Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed, PubMed). Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at Ser-338 and Ser-339 resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at Ser-246 promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization . In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) . Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
131 Tyr Cys Intellectualdevelopmentaldisorderwithmacrocephaly,seizures,andspeechdelay(IDDMSSD) -
429 Tyr Cys Intellectualdevelopmentaldisorderwithmacrocephaly,seizures,andspeechdelay(IDDMSSD) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI002173 LIG_SH3_2 LIG 13 18 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAK1_HUMAN
GO:0017076 purine nucleotide binding 38.5714 4 yes
GO:0032555 purine ribonucleotide binding 38.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.8571 4 yes
GO:0030554 adenyl nucleotide binding 30.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 30.0000 5 yes
GO:0005524 ATP binding 29.2857 5 yes
GO:0019900 kinase binding 27.1429 4 no
GO:0019901 protein kinase binding 25.7143 5 no
GO:0046872 metal ion binding 22.8571 4 no
GO:0016301 kinase activity 22.1429 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.4286 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 18.5714 4 yes
GO:0004674 protein serine/threonine kinase activity 12.1429 4 yes
GO:0106310 protein serine kinase activity 12.1429 4 yes
GO:0015631 tubulin binding 7.8571 4 yes
GO:0043015 gamma-tubulin binding 4.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAK1_HUMAN
GO:0048522 positive regulation of cellular process 65.0000 4 yes
GO:0048523 negative regulation of cellular process 52.1429 4 yes
GO:0051128 regulation of cellular component organization 51.4286 4 yes
GO:0010646 regulation of cell communication 50.7143 4 yes
GO:0031323 regulation of cellular metabolic process 50.7143 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.8571 4 yes
GO:0080090 regulation of primary metabolic process 47.1429 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 45.7143 4 yes
GO:0009893 positive regulation of metabolic process 45.0000 4 yes
GO:0009966 regulation of signal transduction 45.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.4286 5 yes
GO:0031325 positive regulation of cellular metabolic process 39.2857 5 yes
GO:0051246 regulation of protein metabolic process 39.2857 5 yes
GO:0006996 organelle organization 37.8571 4 yes
GO:0010468 regulation of gene expression 37.8571 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.1429 5 yes
GO:0010941 regulation of cell death 35.0000 4 no
GO:1902531 regulation of intracellular signal transduction 34.2857 5 yes
GO:0043067 regulation of programmed cell death 33.5714 5 no
GO:0042981 regulation of apoptotic process 32.8571 6 no
GO:0033043 regulation of organelle organization 32.1429 5 yes
GO:0051247 positive regulation of protein metabolic process 32.1429 6 yes
GO:0009889 regulation of biosynthetic process 32.1429 4 no
GO:0051049 regulation of transport 32.1429 4 no
GO:0022607 cellular component assembly 32.1429 4 no
GO:0071310 cellular response to organic substance 32.1429 4 no
GO:0006796 phosphate-containing compound metabolic process 31.4286 4 yes
GO:0048584 positive regulation of response to stimulus 31.4286 4 yes
GO:0031326 regulation of cellular biosynthetic process 31.4286 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7143 5 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 yes
GO:0031399 regulation of protein modification process 30.0000 6 yes
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 yes
GO:0023056 positive regulation of signaling 29.2857 4 yes
GO:0030030 cell projection organization 29.2857 4 yes
GO:0042325 regulation of phosphorylation 29.2857 7 yes
GO:0051130 positive regulation of cellular component organization 29.2857 5 yes
GO:0010647 positive regulation of cell communication 28.5714 5 yes
GO:0044087 regulation of cellular component biogenesis 27.8571 4 yes
GO:0045595 regulation of cell differentiation 27.8571 4 no
GO:0009967 positive regulation of signal transduction 27.1429 5 yes
GO:0043085 positive regulation of catalytic activity 27.1429 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.1429 5 no
GO:0001932 regulation of protein phosphorylation 26.4286 7 yes
GO:0036211 protein modification process 26.4286 4 yes
GO:0043412 macromolecule modification 26.4286 4 yes
