Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GDIR1_HUMAN

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

ELM instance Name Type Start End Partner
ELMI001421 MOD_PKA_2 MOD 171 177 -

Molecular function

Term Name % Distance from the top of the tree Annotated in GDIR1_HUMAN
GO:0017076 purine nucleotide binding 34.9206 4 no
GO:0032555 purine ribonucleotide binding 34.9206 4 no
GO:0035639 purine ribonucleoside triphosphate binding 34.9206 4 no
GO:0019900 kinase binding 30.1587 4 no
GO:0019901 protein kinase binding 26.9841 5 no
GO:0046872 metal ion binding 25.3968 4 no
GO:0003723 RNA binding 23.8095 4 no
GO:0030695 GTPase regulator activity 7.9365 4 yes
GO:0005092 GDP-dissociation inhibitor activity 4.7619 5 yes
GO:0005096 GTPase activator activity 4.7619 4 yes
GO:0005094 Rho GDP-dissociation inhibitor activity 3.1746 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GDIR1_HUMAN
GO:0048522 positive regulation of cellular process 68.2540 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0051128 regulation of cellular component organization 53.9683 4 yes
GO:0031323 regulation of cellular metabolic process 50.7937 4 no
GO:0010646 regulation of cell communication 49.2063 4 yes
GO:0009893 positive regulation of metabolic process 47.6190 4 no
GO:0010468 regulation of gene expression 47.6190 5 no
GO:0009966 regulation of signal transduction 46.0317 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.0317 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0033043 regulation of organelle organization 41.2698 5 yes
GO:0022607 cellular component assembly 39.6825 4 no
GO:0051246 regulation of protein metabolic process 39.6825 5 no
GO:0051049 regulation of transport 39.6825 4 no
GO:0010941 regulation of cell death 36.5079 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.5079 5 no
GO:0031325 positive regulation of cellular metabolic process 36.5079 5 no
GO:0022603 regulation of anatomical structure morphogenesis 36.5079 4 no
GO:1902531 regulation of intracellular signal transduction 34.9206 5 yes
GO:0009889 regulation of biosynthetic process 34.9206 4 no
GO:0031326 regulation of cellular biosynthetic process 34.9206 5 no
GO:0051094 positive regulation of developmental process 34.9206 4 no
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0060341 regulation of cellular localization 33.3333 4 yes
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0032880 regulation of protein localization 31.7460 5 yes
GO:0042981 regulation of apoptotic process 31.7460 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 31.7460 5 no
GO:0044087 regulation of cellular component biogenesis 31.7460 4 no
GO:0006355 regulation of DNA-templated transcription 30.1587 6 no
GO:1903506 regulation of nucleic acid-templated transcription 30.1587 7 no
GO:2001141 regulation of RNA biosynthetic process 30.1587 6 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0036211 protein modification process 26.9841 4 no
GO:0042127 regulation of cell population proliferation 26.9841 4 no
GO:0030334 regulation of cell migration 26.9841 5 no
GO:0043085 positive regulation of catalytic activity 26.9841 4 no
GO:0007010 cytoskeleton organization 26.9841 5 no
GO:0051493 regulation of cytoskeleton organization 25.3968 6 yes
GO:0031399 regulation of protein modification process 25.3968 6 no
GO:0051129 negative regulation of cellular component organization 25.3968 5 no
GO:2000026 regulation of multicellular organismal development 25.3968 4 no
GO:0051240 positive regulation of multicellular organismal process 25.3968 4 no
GO:0010647 positive regulation of cell communication 25.3968 5 no
GO:0023056 positive regulation of signaling 25.3968 4 no
GO:0030155 regulation of cell adhesion 23.8095 4 yes
GO:0019220 regulation of phosphate metabolic process 23.8095 6 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0045597 positive regulation of cell differentiation 23.8095 5 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0051174 regulation of phosphorus metabolic process 23.8095 5 no
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0016310 phosphorylation 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:1903829 positive regulation of protein localization 23.8095 5 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0007264 small GTPase mediated signal transduction 22.2222 4 yes
GO:0032970 regulation of actin filament-based process 22.2222 4 yes
GO:0060548 negative regulation of cell death 22.2222 5 yes
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0007265 Ras protein signal transduction 20.6349 5 yes
GO:0032956 regulation of actin cytoskeleton organization 20.6349 5 yes
GO:0043069 negative regulation of programmed cell death 20.6349 6 yes
GO:0001932 regulation of protein phosphorylation 20.6349 7 no
GO:0006357 regulation of transcription by RNA polymerase II 20.6349 7 no
GO:0009891 positive regulation of biosynthetic process 20.6349 5 no
GO:0010605 negative regulation of macromolecule metabolic process 20.6349 5 no
GO:0031324 negative regulation of cellular metabolic process 20.6349 5 no
GO:0031328 positive regulation of cellular biosynthetic process 20.6349 6 no
GO:0043254 regulation of protein-containing complex assembly 20.6349 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.6349 6 no
GO:0051726 regulation of cell cycle 20.6349 4 no
GO:0080134 regulation of response to stress 20.6349 4 no
GO:0043933 protein-containing complex organization 20.6349 4 no
GO:0010562 positive regulation of phosphorus metabolic process 20.6349 6 no
GO:0031401 positive regulation of protein modification process 20.6349 7 no
GO:0042327 positive regulation of phosphorylation 20.6349 8 no
GO:0045937 positive regulation of phosphate metabolic process 20.6349 7 no
GO:0051050 positive regulation of transport 20.6349 4 no
GO:0051336 regulation of hydrolase activity 20.6349 4 no
GO:0060627 regulation of vesicle-mediated transport 20.6349 4 no
GO:0043066 negative regulation of apoptotic process 19.0476 7 yes
GO:0007266 Rho protein signal transduction 11.1111 6 yes
GO:0046578 regulation of Ras protein signal transduction 11.1111 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.1111 6 yes
GO:0007162 negative regulation of cell adhesion 7.9365 5 yes
GO:0035023 regulation of Rho protein signal transduction 7.9365 8 yes
GO:2000249 regulation of actin cytoskeleton reorganization 6.3492 6 yes
