Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MTOR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) . Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed, PubMed, PubMed). This also includes mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3: in the presence of nutrients, mediates phosphorylation of TFEB and TFE3, promoting their cytosolic retention and inactivation (PubMed, PubMed, PubMed). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed, PubMed, PubMed). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed, PubMed). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 . To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A . mTORC1 also negatively regulates autophagy through phosphorylation of ULK1 . Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1 . Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed). As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton (PubMed, PubMed). Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1 (PubMed). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed). mTORC2 also regulates the phosphorylation of SGK1 at Ser-422 (PubMed). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms . Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks . Phosphorylates SQSTM1, promoting interaction between SQSTM1 and KEAP1 and subsequent inactivation of the BCR(KEAP1) complex . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
2215 Ser Tyr Focalcorticaldysplasia2(FCORD2) -
1799 Glu Lys Smith-Kingsmoresyndrome(SKS) -
1450 Tyr Asp Focalcorticaldysplasia2(FCORD2) -
1456 Trp Gly Focalcorticaldysplasia2(FCORD2) -
1459 Ala Asp Focalcorticaldysplasia2(FCORD2) -
1459 Ala Ser Focalcorticaldysplasia2(FCORD2) -
1460 Leu Pro Focalcorticaldysplasia2(FCORD2) -
1483 Cys Arg Focalcorticaldysplasia2(FCORD2) -
1490 Trp Arg Smith-Kingsmoresyndrome(SKS) -
1595 Met Ile Smith-Kingsmoresyndrome(SKS) -
1832 Ala Thr Smith-Kingsmoresyndrome(SKS) -
1888 Phe Cys Smith-Kingsmoresyndrome(SKS) -
1977 Thr Lys Focalcorticaldysplasia2(FCORD2) -
2193 Arg Cys Focalcorticaldysplasia2(FCORD2) -
2215 Ser Phe Focalcorticaldysplasia2(FCORD2) -
2327 Met Ile Smith-Kingsmoresyndrome(SKS) -
2427 Leu Pro Focalcorticaldysplasia2(FCORD2) -
2427 Leu Gln Focalcorticaldysplasia2(FCORD2) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MTOR_HUMAN
GO:0017076 purine nucleotide binding 36.2903 4 yes
GO:0032555 purine ribonucleotide binding 36.2903 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.4839 4 yes
GO:0019900 kinase binding 25.8065 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 24.1935 5 yes
GO:0032559 adenyl ribonucleotide binding 24.1935 5 yes
GO:0005524 ATP binding 23.3871 5 yes
GO:0003723 RNA binding 23.3871 4 no
GO:0046872 metal ion binding 20.9677 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 17.7419 4 yes
GO:0016301 kinase activity 17.7419 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.7419 4 yes
GO:0004674 protein serine/threonine kinase activity 15.3226 4 yes
GO:0106310 protein serine kinase activity 15.3226 4 yes
GO:0003677 DNA binding 8.0645 4 yes
GO:0003690 double-stranded DNA binding 5.6452 5 yes
GO:0043565 sequence-specific DNA binding 5.6452 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 4.8387 6 yes
GO:0000976 transcription cis-regulatory region binding 4.0323 5 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 4.0323 6 yes
GO:0001067 transcription regulatory region nucleic acid binding 4.0323 4 yes
GO:0043022 ribosome binding 3.2258 4 yes
GO:0140296 general transcription initiation factor binding 2.4194 4 yes
GO:0000182 rDNA binding 1.6129 7 yes
GO:0000992 RNA polymerase III cis-regulatory region sequence-specific DNA binding 1.6129 7 yes
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding 1.6129 8 yes
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding 1.6129 8 yes
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding 1.6129 8 yes
GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding 1.6129 6 yes
GO:0001025 RNA polymerase III general transcription initiation factor binding 1.6129 5 yes
GO:0001156 TFIIIC-class transcription factor complex binding 1.6129 6 yes
GO:0080084 5S rDNA binding 1.6129 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MTOR_HUMAN
GO:0048522 positive regulation of cellular process 68.5484 4 yes
GO:0031323 regulation of cellular metabolic process 66.1290 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.5161 4 yes
GO:0080090 regulation of primary metabolic process 64.5161 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.9032 4 yes
GO:0048523 negative regulation of cellular process 62.9032 4 yes
GO:0010646 regulation of cell communication 57.2581 4 yes
GO:0009966 regulation of signal transduction 52.4194 4 yes
GO:0051246 regulation of protein metabolic process 50.8065 5 yes
GO:0009893 positive regulation of metabolic process 49.1935 4 yes
GO:0010468 regulation of gene expression 47.5806 5 yes
GO:0009892 negative regulation of metabolic process 45.1613 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.1613 5 yes
GO:0031325 positive regulation of cellular metabolic process 45.1613 5 yes