GO:0007010 cytoskeleton organization 25.7143 5 yes
GO:0042127 regulation of cell population proliferation 25.7143 4 yes
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.2857 6 yes
GO:0045937 positive regulation of phosphate metabolic process 24.2857 7 yes
GO:0060341 regulation of cellular localization 24.2857 4 no
GO:0008104 protein localization 24.2857 4 no
GO:0031344 regulation of cell projection organization 23.5714 5 yes
GO:0042327 positive regulation of phosphorylation 23.5714 8 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5714 6 yes
GO:0009892 negative regulation of metabolic process 23.5714 4 no
GO:0051252 regulation of RNA metabolic process 23.5714 5 no
GO:0031401 positive regulation of protein modification process 22.8571 7 yes
GO:0051338 regulation of transferase activity 22.8571 4 yes
GO:0051493 regulation of cytoskeleton organization 22.8571 6 yes
GO:0080134 regulation of response to stress 22.8571 4 yes
GO:0030155 regulation of cell adhesion 22.8571 4 no
GO:0048585 negative regulation of response to stimulus 22.8571 4 no
GO:0060548 negative regulation of cell death 22.8571 5 no
GO:0043549 regulation of kinase activity 22.1429 5 yes
GO:2000145 regulation of cell motility 22.1429 4 yes
GO:0032880 regulation of protein localization 22.1429 5 no
GO:0006355 regulation of DNA-templated transcription 22.1429 6 no
GO:1903506 regulation of nucleic acid-templated transcription 22.1429 7 no
GO:2001141 regulation of RNA biosynthetic process 22.1429 6 no
GO:0051240 positive regulation of multicellular organismal process 22.1429 4 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 yes
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:0010628 positive regulation of gene expression 21.4286 6 no
GO:0016310 phosphorylation 20.7143 5 yes
GO:0030334 regulation of cell migration 20.7143 5 yes
GO:0051129 negative regulation of cellular component organization 20.7143 5 no
GO:1901701 cellular response to oxygen-containing compound 20.7143 4 no
GO:0071702 organic substance transport 20.7143 4 no
GO:0043069 negative regulation of programmed cell death 20.7143 6 no
GO:0006468 protein phosphorylation 20.0000 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 20.0000 4 yes
GO:0045859 regulation of protein kinase activity 20.0000 6 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 19.2857 5 yes
GO:0032970 regulation of actin filament-based process 19.2857 4 yes
GO:0016192 vesicle-mediated transport 18.5714 4 yes
GO:1902903 regulation of supramolecular fiber organization 18.5714 5 yes
GO:0002684 positive regulation of immune system process 17.8571 4 yes
GO:0032956 regulation of actin cytoskeleton organization 17.8571 5 yes
GO:0043254 regulation of protein-containing complex assembly 17.8571 5 yes
GO:0010638 positive regulation of organelle organization 17.1429 6 yes
GO:0010975 regulation of neuron projection development 17.1429 7 yes
GO:0043408 regulation of MAPK cascade 17.1429 6 yes
GO:0051347 positive regulation of transferase activity 17.1429 5 yes
GO:0008284 positive regulation of cell population proliferation 16.4286 5 yes
GO:0032101 regulation of response to external stimulus 16.4286 4 yes
GO:0033674 positive regulation of kinase activity 16.4286 6 yes
GO:0030335 positive regulation of cell migration 15.7143 6 yes
GO:0040017 positive regulation of locomotion 15.7143 4 yes
GO:0044089 positive regulation of cellular component biogenesis 15.7143 5 yes
GO:2000147 positive regulation of cell motility 15.7143 5 yes
GO:0032271 regulation of protein polymerization 14.2857 6 yes
GO:0050776 regulation of immune response 14.2857 4 yes
GO:0032990 cell part morphogenesis 13.5714 4 yes
GO:0048812 neuron projection morphogenesis 13.5714 7 yes
GO:0048858 cell projection morphogenesis 13.5714 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 13.5714 6 yes
GO:0006915 apoptotic process 12.8571 4 yes
GO:0045860 positive regulation of protein kinase activity 12.8571 7 yes
GO:0110053 regulation of actin filament organization 12.8571 6 yes
GO:0051495 positive regulation of cytoskeleton organization 12.1429 7 yes
GO:0008285 negative regulation of cell population proliferation 11.4286 5 yes
GO:0048013 ephrin receptor signaling pathway 11.4286 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 11.4286 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 11.4286 6 yes
GO:0043410 positive regulation of MAPK cascade 10.7143 7 yes
