Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

5NTD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 5NTD_HUMAN
GO:0017076 purine nucleotide binding 28.0000 4 no
GO:0032555 purine ribonucleotide binding 28.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.0000 4 no
GO:0046872 metal ion binding 24.0000 4 yes
GO:0008252 nucleotidase activity 12.0000 6 yes
GO:0008253 5-nucleotidase activity 12.0000 7 yes
GO:0016791 phosphatase activity 12.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 12.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 5NTD_HUMAN
GO:0048523 negative regulation of cellular process 44.0000 4 no
GO:0048522 positive regulation of cellular process 44.0000 4 no
GO:0048585 negative regulation of response to stimulus 40.0000 4 yes
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0080134 regulation of response to stress 36.0000 4 yes
GO:0008104 protein localization 36.0000 4 no
GO:0051049 regulation of transport 36.0000 4 no
GO:0031323 regulation of cellular metabolic process 36.0000 4 no
GO:0048584 positive regulation of response to stimulus 36.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 36.0000 4 no
GO:0080090 regulation of primary metabolic process 36.0000 4 no
GO:0022607 cellular component assembly 36.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 36.0000 4 yes
GO:0071702 organic substance transport 32.0000 4 no
GO:0071705 nitrogen compound transport 32.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 32.0000 4 no
GO:0030334 regulation of cell migration 32.0000 5 no
GO:2000145 regulation of cell motility 32.0000 4 no
GO:0009892 negative regulation of metabolic process 32.0000 4 no
GO:0010468 regulation of gene expression 32.0000 5 no
GO:0010648 negative regulation of cell communication 28.0000 5 no
GO:0023057 negative regulation of signaling 28.0000 4 no
GO:0042127 regulation of cell population proliferation 28.0000 4 no
GO:1902531 regulation of intracellular signal transduction 28.0000 5 no
GO:2000026 regulation of multicellular organismal development 28.0000 4 no
GO:0006996 organelle organization 28.0000 4 no
GO:0009889 regulation of biosynthetic process 28.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 28.0000 4 no
GO:0009967 positive regulation of signal transduction 28.0000 5 no
GO:0010647 positive regulation of cell communication 28.0000 5 no
GO:0023056 positive regulation of signaling 28.0000 4 no
GO:0009117 nucleotide metabolic process 24.0000 5 yes
GO:0018130 heterocycle biosynthetic process 24.0000 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 24.0000 4 yes
GO:0072521 purine-containing compound metabolic process 24.0000 4 yes
GO:1901362 organic cyclic compound biosynthetic process 24.0000 4 yes
GO:1901566 organonitrogen compound biosynthetic process 24.0000 4 yes
GO:0006886 intracellular protein transport 24.0000 4 no
GO:0015031 protein transport 24.0000 4 no
GO:0006355 regulation of DNA-templated transcription 24.0000 6 no
GO:0009893 positive regulation of metabolic process 24.0000 4 no
GO:0010243 response to organonitrogen compound 24.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 24.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 24.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.0000 5 no
GO:0043085 positive regulation of catalytic activity 24.0000 4 no
GO:0045595 regulation of cell differentiation 24.0000 4 no
GO:0051094 positive regulation of developmental process 24.0000 4 no
GO:0051246 regulation of protein metabolic process 24.0000 5 no
GO:0051252 regulation of RNA metabolic process 24.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 24.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 24.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 24.0000 5 no
GO:0010941 regulation of cell death 24.0000 4 no
GO:0016192 vesicle-mediated transport 24.0000 4 no
GO:0060548 negative regulation of cell death 24.0000 5 no
GO:0006163 purine nucleotide metabolic process 24.0000 5 yes
GO:0006753 nucleoside phosphate metabolic process 24.0000 4 yes
GO:0019438 aromatic compound biosynthetic process 20.0000 4 yes
GO:0031347 regulation of defense response 20.0000 5 yes
GO:0031348 negative regulation of defense response 20.0000 5 yes
GO:0032101 regulation of response to external stimulus 20.0000 4 yes
GO:0032102 negative regulation of response to external stimulus 20.0000 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 20.0000 4 yes
GO:0050727 regulation of inflammatory response 20.0000 5 yes
GO:0050728 negative regulation of inflammatory response 20.0000 6 yes
GO:0072522 purine-containing compound biosynthetic process 20.0000 5 yes
GO:1901137 carbohydrate derivative biosynthetic process 20.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 20.0000 4 yes
GO:0009116 nucleoside metabolic process 16.0000 4 yes
GO:0009123 nucleoside monophosphate metabolic process 16.0000 5 yes
GO:0009126 purine nucleoside monophosphate metabolic process 16.0000 6 yes
GO:0009132 nucleoside diphosphate metabolic process 16.0000 5 yes
GO:0009135 purine nucleoside diphosphate metabolic process 16.0000 6 yes
GO:0009150 purine ribonucleotide metabolic process 16.0000 6 yes
GO:0009161 ribonucleoside monophosphate metabolic process 16.0000 6 yes
GO:0009167 purine ribonucleoside monophosphate metabolic process 16.0000 7 yes
GO:0009259 ribonucleotide metabolic process 16.0000 5 yes
GO:0019693 ribose phosphate metabolic process 16.0000 4 yes
GO:0046033 AMP metabolic process 16.0000 7 yes
GO:1901657 glycosyl compound metabolic process 16.0000 4 yes
GO:0007159 leukocyte cell-cell adhesion 12.0000 4 yes
GO:0009119 ribonucleoside metabolic process 12.0000 5 yes
GO:0009166 nucleotide catabolic process 12.0000 6 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 12.0000 7 yes
GO:0009185 ribonucleoside diphosphate metabolic process 12.0000 6 yes
GO:0019439 aromatic compound catabolic process 12.0000 4 yes
GO:0034655 nucleobase-containing compound catabolic process 12.0000 4 yes
GO:0042278 purine nucleoside metabolic process 12.0000 5 yes
GO:0044270 cellular nitrogen compound catabolic process 12.0000 4 yes
GO:0046031 ADP metabolic process 12.0000 7 yes
GO:0046085 adenosine metabolic process 12.0000 7 yes
GO:0046128 purine ribonucleoside metabolic process 12.0000 6 yes
GO:0046434 organophosphate catabolic process 12.0000 4 yes
GO:0046700 heterocycle catabolic process 12.0000 4 yes
GO:0072523 purine-containing compound catabolic process 12.0000 5 yes
GO:1901292 nucleoside phosphate catabolic process 12.0000 5 yes
GO:1901361 organic cyclic compound catabolic process 12.0000 4 yes
GO:0006195 purine nucleotide catabolic process 12.0000 6 yes
GO:0009125 nucleoside monophosphate catabolic process 8.0000 6 yes
GO:0009128 purine nucleoside monophosphate catabolic process 8.0000 7 yes
GO:0009134 nucleoside diphosphate catabolic process 8.0000 6 yes
GO:0009137 purine nucleoside diphosphate catabolic process 8.0000 7 yes
GO:0009154 purine ribonucleotide catabolic process 8.0000 6 yes
GO:0009158 ribonucleoside monophosphate catabolic process 8.0000 7 yes
GO:0009163 nucleoside biosynthetic process 8.0000 5 yes
GO:0009169 purine ribonucleoside monophosphate catabolic process 8.0000 8 yes
GO:0009181 purine ribonucleoside diphosphate catabolic process 8.0000 8 yes
GO:0009191 ribonucleoside diphosphate catabolic process 8.0000 7 yes
GO:0009261 ribonucleotide catabolic process 8.0000 5 yes
GO:0034404 nucleobase-containing small molecule biosynthetic process 8.0000 4 yes
GO:0042451 purine nucleoside biosynthetic process 8.0000 6 yes
GO:0042455 ribonucleoside biosynthetic process 8.0000 6 yes
GO:0046032 ADP catabolic process 8.0000 7 yes
GO:0046086 adenosine biosynthetic process 8.0000 8 yes
GO:0046129 purine ribonucleoside biosynthetic process 8.0000 7 yes
GO:0090304 nucleic acid metabolic process 8.0000 4 yes
GO:1901136 carbohydrate derivative catabolic process 8.0000 4 yes
GO:1901659 glycosyl compound biosynthetic process 8.0000 5 yes
GO:0006196 AMP catabolic process 8.0000 7 yes
GO:0006259 DNA metabolic process 8.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
5NTD_HUMAN [view entry] [view interactions] Low throughput yes yes
AFF1_HUMAN [view interactions] Low throughput no no
GHITM_HUMAN [view interactions] High throughput no yes
TNPO2_HUMAN [view interactions] High throughput no yes
PLAP_HUMAN [view interactions] High throughput no yes
CTR2_HUMAN [view interactions] High throughput no no
STEA3_HUMAN [view interactions] High throughput no yes
S41A1_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
DEGS1_HUMAN [view interactions] High throughput no no
CTL1_HUMAN [view interactions] High throughput no no
GNL3L_HUMAN [view interactions] High throughput no yes
S26A6_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
RAD18_HUMAN [view interactions] High throughput no yes
CXCR4_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF6_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
SC5A5_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM3_HUMAN [view interactions] High throughput no no
ARGI2_HUMAN [view interactions] High throughput no yes
BRID5_HUMAN [view interactions] High throughput no no
TNFL8_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
T106A_HUMAN [view interactions] High throughput no no
I13R2_HUMAN [view interactions] High throughput no no