GO:0051128 regulation of cellular component organization 42.7419 4 yes
GO:1902531 regulation of intracellular signal transduction 42.7419 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 41.9355 5 yes
GO:0009889 regulation of biosynthetic process 41.9355 4 yes
GO:0031326 regulation of cellular biosynthetic process 41.9355 5 yes
GO:0051174 regulation of phosphorus metabolic process 39.5161 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 39.5161 5 no
GO:0019220 regulation of phosphate metabolic process 39.5161 6 yes
GO:0031324 negative regulation of cellular metabolic process 39.5161 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 38.7097 5 yes
GO:0031399 regulation of protein modification process 38.7097 6 yes
GO:0048584 positive regulation of response to stimulus 37.9032 4 yes
GO:0006996 organelle organization 35.4839 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 35.4839 5 no
GO:0051247 positive regulation of protein metabolic process 34.6774 6 yes
GO:0010647 positive regulation of cell communication 34.6774 5 no
GO:0023056 positive regulation of signaling 34.6774 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.8710 5 yes
GO:0042325 regulation of phosphorylation 33.8710 7 yes
GO:0010941 regulation of cell death 33.0645 4 no
GO:0071310 cellular response to organic substance 32.2581 4 yes
GO:0009967 positive regulation of signal transduction 31.4516 5 no
GO:0043412 macromolecule modification 31.4516 4 yes
GO:0042981 regulation of apoptotic process 30.6452 6 no
GO:0043067 regulation of programmed cell death 30.6452 5 no
GO:0036211 protein modification process 30.6452 4 yes
GO:0001932 regulation of protein phosphorylation 29.8387 7 yes
GO:0008104 protein localization 29.8387 4 no
GO:0043085 positive regulation of catalytic activity 29.8387 4 yes
GO:0042127 regulation of cell population proliferation 29.0323 4 no
GO:0022607 cellular component assembly 29.0323 4 no
GO:0010243 response to organonitrogen compound 29.0323 4 yes
GO:0051338 regulation of transferase activity 28.2258 4 yes
GO:0051049 regulation of transport 28.2258 4 no
GO:0009894 regulation of catabolic process 27.4194 4 yes
GO:0051252 regulation of RNA metabolic process 26.6129 5 yes
GO:0051248 negative regulation of protein metabolic process 26.6129 6 no
GO:0009891 positive regulation of biosynthetic process 26.6129 5 yes
GO:0060548 negative regulation of cell death 26.6129 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.6129 6 yes
GO:0033043 regulation of organelle organization 26.6129 5 yes
GO:0045595 regulation of cell differentiation 26.6129 4 yes
GO:0048585 negative regulation of response to stimulus 26.6129 4 yes
GO:1901701 cellular response to oxygen-containing compound 25.8065 4 yes
GO:0006796 phosphate-containing compound metabolic process 25.8065 4 yes
GO:0051130 positive regulation of cellular component organization 25.0000 5 yes
GO:0080134 regulation of response to stress 25.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 yes
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 yes
GO:0023057 negative regulation of signaling 25.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 25.0000 4 yes
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 yes
GO:0051336 regulation of hydrolase activity 24.1935 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 24.1935 7 yes
GO:0006355 regulation of DNA-templated transcription 24.1935 6 yes
GO:2001141 regulation of RNA biosynthetic process 24.1935 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 24.1935 6 yes
GO:0010628 positive regulation of gene expression 24.1935 6 yes
GO:0031401 positive regulation of protein modification process 24.1935 7 yes
GO:0043549 regulation of kinase activity 24.1935 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.3871 6 yes
GO:0051726 regulation of cell cycle 23.3871 4 no
GO:0071702 organic substance transport 23.3871 4 no
GO:0031344 regulation of cell projection organization 23.3871 5 yes
GO:0051094 positive regulation of developmental process 22.5806 4 yes
GO:0008284 positive regulation of cell population proliferation 22.5806 5 no
GO:0009968 negative regulation of signal transduction 22.5806 5 yes
GO:0042327 positive regulation of phosphorylation 22.5806 8 yes
GO:0051493 regulation of cytoskeleton organization 21.7742 6 yes
GO:0071705 nitrogen compound transport 21.7742 4 no
GO:0060341 regulation of cellular localization 21.7742 4 no
GO:0030030 cell projection organization 21.7742 4 yes
GO:0031329 regulation of cellular catabolic process 21.7742 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.7742 6 yes
GO:0045859 regulation of protein kinase activity 20.9677 6 yes
GO:0001934 positive regulation of protein phosphorylation 20.1613 8 yes
GO:2000145 regulation of cell motility 20.1613 4 yes
GO:0032880 regulation of protein localization 20.1613 5 no
GO:0043408 regulation of MAPK cascade 20.1613 6 no
GO:0030334 regulation of cell migration 20.1613 5 yes
GO:0051345 positive regulation of hydrolase activity 19.3548 5 yes
GO:0071417 cellular response to organonitrogen compound 19.3548 4 yes
GO:1901699 cellular response to nitrogen compound 19.3548 4 yes
