ATR_HUMAN
Evidence for PS localization
Functions
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Recognizes the substrate consensus sequence [ST]-Q (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed, PubMed, PubMed, PubMed, PubMed). Phosphorylates Ser-139 of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed). Required for FANCD2 ubiquitination (PubMed). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 2144 | Gln | Arg | Cutaneoustelangiectasiaandcancersyndrome,familial(FCTCS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ATR_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 41.0256 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 38.4615 | 5 | yes |
| GO:0043168 | anion binding | 38.4615 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.8974 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.8974 | 4 | yes |
| GO:0043169 | cation binding | 30.7692 | 4 | no |
| GO:0046872 | metal ion binding | 30.7692 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 28.2051 | 6 | yes |
| GO:0005524 | ATP binding | 25.6410 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.6410 | 5 | yes |
| GO:0019900 | kinase binding | 20.5128 | 4 | no |
| GO:0019901 | protein kinase binding | 20.5128 | 5 | no |
| GO:0003723 | RNA binding | 20.5128 | 4 | no |
| GO:0003677 | DNA binding | 17.9487 | 4 | yes |
| GO:0016301 | kinase activity | 15.3846 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 15.3846 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 12.8205 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 12.8205 | 4 | yes |
| GO:0035173 | histone kinase activity | 7.6923 | 4 | yes |
| GO:0035979 | histone H2AXS139 kinase activity | 7.6923 | 5 | yes |
| GO:0141003 | histone H2AX kinase activity | 7.6923 | 5 | yes |
| GO:0032405 | MutLalpha complex binding | 5.1282 | 4 | yes |
| GO:0032407 | MutSalpha complex binding | 5.1282 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ATR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.7949 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 61.5385 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 61.5385 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 58.9744 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 58.9744 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 58.9744 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 58.9744 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 53.8462 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 53.8462 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.2821 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 51.2821 | 4 | yes |
| GO:0010468 | regulation of gene expression | 51.2821 | 6 | no |
| GO:0006996 | organelle organization | 48.7179 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 48.7179 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 46.1538 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 46.1538 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 46.1538 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 43.5897 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 43.5897 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 43.5897 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 41.0256 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 41.0256 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 41.0256 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 41.0256 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 41.0256 | 5 | yes |
| GO:0022607 | cellular component assembly | 41.0256 | 4 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | yes |
| GO:0080134 | regulation of response to stress | 38.4615 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.4615 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 35.8974 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 35.8974 | 5 | no |
| GO:0043933 | protein-containing complex organization | 35.8974 | 4 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | yes |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 33.3333 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 33.3333 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.7692 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 30.7692 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.7692 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 30.7692 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.7692 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 30.7692 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.7692 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 30.7692 | 6 | no |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 28.2051 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 28.2051 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 28.2051 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.2051 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 28.2051 | 8 | no |
| GO:0009894 | regulation of catabolic process | 28.2051 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 28.2051 | 7 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 28.2051 | 8 | no |
| GO:0051094 | positive regulation of developmental process | 28.2051 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 28.2051 | 7 | no |
| GO:0032880 | regulation of protein localization | 28.2051 | 5 | no |
| GO:0006259 | DNA metabolic process | 25.6410 | 5 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 25.6410 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 25.6410 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 25.6410 | 4 | no |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 25.6410 | 9 | no |
| GO:0051049 | regulation of transport | 25.6410 | 4 | no |
| GO:0060284 | regulation of cell development | 25.6410 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 25.6410 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.6410 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.0769 | 4 | yes |
| GO:0006974 | DNA damage response | 23.0769 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | yes |
| GO:0051052 | regulation of DNA metabolic process | 23.0769 | 5 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 23.0769 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 23.0769 | 7 | no |
| GO:1903829 | positive regulation of protein localization | 23.0769 | 5 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:0006281 | DNA repair | 20.5128 | 5 | yes |
| GO:0033365 | protein localization to organelle | 20.5128 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 20.5128 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 20.5128 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.5128 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5128 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.5128 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5128 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.5128 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.5128 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.5128 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.5128 | 6 | no |
| GO:0010720 | positive regulation of cell development | 20.5128 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.5128 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 17.9487 | 6 | yes |
| GO:0045786 | negative regulation of cell cycle | 17.9487 | 5 | yes |
| GO:0051276 | chromosome organization | 17.9487 | 5 | yes |
| GO:0010948 | negative regulation of cell cycle process | 15.3846 | 6 | yes |
| GO:0016310 | phosphorylation | 15.3846 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 15.3846 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 15.3846 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 15.3846 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 15.3846 | 6 | yes |
| GO:0000723 | telomere maintenance | 12.8205 | 6 | yes |
| GO:0006282 | regulation of DNA repair | 12.8205 | 5 | yes |
| GO:0006302 | double-strand break repair | 12.8205 | 6 | yes |
| GO:0006468 | protein phosphorylation | 12.8205 | 5 | yes |
| GO:0009416 | response to light stimulus | 12.8205 | 4 | yes |
| GO:0032200 | telomere organization | 12.8205 | 6 | yes |
| GO:0042770 | signal transduction in response to DNA damage | 12.8205 | 4 | yes |
| GO:1901988 | negative regulation of cell cycle phase transition | 12.8205 | 7 | yes |
| GO:2000779 | regulation of double-strand break repair | 12.8205 | 6 | yes |
| GO:0000075 | cell cycle checkpoint signaling | 10.2564 | 4 | yes |
| GO:0000077 | DNA damage checkpoint signaling | 10.2564 | 5 | yes |
| GO:0010212 | response to ionizing radiation | 10.2564 | 4 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 10.2564 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 10.2564 | 6 | yes |
| GO:0031570 | DNA integrity checkpoint signaling | 10.2564 | 5 | yes |
| GO:0033044 | regulation of chromosome organization | 10.2564 | 6 | yes |
| GO:0046777 | protein autophosphorylation | 10.2564 | 6 | yes |
| GO:0051053 | negative regulation of DNA metabolic process | 10.2564 | 6 | yes |
| GO:0071478 | cellular response to radiation | 10.2564 | 4 | yes |
| GO:1901796 | regulation of signal transduction by p53 class mediator | 10.2564 | 6 | yes |
| GO:0006260 | DNA replication | 7.6923 | 6 | yes |
| GO:0006275 | regulation of DNA replication | 7.6923 | 6 | yes |
| GO:0009411 | response to UV | 7.6923 | 5 | yes |
| GO:0010332 | response to gamma radiation | 7.6923 | 5 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 7.6923 | 6 | yes |
| GO:0032204 | regulation of telomere maintenance | 7.6923 | 6 | yes |
| GO:0034644 | cellular response to UV | 7.6923 | 6 | yes |
| GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator | 7.6923 | 5 | yes |
| GO:0071479 | cellular response to ionizing radiation | 7.6923 | 5 | yes |
| GO:0071482 | cellular response to light stimulus | 7.6923 | 5 | yes |
| GO:2000278 | regulation of DNA biosynthetic process | 7.6923 | 6 | yes |
| GO:2000573 | positive regulation of DNA biosynthetic process | 7.6923 | 7 | yes |
| GO:0008156 | negative regulation of DNA replication | 5.1282 | 7 | yes |
| GO:0031297 | replication fork processing | 5.1282 | 7 | yes |
| GO:0032206 | positive regulation of telomere maintenance | 5.1282 | 7 | yes |
| GO:0032210 | regulation of telomere maintenance via telomerase | 5.1282 | 7 | yes |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | 5.1282 | 8 | yes |
| GO:0034502 | protein localization to chromosome | 5.1282 | 6 | yes |
| GO:0036297 | interstrand cross-link repair | 5.1282 | 6 | yes |
| GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator | 5.1282 | 6 | yes |
| GO:0045005 | DNA-templated DNA replication maintenance of fidelity | 5.1282 | 6 | yes |
| GO:0070198 | protein localization to chromosome, telomeric region | 5.1282 | 7 | yes |
| GO:0071480 | cellular response to gamma radiation | 5.1282 | 6 | yes |
| GO:0097694 | establishment of RNA localization to telomere | 5.1282 | 4 | yes |
| GO:1900034 | regulation of cellular response to heat | 5.1282 | 5 | yes |
| GO:1901798 | positive regulation of signal transduction by p53 class mediator | 5.1282 | 7 | yes |
| GO:1904356 | regulation of telomere maintenance via telomere lengthening | 5.1282 | 7 | yes |
| GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 5.1282 | 8 | yes |
| GO:1904882 | regulation of telomerase catalytic core complex assembly | 5.1282 | 6 | yes |
| GO:1904884 | positive regulation of telomerase catalytic core complex assembly | 5.1282 | 7 | yes |
| GO:2001252 | positive regulation of chromosome organization | 5.1282 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SIR7_HUMAN | [view interactions] | Low throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MSH3_HUMAN | [view interactions] | Low throughput | no | no |
