SIR2_HUMAN
Lacks deacetylation activity. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SIR2_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 29.7872 | 4 | no |
GO:0046872 | metal ion binding | 25.5319 | 4 | yes |
GO:0019901 | protein kinase binding | 25.5319 | 5 | no |
GO:0008270 | zinc ion binding | 10.6383 | 6 | yes |
GO:0046914 | transition metal ion binding | 10.6383 | 5 | yes |
GO:0140297 | DNA-binding transcription factor binding | 10.6383 | 4 | yes |
GO:0042826 | histone deacetylase binding | 8.5106 | 4 | yes |
GO:0051287 | NAD binding | 8.5106 | 4 | yes |
GO:0003950 | NAD+ ADP-ribosyltransferase activity | 4.2553 | 5 | yes |
GO:0004407 | histone deacetylase activity | 4.2553 | 4 | yes |
GO:0016763 | pentosyltransferase activity | 4.2553 | 4 | yes |
GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 4.2553 | 4 | yes |
GO:0017136 | NAD-dependent histone deacetylase activity | 4.2553 | 5 | yes |
GO:0034739 | histone deacetylase activity (H4-K16 specific) | 4.2553 | 5 | yes |
GO:0034979 | NAD-dependent protein deacetylase activity | 4.2553 | 4 | yes |
GO:0035035 | histone acetyltransferase binding | 4.2553 | 4 | yes |
GO:0042903 | tubulin deacetylase activity | 4.2553 | 4 | yes |
GO:0043130 | ubiquitin binding | 4.2553 | 4 | yes |
GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) | 4.2553 | 6 | yes |
GO:0070403 | NAD+ binding | 4.2553 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SIR2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.7021 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 59.5745 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 55.3191 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 55.3191 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.0638 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 48.9362 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 48.9362 | 4 | yes |
GO:0006996 | organelle organization | 48.9362 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 46.8085 | 5 | yes |
GO:0010646 | regulation of cell communication | 44.6809 | 4 | no |
GO:0008104 | protein localization | 44.6809 | 4 | no |
GO:0009966 | regulation of signal transduction | 38.2979 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 38.2979 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 38.2979 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 38.2979 | 5 | yes |
GO:0051049 | regulation of transport | 36.1702 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.1702 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 34.0426 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 34.0426 | 5 | yes |
GO:0031399 | regulation of protein modification process | 34.0426 | 6 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.9149 | 5 | yes |
GO:0010468 | regulation of gene expression | 31.9149 | 5 | yes |
GO:0010941 | regulation of cell death | 31.9149 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 31.9149 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 29.7872 | 6 | yes |
GO:0007010 | cytoskeleton organization | 29.7872 | 5 | no |
GO:0022607 | cellular component assembly | 29.7872 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 27.6596 | 4 | yes |
GO:0051248 | negative regulation of protein metabolic process | 27.6596 | 6 | yes |
GO:1902531 | regulation of intracellular signal transduction | 27.6596 | 5 | no |
GO:0033365 | protein localization to organelle | 27.6596 | 5 | no |
GO:0009894 | regulation of catabolic process | 27.6596 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 27.6596 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 27.6596 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 25.5319 | 5 | yes |
GO:0071310 | cellular response to organic substance | 25.5319 | 4 | yes |
GO:0030030 | cell projection organization | 25.5319 | 4 | no |
GO:0060341 | regulation of cellular localization | 25.5319 | 4 | no |
GO:0010647 | positive regulation of cell communication | 25.5319 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 25.5319 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.5319 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 25.5319 | 6 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 25.5319 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 25.5319 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 23.4043 | 5 | yes |
GO:0043269 | regulation of ion transport | 23.4043 | 5 | no |
GO:0051050 | positive regulation of transport | 23.4043 | 4 | no |
GO:0032880 | regulation of protein localization | 23.4043 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 23.4043 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.4043 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 23.4043 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 23.4043 | 5 | yes |
GO:0031400 | negative regulation of protein modification process | 23.4043 | 7 | yes |
GO:0033043 | regulation of organelle organization | 23.4043 | 5 | yes |
GO:0042325 | regulation of phosphorylation | 23.4043 | 7 | yes |
GO:0044087 | regulation of cellular component biogenesis | 23.4043 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 21.2766 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 21.2766 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 21.2766 | 7 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.2766 | 4 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 19.1489 | 7 | yes |
GO:0051252 | regulation of RNA metabolic process | 19.1489 | 5 | yes |
GO:0051726 | regulation of cell cycle | 19.1489 | 4 | yes |
GO:0060284 | regulation of cell development | 19.1489 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 19.1489 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 19.1489 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 19.1489 | 6 | yes |
GO:0010243 | response to organonitrogen compound | 19.1489 | 4 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 19.1489 | 6 | yes |
GO:0010564 | regulation of cell cycle process | 19.1489 | 5 | yes |
GO:0014070 | response to organic cyclic compound | 19.1489 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 19.1489 | 5 | yes |
GO:0042127 | regulation of cell population proliferation | 19.1489 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 19.1489 | 5 | yes |
GO:0050767 | regulation of neurogenesis | 17.0213 | 6 | yes |
GO:0051129 | negative regulation of cellular component organization | 17.0213 | 5 | yes |
GO:0051960 | regulation of nervous system development | 17.0213 | 5 | yes |
GO:0071417 | cellular response to organonitrogen compound | 17.0213 | 4 | yes |
GO:0080134 | regulation of response to stress | 17.0213 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 17.0213 | 4 | yes |
GO:0009896 | positive regulation of catabolic process | 17.0213 | 5 | yes |
GO:0010506 | regulation of autophagy | 17.0213 | 6 | yes |
GO:0036211 | protein modification process | 17.0213 | 4 | yes |
GO:0043412 | macromolecule modification | 17.0213 | 4 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 14.8936 | 7 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 14.8936 | 6 | yes |
GO:0048585 | negative regulation of response to stimulus | 14.8936 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 14.8936 | 4 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 14.8936 | 6 | yes |
GO:0071407 | cellular response to organic cyclic compound | 14.8936 | 5 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 14.8936 | 7 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 14.8936 | 8 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 14.8936 | 7 | yes |
GO:0009890 | negative regulation of biosynthetic process | 14.8936 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 14.8936 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 14.8936 | 6 | yes |
GO:0010638 | positive regulation of organelle organization | 14.8936 | 6 | yes |
GO:0010720 | positive regulation of cell development | 14.8936 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 14.8936 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 14.8936 | 6 | yes |
GO:0031331 | positive regulation of cellular catabolic process | 14.8936 | 6 | yes |
GO:0042176 | regulation of protein catabolic process | 14.8936 | 5 | yes |
GO:0042326 | negative regulation of phosphorylation | 14.8936 | 8 | yes |
GO:0051093 | negative regulation of developmental process | 12.7660 | 4 | yes |
GO:0051099 | positive regulation of binding | 12.7660 | 4 | yes |
GO:0051302 | regulation of cell division | 12.7660 | 4 | yes |
GO:0061024 | membrane organization | 12.7660 | 4 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 12.7660 | 8 | yes |
GO:0010629 | negative regulation of gene expression | 12.7660 | 6 | yes |
GO:0010942 | positive regulation of cell death | 12.7660 | 5 | yes |
GO:0021762 | substantia nigra development | 12.7660 | 4 | yes |
GO:0030162 | regulation of proteolysis | 12.7660 | 6 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 10.6383 | 7 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 10.6383 | 6 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 10.6383 | 8 | yes |
GO:0051101 | regulation of DNA binding | 10.6383 | 4 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 10.6383 | 6 | yes |
GO:0062197 | cellular response to chemical stress | 10.6383 | 4 | yes |
GO:0070848 | response to growth factor | 10.6383 | 4 | yes |
GO:0071363 | cellular response to growth factor stimulus | 10.6383 | 5 | yes |
GO:1901987 | regulation of cell cycle phase transition | 10.6383 | 6 | yes |
GO:1901990 | regulation of mitotic cell cycle phase transition | 10.6383 | 6 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 10.6383 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 10.6383 | 8 | yes |
GO:0000122 | negative regulation of transcription by RNA polymerase II | 10.6383 | 8 | yes |
GO:0007346 | regulation of mitotic cell cycle | 10.6383 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 10.6383 | 6 | yes |
GO:0010799 | regulation of peptidyl-threonine phosphorylation | 10.6383 | 8 | yes |
GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | 10.6383 | 9 | yes |
GO:0034599 | cellular response to oxidative stress | 10.6383 | 4 | yes |
GO:0043065 | positive regulation of apoptotic process | 10.6383 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 10.6383 | 6 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 10.6383 | 5 | yes |
GO:0043388 | positive regulation of DNA binding | 10.6383 | 5 | yes |
GO:0045596 | negative regulation of cell differentiation | 10.6383 | 5 | yes |
GO:0045862 | positive regulation of proteolysis | 8.5106 | 7 | yes |
GO:0050768 | negative regulation of neurogenesis | 8.5106 | 6 | yes |
GO:0051961 | negative regulation of nervous system development | 8.5106 | 5 | yes |
GO:0061136 | regulation of proteasomal protein catabolic process | 8.5106 | 6 | yes |
GO:0071453 | cellular response to oxygen levels | 8.5106 | 4 | yes |
GO:0071456 | cellular response to hypoxia | 8.5106 | 4 | yes |
GO:0090068 | positive regulation of cell cycle process | 8.5106 | 6 | yes |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 8.5106 | 7 | yes |
GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 8.5106 | 6 | yes |
GO:2000377 | regulation of reactive oxygen species metabolic process | 8.5106 | 5 | yes |
GO:0002831 | regulation of response to biotic stimulus | 8.5106 | 4 | yes |
GO:0007096 | regulation of exit from mitosis | 8.5106 | 7 | yes |
GO:0008285 | negative regulation of cell population proliferation | 8.5106 | 5 | yes |
GO:0010721 | negative regulation of cell development | 8.5106 | 6 | yes |
GO:0018193 | peptidyl-amino acid modification | 8.5106 | 5 | yes |
GO:0031347 | regulation of defense response | 8.5106 | 5 | yes |
GO:0032101 | regulation of response to external stimulus | 8.5106 | 4 | yes |
GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 8.5106 | 7 | yes |
GO:0036293 | response to decreased oxygen levels | 8.5106 | 4 | yes |
GO:0036294 | cellular response to decreased oxygen levels | 8.5106 | 5 | yes |
GO:0045732 | positive regulation of protein catabolic process | 8.5106 | 6 | yes |
GO:0045787 | positive regulation of cell cycle | 8.5106 | 5 | yes |
GO:0048015 | phosphatidylinositol-mediated signaling | 6.3830 | 5 | yes |
GO:0048017 | inositol lipid-mediated signaling | 6.3830 | 4 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 6.3830 | 5 | yes |
GO:0051783 | regulation of nuclear division | 6.3830 | 6 | yes |