GO:0016310 phosphorylation 19.3548 5 yes
GO:0051240 positive regulation of multicellular organismal process 18.5484 4 yes
GO:0051347 positive regulation of transferase activity 18.5484 5 yes
GO:0120036 plasma membrane bounded cell projection organization 18.5484 5 yes
GO:2000026 regulation of multicellular organismal development 18.5484 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 18.5484 4 yes
GO:0080135 regulation of cellular response to stress 17.7419 4 yes
GO:0006468 protein phosphorylation 17.7419 5 yes
GO:0045597 positive regulation of cell differentiation 17.7419 5 yes
GO:0010608 post-transcriptional regulation of gene expression 16.9355 6 yes
GO:0018193 peptidyl-amino acid modification 16.9355 5 yes
GO:0044089 positive regulation of cellular component biogenesis 16.9355 5 yes
GO:1902532 negative regulation of intracellular signal transduction 16.1290 6 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 16.1290 6 yes
GO:2000147 positive regulation of cell motility 16.1290 5 yes
GO:0010638 positive regulation of organelle organization 16.1290 6 yes
GO:0030335 positive regulation of cell migration 16.1290 6 yes
GO:0033674 positive regulation of kinase activity 16.1290 6 yes
GO:0034248 regulation of cellular amide metabolic process 16.1290 5 yes
GO:0040017 positive regulation of locomotion 16.1290 4 yes
GO:1901652 response to peptide 15.3226 4 yes
GO:0043254 regulation of protein-containing complex assembly 15.3226 5 yes
GO:0051254 positive regulation of RNA metabolic process 14.5161 6 yes
GO:0060284 regulation of cell development 14.5161 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 14.5161 7 yes
GO:1902903 regulation of supramolecular fiber organization 14.5161 5 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 14.5161 8 yes
GO:0006417 regulation of translation 14.5161 6 yes
GO:0009895 negative regulation of catabolic process 14.5161 5 yes
GO:0032956 regulation of actin cytoskeleton organization 14.5161 5 yes
GO:0032970 regulation of actin filament-based process 14.5161 4 yes
GO:0045893 positive regulation of DNA-templated transcription 14.5161 7 yes
GO:0006915 apoptotic process 13.7097 4 yes
GO:0031346 positive regulation of cell projection organization 13.7097 6 yes
GO:0043087 regulation of GTPase activity 13.7097 5 yes
GO:0043434 response to peptide hormone 13.7097 4 yes
GO:0045860 positive regulation of protein kinase activity 13.7097 7 yes
GO:1901566 organonitrogen compound biosynthetic process 12.9032 4 yes
GO:0018105 peptidyl-serine phosphorylation 12.9032 6 yes
GO:0018209 peptidyl-serine modification 12.9032 6 yes
GO:0051495 positive regulation of cytoskeleton organization 11.2903 7 yes
GO:0031330 negative regulation of cellular catabolic process 11.2903 6 yes
GO:0110053 regulation of actin filament organization 10.4839 6 yes
GO:0010506 regulation of autophagy 10.4839 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 10.4839 6 yes
GO:0032271 regulation of protein polymerization 10.4839 6 yes
GO:0034250 positive regulation of cellular amide metabolic process 10.4839 6 yes
GO:0035303 regulation of dephosphorylation 10.4839 7 yes
GO:1901362 organic cyclic compound biosynthetic process 9.6774 4 yes
GO:0001558 regulation of cell growth 9.6774 4 yes
GO:1902905 positive regulation of supramolecular fiber organization 9.6774 6 yes
GO:0018130 heterocycle biosynthetic process 9.6774 4 yes
GO:0032535 regulation of cellular component size 9.6774 4 yes
GO:0032868 response to insulin 9.6774 5 yes
GO:0051896 regulation of protein kinase B signaling 8.8710 6 yes
GO:0051960 regulation of nervous system development 8.8710 5 yes
GO:0060491 regulation of cell projection assembly 8.8710 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 8.8710 6 yes
GO:0010720 positive regulation of cell development 8.8710 6 yes
GO:0018107 peptidyl-threonine phosphorylation 8.8710 6 yes
GO:0018210 peptidyl-threonine modification 8.8710 6 yes
GO:0035304 regulation of protein dephosphorylation 8.8710 7 yes
GO:0045727 positive regulation of translation 8.8710 7 yes
GO:1901565 organonitrogen compound catabolic process 8.0645 4 yes
GO:1903034 regulation of response to wounding 8.0645 5 yes
GO:0009057 macromolecule catabolic process 8.0645 4 yes
GO:0010632 regulation of epithelial cell migration 8.0645 4 yes
GO:0031667 response to nutrient levels 8.0645 4 yes
GO:0050767 regulation of neurogenesis 8.0645 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7.2581 6 yes
GO:1903706 regulation of hemopoiesis 7.2581 4 yes
GO:0006954 inflammatory response 7.2581 4 yes
GO:0016241 regulation of macroautophagy 7.2581 7 yes
GO:0019216 regulation of lipid metabolic process 7.2581 5 yes
GO:0032231 regulation of actin filament bundle assembly 7.2581 5 yes
GO:0032273 positive regulation of protein polymerization 7.2581 7 yes
GO:0046777 protein autophosphorylation 7.2581 6 yes
GO:0008064 regulation of actin polymerization or depolymerization 6.4516 6 yes
GO:0008361 regulation of cell size 6.4516 5 yes
GO:0010634 positive regulation of epithelial cell migration 6.4516 5 yes
GO:0010921 regulation of phosphatase activity 6.4516 5 yes
GO:0030163 protein catabolic process 6.4516 4 yes
GO:0030832 regulation of actin filament length 6.4516 5 yes
GO:0032233 positive regulation of actin filament bundle assembly 6.4516 6 yes
GO:0043200 response to amino acid 6.4516 4 yes
GO:0045834 positive regulation of lipid metabolic process 6.4516 5 yes
GO:0051492 regulation of stress fiber assembly 5.6452 6 yes
GO:0051496 positive regulation of stress fiber assembly 5.6452 7 yes
GO:0110020 regulation of actomyosin structure organization 5.6452 6 yes
GO:1901796 regulation of signal transduction by p53 class mediator 5.6452 6 yes
GO:1902105 regulation of leukocyte differentiation 5.6452 5 yes
GO:1902743 regulation of lamellipodium organization 5.6452 7 yes
GO:1902745 positive regulation of lamellipodium organization 5.6452 7 yes
GO:0010507 negative regulation of autophagy 5.6452 7 yes
GO:0015980 energy derivation by oxidation of organic compounds 5.6452 4 yes
GO:0031929 TOR signaling 5.6452 4 yes
GO:0032147 activation of protein kinase activity 5.6452 8 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 5.6452 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 5.6452 8 yes
GO:0050905 neuromuscular process 4.8387 4 yes
GO:0061041 regulation of wound healing 4.8387 6 yes
GO:1903036 positive regulation of response to wounding 4.8387 5 yes
GO:0010591 regulation of lamellipodium assembly 4.8387 7 yes
GO:0010592 positive regulation of lamellipodium assembly 4.8387 7 yes
GO:0016242 negative regulation of macroautophagy 4.8387 8 yes
GO:0035306 positive regulation of dephosphorylation 4.8387 8 yes
GO:0036293 response to decreased oxygen levels 4.8387 4 yes
GO:0045637 regulation of myeloid cell differentiation 4.8387 5 yes
GO:0050769 positive regulation of neurogenesis 4.0323 6 yes
GO:0050848 regulation of calcium-mediated signaling 4.0323 6 yes
GO:0051962 positive regulation of nervous system development 4.0323 5 yes
GO:0071229 cellular response to acid chemical 4.0323 4 yes
GO:0071453 cellular response to oxygen levels 4.0323 4 yes
GO:0002360 T cell lineage commitment 4.0323 4 yes
GO:0006112 energy reserve metabolic process 4.0323 5 yes
GO:0006446 regulation of translational initiation 4.0323 7 yes
GO:0006936 muscle contraction 4.0323 4 yes
GO:0007033 vacuole organization 4.0323 5 yes
GO:0030833 regulation of actin filament polymerization 4.0323 7 yes
GO:0031529 ruffle organization 4.0323 6 yes
GO:0031669 cellular response to nutrient levels 4.0323 4 yes
GO:0032148 activation of protein kinase B activity 4.0323 9 yes
GO:0035307 positive regulation of protein dephosphorylation 4.0323 8 yes
GO:0036294 cellular response to decreased oxygen levels 4.0323 5 yes
GO:0043276 anoikis 4.0323 5 yes
GO:0045792 negative regulation of cell size 4.0323 6 yes
GO:0046889 positive regulation of lipid biosynthetic process 4.0323 6 yes
GO:0046890 regulation of lipid biosynthetic process 4.0323 5 yes
GO:0050849 negative regulation of calcium-mediated signaling 3.2258 7 yes
GO:0071230 cellular response to amino acid stimulus 3.2258 5 yes
GO:0090303 positive regulation of wound healing 3.2258 6 yes
GO:0002363 alpha-beta T cell lineage commitment 3.2258 5 yes
GO:1990928 response to amino acid starvation 3.2258 4 yes
GO:0006941 striated muscle contraction 3.2258 5 yes
GO:2000765 regulation of cytoplasmic translation 3.2258 7 yes
GO:0009112 nucleobase metabolic process 3.2258 4 yes
GO:0009267 cellular response to starvation 3.2258 4 yes
GO:0010717 regulation of epithelial to mesenchymal transition 3.2258 5 yes
GO:0010922 positive regulation of phosphatase activity 3.2258 6 yes
GO:0014013 regulation of gliogenesis 3.2258 7 yes
GO:0030838 positive regulation of actin filament polymerization 3.2258 7 yes
GO:0031641 regulation of myelination 3.2258 4 yes
GO:0034198 cellular response to amino acid starvation 3.2258 5 yes
GO:0043201 response to leucine 3.2258 5 yes
GO:0045685 regulation of glial cell differentiation 3.2258 5 yes
GO:0050795 regulation of behavior 2.4194 4 yes
GO:0051547 regulation of keratinocyte migration 2.4194 5 yes
GO:0060048 cardiac muscle contraction 2.4194 6 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 2.4194 8 yes
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 2.4194 9 yes
GO:0071456 cellular response to hypoxia 2.4194 4 yes
GO:0072527 pyrimidine-containing compound metabolic process 2.4194 4 yes
GO:0080171 lytic vacuole organization 2.4194 6 yes
GO:0106056 regulation of calcineurin-mediated signaling 2.4194 7 yes
GO:0106057 negative regulation of calcineurin-mediated signaling 2.4194 8 yes
GO:1900034 regulation of cellular response to heat 2.4194 5 yes
GO:0001508 action potential 2.4194 4 yes
GO:0002295 T-helper cell lineage commitment 2.4194 7 yes
GO:0002761 regulation of myeloid leukocyte differentiation 2.4194 6 yes
GO:0006206 pyrimidine nucleobase metabolic process 2.4194 5 yes
GO:1903689 regulation of wound healing, spreading of epidermal cells 2.4194 6 yes
GO:0007040 lysosome organization 2.4194 7 yes
GO:0014015 positive regulation of gliogenesis 2.4194 7 yes
GO:0032516 positive regulation of phosphoprotein phosphatase activity 2.4194 7 yes
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 2.4194 5 yes
GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 2.4194 6 yes
GO:0045687 positive regulation of glial cell differentiation 2.4194 6 yes
GO:0045948 positive regulation of translational initiation 2.4194 8 yes
GO:0046112 nucleobase biosynthetic process 2.4194 5 yes
GO:0048713 regulation of oligodendrocyte differentiation 2.4194 6 yes
GO:0048714 positive regulation of oligodendrocyte differentiation 2.4194 7 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2.4194 9 yes
GO:0050882 voluntary musculoskeletal movement 1.6129 4 yes
GO:0051147 regulation of muscle cell differentiation 1.6129 5 yes
GO:0051149 positive regulation of muscle cell differentiation 1.6129 6 yes
GO:0051153 regulation of striated muscle cell differentiation 1.6129 6 yes
GO:0051155 positive regulation of striated muscle cell differentiation 1.6129 7 yes
GO:0051549 positive regulation of keratinocyte migration 1.6129 6 yes
GO:0055001 muscle cell development 1.6129 4 yes
GO:0055006 cardiac cell development 1.6129 4 yes
GO:0055013 cardiac muscle cell development 1.6129 5 yes
GO:0071233 cellular response to leucine 1.6129 6 yes
GO:0072528 pyrimidine-containing compound biosynthetic process 1.6129 5 yes
GO:0140747 regulation of ncRNA transcription 1.6129 7 yes
GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1.6129 8 yes
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1.6129 9 yes
GO:0002296 T-helper 1 cell lineage commitment 1.6129 8 yes
GO:0003007 heart morphogenesis 1.6129 4 yes
GO:0006207 de novo pyrimidine nucleobase biosynthetic process 1.6129 7 yes
GO:1903691 positive regulation of wound healing, spreading of epidermal cells 1.6129 7 yes
GO:0006356 regulation of transcription by RNA polymerase I 1.6129 7 yes
GO:1904059 regulation of locomotor rhythm 1.6129 4 yes
GO:0006359 regulation of transcription by RNA polymerase III 1.6129 7 yes
GO:1904688 regulation of cytoplasmic translational initiation 1.6129 8 yes
GO:1904690 positive regulation of cytoplasmic translational initiation 1.6129 9 yes
GO:1990253 cellular response to leucine starvation 1.6129 6 yes
GO:0010718 positive regulation of epithelial to mesenchymal transition 1.6129 5 yes
GO:0010830 regulation of myotube differentiation 1.6129 7 yes
GO:0010831 positive regulation of myotube differentiation 1.6129 8 yes
GO:0019228 neuronal action potential 1.6129 5 yes
GO:0019856 pyrimidine nucleobase biosynthetic process 1.6129 6 yes
GO:0038202 TORC1 signaling 1.6129 5 yes
GO:0045670 regulation of osteoclast differentiation 1.6129 7 yes
GO:0045943 positive regulation of transcription by RNA polymerase I 1.6129 8 yes
GO:0045945 positive regulation of transcription by RNA polymerase III 1.6129 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in MTOR_HUMAN
DOID:0050686 organ system cancer 3.2258 3 no
DOID:612 primary immunodeficiency disease 3.2258 3 no
DOID:0060038 specific developmental disorder 1.6129 3 no
DOID:1059 intellectual disability 1.6129 4 no
DOID:1289 neurodegenerative disease 1.6129 4 no
DOID:331 central nervous system disease 1.6129 3 no
DOID:0111962 combined immunodeficiency 1.6129 4 no
DOID:6457 Cowden syndrome 1.6129 3 no
DOID:0081062 diabetes 1.6129 5 no
DOID:2978 carbohydrate metabolic disorder 1.6129 3 no
DOID:4194 glucose metabolism disease 1.6129 4 no
DOID:9351 diabetes mellitus 1.6129 6 no
DOID:9352 type 2 diabetes mellitus 1.6129 7 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P53_HUMAN [view interactions] Low throughput no no
RS6_HUMAN [view entry] [view interactions] Low throughput yes yes
RL7A_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
FKBP3_HUMAN [view interactions] Low throughput no yes
SIR1_HUMAN [view interactions] Low throughput no yes
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
TF3C2_HUMAN [view interactions] Low throughput no no
TF3C5_HUMAN [view interactions] Low throughput no yes
FKBP5_HUMAN [view interactions] Low throughput no yes
TM9S4_HUMAN [view interactions] Low throughput no yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAF1_HUMAN [view interactions] Low throughput no no
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
RRAGC_HUMAN [view interactions] Low throughput no yes
UBQL1_HUMAN [view interactions] Low throughput no yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
PLD2_HUMAN [view interactions] Low throughput no yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PML_HUMAN [view interactions] Low throughput no yes
CLIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
TERT_HUMAN [view interactions] Low throughput no no
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
IKKA_HUMAN [view interactions] Low throughput no yes
SQSTM_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
RRAGD_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view interactions] Low throughput no yes
FKBP4_HUMAN [view entry] [view interactions] Low throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] Low throughput yes yes
RRAGB_HUMAN [view interactions] Low throughput no yes
ILK_HUMAN [view interactions] Low throughput no no
IKKB_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
GA45A_HUMAN [view interactions] Low throughput no no
