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GIT1_HUMAN

GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors . Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed, PubMed). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning . Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed, PubMed). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 . In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane . In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input . Required for successful bone regeneration during fracture healing . The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis . May play a role in angiogenesis during fracture healing . In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and Lys-63-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GIT1_HUMAN
GO:0017076 purine nucleotide binding 37.7778 4 no
GO:0032555 purine ribonucleotide binding 37.7778 4 no
GO:0035639 purine ribonucleoside triphosphate binding 36.6667 4 no
GO:0019900 kinase binding 30.0000 4 no
GO:0030554 adenyl nucleotide binding 30.0000 5 no
GO:0032559 adenyl ribonucleotide binding 30.0000 5 no
GO:0019901 protein kinase binding 28.8889 5 no
GO:0005524 ATP binding 28.8889 5 no
GO:0016301 kinase activity 24.4444 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.4444 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.1111 4 no
GO:0046872 metal ion binding 20.0000 4 yes
GO:0015631 tubulin binding 7.7778 4 yes
GO:0030695 GTPase regulator activity 7.7778 4 yes
GO:0005096 GTPase activator activity 5.5556 4 yes
GO:0043015 gamma-tubulin binding 4.4444 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GIT1_HUMAN
GO:0048522 positive regulation of cellular process 62.2222 4 yes
GO:0010646 regulation of cell communication 56.6667 4 yes
GO:0051128 regulation of cellular component organization 54.4444 4 yes
GO:0048523 negative regulation of cellular process 53.3333 4 yes
GO:0031323 regulation of cellular metabolic process 53.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 51.1111 4 yes
GO:0080090 regulation of primary metabolic process 48.8889 4 yes
GO:0009966 regulation of signal transduction 48.8889 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.7778 4 yes
GO:0051049 regulation of transport 43.3333 4 yes
GO:0009893 positive regulation of metabolic process 42.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0008104 protein localization 38.8889 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0051246 regulation of protein metabolic process 36.6667 5 no
GO:0006996 organelle organization 36.6667 4 no
GO:0051174 regulation of phosphorus metabolic process 35.5556 5 yes
GO:0022607 cellular component assembly 35.5556 4 no
GO:0019220 regulation of phosphate metabolic process 35.5556 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 34.4444 5 no
GO:0031344 regulation of cell projection organization 34.4444 5 no
GO:0033043 regulation of organelle organization 34.4444 5 yes
GO:0042325 regulation of phosphorylation 34.4444 7 yes
GO:0016192 vesicle-mediated transport 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0051130 positive regulation of cellular component organization 32.2222 5 yes
GO:0006796 phosphate-containing compound metabolic process 32.2222 4 no
GO:0031399 regulation of protein modification process 31.1111 6 no
GO:0030030 cell projection organization 31.1111 4 no
GO:0044087 regulation of cellular component biogenesis 31.1111 4 yes
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0036211 protein modification process 30.0000 4 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0009892 negative regulation of metabolic process 30.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 28.8889 6 no
GO:0022603 regulation of anatomical structure morphogenesis 28.8889 4 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0048584 positive regulation of response to stimulus 27.7778 4 no
GO:0045595 regulation of cell differentiation 27.7778 4 no
GO:0010468 regulation of gene expression 27.7778 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 27.7778 5 yes
GO:0071702 organic substance transport 26.6667 4 no
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 no
GO:0042327 positive regulation of phosphorylation 26.6667 8 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0043549 regulation of kinase activity 26.6667 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 no
GO:0006468 protein phosphorylation 26.6667 5 no
GO:0016310 phosphorylation 26.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 26.6667 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 25.5556 5 yes
GO:0071705 nitrogen compound transport 25.5556 4 no
GO:0010941 regulation of cell death 25.5556 4 no
GO:0042981 regulation of apoptotic process 25.5556 6 no
GO:0043067 regulation of programmed cell death 25.5556 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.5556 5 no
GO:0050804 modulation of chemical synaptic transmission 24.4444 5 yes
GO:0051493 regulation of cytoskeleton organization 24.4444 6 yes
GO:0080134 regulation of response to stress 24.4444 4 yes
GO:0099177 regulation of trans-synaptic signaling 24.4444 4 yes
GO:0001934 positive regulation of protein phosphorylation 24.4444 8 no
GO:0031401 positive regulation of protein modification process 24.4444 7 no
GO:0045859 regulation of protein kinase activity 24.4444 6 no
GO:0051050 positive regulation of transport 24.4444 4 no
GO:0051094 positive regulation of developmental process 24.4444 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 24.4444 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.4444 5 yes
GO:0071310 cellular response to organic substance 23.3333 4 yes
GO:0015031 protein transport 23.3333 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 23.3333 5 yes
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0051248 negative regulation of protein metabolic process 21.1111 6 no
GO:0051347 positive regulation of transferase activity 21.1111 5 no
GO:0009889 regulation of biosynthetic process 21.1111 4 no
GO:0010647 positive regulation of cell communication 21.1111 5 no
GO:0031326 regulation of cellular biosynthetic process 21.1111 5 no
GO:0010975 regulation of neuron projection development 21.1111 7 no
GO:0044089 positive regulation of cellular component biogenesis 21.1111 5 yes
GO:0060627 regulation of vesicle-mediated transport 20.0000 4 yes
GO:1902903 regulation of supramolecular fiber organization 18.8889 5 yes
GO:0009894 regulation of catabolic process 18.8889 4 yes
GO:0010638 positive regulation of organelle organization 18.8889 6 yes
GO:0048585 negative regulation of response to stimulus 17.7778 4 yes
GO:0032101 regulation of response to external stimulus 17.7778 4 yes
GO:0051046 regulation of secretion 16.6667 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 16.6667 6 yes
GO:0045936 negative regulation of phosphate metabolic process 16.6667 7 yes
GO:1903530 regulation of secretion by cell 15.5556 4 yes
GO:0042326 negative regulation of phosphorylation 15.5556 8 yes
GO:0043254 regulation of protein-containing complex assembly 15.5556 5 yes
GO:0051726 regulation of cell cycle 14.4444 4 yes
GO:1901701 cellular response to oxygen-containing compound 14.4444 4 yes
GO:0050890 cognition 12.2222 4 yes
GO:0031334 positive regulation of protein-containing complex assembly 12.2222 6 yes
GO:0032271 regulation of protein polymerization 12.2222 6 yes
GO:0048013 ephrin receptor signaling pathway 12.2222 6 yes
GO:0051495 positive regulation of cytoskeleton organization 11.1111 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 11.1111 6 yes
GO:0051241 negative regulation of multicellular organismal process 10.0000 4 yes
GO:1903034 regulation of response to wounding 10.0000 5 yes
GO:0010564 regulation of cell cycle process 10.0000 5 yes
GO:0010629 negative regulation of gene expression 10.0000 6 yes
GO:0032273 positive regulation of protein polymerization 10.0000 7 yes
GO:0009895 negative regulation of catabolic process 8.8889 5 yes
GO:0017157 regulation of exocytosis 8.8889 5 yes
GO:0031347 regulation of defense response 8.8889 5 yes
GO:0033993 response to lipid 8.8889 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 8.8889 6 yes
GO:0051302 regulation of cell division 7.7778 4 yes
GO:0071396 cellular response to lipid 7.7778 5 yes
GO:0007612 learning 7.7778 4 yes
GO:0032465 regulation of cytokinesis 7.7778 5 yes
GO:0032886 regulation of microtubule-based process 7.7778 4 yes
GO:0051588 regulation of neurotransmitter transport 6.6667 5 yes
GO:1903305 regulation of regulated secretory pathway 6.6667 6 yes
GO:0001817 regulation of cytokine production 6.6667 4 yes
GO:0062012 regulation of small molecule metabolic process 5.5556 4 yes
GO:0070507 regulation of microtubule cytoskeleton organization 5.5556 5 yes
GO:0006109 regulation of carbohydrate metabolic process 5.5556 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 5.5556 5 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 5.5556 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 5.5556 6 yes
GO:0031113 regulation of microtubule polymerization 5.5556 6 yes
GO:0046928 regulation of neurotransmitter secretion 5.5556 4 yes
GO:0048666 neuron development 4.4444 4 yes
GO:0050727 regulation of inflammatory response 4.4444 5 yes
GO:0050728 negative regulation of inflammatory response 4.4444 6 yes
GO:0071219 cellular response to molecule of bacterial origin 4.4444 4 yes
GO:0071222 cellular response to lipopolysaccharide 4.4444 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 4.4444 5 yes
GO:0001818 negative regulation of cytokine production 4.4444 5 yes
GO:0002237 response to molecule of bacterial origin 4.4444 4 yes
GO:0010968 regulation of microtubule nucleation 4.4444 7 yes
GO:0031112 positive regulation of microtubule polymerization or depolymerization 4.4444 7 yes
GO:0031116 positive regulation of microtubule polymerization 4.4444 7 yes
GO:0031348 negative regulation of defense response 4.4444 5 yes
GO:0032102 negative regulation of response to external stimulus 4.4444 5 yes
GO:0032496 response to lipopolysaccharide 4.4444 4 yes
GO:0062014 negative regulation of small molecule metabolic process 3.3333 5 yes
GO:0090063 positive regulation of microtubule nucleation 3.3333 8 yes
GO:0007420 brain development 3.3333 4 yes
GO:0043467 regulation of generation of precursor metabolites and energy 3.3333 5 yes
GO:0061743 motor learning 2.2222 5 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 2.2222 6 yes
GO:0106014 regulation of inflammatory response to wounding 2.2222 6 yes
GO:0106015 negative regulation of inflammatory response to wounding 2.2222 6 yes
GO:1900542 regulation of purine nucleotide metabolic process 2.2222 6 yes
GO:1900543 negative regulation of purine nucleotide metabolic process 2.2222 7 yes
GO:1903035 negative regulation of response to wounding 2.2222 5 yes
GO:1903578 regulation of ATP metabolic process 2.2222 7 yes
GO:1903579 negative regulation of ATP metabolic process 2.2222 8 yes
GO:0001957 intramembranous ossification 2.2222 4 yes
GO:0006110 regulation of glycolytic process 2.2222 6 yes
GO:0006140 regulation of nucleotide metabolic process 2.2222 5 yes
GO:0010677 negative regulation of cellular carbohydrate metabolic process 2.2222 6 yes
GO:0032651 regulation of interleukin-1 beta production 2.2222 6 yes
GO:0032652 regulation of interleukin-1 production 2.2222 5 yes
GO:0032691 negative regulation of interleukin-1 beta production 2.2222 7 yes
GO:0032692 negative regulation of interleukin-1 production 2.2222 6 yes
GO:0043470 regulation of carbohydrate catabolic process 2.2222 5 yes
GO:0045820 negative regulation of glycolytic process 2.2222 6 yes
GO:0045912 negative regulation of carbohydrate metabolic process 2.2222 5 yes
GO:0045980 negative regulation of nucleotide metabolic process 2.2222 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in GIT1_HUMAN
DOID:0050700 cardiomyopathy 2.2222 4 no
DOID:0060036 intrinsic cardiomyopathy 2.2222 5 no
DOID:114 heart disease 2.2222 3 no
DOID:2843 long QT syndrome 2.2222 6 no
DOID:0060038 specific developmental disorder 2.2222 3 no
DOID:1059 intellectual disability 2.2222 4 no
DOID:0050686 organ system cancer 2.2222 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG6_HUMAN [view interactions] Low throughput no no
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PAXI_HUMAN [view interactions] Low throughput no yes
NAA10_HUMAN [view interactions] Low throughput no yes
GIT2_HUMAN [view interactions] Low throughput no yes
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
ENTR1_HUMAN [view interactions] Low throughput no no
LIPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA4_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA2_HUMAN [view entry] [view interactions] Low throughput yes no
LIPA3_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFI1_HUMAN [view interactions] Low throughput no no
SNX6_HUMAN [view entry] [view interactions] Low throughput yes no
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP2_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
ARBK2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
LPXN_HUMAN [view interactions] Low throughput no yes
PTN13_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
BARD1_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
CE126_HUMAN [view interactions] High throughput no no
CHD3_HUMAN [view interactions] High throughput no yes
IKKA_HUMAN [view interactions] High throughput no yes
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
CH033_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
TAB1_HUMAN [view interactions] High throughput no yes
CENPU_HUMAN [view interactions] High throughput no no
NEK2_HUMAN [view interactions] High throughput no no
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
RGS2_HUMAN [view interactions] High throughput no no
ACATN_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
CDC73_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
MED4_HUMAN [view interactions] High throughput no yes
TRI55_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
MAST1_HUMAN [view interactions] High throughput no yes
PUM1_HUMAN [view interactions] High throughput no yes
PAK3_HUMAN [view entry] [view interactions] High throughput yes no
LYSC_HUMAN [view interactions] High throughput no no
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1C_HUMAN [view interactions] High throughput no yes
SV2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
MFAP1_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC5_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SRRT_HUMAN [view interactions] High throughput no yes
TRIB3_HUMAN [view interactions] High throughput no yes
DDX24_HUMAN [view interactions] High throughput no yes
LTOR5_HUMAN [view interactions] High throughput no yes
CENPR_HUMAN [view interactions] High throughput no yes
PMF1_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
WDR33_HUMAN [view interactions] High throughput no yes
TXND9_HUMAN [view interactions] High throughput no yes
CC113_HUMAN [view interactions] High throughput no no
MA2A2_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SKP1_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
NDEL1_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
PKN3_HUMAN [view interactions] High throughput no yes
NCK5L_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
PGTB2_HUMAN [view interactions] High throughput no yes
MAFF_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
ICAM1_HUMAN [view interactions] High throughput no no
FBX28_HUMAN [view interactions] High throughput no yes
SYNCI_HUMAN [view interactions] High throughput no no
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD4_HUMAN [view interactions] High throughput no no
PRS8_HUMAN [view interactions] High throughput no yes
POTB3_HUMAN [view interactions] High throughput no no
CROCC_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
TEDC2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
PPT1_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
R113B_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
NHRF1_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
CENPQ_HUMAN [view interactions] High throughput no yes
TM154_HUMAN [view interactions] High throughput no no
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL1_HUMAN [view interactions] High throughput no no
ZNHI1_HUMAN [view interactions] High throughput no yes
SENP3_HUMAN [view interactions] High throughput no yes
FND11_HUMAN [view interactions] High throughput no no
CIA2A_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
EFMT3_HUMAN [view interactions] High throughput no no
D2HDH_HUMAN [view interactions] High throughput no no
TFPT_HUMAN [view interactions] High throughput no yes
INAVA_HUMAN [view interactions] High throughput no yes
AT2L2_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
SNRPA_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
MEX3B_HUMAN [view interactions] High throughput no no
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
ML12A_HUMAN [view interactions] Computational no no
EPHA2_HUMAN [view interactions] Computational no no
ARF1_HUMAN [view entry] [view interactions] Computational yes yes
CLCA_HUMAN [view entry] [view interactions] Computational yes no
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
FINC_HUMAN [view interactions] Computational no yes
KCC1A_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
EREG_HUMAN [view interactions] Computational no no
MAT2B_HUMAN [view interactions] Computational no yes
AURKA_HUMAN [view entry] [view interactions] Computational yes no
ITA2B_HUMAN [view interactions] Computational no no
CLCB_HUMAN [view entry] [view interactions] Computational yes yes
ITB3_HUMAN [view entry] [view interactions] Computational yes no
ARF6_HUMAN [view entry] [view interactions] Computational yes yes
COPA_HUMAN [view entry] [view interactions] Computational yes yes
NOS3_HUMAN [view interactions] Computational no no
EFNA1_HUMAN [view interactions] Computational no no