GO:0051785 | positive regulation of nuclear division | 6.3830 | 7 | yes |
GO:0071219 | cellular response to molecule of bacterial origin | 6.3830 | 4 | yes |
GO:0071709 | membrane assembly | 6.3830 | 5 | yes |
GO:1900193 | regulation of oocyte maturation | 6.3830 | 4 | yes |
GO:1900195 | positive regulation of oocyte maturation | 6.3830 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 6.3830 | 4 | yes |
GO:1901800 | positive regulation of proteasomal protein catabolic process | 6.3830 | 7 | yes |
GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 6.3830 | 8 | yes |
GO:1903429 | regulation of cell maturation | 6.3830 | 6 | yes |
GO:1903431 | positive regulation of cell maturation | 6.3830 | 7 | yes |
GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 6.3830 | 7 | yes |
GO:2000177 | regulation of neural precursor cell proliferation | 6.3830 | 5 | yes |
GO:2000178 | negative regulation of neural precursor cell proliferation | 6.3830 | 6 | yes |
GO:2000243 | positive regulation of reproductive process | 6.3830 | 4 | yes |
GO:2000378 | negative regulation of reactive oxygen species metabolic process | 6.3830 | 6 | yes |
GO:0002237 | response to molecule of bacterial origin | 6.3830 | 4 | yes |
GO:0006325 | chromatin organization | 6.3830 | 4 | yes |
GO:0006508 | proteolysis | 6.3830 | 4 | yes |
GO:0009057 | macromolecule catabolic process | 6.3830 | 4 | yes |
GO:0009895 | negative regulation of catabolic process | 6.3830 | 5 | yes |
GO:0014013 | regulation of gliogenesis | 6.3830 | 7 | yes |
GO:0016042 | lipid catabolic process | 6.3830 | 4 | yes |
GO:0019941 | modification-dependent protein catabolic process | 6.3830 | 6 | yes |
GO:0031667 | response to nutrient levels | 6.3830 | 4 | yes |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 6.3830 | 8 | yes |
GO:0035728 | response to hepatocyte growth factor | 6.3830 | 5 | yes |
GO:0035729 | cellular response to hepatocyte growth factor stimulus | 6.3830 | 6 | yes |
GO:0042177 | negative regulation of protein catabolic process | 6.3830 | 6 | yes |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 6.3830 | 4 | yes |
GO:0043632 | modification-dependent macromolecule catabolic process | 6.3830 | 5 | yes |
GO:0044242 | cellular lipid catabolic process | 6.3830 | 4 | yes |
GO:0044265 | cellular macromolecule catabolic process | 6.3830 | 4 | yes |
GO:0045836 | positive regulation of meiotic nuclear division | 4.2553 | 6 | yes |
GO:0045843 | negative regulation of striated muscle tissue development | 4.2553 | 6 | yes |
GO:0048012 | hepatocyte growth factor receptor signaling pathway | 4.2553 | 6 | yes |
GO:0048634 | regulation of muscle organ development | 4.2553 | 4 | yes |
GO:0048635 | negative regulation of muscle organ development | 4.2553 | 5 | yes |
GO:0051445 | regulation of meiotic cell cycle | 4.2553 | 4 | yes |
GO:0051446 | positive regulation of meiotic cell cycle | 4.2553 | 5 | yes |
GO:0051781 | positive regulation of cell division | 4.2553 | 5 | yes |
GO:0051983 | regulation of chromosome segregation | 4.2553 | 4 | yes |
GO:0051984 | positive regulation of chromosome segregation | 4.2553 | 5 | yes |
GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | 4.2553 | 6 | yes |
GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | 4.2553 | 6 | yes |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 4.2553 | 6 | yes |
GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | 4.2553 | 7 | yes |
GO:0061433 | cellular response to caloric restriction | 4.2553 | 4 | yes |
GO:0070445 | regulation of oligodendrocyte progenitor proliferation | 4.2553 | 6 | yes |
GO:0070446 | negative regulation of oligodendrocyte progenitor proliferation | 4.2553 | 7 | yes |
GO:0070828 | heterochromatin organization | 4.2553 | 6 | yes |
GO:0070932 | histone H3 deacetylation | 4.2553 | 7 | yes |
GO:0070933 | histone H4 deacetylation | 4.2553 | 7 | yes |
GO:0071763 | nuclear membrane organization | 4.2553 | 5 | yes |
GO:0071867 | response to monoamine | 4.2553 | 5 | yes |
GO:0071868 | cellular response to monoamine stimulus | 4.2553 | 5 | yes |
GO:0071869 | response to catecholamine | 4.2553 | 4 | yes |
GO:0071870 | cellular response to catecholamine stimulus | 4.2553 | 5 | yes |
GO:0071871 | response to epinephrine | 4.2553 | 5 | yes |
GO:0071872 | cellular response to epinephrine stimulus | 4.2553 | 6 | yes |
GO:0090042 | tubulin deacetylation | 4.2553 | 7 | yes |
GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 4.2553 | 6 | yes |
GO:0098732 | macromolecule deacylation | 4.2553 | 5 | yes |
GO:0101024 | mitotic nuclear membrane organization | 4.2553 | 4 | yes |
GO:0140718 | facultative heterochromatin formation | 4.2553 | 8 | yes |
GO:0140719 | constitutive heterochromatin formation | 4.2553 | 8 | yes |
GO:1900117 | regulation of execution phase of apoptosis | 4.2553 | 4 | yes |
GO:1900119 | positive regulation of execution phase of apoptosis | 4.2553 | 5 | yes |
GO:1900225 | regulation of NLRP3 inflammasome complex assembly | 4.2553 | 6 | yes |
GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly | 4.2553 | 7 | yes |
GO:1900424 | regulation of defense response to bacterium | 4.2553 | 5 | yes |
GO:1900425 | negative regulation of defense response to bacterium | 4.2553 | 6 | yes |
GO:1901861 | regulation of muscle tissue development | 4.2553 | 4 | yes |
GO:1901862 | negative regulation of muscle tissue development | 4.2553 | 5 | yes |
GO:2000777 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia | 4.2553 | 9 | yes |
GO:0000183 | rDNA heterochromatin formation | 4.2553 | 9 | yes |
GO:0002832 | negative regulation of response to biotic stimulus | 4.2553 | 5 | yes |
GO:0006338 | chromatin remodeling | 4.2553 | 5 | yes |
GO:0006471 | protein ADP-ribosylation | 4.2553 | 5 | yes |
GO:0006476 | protein deacetylation | 4.2553 | 6 | yes |
GO:0006511 | ubiquitin-dependent protein catabolic process | 4.2553 | 7 | yes |
GO:0007084 | mitotic nuclear membrane reassembly | 4.2553 | 5 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 4.2553 | 4 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 4.2553 | 5 | yes |
GO:0010498 | proteasomal protein catabolic process | 4.2553 | 5 | yes |
GO:0010507 | negative regulation of autophagy | 4.2553 | 7 | yes |
GO:0014014 | negative regulation of gliogenesis | 4.2553 | 7 | yes |
GO:0014065 | phosphatidylinositol 3-kinase signaling | 4.2553 | 6 | yes |
GO:0016202 | regulation of striated muscle tissue development | 4.2553 | 5 | yes |
GO:0016570 | histone modification | 4.2553 | 5 | yes |
GO:0016575 | histone deacetylation | 4.2553 | 6 | yes |
GO:0018205 | peptidyl-lysine modification | 4.2553 | 6 | yes |
GO:0022011 | myelination in peripheral nervous system | 4.2553 | 5 | yes |
GO:0030163 | protein catabolic process | 4.2553 | 4 | yes |
GO:0031330 | negative regulation of cellular catabolic process | 4.2553 | 6 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 4.2553 | 6 | yes |
GO:0031348 | negative regulation of defense response | 4.2553 | 5 | yes |
GO:0031468 | nuclear membrane reassembly | 4.2553 | 6 | yes |
GO:0031507 | heterochromatin formation | 4.2553 | 7 | yes |
GO:0031509 | subtelomeric heterochromatin formation | 4.2553 | 9 | yes |
GO:0031641 | regulation of myelination | 4.2553 | 4 | yes |
GO:0032102 | negative regulation of response to external stimulus | 4.2553 | 5 | yes |
GO:0032292 | peripheral nervous system axon ensheathment | 4.2553 | 4 | yes |
GO:0034983 | peptidyl-lysine deacetylation | 4.2553 | 7 | yes |
GO:0035601 | protein deacylation | 4.2553 | 5 | yes |
GO:0040020 | regulation of meiotic nuclear division | 4.2553 | 5 | yes |
GO:0040029 | epigenetic regulation of gene expression | 4.2553 | 6 | yes |
GO:0042552 | myelination | 4.2553 | 4 | yes |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 4.2553 | 6 | yes |
GO:0043491 | protein kinase B signaling | 4.2553 | 4 | yes |
GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 4.2553 | 5 | yes |
GO:0045598 | regulation of fat cell differentiation | 4.2553 | 5 | yes |
GO:0045599 | negative regulation of fat cell differentiation | 4.2553 | 6 | yes |
GO:0045814 | negative regulation of gene expression, epigenetic | 4.2553 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SIR2_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 6.3830 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 6.3830 | 5 | no |
DOID:114 | heart disease | 6.3830 | 3 | no |
DOID:2843 | long QT syndrome | 4.2553 | 6 | no |
DOID:331 | central nervous system disease | 4.2553 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
ATR_HUMAN | [view interactions] | Low throughput | no | no |
ATRIP_HUMAN | [view interactions] | Low throughput | no | yes |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
TBA4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
GDIR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MCL1_HUMAN | [view interactions] | Low throughput | no | yes |
RAN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TNFA_HUMAN | [view interactions] | Low throughput | no | no |
KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
KAT2A_HUMAN | [view interactions] | Low throughput | no | no |
MYOD1_HUMAN | [view interactions] | Low throughput | no | no |
HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FZR1_HUMAN | [view interactions] | Low throughput | no | no |
CDC20_HUMAN | [view interactions] | Low throughput | no | no |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
G6PD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
BUB1B_HUMAN | [view interactions] | Low throughput | no | no |
PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
CC14B_HUMAN | [view interactions] | Low throughput | no | no |
SPOP_HUMAN | [view interactions] | Low throughput | no | no |
TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PA24A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EP300_HUMAN | [view interactions] | Low throughput | no | yes |
ING1_HUMAN | [view interactions] | Low throughput | no | yes |
RET1_HUMAN | [view interactions] | Low throughput | no | no |
SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
FOXO1_HUMAN | [view interactions] | Low throughput | no | yes |
RUNX3_HUMAN | [view interactions] | Low throughput | no | no |
CBLB_HUMAN | [view interactions] | Low throughput | no | yes |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
ACLY_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GCKR_HUMAN | [view interactions] | Low throughput | no | no |
SKP2_HUMAN | [view interactions] | Low throughput | no | yes |
CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
GSTT2_HUMAN | [view interactions] | High throughput | no | no |
MANS1_HUMAN | [view interactions] | High throughput | no | yes |
K0930_HUMAN | [view interactions] | High throughput | no | yes |
RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
NAR1_HUMAN | [view interactions] | High throughput | no | no |
CYTD_HUMAN | [view interactions] | High throughput | no | no |
HORM2_HUMAN | [view interactions] | High throughput | no | no |
RP9_HUMAN | [view interactions] | High throughput | no | yes |
FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
OTULL_HUMAN | [view interactions] | High throughput | no | no |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
ENTR1_HUMAN | [view interactions] | High throughput | no | no |
TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBXL4_HUMAN | [view interactions] | High throughput | no | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADAS_HUMAN | [view interactions] | High throughput | no | yes |
ANC2_HUMAN | [view interactions] | High throughput | no | no |
ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DERL1_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHB11_HUMAN | [view interactions] | High throughput | no | yes |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
K2C8_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PANX1_HUMAN | [view interactions] | High throughput | no | no |
PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEP10_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
STIM1_HUMAN | [view interactions] | High throughput | no | yes |
UTP4_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APC1_HUMAN | [view interactions] | High throughput | no | no |
CDC27_HUMAN | [view interactions] | High throughput | no | yes |
CDC16_HUMAN | [view interactions] | High throughput | no | yes |
APC4_HUMAN | [view interactions] | High throughput | no | yes |
CDC23_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYSC_HUMAN | [view interactions] | High throughput | no | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GYS1_HUMAN | [view interactions] | High throughput | no | yes |
K2C78_HUMAN | [view interactions] | High throughput | no | no |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
RAD51_HUMAN | [view interactions] | High throughput | no | yes |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
SRTD1_HUMAN | [view interactions] | High throughput | no | no |
TLX3_HUMAN | [view interactions] | High throughput | no | no |
NFE2_HUMAN | [view interactions] | High throughput | no | no |
SSBP3_HUMAN | [view interactions] | High throughput | no | no |
ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
OXYR_HUMAN | [view interactions] | High throughput | no | no |
PUR2_HUMAN | [view interactions] | High throughput | no | yes |
AHI1_HUMAN | [view interactions] | High throughput | no | yes |
FBF1_HUMAN | [view interactions] | High throughput | no | no |
CEP89_HUMAN | [view interactions] | High throughput | no | no |
ODFP2_HUMAN | [view interactions] | High throughput | no | no |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
ELL_HUMAN | [view interactions] | High throughput | no | no |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJB8_HUMAN | [view interactions] | High throughput | no | no |
CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
PAPOA_HUMAN | [view interactions] | High throughput | no | yes |
PCKGC_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPAT1_HUMAN | [view interactions] | High throughput | no | no |
RB3GP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCFD2_HUMAN | [view interactions] | High throughput | no | yes |
FADS1_HUMAN | [view interactions] | High throughput | no | yes |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DEGS1_HUMAN | [view interactions] | High throughput | no | no |
ORC2_HUMAN | [view interactions] | High throughput | no | yes |
TPC12_HUMAN | [view interactions] | High throughput | no | yes |
VAMP7_HUMAN | [view interactions] | High throughput | no | yes |
NUD12_HUMAN | [view interactions] | High throughput | no | yes |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TINF2_HUMAN | [view interactions] | High throughput | no | no |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S22AN_HUMAN | [view interactions] | High throughput | no | yes |
GSTT1_HUMAN | [view interactions] | High throughput | no | no |
RRP8_HUMAN | [view interactions] | Computational | no | yes |
NAMPT_HUMAN | [view interactions] | Computational | no | no |
HDAC1_HUMAN | [view interactions] | Computational | no | no |
FOXO3_HUMAN | [view interactions] | Computational | no | yes |
TBB2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PNPH_HUMAN | [view interactions] | Computational | no | no |
RIPK3_HUMAN | [view interactions] | Computational | no | no |
NADE_HUMAN | [view interactions] | Computational | no | yes |
CD38_HUMAN | [view interactions] | Computational | no | no |
ANKL2_HUMAN | [view interactions] | Computational | no | yes |
BAHD1_HUMAN | [view interactions] | Computational | no | no |
NMNA3_HUMAN | [view interactions] | Computational | no | yes |
NMNA2_HUMAN | [view interactions] | Computational | no | no |
HDAC4_HUMAN | [view interactions] | Computational | no | yes |
NNTM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HDAC2_HUMAN | [view interactions] | Computational | no | yes |
BST1_HUMAN | [view interactions] | Computational | no | no |
CC14A_HUMAN | [view interactions] | Computational | no | yes |
HDA11_HUMAN | [view interactions] | Computational | no | no |
HXA10_HUMAN | [view interactions] | Computational | no | no |
1433B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HDAC8_HUMAN | [view interactions] | Computational | no | yes |
SUV91_HUMAN | [view interactions] | Computational | no | no |
TBA1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NAKD2_HUMAN | [view interactions] | Computational | no | yes |
NNMT_HUMAN | [view interactions] | Computational | no | no |
NMNA1_HUMAN | [view interactions] | Computational | no | yes |
HDAC3_HUMAN | [view interactions] | Computational | no | yes |