NBN_HUMAN [view interactions] Low throughput no yes
TF3C1_HUMAN [view interactions] Low throughput no yes
KAP0_HUMAN [view entry] [view interactions] Low throughput yes yes
MLXIP_HUMAN [view interactions] Low throughput no yes
MLXPL_HUMAN [view interactions] Low throughput no no
PDK1_HUMAN [view interactions] Low throughput no yes
TNAP3_HUMAN [view interactions] Low throughput no yes
RAP2A_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
BRAT1_HUMAN [view interactions] Low throughput no yes
M3K3_HUMAN [view interactions] Low throughput no no
ZNRF2_HUMAN [view interactions] Low throughput no yes
FBX8_HUMAN [view interactions] Low throughput no yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
ESR1_HUMAN [view interactions] Low throughput no no
SKP2_HUMAN [view interactions] Low throughput no yes
IRS2_HUMAN [view interactions] Low throughput no yes
MDM4_HUMAN [view interactions] Low throughput no yes
RASN_HUMAN [view entry] [view interactions] Low throughput yes no
UVRAG_HUMAN [view interactions] Low throughput no yes
SHOC2_HUMAN [view interactions] Low throughput no yes
TRI37_HUMAN [view entry] [view interactions] Low throughput yes yes
WWOX_HUMAN [view interactions] Low throughput no yes
MUC18_HUMAN [view interactions] Low throughput no yes
RN126_HUMAN [view interactions] Low throughput no yes
LNP_HUMAN [view interactions] Low throughput no yes
EIF3F_HUMAN [view interactions] Low throughput no yes
PREX1_HUMAN [view entry] [view interactions] Low throughput yes no
RHEB_HUMAN [view entry] [view interactions] Low throughput yes yes
REBL1_HUMAN [view interactions] Low throughput no yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
PRR5L_HUMAN [view interactions] Low throughput no no
TELO2_HUMAN [view interactions] Low throughput no yes
RPTOR_HUMAN [view interactions] Low throughput no yes
RICTR_HUMAN [view interactions] Low throughput no yes
SIN1_HUMAN [view interactions] Low throughput no yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
DPTOR_HUMAN [view interactions] Low throughput no no
AKTS1_HUMAN [view interactions] Low throughput no yes
LST8_HUMAN [view interactions] Low throughput no yes
RL23_HUMAN [view entry] [view interactions] Low throughput yes yes
RL23A_HUMAN [view entry] [view interactions] Low throughput yes yes
TTI1_HUMAN [view interactions] Low throughput no yes
SYLC_HUMAN [view interactions] Low throughput no yes
TPC2_HUMAN [view interactions] Low throughput no no
TPC1_HUMAN [view interactions] Low throughput no yes
PIHD1_HUMAN [view interactions] Low throughput no yes
RAB1A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP11_HUMAN [view interactions] Low throughput no yes
SOCS2_HUMAN [view interactions] Low throughput no yes
MTMR3_HUMAN [view interactions] Low throughput no no
SGK1_HUMAN [view interactions] Low throughput no yes
TYY1_HUMAN [view interactions] Low throughput no yes
ULK1_HUMAN [view interactions] Low throughput no no
PKHM1_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
4EBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
KS6A1_HUMAN [view interactions] Low throughput no yes
PA2G4_HUMAN [view interactions] Low throughput no yes
LTOR1_HUMAN [view entry] [view interactions] Low throughput yes yes
PROP_HUMAN [view interactions] Low throughput no no
LTOR4_HUMAN [view interactions] Low throughput no yes
2ABA_HUMAN [view interactions] Low throughput no yes
LTOR2_HUMAN [view interactions] Low throughput no yes
BICD2_HUMAN [view interactions] Low throughput no yes
LTOR5_HUMAN [view interactions] Low throughput no yes
WIPI2_HUMAN [view interactions] Low throughput no yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
PCNA_HUMAN [view interactions] Low throughput no no
PREX2_HUMAN [view interactions] Low throughput no no
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
RL5_HUMAN [view entry] [view interactions] Low throughput yes yes
4EBP2_HUMAN [view entry] [view interactions] Low throughput yes yes
AMRA1_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view interactions] Low throughput no yes
DCP2_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
KS6B2_HUMAN [view interactions] Low throughput no yes
AAPK1_HUMAN [view interactions] Low throughput no no
LAMP2_HUMAN [view interactions] Low throughput no yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
FKB1A_HUMAN [view interactions] Low throughput no yes
EIF3B_HUMAN [view interactions] High throughput no yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
STK38_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3I_HUMAN [view interactions] High throughput no yes
RL26_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF2_HUMAN [view interactions] High throughput no yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
EMRE_HUMAN [view interactions] High throughput no yes
XPO4_HUMAN [view interactions] High throughput no no
XPO6_HUMAN [view interactions] High throughput no yes
THADA_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
AMRP_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
MAP2_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB3_HUMAN [view interactions] High throughput no yes
GNB5_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CD244_HUMAN [view interactions] High throughput no no
5HT6R_HUMAN [view interactions] High throughput no yes
LARP1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
ZUP1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
BECN1_HUMAN [view interactions] High throughput no yes
PI3R4_HUMAN [view interactions] High throughput no yes
PK3C3_HUMAN [view interactions] High throughput no yes
RUBIC_HUMAN [view interactions] High throughput no no
LANC2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
PPAP_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
EDEM1_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
SOSD1_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
ARSL_HUMAN [view interactions] High throughput no no
CML1_HUMAN [view interactions] High throughput no yes
FPR1_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
CC167_HUMAN [view interactions] High throughput no yes
TNR5_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
CD80_HUMAN [view interactions] High throughput no no
CXCR4_HUMAN [view interactions] High throughput no no
LRC25_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
TACD2_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
F234A_HUMAN [view interactions] High throughput no yes
HYPM_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
CC018_HUMAN [view interactions] High throughput no yes
EFNA5_HUMAN [view interactions] High throughput no yes
GPR17_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
HACL2_HUMAN [view interactions] High throughput no yes
CCG4_HUMAN [view entry] [view interactions] High throughput yes no
F174A_HUMAN [view interactions] High throughput no yes
APJ_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
GPR55_HUMAN [view interactions] High throughput no no
VSIG4_HUMAN [view interactions] High throughput no no
TNFL8_HUMAN [view interactions] High throughput no no
CG025_HUMAN [view interactions] High throughput no yes
MICA_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
P2RY8_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
LEUK_HUMAN [view interactions] High throughput no no
SEPT2_HUMAN [view interactions] High throughput no no
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
ISLR_HUMAN [view interactions] High throughput no no
PRR5_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
NCBP1_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PRS10_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
PRS8_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
L2GL2_HUMAN [view interactions] High throughput no yes
KLC4_HUMAN [view interactions] High throughput no yes
M3K12_HUMAN [view entry] [view interactions] High throughput yes yes
FOXP1_HUMAN [view interactions] High throughput no yes
ASPM_HUMAN [view interactions] High throughput no no
VMP1_HUMAN [view interactions] High throughput no yes
VPS16_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
PHOP1_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
KIF19_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ZSC26_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
NAF1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
JUNB_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
SGTB_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
KDM5C_HUMAN [view interactions] High throughput no no
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
TOP1_HUMAN [view interactions] High throughput no yes
YETS4_HUMAN [view interactions] High throughput no no
CASP8_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
DPEP1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
VIPR2_HUMAN [view interactions] High throughput no no
PGTB2_HUMAN [view interactions] High throughput no yes
NPY2R_HUMAN [view interactions] High throughput no no
FNTA_HUMAN [view interactions] High throughput no yes
PACC1_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
LYPD3_HUMAN [view interactions] High throughput no no
WEE1_HUMAN [view interactions] High throughput no yes
LFTY1_HUMAN [view interactions] High throughput no no
ATPA_HUMAN [view interactions] High throughput no yes
XRP2_HUMAN [view entry] [view interactions] High throughput yes no
BTF3_HUMAN [view interactions] High throughput no yes
CAH14_HUMAN [view interactions] High throughput no yes
NEUA_HUMAN [view interactions] High throughput no yes
SCN2B_HUMAN [view interactions] High throughput no no
EIF3D_HUMAN [view interactions] High throughput no yes
CD83_HUMAN [view interactions] High throughput no yes
GFI1B_HUMAN [view interactions] High throughput no no
5NTD_HUMAN [view entry] [view interactions] High throughput yes yes
MAX_HUMAN [view interactions] High throughput no yes
SCN3B_HUMAN [view interactions] High throughput no no
RM13_HUMAN [view interactions] High throughput no yes
VSIG2_HUMAN [view interactions] High throughput no no
RM19_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
RT05_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
FBX9_HUMAN [view interactions] High throughput no no
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB2_HUMAN [view interactions] High throughput no yes
CLN6_HUMAN [view interactions] High throughput no no
SNPC1_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
DMAC1_HUMAN [view interactions] High throughput no no
RUVB1_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
P2RY6_HUMAN [view interactions] High throughput no no
TN13B_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
GAB1_HUMAN [view interactions] High throughput no yes
GAB2_HUMAN [view interactions] High throughput no yes
MTA2_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
DIAP1_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
TRM61_HUMAN [view interactions] High throughput no no
PGRC2_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
SLIK6_HUMAN [view interactions] High throughput no yes
ATX10_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
F16P2_HUMAN [view interactions] High throughput no no
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
FKB1B_HUMAN [view entry] [view interactions] Computational yes yes
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
AAKG1_HUMAN [view interactions] Computational no no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
CAST1_HUMAN [view interactions] Computational no yes
KEAP1_HUMAN [view interactions] Computational no yes
INS_HUMAN [view interactions] Computational no no
ULK2_HUMAN [view interactions] Computational no yes
TSC1_HUMAN [view entry] [view interactions] Computational yes yes
CD79B_HUMAN [view interactions] Computational no no
AAKB1_HUMAN [view interactions] Computational no yes
AAKB2_HUMAN [view interactions] Computational no yes
ULK3_HUMAN [view interactions] Computational no yes
SESN1_HUMAN [view interactions] Computational no no
SZT2_HUMAN [view interactions] Computational no yes
LPIN2_HUMAN [view interactions] Computational no yes
P85B_HUMAN [view interactions] Computational no yes
Q5VVH2_HUMAN [view interactions] Computational no no
SEH1_HUMAN [view interactions] Computational no no
PPARG_HUMAN [view interactions] Computational no yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
SGK3_HUMAN [view interactions] Computational no yes
TSC2_HUMAN [view entry] [view interactions] Computational yes yes
SEC13_HUMAN [view entry] [view interactions] Computational yes yes
RRAGA_HUMAN [view interactions] Computational no yes
PK3CD_HUMAN [view interactions] Computational no no
ATGA1_HUMAN [view interactions] Computational no yes
IL2_HUMAN [view interactions] Computational no no
LPIN1_HUMAN [view interactions] Computational no no
WDR59_HUMAN [view interactions] Computational no yes
CD79A_HUMAN [view interactions] Computational no no
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
E2AK4_HUMAN [view interactions] Computational no yes
SAMTR_HUMAN [view interactions] Computational no yes
P55G_HUMAN [view interactions] Computational no yes
PRGC1_HUMAN [view interactions] Computational no no
RBCC1_HUMAN [view interactions] Computational no no
ITFG2_HUMAN [view interactions] Computational no yes
HSF1_HUMAN [view interactions] Computational no yes
IQGA1_HUMAN [view entry] [view interactions] Computational yes no
RRN3_HUMAN [view interactions] Computational no yes
S38A9_HUMAN [view interactions] Computational no yes
NFKB1_HUMAN [view interactions] Computational no yes
TF65_HUMAN [view entry] [view interactions] Computational yes yes
CAST2_HUMAN [view interactions] Computational no no
PLEK_HUMAN [view entry] [view interactions] Computational yes no
BCR_HUMAN [view entry] [view interactions] Computational yes yes
ATG13_HUMAN [view interactions] Computational no no
GRB2_HUMAN [view entry] [view interactions] Computational yes yes
VA0D2_HUMAN [view interactions] Computational no no
SESN2_HUMAN [view interactions] Computational no no
LPIN3_HUMAN [view interactions] Computational no yes
P85A_HUMAN [view interactions] Computational no yes
EGF_HUMAN [view interactions] Computational no no
FLCN_HUMAN [view interactions] Computational no yes
MIO_HUMAN [view interactions] Computational no yes
PP2AA_HUMAN [view entry] [view interactions] Computational yes yes
IGBP1_HUMAN [view interactions] Computational no yes
FOXO3_HUMAN [view interactions] Computational no yes
WDR24_HUMAN [view interactions] Computational no yes
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
DKC1_HUMAN [view interactions] Computational no yes
1433S_HUMAN [view entry] [view interactions] Computational yes yes
ETV7_HUMAN [view interactions] Computational no no
PK3CB_HUMAN [view interactions] Computational no yes
AKT3_HUMAN [view interactions] Computational no yes
KPTN_HUMAN [view entry] [view interactions] Computational yes yes
ATG5_HUMAN [view interactions] Computational no no
AAKG2_HUMAN [view interactions] Computational no yes
PLPP1_HUMAN [view interactions] Computational no no
SRBP1_HUMAN [view interactions] Computational no yes
AAPK2_HUMAN [view interactions] Computational no yes
AAKG3_HUMAN [view interactions] Computational no no
SHC1_HUMAN [view entry] [view interactions] Computational yes yes
MYD88_HUMAN [view entry] [view interactions] Computational yes yes
NPRL2_HUMAN [view interactions] Computational no yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes