GIT1_HUMAN
GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors . Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed, PubMed). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning . Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed, PubMed). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 . In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane . In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input . Required for successful bone regeneration during fracture healing . The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis . May play a role in angiogenesis during fracture healing . In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and Lys-63-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GIT1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 37.7778 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 37.7778 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 36.6667 | 4 | no |
GO:0019900 | kinase binding | 30.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 30.0000 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 30.0000 | 5 | no |
GO:0019901 | protein kinase binding | 28.8889 | 5 | no |
GO:0005524 | ATP binding | 28.8889 | 5 | no |
GO:0016301 | kinase activity | 24.4444 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 24.4444 | 4 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 21.1111 | 4 | no |
GO:0046872 | metal ion binding | 20.0000 | 4 | yes |
GO:0015631 | tubulin binding | 7.7778 | 4 | yes |
GO:0030695 | GTPase regulator activity | 7.7778 | 4 | yes |
GO:0005096 | GTPase activator activity | 5.5556 | 4 | yes |
GO:0043015 | gamma-tubulin binding | 4.4444 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GIT1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 62.2222 | 4 | yes |
GO:0010646 | regulation of cell communication | 56.6667 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 54.4444 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 53.3333 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 51.1111 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 48.8889 | 4 | yes |
GO:0009966 | regulation of signal transduction | 48.8889 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 47.7778 | 4 | yes |
GO:0051049 | regulation of transport | 43.3333 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 42.2222 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
GO:0008104 | protein localization | 38.8889 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.8889 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 36.6667 | 5 | no |
GO:0006996 | organelle organization | 36.6667 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 35.5556 | 5 | yes |
GO:0022607 | cellular component assembly | 35.5556 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 35.5556 | 6 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.4444 | 5 | no |
GO:0031344 | regulation of cell projection organization | 34.4444 | 5 | no |
GO:0033043 | regulation of organelle organization | 34.4444 | 5 | yes |
GO:0042325 | regulation of phosphorylation | 34.4444 | 7 | yes |
GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 32.2222 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 32.2222 | 4 | no |
GO:0031399 | regulation of protein modification process | 31.1111 | 6 | no |
GO:0030030 | cell projection organization | 31.1111 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.1111 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
GO:0036211 | protein modification process | 30.0000 | 4 | no |
GO:0043412 | macromolecule modification | 30.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 28.8889 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 28.8889 | 4 | no |
GO:0051338 | regulation of transferase activity | 27.7778 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 27.7778 | 4 | no |
GO:0045595 | regulation of cell differentiation | 27.7778 | 4 | no |
GO:0010468 | regulation of gene expression | 27.7778 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | yes |
GO:0071702 | organic substance transport | 26.6667 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 26.6667 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 26.6667 | 4 | no |
GO:0043549 | regulation of kinase activity | 26.6667 | 5 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
GO:0006468 | protein phosphorylation | 26.6667 | 5 | no |
GO:0016310 | phosphorylation | 26.6667 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.5556 | 5 | yes |
GO:0071705 | nitrogen compound transport | 25.5556 | 4 | no |
GO:0010941 | regulation of cell death | 25.5556 | 4 | no |
GO:0042981 | regulation of apoptotic process | 25.5556 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.5556 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.5556 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 24.4444 | 5 | yes |