| PPP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TIPIN_HUMAN | [view interactions] | Low throughput | no | no |
| ATR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DCA13_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC73_HUMAN | [view interactions] | Low throughput | no | yes |
| RN126_HUMAN | [view interactions] | Low throughput | no | yes |
| CHK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| UHRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM2_HUMAN | [view interactions] | Low throughput | no | no |
| FANCA_HUMAN | [view interactions] | Low throughput | no | no |
| RENT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPOLN_HUMAN | [view interactions] | Low throughput | no | no |
| FACD2_HUMAN | [view interactions] | Low throughput | no | no |
| E2F1_HUMAN | [view interactions] | Low throughput | no | yes |
| DCAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| DCR1C_HUMAN | [view interactions] | Low throughput | no | no |
| DTL_HUMAN | [view interactions] | Low throughput | no | no |
| BID_HUMAN | [view interactions] | Low throughput | no | no |
| FANCI_HUMAN | [view interactions] | Low throughput | no | yes |
| MCPH1_HUMAN | [view interactions] | Low throughput | no | yes |
| APBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PALB2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYCP3_HUMAN | [view interactions] | Low throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAP24_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM_HUMAN | [view interactions] | Low throughput | no | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK9_HUMAN | [view interactions] | Low throughput | no | yes |
| TTI1_HUMAN | [view interactions] | Low throughput | no | yes |
| ATRIP_HUMAN | [view interactions] | Low throughput | no | yes |
| CINP_HUMAN | [view interactions] | Low throughput | no | no |
| CDC5L_HUMAN | [view interactions] | Low throughput | no | yes |
| TELO2_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| CREB1_HUMAN | [view interactions] | Low throughput | no | yes |
| AATF_HUMAN | [view interactions] | Low throughput | no | yes |
| CHK1_HUMAN | [view interactions] | Low throughput | no | no |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
| NBN_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM7_HUMAN | [view interactions] | Low throughput | no | no |
| MSH2_HUMAN | [view interactions] | Low throughput | no | yes |
| CLSPN_HUMAN | [view interactions] | Low throughput | no | no |
| CHD4_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| MTA1_HUMAN | [view interactions] | Low throughput | no | yes |
| MTA2_HUMAN | [view interactions] | Low throughput | no | yes |
| RHEB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAD17_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC6_HUMAN | [view interactions] | Low throughput | no | yes |
| TOPB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | Low throughput | no | yes |
| CE164_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD1_HUMAN | [view interactions] | Low throughput | no | yes |
| HUS1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD9A_HUMAN | [view interactions] | Low throughput | no | yes |
| RFA1_HUMAN | [view interactions] | Low throughput | no | yes |
| BLM_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | Low throughput | no | no |
| WRN_HUMAN | [view interactions] | Low throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOCS1_HUMAN | [view interactions] | Low throughput | no | yes |
| XPA_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN2C_HUMAN | [view interactions] | Low throughput | no | yes |
| RFA2_HUMAN | [view interactions] | Low throughput | no | yes |
| XPC_HUMAN | [view interactions] | Low throughput | no | yes |
| ETV1_HUMAN | [view interactions] | Low throughput | no | no |
| UBP20_HUMAN | [view interactions] | Low throughput | no | yes |
| UHRF2_HUMAN | [view interactions] | Low throughput | no | no |
| FBX32_HUMAN | [view interactions] | Low throughput | no | no |
| ETAA1_HUMAN | [view interactions] | Low throughput | no | no |
| INT3_HUMAN | [view interactions] | Low throughput | no | yes |
| SPSB1_HUMAN | [view interactions] | Low throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| EFNA5_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN8_HUMAN | [view interactions] | High throughput | no | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| LEUK_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| GPR55_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| TERT_HUMAN | [view interactions] | High throughput | no | no |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| BCAT2_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| PA24C_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ALKB4_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| E4F1_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| P2R3A_HUMAN | [view interactions] | High throughput | no | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNB2_HUMAN | [view interactions] | High throughput | no | yes |
| NOSIP_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| PABP2_HUMAN | [view interactions] | High throughput | no | yes |
| F133B_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| NR3L1_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| LYPD3_HUMAN | [view interactions] | High throughput | no | no |
| VASN_HUMAN | [view interactions] | High throughput | no | yes |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| VSIG2_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| HELQ_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA2_HUMAN | [view interactions] | High throughput | no | no |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| NAR1_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |