Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAP1A_HUMAN

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAP1A_HUMAN
GO:0043168 anion binding 43.9394 4 yes
GO:0000166 nucleotide binding 37.8788 4 yes
GO:0017076 purine nucleotide binding 37.8788 5 yes
GO:0032555 purine ribonucleotide binding 37.8788 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 34.8485 4 yes
GO:0016462 pyrophosphatase activity 27.2727 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 27.2727 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 27.2727 6 yes
GO:0003924 GTPase activity 25.7576 7 yes
GO:0043169 cation binding 24.2424 4 no
GO:0046872 metal ion binding 24.2424 5 no
GO:0005525 GTP binding 21.2121 5 yes
GO:0019001 guanyl nucleotide binding 21.2121 6 yes
GO:0032561 guanyl ribonucleotide binding 21.2121 5 yes
GO:0019003 GDP binding 18.1818 5 yes
GO:0051020 GTPase binding 18.1818 4 yes
GO:0031267 small GTPase binding 15.1515 5 yes
GO:0030695 GTPase regulator activity 13.6364 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 6.0606 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAP1A_HUMAN
GO:0048522 positive regulation of cellular process 60.6061 4 yes
GO:0010646 regulation of cell communication 51.5152 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0008104 protein localization 48.4848 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.4848 4 yes
GO:0051128 regulation of cellular component organization 45.4545 4 yes
GO:0031323 regulation of cellular metabolic process 43.9394 4 yes
GO:0080090 regulation of primary metabolic process 43.9394 4 yes
GO:0009966 regulation of signal transduction 40.9091 4 yes
GO:0006996 organelle organization 40.9091 4 no
GO:0022607 cellular component assembly 40.9091 4 no
GO:0009893 positive regulation of metabolic process 37.8788 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 34.8485 5 yes
GO:0051246 regulation of protein metabolic process 34.8485 5 yes
GO:1902531 regulation of intracellular signal transduction 34.8485 5 yes
GO:0009889 regulation of biosynthetic process 34.8485 4 no
GO:0071702 organic substance transport 34.8485 4 no
GO:0071705 nitrogen compound transport 34.8485 4 no
GO:0051049 regulation of transport 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0010647 positive regulation of cell communication 31.8182 5 yes
GO:0023056 positive regulation of signaling 31.8182 4 yes
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0031325 positive regulation of cellular metabolic process 30.3030 5 yes
GO:0042981 regulation of apoptotic process 30.3030 5 no
GO:0043067 regulation of programmed cell death 30.3030 4 no
GO:0045595 regulation of cell differentiation 28.7879 4 yes
GO:0048584 positive regulation of response to stimulus 28.7879 4 yes
GO:0015031 protein transport 28.7879 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 yes
GO:0141124 intracellular signaling cassette 27.2727 4 yes
GO:0051094 positive regulation of developmental process 25.7576 4 yes
GO:0051247 positive regulation of protein metabolic process 25.7576 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.7576 5 no
GO:0031399 regulation of protein modification process 24.2424 6 yes
GO:0044087 regulation of cellular component biogenesis 24.2424 4 yes
GO:0031324 negative regulation of cellular metabolic process 24.2424 5 no
GO:0001932 regulation of protein phosphorylation 22.7273 7 yes
GO:0019220 regulation of phosphate metabolic process 22.7273 6 yes
GO:0042325 regulation of phosphorylation 22.7273 7 yes
GO:0051130 positive regulation of cellular component organization 22.7273 5 yes
GO:0051174 regulation of phosphorus metabolic process 22.7273 5 yes
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 yes
GO:0051240 positive regulation of multicellular organismal process 22.7273 4 no
GO:0009891 positive regulation of biosynthetic process 22.7273 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.7273 5 no
GO:0006886 intracellular protein transport 22.7273 4 no
GO:0031344 regulation of cell projection organization 21.2121 5 yes
GO:0043408 regulation of MAPK cascade 21.2121 6 yes
GO:0045597 positive regulation of cell differentiation 21.2121 5 yes
GO:0050804 modulation of chemical synaptic transmission 21.2121 5 yes
GO:0051046 regulation of secretion 21.2121 5 yes
GO:0060341 regulation of cellular localization 21.2121 4 yes
GO:0099177 regulation of trans-synaptic signaling 21.2121 4 yes
GO:1902533 positive regulation of intracellular signal transduction 21.2121 6 yes
GO:1903530 regulation of secretion by cell 21.2121 4 yes
GO:2000026 regulation of multicellular organismal development 21.2121 4 no
GO:2000145 regulation of cell motility 21.2121 4 no
GO:0033043 regulation of organelle organization 21.2121 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.2121 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.2121 6 no
GO:0051129 negative regulation of cellular component organization 21.2121 5 no
GO:0051252 regulation of RNA metabolic process 21.2121 5 no
GO:0010243 response to organonitrogen compound 19.6970 4 yes
GO:0032880 regulation of protein localization 19.6970 5 yes
GO:0071310 cellular response to organic substance 19.6970 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.6970 6 yes
GO:0031401 positive regulation of protein modification process 18.1818 7 yes
GO:0043085 positive regulation of catalytic activity 18.1818 4 yes
GO:0046903 secretion 18.1818 4 yes
GO:1901701 cellular response to oxygen-containing compound 18.1818 4 yes
GO:0007264 small GTPase-mediated signal transduction 16.6667 5 yes
GO:0051338 regulation of transferase activity 16.6667 4 yes
GO:0001934 positive regulation of protein phosphorylation 15.1515 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 15.1515 6 yes
GO:0017157 regulation of exocytosis 15.1515 5 yes
GO:0031346 positive regulation of cell projection organization 15.1515 6 yes
GO:0042327 positive regulation of phosphorylation 15.1515 8 yes
GO:0043549 regulation of kinase activity 15.1515 5 yes
GO:0045937 positive regulation of phosphate metabolic process 15.1515 7 yes
GO:0051336 regulation of hydrolase activity 15.1515 4 yes
GO:0072657 protein localization to membrane 15.1515 4 yes
GO:0014070 response to organic cyclic compound 13.6364 4 yes
GO:0045859 regulation of protein kinase activity 13.6364 6 yes
GO:0071417 cellular response to organonitrogen compound 13.6364 4 yes
GO:1901699 cellular response to nitrogen compound 13.6364 4 yes
GO:0043410 positive regulation of MAPK cascade 12.1212 7 yes
GO:0051345 positive regulation of hydrolase activity 12.1212 5 yes
GO:0023061 signal release 10.6061 4 yes
GO:0071363 cellular response to growth factor stimulus 10.6061 4 yes
GO:0072659 protein localization to plasma membrane 10.6061 5 yes
GO:1990778 protein localization to cell periphery 10.6061 5 yes
GO:0010975 regulation of neuron projection development 9.0909 7 yes
GO:0051051 negative regulation of transport 9.0909 4 yes
GO:0051347 positive regulation of transferase activity 9.0909 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 9.0909 7 yes
GO:0071407 cellular response to organic cyclic compound 9.0909 5 yes
GO:0010976 positive regulation of neuron projection development 7.5758 7 yes
GO:0014074 response to purine-containing compound 7.5758 5 yes
GO:0033674 positive regulation of kinase activity 7.5758 6 yes
GO:0045055 regulated exocytosis 7.5758 4 yes
GO:0045860 positive regulation of protein kinase activity 7.5758 7 yes
GO:0046683 response to organophosphorus 7.5758 4 yes
GO:0046928 regulation of neurotransmitter secretion 7.5758 5 yes
GO:0051048 negative regulation of secretion 7.5758 5 yes
GO:0051588 regulation of neurotransmitter transport 7.5758 5 yes
GO:1903531 negative regulation of secretion by cell 7.5758 5 yes
GO:1990089 response to nerve growth factor 7.5758 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 7.5758 5 yes
GO:0002064 epithelial cell development 6.0606 4 yes
GO:0043087 regulation of GTPase activity 6.0606 5 yes
GO:0043547 positive regulation of GTPase activity 6.0606 6 yes
GO:0045920 negative regulation of exocytosis 6.0606 6 yes
GO:0051591 response to cAMP 6.0606 4 yes
GO:1901888 regulation of cell junction assembly 6.0606 5 yes
GO:1903305 regulation of regulated secretory pathway 6.0606 6 yes
GO:0001885 endothelial cell development 4.5455 5 yes
GO:0016079 synaptic vesicle exocytosis 4.5455 4 yes
GO:0038179 neurotrophin signaling pathway 4.5455 4 yes
GO:0061028 establishment of endothelial barrier 4.5455 6 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 4.5455 8 yes
GO:0099643 signal release from synapse 4.5455 5 yes
GO:1905475 regulation of protein localization to membrane 4.5455 6 yes
GO:2000300 regulation of synaptic vesicle exocytosis 4.5455 6 yes
GO:0007399 nervous system development 3.0303 4 yes
GO:0032486 Rap protein signal transduction 3.0303 6 yes
GO:0038180 nerve growth factor signaling pathway 3.0303 5 yes
GO:0071320 cellular response to cAMP 3.0303 5 yes
GO:1902683 regulation of receptor localization to synapse 3.0303 4 yes
GO:1903306 negative regulation of regulated secretory pathway 3.0303 7 yes
GO:1904375 regulation of protein localization to cell periphery 3.0303 6 yes
GO:2000301 negative regulation of synaptic vesicle exocytosis 3.0303 7 yes
GO:2001212 regulation of vasculogenesis 3.0303 5 yes
GO:2001214 positive regulation of vasculogenesis 3.0303 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNDS_HUMAN [view interactions] Low throughput no yes
RASF5_HUMAN [view interactions] Low throughput no yes
GDS1_HUMAN [view entry] [view interactions] Low throughput yes yes
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
PRAF1_HUMAN [view interactions] Low throughput no yes
RPGF2_HUMAN [view entry] [view interactions] Low throughput yes no
KRIT1_HUMAN [view interactions] Low throughput no no
PDE6D_HUMAN [view interactions] Low throughput no yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
RPGF1_HUMAN [view interactions] Low throughput no yes
TNR6_HUMAN [view interactions] Low throughput no no
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
RHEB_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK1_HUMAN [view interactions] Low throughput no yes
RADIL_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKI_HUMAN [view entry] [view interactions] Low throughput yes no
SIR1_HUMAN [view interactions] Low throughput no yes
RGDSR_HUMAN [view interactions] Low throughput no no
RUN3A_HUMAN [view interactions] Low throughput no yes
RGS14_HUMAN [view entry] [view interactions] Low throughput yes yes
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
BMX_HUMAN [view interactions] Low throughput no no
SMCA2_HUMAN [view interactions] Low throughput no yes
TR10C_HUMAN [view interactions] Low throughput no no
ELOA1_HUMAN [view interactions] Low throughput no yes
FADD_HUMAN [view interactions] Low throughput no yes
FAF1_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
RGL2_HUMAN [view interactions] Low throughput no yes
GBRL2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG1_HUMAN [view interactions] Low throughput no no
RPGF3_HUMAN [view interactions] Low throughput no yes
RPGF4_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF5_HUMAN [view interactions] Low throughput no yes
RPGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF6_HUMAN [view interactions] Low throughput no yes
AB1IP_HUMAN [view interactions] Low throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
RM34_HUMAN [view interactions] High throughput no yes
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
CPLX2_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD4_HUMAN [view interactions] High throughput no yes
CAV2_HUMAN [view interactions] High throughput no no
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRDL_HUMAN [view interactions] High throughput no yes
TRM7_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
AAKB1_HUMAN [view interactions] High throughput no yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
CD177_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
GANAB_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
GRP4_HUMAN [view interactions] High throughput no no
IMP2L_HUMAN [view interactions] High throughput no yes
PARL_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
FOXP3_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
UNK_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
DUS9_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
REQU_HUMAN [view interactions] High throughput no yes
GLP1R_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
EMC5_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
RGL1_HUMAN [view interactions] High throughput no yes
DPOE3_HUMAN [view interactions] High throughput no yes
O2T10_HUMAN [view interactions] High throughput no no
PIGO_HUMAN [view interactions] High throughput no no
TMM31_HUMAN [view interactions] High throughput no no
INSC_HUMAN [view interactions] High throughput no yes
NK3R_HUMAN [view interactions] High throughput no no
HYPM_HUMAN [view interactions] High throughput no no
BORC8_HUMAN [view interactions] High throughput no yes
CC85A_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
IFT22_HUMAN [view interactions] High throughput no yes
CD53_HUMAN [view interactions] High throughput no yes
AGRF3_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
SAAL1_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
PCDA8_HUMAN [view interactions] High throughput no no
CACL1_HUMAN [view interactions] High throughput no no
GPC3_HUMAN [view interactions] High throughput no no
MSS4_HUMAN [view interactions] High throughput no yes
WASC3_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
PP4R2_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
NKG2F_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
PON2_HUMAN [view interactions] High throughput no yes
FEN1_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
CD11B_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
ECHM_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PPCT_HUMAN [view interactions] High throughput no yes
SYVN1_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
CACO2_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB4_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes