Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

5NTD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 5NTD_HUMAN
GO:0000166 nucleotide binding 47.6190 4 yes
GO:0017076 purine nucleotide binding 38.0952 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0030554 adenyl nucleotide binding 23.8095 6 no
GO:0008270 zinc ion binding 14.2857 7 yes
GO:0046914 transition metal ion binding 14.2857 6 yes
GO:0002953 5-deoxynucleotidase activity 9.5238 6 yes
GO:0008252 nucleotidase activity 9.5238 6 yes
GO:0008253 5-nucleotidase activity 9.5238 7 yes
GO:0016791 phosphatase activity 9.5238 5 yes
GO:0042578 phosphoric ester hydrolase activity 9.5238 4 yes
GO:0050340 thymidylate 5-phosphatase activity 9.5238 8 yes
GO:0050483 IMP 5-nucleotidase activity 9.5238 8 yes
GO:0050484 GMP 5-nucleotidase activity 9.5238 8 yes
GO:0106411 XMP 5-nucleosidase activity 9.5238 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 5NTD_HUMAN
GO:0051128 regulation of cellular component organization 47.6190 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0008104 protein localization 42.8571 4 no
GO:0006996 organelle organization 42.8571 4 no
GO:0010646 regulation of cell communication 38.0952 4 no
GO:0031323 regulation of cellular metabolic process 38.0952 4 no
GO:0033043 regulation of organelle organization 38.0952 5 no
GO:0044087 regulation of cellular component biogenesis 38.0952 4 no
GO:0048523 negative regulation of cellular process 38.0952 4 no
GO:0060255 regulation of macromolecule metabolic process 38.0952 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 yes
GO:0010243 response to organonitrogen compound 28.5714 4 yes
GO:0048585 negative regulation of response to stimulus 28.5714 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.8095 5 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.8095 6 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0006886 intracellular protein transport 23.8095 4 no
GO:0015031 protein transport 23.8095 4 no
GO:0080134 regulation of response to stress 23.8095 4 yes
GO:1901362 organic cyclic compound biosynthetic process 23.8095 4 yes
GO:0001894 tissue homeostasis 19.0476 4 yes
GO:0014070 response to organic cyclic compound 19.0476 4 yes
GO:0034654 nucleobase-containing compound biosynthetic process 19.0476 4 yes
GO:0090304 nucleic acid metabolic process 19.0476 4 yes
GO:1901565 organonitrogen compound catabolic process 19.0476 4 yes
GO:1901566 organonitrogen compound biosynthetic process 19.0476 4 yes
GO:0006163 purine nucleotide metabolic process 14.2857 5 yes
GO:0006259 DNA metabolic process 14.2857 5 yes
GO:0006753 nucleoside phosphate metabolic process 14.2857 4 yes
GO:0009117 nucleotide metabolic process 14.2857 5 yes
GO:0009141 nucleoside triphosphate metabolic process 14.2857 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 14.2857 6 yes
GO:0009150 purine ribonucleotide metabolic process 14.2857 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 14.2857 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 14.2857 7 yes
GO:0009259 ribonucleotide metabolic process 14.2857 5 yes
GO:0019693 ribose phosphate metabolic process 14.2857 4 yes
GO:0031347 regulation of defense response 14.2857 5 yes
GO:0031348 negative regulation of defense response 14.2857 5 yes
GO:0032101 regulation of response to external stimulus 14.2857 4 yes
GO:0032102 negative regulation of response to external stimulus 14.2857 5 yes
GO:0046034 ATP metabolic process 14.2857 7 yes
GO:0050727 regulation of inflammatory response 14.2857 5 yes
GO:0050728 negative regulation of inflammatory response 14.2857 6 yes
GO:0072521 purine-containing compound metabolic process 14.2857 4 yes
GO:0072522 purine-containing compound biosynthetic process 14.2857 5 yes
GO:1901137 carbohydrate derivative biosynthetic process 14.2857 4 yes
GO:0006195 purine nucleotide catabolic process 9.5238 6 yes
GO:0006196 AMP catabolic process 9.5238 7 yes
GO:0007159 leukocyte cell-cell adhesion 9.5238 4 yes
GO:0009116 nucleoside metabolic process 9.5238 4 yes
GO:0009119 ribonucleoside metabolic process 9.5238 5 yes
GO:0009123 nucleoside monophosphate metabolic process 9.5238 5 yes
GO:0009125 nucleoside monophosphate catabolic process 9.5238 6 yes
GO:0009126 purine nucleoside monophosphate metabolic process 9.5238 6 yes
GO:0009128 purine nucleoside monophosphate catabolic process 9.5238 7 yes
GO:0009132 nucleoside diphosphate metabolic process 9.5238 5 yes
GO:0009134 nucleoside diphosphate catabolic process 9.5238 6 yes
GO:0009135 purine nucleoside diphosphate metabolic process 9.5238 6 yes
GO:0009137 purine nucleoside diphosphate catabolic process 9.5238 7 yes
GO:0009154 purine ribonucleotide catabolic process 9.5238 6 yes
GO:0009158 ribonucleoside monophosphate catabolic process 9.5238 7 yes
GO:0009161 ribonucleoside monophosphate metabolic process 9.5238 6 yes
GO:0009163 nucleoside biosynthetic process 9.5238 5 yes
GO:0009166 nucleotide catabolic process 9.5238 6 yes
GO:0009167 purine ribonucleoside monophosphate metabolic process 9.5238 7 yes
GO:0009169 purine ribonucleoside monophosphate catabolic process 9.5238 8 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 9.5238 7 yes
GO:0009181 purine ribonucleoside diphosphate catabolic process 9.5238 8 yes
GO:0009185 ribonucleoside diphosphate metabolic process 9.5238 6 yes
GO:0009191 ribonucleoside diphosphate catabolic process 9.5238 7 yes
GO:0009261 ribonucleotide catabolic process 9.5238 5 yes
GO:0014074 response to purine-containing compound 9.5238 5 yes
GO:0033198 response to ATP 9.5238 4 yes
GO:0034404 nucleobase-containing small molecule biosynthetic process 9.5238 4 yes
GO:0034655 nucleobase-containing compound catabolic process 9.5238 4 yes
GO:0042278 purine nucleoside metabolic process 9.5238 5 yes
GO:0042451 purine nucleoside biosynthetic process 9.5238 6 yes
GO:0042455 ribonucleoside biosynthetic process 9.5238 6 yes
GO:0046031 ADP metabolic process 9.5238 7 yes
GO:0046032 ADP catabolic process 9.5238 7 yes
GO:0046033 AMP metabolic process 9.5238 7 yes
GO:0046085 adenosine metabolic process 9.5238 7 yes
GO:0046086 adenosine biosynthetic process 9.5238 8 yes
GO:0046128 purine ribonucleoside metabolic process 9.5238 6 yes
GO:0046129 purine ribonucleoside biosynthetic process 9.5238 7 yes
GO:0046434 organophosphate catabolic process 9.5238 4 yes
GO:0046683 response to organophosphorus 9.5238 4 yes
GO:0055074 calcium ion homeostasis 9.5238 4 yes
GO:0055080 monoatomic cation homeostasis 9.5238 4 yes
GO:0072523 purine-containing compound catabolic process 9.5238 5 yes
GO:0140928 inhibition of non-skeletal tissue mineralization 9.5238 5 yes
GO:1901136 carbohydrate derivative catabolic process 9.5238 4 yes
GO:1901292 nucleoside phosphate catabolic process 9.5238 5 yes
GO:1901361 organic cyclic compound catabolic process 9.5238 4 yes
GO:1901657 glycosyl compound metabolic process 9.5238 4 yes
GO:1901659 glycosyl compound biosynthetic process 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
5NTD_HUMAN [view entry] [view interactions] Low throughput yes yes
AFF1_HUMAN [view interactions] Low throughput no no
UBP22_HUMAN [view interactions] Low throughput no yes
CTR2_HUMAN [view interactions] High throughput no no
STEA3_HUMAN [view interactions] High throughput no yes
S41A1_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
DEGS1_HUMAN [view interactions] High throughput no no
CTL1_HUMAN [view interactions] High throughput no no
GNL3L_HUMAN [view interactions] High throughput no yes
S26A6_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
RAD18_HUMAN [view interactions] High throughput no yes
CXCR4_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF6_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
SC5A5_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM3_HUMAN [view interactions] High throughput no no
ARGI2_HUMAN [view interactions] High throughput no yes
BRID5_HUMAN [view interactions] High throughput no no
TNFL8_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
T106A_HUMAN [view interactions] High throughput no no
I13R2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
CREM_HUMAN [view interactions] High throughput no no
RNF38_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
HAPR1_HUMAN [view interactions] High throughput no yes
ZNT5_HUMAN [view interactions] High throughput no yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
SYJ2B_HUMAN [view interactions] High throughput no no
PCDH7_HUMAN [view entry] [view interactions] High throughput yes no
TM177_HUMAN [view interactions] High throughput no no
SCAM1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
COT2_HUMAN [view interactions] High throughput no no
MOT8_HUMAN [view interactions] High throughput no no
ARL2_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A8_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
PDS5A_HUMAN [view interactions] High throughput no yes
HSDL1_HUMAN [view entry] [view interactions] High throughput yes no
DAAF5_HUMAN [view interactions] High throughput no no
RPTOR_HUMAN [view interactions] High throughput no yes
RDH13_HUMAN [view interactions] High throughput no no
GLMN_HUMAN [view interactions] High throughput no no
PAQR1_HUMAN [view interactions] High throughput no no
ARL8A_HUMAN [view interactions] High throughput no no
UBP36_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
VANG2_HUMAN [view entry] [view interactions] High throughput yes no
FLVC1_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
UBP3_HUMAN [view interactions] High throughput no no
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
TX101_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
ZNRF4_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RNF24_HUMAN [view interactions] High throughput no yes
CHD1L_HUMAN [view interactions] High throughput no yes
ATR_HUMAN [view entry] [view interactions] High throughput yes no
RFC2_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
TNPO2_HUMAN [view interactions] High throughput no yes
PLAP_HUMAN [view interactions] High throughput no yes