GO:0046777 protein autophosphorylation 10.7143 6 yes
GO:0050778 positive regulation of immune response 10.7143 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 10.0000 6 yes
GO:0031347 regulation of defense response 10.0000 5 yes
GO:0032103 positive regulation of response to external stimulus 10.0000 5 yes
GO:0032886 regulation of microtubule-based process 10.0000 4 yes
GO:0050770 regulation of axonogenesis 10.0000 5 yes
GO:0032273 positive regulation of protein polymerization 9.2857 7 yes
GO:0002009 morphogenesis of an epithelium 8.5714 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 8.5714 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 8.5714 4 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 8.5714 8 yes
GO:0070507 regulation of microtubule cytoskeleton organization 7.8571 5 yes
GO:0043405 regulation of MAP kinase activity 7.1429 8 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 6.4286 6 yes
GO:0031349 positive regulation of defense response 6.4286 5 yes
GO:0046903 secretion 6.4286 4 yes
GO:0002831 regulation of response to biotic stimulus 5.7143 4 yes
GO:0002833 positive regulation of response to biotic stimulus 5.7143 5 yes
GO:0031113 regulation of microtubule polymerization 5.7143 6 yes
GO:0038093 Fc receptor signaling pathway 5.7143 5 yes
GO:0045088 regulation of innate immune response 5.7143 5 yes
GO:0045089 positive regulation of innate immune response 5.7143 6 yes
GO:0048754 branching morphogenesis of an epithelial tube 5.7143 4 yes
GO:0002220 innate immune response activating cell surface receptor signaling pathway 5.0000 5 yes
GO:0002223 stimulatory C-type lectin receptor signaling pathway 5.0000 5 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 5.0000 5 yes
GO:0002758 innate immune response-activating signal transduction 5.0000 4 yes
GO:0006974 cellular response to DNA damage stimulus 5.0000 4 yes
GO:0031112 positive regulation of microtubule polymerization or depolymerization 5.0000 7 yes
GO:0031116 positive regulation of microtubule polymerization 5.0000 7 yes
GO:0031532 actin cytoskeleton reorganization 5.0000 4 yes
GO:0032231 regulation of actin filament bundle assembly 5.0000 5 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 5.0000 8 yes
GO:0038094 Fc-gamma receptor signaling pathway 5.0000 6 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 5.0000 4 yes
GO:0043406 positive regulation of MAP kinase activity 5.0000 8 yes
GO:1990858 cellular response to lectin 5.0000 4 yes
GO:0010968 regulation of microtubule nucleation 4.2857 7 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 4.2857 9 yes
GO:0051492 regulation of stress fiber assembly 4.2857 6 yes
GO:0110020 regulation of actomyosin structure organization 4.2857 6 yes
GO:0006887 exocytosis 3.5714 4 yes
GO:0032233 positive regulation of actin filament bundle assembly 3.5714 6 yes
GO:0042060 wound healing 3.5714 4 yes
GO:0051496 positive regulation of stress fiber assembly 3.5714 7 yes
GO:0090063 positive regulation of microtubule nucleation 3.5714 8 yes
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 2.8571 5 yes
GO:0043506 regulation of JUN kinase activity 2.8571 9 yes
GO:0006325 chromatin organization 2.1429 4 yes
GO:0033146 regulation of intracellular estrogen receptor signaling pathway 2.1429 6 yes
GO:0043507 positive regulation of JUN kinase activity 2.1429 9 yes
GO:0048012 hepatocyte growth factor receptor signaling pathway 2.1429 6 yes
GO:0006338 chromatin remodeling 1.4286 5 yes
GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 1.4286 6 yes
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1.4286 7 yes
GO:0060244 negative regulation of cell proliferation involved in contact inhibition 1.4286 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PAK1_HUMAN
DOID:440 neuromuscular disease 3.5714 5 no
DOID:574 peripheral nervous system disease 3.5714 3 no
DOID:870 neuropathy 3.5714 4 no
DOID:0060038 specific developmental disorder 2.8571 3 no
DOID:1059 intellectual disability 2.8571 4 no
DOID:0050155 sensory system disease 2.1429 3 no
DOID:0050563 nonsyndromic deafness 2.1429 5 no
DOID:10595 Charcot-Marie-Tooth disease 2.1429 6 no
DOID:2742 auditory system disease 2.1429 4 no
DOID:0050686 organ system cancer 2.1429 3 no
DOID:114 heart disease 2.1429 3 no
DOID:0050542 Charcot-Marie-Tooth disease type X 1.4286 7 no
DOID:0060307 autosomal dominant intellectual developmental disorder 1.4286 5 no
DOID:0111962 combined immunodeficiency 1.4286 4 no
DOID:612 primary immunodeficiency disease 1.4286 3 no
DOID:331 central nervous system disease 1.4286 3 no
DOID:193 reproductive organ cancer 1.4286 4 no
DOID:3635 congenital myasthenic syndrome 1.4286 7 no
DOID:439 neuromuscular junction disease 1.4286 6 no
DOID:0050564 autosomal dominant nonsyndromic deafness 1.4286 6 no
DOID:0080000 muscular disease 1.4286 3 no
DOID:423 myopathy 1.4286 5 no
DOID:66 muscle tissue disease 1.4286 4 no
DOID:9884 muscular dystrophy 1.4286 6 no
DOID:0050700 cardiomyopathy 1.4286 4 no
DOID:0060036 intrinsic cardiomyopathy 1.4286 5 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ABI3_HUMAN [view entry] [view interactions] Low throughput yes no
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ELF3_HUMAN [view interactions] Low throughput no no
H31_HUMAN [view interactions] Low throughput no yes
MYLK_HUMAN [view interactions] Low throughput no no
H4_HUMAN [view interactions] Low throughput no yes
M3K1_HUMAN [view interactions] Low throughput no yes
MYO6_HUMAN [view entry] [view interactions] Low throughput yes no
BAD_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1A_HUMAN [view interactions] Low throughput no yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
HACE1_HUMAN [view interactions] Low throughput no no
CD11B_HUMAN [view interactions] Low throughput no yes
OXSR1_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
CRPAK_HUMAN [view interactions] Low throughput no no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
PCBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOU_HUMAN [view interactions] Low throughput no no
SRGP2_HUMAN [view entry] [view interactions] Low throughput yes no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ASC_HUMAN [view interactions] Low throughput no no
GIT2_HUMAN [view interactions] Low throughput no yes
PLK1_HUMAN [view interactions] Low throughput no yes
LIMK1_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
TR10B_HUMAN [view interactions] Low throughput no no
TNF10_HUMAN [view interactions] Low throughput no no
PK3CB_HUMAN [view interactions] Low throughput no yes
RGAP1_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
RIT1_HUMAN [view interactions] Low throughput no yes
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
CIB1_HUMAN [view interactions] Low throughput no no
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOJ_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD11A_HUMAN [view interactions] Low throughput no yes
PK1IP_HUMAN [view interactions] Low throughput no yes
CHRD1_HUMAN [view interactions] Low throughput no yes
TGFR1_HUMAN [view interactions] Low throughput no no
TGFR2_HUMAN [view interactions] Low throughput no no
ARHG2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC1B_HUMAN [view interactions] Low throughput no no
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
KPYR_HUMAN [view entry] [view interactions] Low throughput yes no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
BMX_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ESR1_HUMAN [view interactions] Low throughput no no
BRSK1_HUMAN [view entry] [view interactions] Low throughput yes no
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
WDR26_HUMAN [view interactions] Low throughput no yes
GDIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
BCL6_HUMAN [view interactions] Low throughput no no
RAC3_HUMAN [view entry] [view interactions] Low throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ILKAP_HUMAN [view interactions] High throughput no yes
PUR1_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
CD47_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
ZN768_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
ARHG6_HUMAN [view interactions] High throughput no no
TGM2_HUMAN [view interactions] High throughput no no
ROAA_HUMAN [view interactions] High throughput no yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
SRSF2_HUMAN [view interactions] High throughput no yes
TBCB_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF5_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MERL_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
HSP77_HUMAN [view interactions] High throughput no no
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
ARL1_HUMAN [view interactions] High throughput no yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
TMM33_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
LAT1_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
ASPH_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
RCN2_HUMAN [view interactions] High throughput no yes
KPRA_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
TBB8_HUMAN [view interactions] High throughput no no
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3E_HUMAN [view interactions] High throughput no no
S39A7_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
PGAM5_HUMAN [view entry] [view interactions] High throughput yes yes
MMS19_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
TBB6_HUMAN [view entry] [view interactions] High throughput yes yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
PDP1_HUMAN [view interactions] High throughput no yes
ACSL5_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
HIG1A_HUMAN [view entry] [view interactions] High throughput yes yes
HIG1C_HUMAN [view interactions] High throughput no no
RUVB1_HUMAN [view interactions] High throughput no yes
NS1BP_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
KPRB_HUMAN [view interactions] High throughput no yes
DPM1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
UBR5_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
4F2_HUMAN [view entry] [view interactions] High throughput yes no
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
MGST1_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS2_HUMAN [view interactions] High throughput no no
MOT4_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
HLAA_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
HLAB_HUMAN [view interactions] High throughput no yes
RPB2_HUMAN [view interactions] High throughput no yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
VAT1_HUMAN [view entry] [view interactions] High throughput yes no
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
T161A_HUMAN [view interactions] High throughput no yes
TECR_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view interactions] High throughput no no
IKKE_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TSACC_HUMAN [view interactions] High throughput no no
ZHX1R_HUMAN [view interactions] High throughput no yes
SPSB1_HUMAN [view interactions] High throughput no no
TEX12_HUMAN [view interactions] High throughput no no
KLH20_HUMAN [view interactions] High throughput no yes
NOD1_HUMAN [view interactions] High throughput no no
TI17B_HUMAN [view interactions] High throughput no no
STX11_HUMAN [view interactions] High throughput no yes
TELT_HUMAN [view interactions] High throughput no no
MK11_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
PPAL_HUMAN [view interactions] High throughput no no
TCP1L_HUMAN [view interactions] High throughput no no
DYR1B_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
ZN823_HUMAN [view interactions] High throughput no no
MYNN_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
Z3H7A_HUMAN [view interactions] High throughput no no
ZBT18_HUMAN [view interactions] High throughput no yes
ZN418_HUMAN [view interactions] High throughput no no
CPLN1_HUMAN [view interactions] High throughput no yes
ZNF83_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
S2541_HUMAN [view interactions] High throughput no no
T2R41_HUMAN [view interactions] High throughput no no
ICAM1_HUMAN [view interactions] High throughput no no
LPXN_HUMAN [view interactions] High throughput no yes
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
OR2K2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
SETX_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
NANO1_HUMAN [view interactions] High throughput no yes
PARP3_HUMAN [view interactions] High throughput no yes
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
TX1B3_HUMAN [view interactions] High throughput no no
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
MK04_HUMAN [view interactions] High throughput no no
PO3F1_HUMAN [view interactions] High throughput no no
AVR2B_HUMAN [view interactions] High throughput no no
PAQR3_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHOQ_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
PAK3_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] Computational yes yes
KALRN_HUMAN [view entry] [view interactions] Computational yes yes
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
PAK5_HUMAN [view interactions] Computational no yes
LAMB2_HUMAN [view interactions] Computational no yes
MK13_HUMAN [view interactions] Computational no yes
MYPT1_HUMAN [view entry] [view interactions] Computational yes yes
FLNC_HUMAN [view entry] [view interactions] Computational yes no
LAMC2_HUMAN [view interactions] Computational no no
MP2K3_HUMAN [view entry] [view interactions] Computational yes yes
MK12_HUMAN [view interactions] Computational no no
LAMB1_HUMAN [view interactions] Computational no yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
LIMK2_HUMAN [view interactions] Computational no yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
PLAK_HUMAN [view entry] [view interactions] Computational yes yes
MYH9_HUMAN [view entry] [view interactions] Computational yes no
ITB1_HUMAN [view entry] [view interactions] Computational yes no
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
ITA1_HUMAN [view interactions] Computational no yes
ML12A_HUMAN [view interactions] Computational no no
LAT_HUMAN [view interactions] Computational no no
ACHA_HUMAN [view entry] [view interactions] Computational yes no
CADH5_HUMAN [view interactions] Computational no yes
LAMC1_HUMAN [view interactions] Computational no yes
M3K14_HUMAN [view interactions] Computational no yes
LAMA3_HUMAN [view interactions] Computational no no
NET1_HUMAN [view interactions] Computational no no
ROBO2_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LAMB3_HUMAN [view interactions] Computational no yes
MYH11_HUMAN [view entry] [view interactions] Computational yes no
PAK4_HUMAN [view interactions] Computational no yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
DCC_HUMAN [view entry] [view interactions] Computational yes yes
EPHB2_HUMAN [view entry] [view interactions] Computational yes yes
LAMA2_HUMAN [view interactions] Computational no no
CASP3_HUMAN [view interactions] Computational no yes
MUSK_HUMAN [view entry] [view interactions] Computational yes no
NCF2_HUMAN [view interactions] Computational no no
LAMA1_HUMAN [view interactions] Computational no no
M3K4_HUMAN [view interactions] Computational no yes
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
ILK_HUMAN [view interactions] Computational no no
PDGFB_HUMAN [view interactions] Computational no yes
MYL9_HUMAN [view interactions] Computational no no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
ACTS_HUMAN [view interactions] Computational no no
MYL6_HUMAN [view entry] [view interactions] Computational yes no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
FLNB_HUMAN [view interactions] Computational no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
DOK2_HUMAN [view interactions] Computational no no
M3K2_HUMAN [view interactions] Computational no yes
CTND1_HUMAN [view entry] [view interactions] Computational yes no
EFNB1_HUMAN [view interactions] Computational no yes
MYPT2_HUMAN [view interactions] Computational no no
TRIO_HUMAN [view entry] [view interactions] Computational yes yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
AURKA_HUMAN [view entry] [view interactions] Computational yes no
ROBO1_HUMAN [view interactions] Computational no yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
ML12B_HUMAN [view interactions] Computational no no
DAG1_HUMAN [view entry] [view interactions] Computational yes no
PGFRB_HUMAN [view interactions] Computational no yes
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
PP1B_HUMAN [view entry] [view interactions] Computational yes yes
MP2K4_HUMAN [view interactions] Computational no yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
MK08_HUMAN [view interactions] Computational no yes
RAPSN_HUMAN [view entry] [view interactions] Computational yes no
NCF1_HUMAN [view interactions] Computational no no
MP2K2_HUMAN [view entry] [view interactions] Computational yes yes
TIAM1_HUMAN [view entry] [view interactions] Computational yes yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
EFNB3_HUMAN [view entry] [view interactions] Computational yes yes
CD5R1_HUMAN [view entry] [view interactions] Computational yes no
RASN_HUMAN [view entry] [view interactions] Computational yes no
M3K3_HUMAN [view interactions] Computational no no
M3K12_HUMAN [view entry] [view interactions] Computational yes yes
LAMC3_HUMAN [view interactions] Computational no no
MP2K6_HUMAN [view interactions] Computational no yes
MK06_HUMAN [view interactions] Computational no yes