GO:0051493 | regulation of cytoskeleton organization | 24.4444 | 6 | yes |
GO:0080134 | regulation of response to stress | 24.4444 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 24.4444 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 24.4444 | 8 | no |
GO:0031401 | positive regulation of protein modification process | 24.4444 | 7 | no |
GO:0045859 | regulation of protein kinase activity | 24.4444 | 6 | no |
GO:0051050 | positive regulation of transport | 24.4444 | 4 | no |
GO:0051094 | positive regulation of developmental process | 24.4444 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 24.4444 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.4444 | 5 | yes |
GO:0071310 | cellular response to organic substance | 23.3333 | 4 | yes |
GO:0015031 | protein transport | 23.3333 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 23.3333 | 5 | yes |
GO:0043269 | regulation of ion transport | 22.2222 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
GO:0030334 | regulation of cell migration | 22.2222 | 5 | no |
GO:2000145 | regulation of cell motility | 22.2222 | 4 | no |
GO:0034330 | cell junction organization | 22.2222 | 4 | no |
GO:0007010 | cytoskeleton organization | 22.2222 | 5 | no |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.1111 | 6 | no |
GO:0051347 | positive regulation of transferase activity | 21.1111 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 21.1111 | 4 | no |
GO:0010647 | positive regulation of cell communication | 21.1111 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.1111 | 5 | no |
GO:0010975 | regulation of neuron projection development | 21.1111 | 7 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 21.1111 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 18.8889 | 5 | yes |
GO:0009894 | regulation of catabolic process | 18.8889 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 18.8889 | 6 | yes |
GO:0048585 | negative regulation of response to stimulus | 17.7778 | 4 | yes |
GO:0032101 | regulation of response to external stimulus | 17.7778 | 4 | yes |
GO:0051046 | regulation of secretion | 16.6667 | 5 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 16.6667 | 6 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 16.6667 | 7 | yes |
GO:1903530 | regulation of secretion by cell | 15.5556 | 4 | yes |
GO:0042326 | negative regulation of phosphorylation | 15.5556 | 8 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 15.5556 | 5 | yes |
GO:0051726 | regulation of cell cycle | 14.4444 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 14.4444 | 4 | yes |
GO:0050890 | cognition | 12.2222 | 4 | yes |
GO:0031334 | positive regulation of protein-containing complex assembly | 12.2222 | 6 | yes |
GO:0032271 | regulation of protein polymerization | 12.2222 | 6 | yes |
GO:0048013 | ephrin receptor signaling pathway | 12.2222 | 6 | yes |
GO:0051495 | positive regulation of cytoskeleton organization | 11.1111 | 7 | yes |
GO:1902905 | positive regulation of supramolecular fiber organization | 11.1111 | 6 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 10.0000 | 4 | yes |
GO:1903034 | regulation of response to wounding | 10.0000 | 5 | yes |
GO:0010564 | regulation of cell cycle process | 10.0000 | 5 | yes |
GO:0010629 | negative regulation of gene expression | 10.0000 | 6 | yes |
GO:0032273 | positive regulation of protein polymerization | 10.0000 | 7 | yes |
GO:0009895 | negative regulation of catabolic process | 8.8889 | 5 | yes |
GO:0017157 | regulation of exocytosis | 8.8889 | 5 | yes |
GO:0031347 | regulation of defense response | 8.8889 | 5 | yes |
GO:0033993 | response to lipid | 8.8889 | 4 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 8.8889 | 6 | yes |
GO:0051302 | regulation of cell division | 7.7778 | 4 | yes |
GO:0071396 | cellular response to lipid | 7.7778 | 5 | yes |
GO:0007612 | learning | 7.7778 | 4 | yes |
GO:0032465 | regulation of cytokinesis | 7.7778 | 5 | yes |
GO:0032886 | regulation of microtubule-based process | 7.7778 | 4 | yes |
GO:0051588 | regulation of neurotransmitter transport | 6.6667 | 5 | yes |
GO:1903305 | regulation of regulated secretory pathway | 6.6667 | 6 | yes |
GO:0001817 | regulation of cytokine production | 6.6667 | 4 | yes |
GO:0062012 | regulation of small molecule metabolic process | 5.5556 | 4 | yes |
GO:0070507 | regulation of microtubule cytoskeleton organization | 5.5556 | 5 | yes |
GO:0006109 | regulation of carbohydrate metabolic process | 5.5556 | 5 | yes |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 5.5556 | 5 | yes |
GO:0010675 | regulation of cellular carbohydrate metabolic process | 5.5556 | 5 | yes |
GO:0031110 | regulation of microtubule polymerization or depolymerization | 5.5556 | 6 | yes |
GO:0031113 | regulation of microtubule polymerization | 5.5556 | 6 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 5.5556 | 4 | yes |
GO:0048666 | neuron development | 4.4444 | 4 | yes |
GO:0050727 | regulation of inflammatory response | 4.4444 | 5 | yes |
GO:0050728 | negative regulation of inflammatory response | 4.4444 | 6 | yes |
GO:0071219 | cellular response to molecule of bacterial origin | 4.4444 | 4 | yes |
GO:0071222 | cellular response to lipopolysaccharide | 4.4444 | 5 | yes |
GO:2000300 | regulation of synaptic vesicle exocytosis | 4.4444 | 5 | yes |
GO:0001818 | negative regulation of cytokine production | 4.4444 | 5 | yes |
GO:0002237 | response to molecule of bacterial origin | 4.4444 | 4 | yes |
GO:0010968 | regulation of microtubule nucleation | 4.4444 | 7 | yes |
GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 4.4444 | 7 | yes |
GO:0031116 | positive regulation of microtubule polymerization | 4.4444 | 7 | yes |
GO:0031348 | negative regulation of defense response | 4.4444 | 5 | yes |
GO:0032102 | negative regulation of response to external stimulus | 4.4444 | 5 | yes |
GO:0032496 | response to lipopolysaccharide | 4.4444 | 4 | yes |
GO:0062014 | negative regulation of small molecule metabolic process | 3.3333 | 5 | yes |
GO:0090063 | positive regulation of microtubule nucleation | 3.3333 | 8 | yes |
GO:0007420 | brain development | 3.3333 | 4 | yes |
GO:0043467 | regulation of generation of precursor metabolites and energy | 3.3333 | 5 | yes |
GO:0061743 | motor learning | 2.2222 | 5 | yes |
GO:0099171 | presynaptic modulation of chemical synaptic transmission | 2.2222 | 6 | yes |
GO:0106014 | regulation of inflammatory response to wounding | 2.2222 | 6 | yes |
GO:0106015 | negative regulation of inflammatory response to wounding | 2.2222 | 6 | yes |
GO:1900542 | regulation of purine nucleotide metabolic process | 2.2222 | 6 | yes |
GO:1900543 | negative regulation of purine nucleotide metabolic process | 2.2222 | 7 | yes |
GO:1903035 | negative regulation of response to wounding | 2.2222 | 5 | yes |
GO:1903578 | regulation of ATP metabolic process | 2.2222 | 7 | yes |
GO:1903579 | negative regulation of ATP metabolic process | 2.2222 | 8 | yes |
GO:0001957 | intramembranous ossification | 2.2222 | 4 | yes |
GO:0006110 | regulation of glycolytic process | 2.2222 | 6 | yes |
GO:0006140 | regulation of nucleotide metabolic process | 2.2222 | 5 | yes |
GO:0010677 | negative regulation of cellular carbohydrate metabolic process | 2.2222 | 6 | yes |
GO:0032651 | regulation of interleukin-1 beta production | 2.2222 | 6 | yes |
GO:0032652 | regulation of interleukin-1 production | 2.2222 | 5 | yes |
GO:0032691 | negative regulation of interleukin-1 beta production | 2.2222 | 7 | yes |
GO:0032692 | negative regulation of interleukin-1 production | 2.2222 | 6 | yes |
GO:0043470 | regulation of carbohydrate catabolic process | 2.2222 | 5 | yes |
GO:0045820 | negative regulation of glycolytic process | 2.2222 | 6 | yes |
GO:0045912 | negative regulation of carbohydrate metabolic process | 2.2222 | 5 | yes |
GO:0045980 | negative regulation of nucleotide metabolic process | 2.2222 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in GIT1_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 2.2222 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 2.2222 | 5 | no |
DOID:114 | heart disease | 2.2222 | 3 | no |
DOID:2843 | long QT syndrome | 2.2222 | 6 | no |
DOID:0060038 | specific developmental disorder | 2.2222 | 3 | no |
DOID:1059 | intellectual disability | 2.2222 | 4 | no |
DOID:0050686 | organ system cancer | 2.2222 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARHG6_HUMAN | [view interactions] | Low throughput | no | no |
SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
NAA10_HUMAN | [view interactions] | Low throughput | no | yes |
GIT2_HUMAN | [view interactions] | Low throughput | no | yes |
ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ENTR1_HUMAN | [view interactions] | Low throughput | no | no |
LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LIPA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TGFI1_HUMAN | [view interactions] | Low throughput | no | no |
SNX6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARBK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LPXN_HUMAN | [view interactions] | Low throughput | no | yes |
PTN13_HUMAN | [view interactions] | Low throughput | no | yes |
NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BARD1_HUMAN | [view interactions] | High throughput | no | yes |
LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
CE126_HUMAN | [view interactions] | High throughput | no | no |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
IKKA_HUMAN | [view interactions] | High throughput | no | yes |
PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CH033_HUMAN | [view interactions] | High throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAB1_HUMAN | [view interactions] | High throughput | no | yes |
CENPU_HUMAN | [view interactions] | High throughput | no | no |
NEK2_HUMAN | [view interactions] | High throughput | no | no |
PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PFD1_HUMAN | [view interactions] | High throughput | no | yes |
RGS2_HUMAN | [view interactions] | High throughput | no | no |
ACATN_HUMAN | [view interactions] | High throughput | no | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CENPC_HUMAN | [view interactions] | High throughput | no | no |
MED4_HUMAN | [view interactions] | High throughput | no | yes |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
ZAP70_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAST1_HUMAN | [view interactions] | High throughput | no | yes |
PUM1_HUMAN | [view interactions] | High throughput | no | yes |
PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYSC_HUMAN | [view interactions] | High throughput | no | no |
ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
SV2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRRT_HUMAN | [view interactions] | High throughput | no | yes |
TRIB3_HUMAN | [view interactions] | High throughput | no | yes |
DDX24_HUMAN | [view interactions] | High throughput | no | yes |
LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
CENPR_HUMAN | [view interactions] | High throughput | no | yes |
PMF1_HUMAN | [view interactions] | High throughput | no | no |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
WDR33_HUMAN | [view interactions] | High throughput | no | yes |
TXND9_HUMAN | [view interactions] | High throughput | no | yes |
CC113_HUMAN | [view interactions] | High throughput | no | no |
MA2A2_HUMAN | [view interactions] | High throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SKP1_HUMAN | [view interactions] | High throughput | no | yes |
SF01_HUMAN | [view interactions] | High throughput | no | yes |
NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PKN3_HUMAN | [view interactions] | High throughput | no | yes |
NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
IF6_HUMAN | [view interactions] | High throughput | no | yes |
HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
MAFF_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
FBX28_HUMAN | [view interactions] | High throughput | no | yes |
SYNCI_HUMAN | [view interactions] | High throughput | no | no |
EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMOD4_HUMAN | [view interactions] | High throughput | no | no |
PRS8_HUMAN | [view interactions] | High throughput | no | yes |
POTB3_HUMAN | [view interactions] | High throughput | no | no |
CROCC_HUMAN | [view interactions] | High throughput | no | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEDC2_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
R113B_HUMAN | [view interactions] | High throughput | no | no |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
TX1B3_HUMAN | [view interactions] | High throughput | no | no |
NHRF1_HUMAN | [view interactions] | High throughput | no | no |
NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
TM154_HUMAN | [view interactions] | High throughput | no | no |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLHL1_HUMAN | [view interactions] | High throughput | no | no |
ZNHI1_HUMAN | [view interactions] | High throughput | no | yes |
SENP3_HUMAN | [view interactions] | High throughput | no | yes |
FND11_HUMAN | [view interactions] | High throughput | no | no |
CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
D2HDH_HUMAN | [view interactions] | High throughput | no | no |
TFPT_HUMAN | [view interactions] | High throughput | no | yes |
INAVA_HUMAN | [view interactions] | High throughput | no | yes |
AT2L2_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
SIR6_HUMAN | [view interactions] | High throughput | no | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
HOOK1_HUMAN | [view interactions] | High throughput | no | no |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
MEX3B_HUMAN | [view interactions] | High throughput | no | no |
VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ML12A_HUMAN | [view interactions] | Computational | no | no |
EPHA2_HUMAN | [view interactions] | Computational | no | no |
ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MP2K1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FINC_HUMAN | [view interactions] | Computational | no | yes |
KCC1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EREG_HUMAN | [view interactions] | Computational | no | no |
MAT2B_HUMAN | [view interactions] | Computational | no | yes |
AURKA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ITA2B_HUMAN | [view interactions] | Computational | no | no |
CLCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
COPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NOS3_HUMAN | [view interactions] | Computational | no | no |
EFNA1_HUMAN | [view interactions] | Computational | no | no |