GO:0071526 semaphorin-plexin signaling pathway 4.7619 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in GDIR1_HUMAN
DOID:1289 neurodegenerative disease 4.7619 4 no
DOID:331 central nervous system disease 4.7619 3 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 3.1746 7 no
DOID:10595 Charcot-Marie-Tooth disease 3.1746 6 no
DOID:440 neuromuscular disease 3.1746 5 no
DOID:574 peripheral nervous system disease 3.1746 3 no
DOID:870 neuropathy 3.1746 4 no
DOID:231 motor neuron disease 3.1746 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCTD5_HUMAN [view interactions] Low throughput no no
UBC9_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
KAT2B_HUMAN [view interactions] Low throughput no yes
SIR2_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
SET_HUMAN [view interactions] Low throughput no yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
GDIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
TNR19_HUMAN [view interactions] Low throughput no no
KANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC2_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOH_HUMAN [view interactions] Low throughput no yes
RHOG_HUMAN [view entry] [view interactions] Low throughput yes no
ATX3_HUMAN [view interactions] Low throughput no yes
RN128_HUMAN [view interactions] Low throughput no yes
XIAP_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
PSD10_HUMAN [view entry] [view interactions] Low throughput yes yes
NEMO_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
WDR26_HUMAN [view interactions] Low throughput no yes
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
MTPN_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
TBCA_HUMAN [view interactions] High throughput no yes
DOPD_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
CYTB_HUMAN [view interactions] High throughput no no
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
DDX58_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CASP3_HUMAN [view interactions] High throughput no yes
CASP7_HUMAN [view interactions] High throughput no no
BID_HUMAN [view interactions] High throughput no no
TR10B_HUMAN [view interactions] High throughput no no
FADD_HUMAN [view interactions] High throughput no yes
TNFL6_HUMAN [view interactions] High throughput no yes
MK08_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
CASPA_HUMAN [view interactions] High throughput no yes
CASP8_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
TNR1A_HUMAN [view interactions] High throughput no yes
PIR_HUMAN [view interactions] High throughput no no
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
ASSY_HUMAN [view interactions] High throughput no yes
COMD4_HUMAN [view interactions] High throughput no no
COTL1_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
IMPA1_HUMAN [view entry] [view interactions] High throughput yes yes
IMPA2_HUMAN [view interactions] High throughput no no
INO1_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
PLST_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
THIO_HUMAN [view interactions] High throughput no yes
UCHL3_HUMAN [view interactions] High throughput no yes
FA98B_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
HINT1_HUMAN [view interactions] High throughput no yes
PEPL1_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAP_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO4_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
BAK_HUMAN [view interactions] High throughput no no
CBX5_HUMAN [view interactions] High throughput no yes
3HAO_HUMAN [view interactions] High throughput no no
HERP1_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
C560_HUMAN [view interactions] High throughput no no
KCNRG_HUMAN [view interactions] High throughput no no
TWF2_HUMAN [view interactions] High throughput no no
UB2L6_HUMAN [view interactions] High throughput no no
UB2R2_HUMAN [view interactions] High throughput no no
UFM1_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
TINF2_HUMAN [view interactions] High throughput no no
SNF5_HUMAN [view interactions] High throughput no yes
PDPR_HUMAN [view interactions] High throughput no yes
PGS1_HUMAN [view interactions] High throughput no no
FES_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
STA5B_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK_HUMAN [view interactions] High throughput no no
MYLK4_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
EI2BA_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
ROAA_HUMAN [view interactions] High throughput no yes
IF2B1_HUMAN [view interactions] High throughput no no
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
FEN1_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1B_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view interactions] High throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
TIF1A_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BD_HUMAN [view interactions] High throughput no yes
AN13A_HUMAN [view interactions] High throughput no yes
PRC2B_HUMAN [view interactions] High throughput no no
ACL6A_HUMAN [view interactions] High throughput no yes
TRI13_HUMAN [view interactions] High throughput no no
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FBX32_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CUL7_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
SUN2_HUMAN [view interactions] High throughput no yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
RHOJ_HUMAN [view interactions] Computational no yes
LIGO1_HUMAN [view entry] [view interactions] Computational yes no
KAPCG_HUMAN [view interactions] Computational no no
GDIR2_HUMAN [view interactions] Computational no no
RTN4R_HUMAN [view interactions] Computational no no
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
RHOQ_HUMAN [view interactions] Computational no no
RHOV_HUMAN [view interactions] Computational no no
COR1A_HUMAN [view entry] [view interactions] Computational yes no
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
GIPC1_HUMAN [view entry] [view interactions] Computational yes yes
RHOF_HUMAN [view interactions] Computational no no
ARHG7_HUMAN [view entry] [view interactions] Computational yes yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
GDIR3_HUMAN [view interactions] Computational no no
RHOD_HUMAN [view interactions] Computational no no