ZNT5_HUMAN [view interactions] High throughput no yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
PCDH7_HUMAN [view interactions] High throughput no no
TM177_HUMAN [view interactions] High throughput no no
UBP3_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
FLVC1_HUMAN [view interactions] High throughput no yes
VANG2_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
UBP36_HUMAN [view interactions] High throughput no yes
ARL8A_HUMAN [view interactions] High throughput no no
PAQR1_HUMAN [view interactions] High throughput no no
GLMN_HUMAN [view interactions] High throughput no no
RDH13_HUMAN [view interactions] High throughput no no
RPTOR_HUMAN [view interactions] High throughput no yes
DAAF5_HUMAN [view interactions] High throughput no no
HSDL1_HUMAN [view entry] [view interactions] High throughput yes no
PDS5A_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
SC6A8_HUMAN [view entry] [view interactions] High throughput yes no
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
ARL2_HUMAN [view interactions] High throughput no yes
MOT8_HUMAN [view interactions] High throughput no no
COT2_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM1_HUMAN [view interactions] High throughput no no
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
TX101_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
ZNRF4_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RNF24_HUMAN [view interactions] High throughput no yes
CHD1L_HUMAN [view interactions] High throughput no yes
ATR_HUMAN [view interactions] High throughput no no
UBP22_HUMAN [view interactions] High throughput no yes
RFC2_HUMAN [view interactions] High throughput no yes
GUAA_HUMAN [view interactions] Computational no no
ADA_HUMAN [view interactions] Computational no no
AA2BR_HUMAN [view interactions] Computational no no
CDD_HUMAN [view interactions] Computational no no
PNPH_HUMAN [view interactions] Computational no no
NT5C_HUMAN [view interactions] Computational no yes
AMPN_HUMAN [view interactions] Computational no no
NUD12_HUMAN [view interactions] Computational no yes
ENTP3_HUMAN [view interactions] Computational no no
CD34_HUMAN [view interactions] Computational no no
TYSY_HUMAN [view interactions] Computational no yes
ITPA_HUMAN [view interactions] Computational no yes
DGUOK_HUMAN [view interactions] Computational no yes
TYPH_HUMAN [view interactions] Computational no no
DCK_HUMAN [view interactions] Computational no no
CD44_HUMAN [view interactions] Computational no yes
5NTC_HUMAN [view interactions] Computational no yes
PECA1_HUMAN [view interactions] Computational no no
CD38_HUMAN [view interactions] Computational no no
HPRT_HUMAN [view interactions] Computational no yes
CD19_HUMAN [view interactions] Computational no no
CMPK2_HUMAN [view interactions] Computational no yes
NAMPT_HUMAN [view interactions] Computational no no
AMPD1_HUMAN [view interactions] Computational no yes
UPP2_HUMAN [view interactions] Computational no no
NUD16_HUMAN [view interactions] Computational no yes
5NT1A_HUMAN [view interactions] Computational no yes
EGLN_HUMAN [view interactions] Computational no no
NT5M_HUMAN [view interactions] Computational no yes
UPP_HUMAN [view interactions] Computational no no
MUC18_HUMAN [view interactions] Computational no yes
5NT1B_HUMAN [view entry] [view interactions] Computational yes no
KTHY_HUMAN [view interactions] Computational no yes
ENTP1_HUMAN [view interactions] Computational no yes
DCTD_HUMAN [view interactions] Computational no yes
PUR9_HUMAN [view entry] [view interactions] Computational yes yes
KAD3_HUMAN [view entry] [view interactions] Computational yes yes
5NT3B_HUMAN [view interactions] Computational no yes
AA1R_HUMAN [view entry] [view interactions] Computational yes no
IMDH2_HUMAN [view interactions] Computational no yes
ENPP3_HUMAN [view interactions] Computational no no
APT_HUMAN [view interactions] Computational no yes
KGUA_HUMAN [view entry] [view interactions] Computational yes yes
CD166_HUMAN [view interactions] Computational no no
DUT_HUMAN [view interactions] Computational no yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no
IMDH1_HUMAN [view interactions] Computational no yes
GMPR1_HUMAN [view interactions] Computational no yes
DCTP1_HUMAN [view interactions] Computational no no
THY1_HUMAN [view entry] [view interactions] Computational yes yes
AA2AR_HUMAN [view entry] [view interactions] Computational yes yes
ENTP8_HUMAN [view interactions] Computational no no
PUR8_HUMAN [view interactions] Computational no yes
PTPRC_HUMAN [view interactions] Computational no no
UMPS_HUMAN [view interactions] Computational no no