organization 29.4118 5 yes
GO:0071310 cellular response to organic substance 29.4118 4 yes
GO:0110053 regulation of actin filament organization 29.4118 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 29.4118 4 yes
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:0010638 positive regulation of organelle organization 29.4118 6 no
GO:0019220 regulation of phosphate metabolic process 29.4118 6 no
GO:0031110 regulation of microtubule polymerization or depolymerization 29.4118 6 no
GO:0031113 regulation of microtubule polymerization 29.4118 6 no
GO:0031323 regulation of cellular metabolic process 29.4118 4 no
GO:0032886 regulation of microtubule-based process 29.4118 4 no
GO:0043085 positive regulation of catalytic activity 29.4118 4 no
GO:0043933 protein-containing complex organization 29.4118 4 no
GO:0051174 regulation of phosphorus metabolic process 29.4118 5 no
GO:0070507 regulation of microtubule cytoskeleton organization 29.4118 5 no
GO:0002684 positive regulation of immune system process 23.5294 4 yes
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 yes
GO:0031349 positive regulation of defense response 23.5294 5 yes
GO:0043408 regulation of MAPK cascade 23.5294 6 yes
GO:0050807 regulation of synapse organization 23.5294 5 yes
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0010647 positive regulation of cell communication 23.5294 5 no
GO:0023056 positive regulation of signaling 23.5294 4 no
GO:0030334 regulation of cell migration 23.5294 5 no
GO:0030335 positive regulation of cell migration 23.5294 6 no
GO:0031325 positive regulation of cellular metabolic process 23.5294 5 no
GO:0031334 positive regulation of protein-containing complex assembly 23.5294 6 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0040017 positive regulation of locomotion 23.5294 4 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0046903 secretion 23.5294 4 no
GO:0051246 regulation of protein metabolic process 23.5294 5 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0051495 positive regulation of cytoskeleton organization 23.5294 7 no
GO:1902905 positive regulation of supramolecular fiber organization 23.5294 6 no
GO:2000145 regulation of cell motility 23.5294 4 no
GO:2000147 positive regulation of cell motility 23.5294 5 no
GO:0051051 negative regulation of transport 23.5294 4 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0065003 protein-containing complex assembly 23.5294 5 no
GO:0007264 small GTPase-mediated signal transduction 23.5294 5 no
GO:0009889 regulation of biosynthetic process 23.5294 4 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0009892 negative regulation of metabolic process 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.5294 5 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0051056 regulation of small GTPase mediated signal transduction 23.5294 6 no
GO:0051129 negative regulation of cellular component organization 23.5294 5 no
GO:0061024 membrane organization 23.5294 4 no
GO:0141124 intracellular signaling cassette 23.5294 4 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0002220 innate immune response activating cell surface receptor signaling pathway 17.6471 5 yes
GO:0002223 stimulatory C-type lectin receptor signaling pathway 17.6471 5 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 17.6471 4 yes
GO:0002758 innate immune response-activating signaling pathway 17.6471 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 17.6471 4 yes
GO:0002831 regulation of response to biotic stimulus 17.6471 4 yes
GO:0002833 positive regulation of response to biotic stimulus 17.6471 5 yes
GO:0010975 regulation of neuron projection development 17.6471 7 yes
GO:0014070 response to organic cyclic compound 17.6471 4 yes
GO:0016310 phosphorylation 17.6471 5 yes
GO:0032535 regulation of cellular component size 17.6471 4 yes
GO:0045088 regulation of innate immune response 17.6471 5 yes
GO:0045089 positive regulation of innate immune response 17.6471 6 yes
GO:0050770 regulation of axonogenesis 17.6471 5 yes
GO:0050776 regulation of immune response 17.6471 4 yes
GO:0050778 positive regulation of immune response 17.6471 5 yes
GO:0060997 dendritic spine morphogenesis 17.6471 6 yes
GO:0071407 cellular response to organic cyclic compound 17.6471 5 yes
GO:0097061 dendritic spine organization 17.6471 5 yes
GO:0099173 postsynapse organization 17.6471 4 yes
GO:0099175 regulation of postsynapse organization 17.6471 6 yes
GO:0106027 neuron projection organization 17.6471 6 yes
GO:1990858 cellular response to lectin 17.6471 4 yes
GO:0007409 axonogenesis 11.7647 6 yes
GO:0008064 regulation of actin polymerization or depolymerization 11.7647 6 yes
GO:0030832 regulation of actin filament length 11.7647 5 yes
GO:0030833 regulation of actin filament polymerization 11.7647 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
PLK1_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
RHOQ_HUMAN [view interactions] Low throughput no no
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
MSRB2_HUMAN [view interactions] High throughput no no
RASF8_HUMAN [view interactions] High throughput no yes
EFMT2_HUMAN [view interactions] High throughput no yes
ITB8_HUMAN [view interactions] High throughput no no
RAMAC_HUMAN [view interactions] High throughput no yes
RT18C_HUMAN [view interactions] High throughput no yes
PTPR2_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
RM52_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
COMD2_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
POF1B_HUMAN [view interactions] High throughput no no
PALLD_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PAK3_HUMAN [view entry] [view interactions] High throughput yes no
RHG18_HUMAN [view interactions] High throughput no yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
GNB5_HUMAN [view entry] [view interactions] High throughput yes yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K4_HUMAN [view interactions] High throughput no yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes