GIT1_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors . Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed, PubMed). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning . Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed, PubMed). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 . In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane . In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input . Required for successful bone regeneration during fracture healing . The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis . May play a role in angiogenesis during fracture healing . In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and Lys-63-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GIT1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.2500 | 4 | no |
| GO:0000166 | nucleotide binding | 33.7500 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.7500 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.7500 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.5000 | 4 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.5000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.5000 | 5 | no |
| GO:0019901 | protein kinase binding | 27.5000 | 5 | no |
| GO:0005524 | ATP binding | 26.2500 | 5 | no |
| GO:0016301 | kinase activity | 21.2500 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 21.2500 | 4 | no |
| GO:0043169 | cation binding | 20.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 11.2500 | 4 | yes |
| GO:0015631 | tubulin binding | 10.0000 | 4 | yes |
| GO:0005096 | GTPase activator activity | 6.2500 | 4 | yes |
| GO:0031267 | small GTPase binding | 6.2500 | 5 | yes |
| GO:0051020 | GTPase binding | 6.2500 | 4 | yes |
| GO:0043015 | gamma-tubulin binding | 5.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GIT1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 57.5000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.5000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.7500 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7500 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | yes |
| GO:0006996 | organelle organization | 41.2500 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | yes |
| GO:0008104 | protein localization | 37.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 35.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 33.7500 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.7500 | 5 | no |
| GO:0030030 | cell projection organization | 32.5000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 32.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.5000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.2500 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.7500 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 28.7500 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 28.7500 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.5000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 27.5000 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 27.5000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.5000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.5000 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 27.5000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.5000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.5000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.5000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.2500 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 26.2500 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.2500 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.2500 | 7 | no |
| GO:0010468 | regulation of gene expression | 26.2500 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 23.7500 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 23.7500 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.7500 | 5 | no |
| GO:0034330 | cell junction organization | 23.7500 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 23.7500 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.5000 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 22.5000 | 4 | yes |
| GO:0080134 | regulation of response to stress | 22.5000 | 4 | yes |
| GO:0016310 | phosphorylation | 22.5000 | 5 | no |
| GO:0036211 | protein modification process | 22.5000 | 4 | no |
| GO:0043412 | macromolecule modification | 22.5000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.5000 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 21.2500 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.2500 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 21.2500 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.2500 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.2500 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 21.2500 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.0000 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.0000 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 20.0000 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 17.5000 | 6 | yes |
| GO:0051046 | regulation of secretion | 17.5000 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.2500 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 16.2500 | 4 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 15.0000 | 6 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 15.0000 | 7 | yes |
| GO:0050890 | cognition | 15.0000 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 15.0000 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 13.7500 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 13.7500 | 6 | yes |
| GO:0031347 | regulation of defense response | 13.7500 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 13.7500 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 13.7500 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 12.5000 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 12.5000 | 6 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 12.5000 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 11.2500 | 7 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 11.2500 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 11.2500 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 10.0000 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 10.0000 | 7 | yes |
| GO:0051726 | regulation of cell cycle | 10.0000 | 4 | yes |
| GO:0007612 | learning | 10.0000 | 4 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 8.7500 | 5 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 8.7500 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 8.7500 | 5 | yes |
| GO:1903034 | regulation of response to wounding | 8.7500 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 8.7500 | 6 | yes |
| GO:0009895 | negative regulation of catabolic process | 8.7500 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 7.5000 | 4 | yes |
| GO:0033993 | response to lipid | 7.5000 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 7.5000 | 6 | yes |
| GO:0001817 | regulation of cytokine production | 7.5000 | 4 | yes |
| GO:0010564 | regulation of cell cycle process | 6.2500 | 5 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 6.2500 | 6 | yes |
| GO:0031113 | regulation of microtubule polymerization | 6.2500 | 6 | yes |
| GO:0031348 | negative regulation of defense response | 6.2500 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 6.2500 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 6.2500 | 5 | yes |
| GO:0071396 | cellular response to lipid | 6.2500 | 5 | yes |
| GO:0001818 | negative regulation of cytokine production | 6.2500 | 5 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 6.2500 | 5 | yes |
| GO:0010968 | regulation of microtubule nucleation | 5.0000 | 7 | yes |
| GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 5.0000 | 7 | yes |
| GO:0031116 | positive regulation of microtubule polymerization | 5.0000 | 7 | yes |
| GO:0032465 | regulation of cytokinesis | 5.0000 | 5 | yes |
| GO:0048666 | neuron development | 5.0000 | 4 | yes |
| GO:0050727 | regulation of inflammatory response | 5.0000 | 5 | yes |
| GO:0050728 | negative regulation of inflammatory response | 5.0000 | 6 | yes |
| GO:0051302 | regulation of cell division | 5.0000 | 4 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 5.0000 | 4 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 5.0000 | 6 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 5.0000 | 5 | yes |
| GO:0030811 | regulation of nucleotide catabolic process | 3.7500 | 5 | yes |
| GO:0032496 | response to lipopolysaccharide | 3.7500 | 4 | yes |
| GO:0033121 | regulation of purine nucleotide catabolic process | 3.7500 | 6 | yes |
| GO:0043467 | regulation of generation of precursor metabolites and energy | 3.7500 | 5 | yes |
| GO:0043470 | regulation of carbohydrate catabolic process | 3.7500 | 5 | yes |
| GO:0045912 | negative regulation of carbohydrate metabolic process | 3.7500 | 5 | yes |
| GO:0071219 | cellular response to molecule of bacterial origin | 3.7500 | 4 | yes |
| GO:0071222 | cellular response to lipopolysaccharide | 3.7500 | 5 | yes |
| GO:0090063 | positive regulation of microtubule nucleation | 3.7500 | 8 | yes |
| GO:0099171 | presynaptic modulation of chemical synaptic transmission | 3.7500 | 6 | yes |
| GO:1900542 | regulation of purine nucleotide metabolic process | 3.7500 | 6 | yes |
| GO:1903578 | regulation of ATP metabolic process | 3.7500 | 7 | yes |
| GO:0002237 | response to molecule of bacterial origin | 3.7500 | 4 | yes |
| GO:0006110 | regulation of glycolytic process | 3.7500 | 6 | yes |
| GO:0006140 | regulation of nucleotide metabolic process | 3.7500 | 5 | yes |
| GO:0007420 | brain development | 3.7500 | 4 | yes |
| GO:0030812 | negative regulation of nucleotide catabolic process | 2.5000 | 6 | yes |
| GO:0032012 | regulation of ARF protein signal transduction | 2.5000 | 7 | yes |
| GO:0032651 | regulation of interleukin-1 beta production | 2.5000 | 6 | yes |
| GO:0032652 | regulation of interleukin-1 production | 2.5000 | 5 | yes |
| GO:0032691 | negative regulation of interleukin-1 beta production | 2.5000 | 7 | yes |
| GO:0032692 | negative regulation of interleukin-1 production | 2.5000 | 6 | yes |
| GO:0033122 | negative regulation of purine nucleotide catabolic process | 2.5000 | 7 | yes |
| GO:0036465 | synaptic vesicle recycling | 2.5000 | 4 | yes |
| GO:0045820 | negative regulation of glycolytic process | 2.5000 | 6 | yes |
| GO:0045980 | negative regulation of nucleotide metabolic process | 2.5000 | 6 | yes |
| GO:0061743 | motor learning | 2.5000 | 5 | yes |
| GO:0062014 | negative regulation of small molecule metabolic process | 2.5000 | 5 | yes |
| GO:0106014 | regulation of inflammatory response to wounding | 2.5000 | 6 | yes |
| GO:0106015 | negative regulation of inflammatory response to wounding | 2.5000 | 6 | yes |
| GO:1900543 | negative regulation of purine nucleotide metabolic process | 2.5000 | 7 | yes |
| GO:1903035 | negative regulation of response to wounding | 2.5000 | 5 | yes |
| GO:1903579 | negative regulation of ATP metabolic process | 2.5000 | 8 | yes |
| GO:0001957 | intramembranous ossification | 2.5000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | Low throughput | no | no |
| SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| GIT2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENTR1_HUMAN | [view interactions] | Low throughput | no | no |
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGFI1_HUMAN | [view interactions] | Low throughput | no | no |
| SNX6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARBK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LPXN_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN13_HUMAN | [view interactions] | Low throughput | no | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| CE126_HUMAN | [view interactions] | High throughput | no | no |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH033_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPU_HUMAN | [view interactions] | High throughput | no | no |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| ZAP70_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| SV2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYSC_HUMAN | [view interactions] | High throughput | no | no |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| TRIB3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| CENPR_HUMAN | [view interactions] | High throughput | no | yes |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| CC113_HUMAN | [view interactions] | High throughput | no | no |
| MA2A2_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP13_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| MAFF_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD4_HUMAN | [view interactions] | High throughput | no | no |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| POTB3_HUMAN | [view interactions] | High throughput | no | no |
| CROCC_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| R113B_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| TM154_HUMAN | [view interactions] | High throughput | no | no |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL1_HUMAN | [view interactions] | High throughput | no | no |
| ZNHI1_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| FND11_HUMAN | [view interactions] | High throughput | no | no |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| INAVA_HUMAN | [view interactions] | High throughput | no | yes |
| AT2L2_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |