Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BRAF_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed, PubMed). Phosphorylates PFKFB2 (PubMed). May play a role in the postsynaptic responses of hippocampal neurons (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
466 Gly Val Lungcancer(LNCR) -
597 Leu Arg Lungcancer(LNCR) -
462 Arg Ile Colorectalcancer(CRC) -
463 Ile Ser Colorectalcancer(CRC) -
464 Gly Glu Colorectalcancer(CRC) -
469 Gly Ala Familialnon-Hodgkinlymphoma(NHL) -
469 Gly Glu Cardiofaciocutaneoussyndrome1(CFC1) -
469 Gly Arg Familialnon-Hodgkinlymphoma(NHL) -
594 Asp Gly Familialnon-Hodgkinlymphoma(NHL) -
595 Phe Leu Cardiofaciocutaneoussyndrome1(CFC1) -
597 Leu Val Noonansyndrome7(NS7) -
600 Val Glu Colorectalcancer(CRC) -
601 Lys Glu Colorectalcancer(CRC) -
246 Ala Pro Cardiofaciocutaneoussyndrome1(CFC1) -
257 Gln Arg Cardiofaciocutaneoussyndrome1(CFC1) -
485 Leu Phe Cardiofaciocutaneoussyndrome1(CFC1) -
499 Lys Glu Cardiofaciocutaneoussyndrome1(CFC1) -
501 Glu Gly Cardiofaciocutaneoussyndrome1(CFC1) -
501 Glu Lys Cardiofaciocutaneoussyndrome1(CFC1) -
581 Asn Asp Cardiofaciocutaneoussyndrome1(CFC1) -
467 Ser Ala Cardiofaciocutaneoussyndrome1(CFC1) -
468 Phe Ser Cardiofaciocutaneoussyndrome1(CFC1) -
596 Gly Val Cardiofaciocutaneoussyndrome1(CFC1) -
241 Thr Met Noonansyndrome7(NS7) -
241 Thr Pro Cardiofaciocutaneoussyndrome1(CFC1) -
241 Thr Pro LEOPARDsyndrome3(LPRD3) -
241 Thr Arg Noonansyndrome7(NS7) -
245 Leu Phe Cardiofaciocutaneoussyndrome1(CFC1) -
275 Glu Lys Cardiofaciocutaneoussyndrome1(CFC1) -
499 Lys Asn Cardiofaciocutaneoussyndrome1(CFC1) -
525 Leu Pro Cardiofaciocutaneoussyndrome1(CFC1) -
531 Trp Cys Noonansyndrome7(NS7) -
599 Thr Arg Cardiofaciocutaneoussyndrome1(CFC1) -
601 Lys Gln Cardiofaciocutaneoussyndrome1(CFC1) -
638 Asp Glu Cardiofaciocutaneoussyndrome1(CFC1) -
709 Gln Arg Cardiofaciocutaneoussyndrome1(CFC1) -
244 Thr Pro Cardiofaciocutaneoussyndrome1(CFC1) -
262 Gln Lys Cardiofaciocutaneoussyndrome1(CFC1) -
580 Asn Asp Cardiofaciocutaneoussyndrome1(CFC1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BRAF_HUMAN
GO:0043168 anion binding 46.2963 4 yes
GO:0000166 nucleotide binding 45.3704 4 yes
GO:0017076 purine nucleotide binding 45.3704 5 yes
GO:0032555 purine ribonucleotide binding 44.4444 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 yes
GO:0030554 adenyl nucleotide binding 35.1852 6 yes
GO:0005524 ATP binding 34.2593 5 yes
GO:0032559 adenyl ribonucleotide binding 34.2593 5 yes
GO:0003723 RNA binding 27.7778 4 no
GO:0043169 cation binding 25.9259 4 yes
GO:0046872 metal ion binding 25.9259 5 yes
GO:0019900 kinase binding 23.1481 4 yes
GO:0019901 protein kinase binding 23.1481 5 yes
GO:0016462 pyrophosphatase activity 23.1481 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.1481 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.1481 6 no
GO:0016301 kinase activity 18.5185 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 18.5185 4 yes
GO:0004674 protein serine/threonine kinase activity 16.6667 4 yes
GO:0106310 protein serine kinase activity 14.8148 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 7.4074 4 yes
GO:0005509 calcium ion binding 6.4815 6 yes
GO:0004708 MAP kinase kinase activity 5.5556 5 yes
GO:0004709 MAP kinase kinase kinase activity 2.7778 5 yes
GO:0031434 mitogen-activated protein kinase kinase binding 1.8519 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BRAF_HUMAN
GO:0031323 regulation of cellular metabolic process 62.9630 4 yes
GO:0048522 positive regulation of cellular process 62.9630 4 yes
GO:0080090 regulation of primary metabolic process 61.1111 4 yes
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 yes
GO:0048523 negative regulation of cellular process 59.2593 4 yes
GO:0010646 regulation of cell communication 53.7037 4 yes
GO:0009966 regulation of signal transduction 50.9259 4 yes
GO:0009889 regulation of biosynthetic process 47.2222 4 yes
GO:0031326 regulation of cellular biosynthetic process 47.2222 5 yes
GO:0051246 regulation of protein metabolic process 47.2222 5 yes
GO:0009893 positive regulation of metabolic process 46.2963 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 46.2963 5 yes
GO:1902531 regulation of intracellular signal transduction 45.3704 5 yes
GO:0051128 regulation of cellular component organization 45.3704 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 43.5185 5 yes
GO:0010468 regulation of gene expression 42.5926 6 yes
GO:0031325 positive regulation of cellular metabolic process 40.7407 5 yes
GO:0048584 positive regulation of response to stimulus 40.7407 4 yes
GO:0042981 regulation of apoptotic process 39.8148 5 yes
GO:0043067 regulation of programmed cell death 39.8148 4 yes
GO:0008104 protein localization 37.9630 4 yes
GO:0023056 positive regulation of signaling 37.9630 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.0370 5 no
GO:0006996 organelle organization 37.0370 4 yes
GO:0010647 positive regulation of cell communication 37.0370 5 yes
GO:0031399 regulation of protein modification process 37.0370 6 yes
GO:0009967 positive regulation of signal transduction 35.1852 5 yes
GO:0019220 regulation of phosphate metabolic process 34.2593 6 yes
GO:0051174 regulation of phosphorus metabolic process 34.2593 5 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 yes
GO:0051247 positive regulation of protein metabolic process 33.3333 6 yes
GO:0009891 positive regulation of biosynthetic process 32.4074 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 32.4074 6 yes
GO:0043412 macromolecule modification 32.4074 4 yes
GO:0051049 regulation of transport 32.4074 4 yes
GO:0036211 protein modification process 31.4815 4 yes
GO:0043066 negative regulation of apoptotic process 31.4815 6 yes
GO:0043069 negative regulation of programmed cell death 31.4815 5 yes
GO:0080134 regulation of response to stress 30.5556 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 30.5556 5 no
GO:0051252 regulation of RNA metabolic process 30.5556 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.5556 6 yes
GO:0031324 negative regulation of cellular metabolic process 29.6296 5 no
GO:0042325 regulation of phosphorylation 29.6296 7 yes
GO:0006355 regulation of DNA-templated transcription 28.7037 7 no
GO:2001141 regulation of RNA biosynthetic process 28.7037 6 no
GO:0060341 regulation of cellular localization 28.7037 4 no
GO:0001932 regulation of protein phosphorylation 28.7037 7 yes
GO:0022607 cellular component assembly 28.7037 4 yes
GO:1902533 positive regulation of intracellular signal transduction 27.7778 6 yes
GO:0071310 cellular response to organic substance 27.7778 4 no
GO:0048585 negative regulation of response to stimulus 26.8519 4 no
GO:0009894 regulation of catabolic process 26.8519 4 no
GO:0033043 regulation of organelle organization 26.8519 5 yes
GO:0044087 regulation of cellular component biogenesis 26.8519 4 yes
GO:0045595 regulation of cell differentiation 26.8519 4 yes
GO:0051130 positive regulation of cellular component organization 26.8519 5 yes
GO:0009968 negative regulation of signal transduction 25.9259 5 no
GO:0010648 negative regulation of cell communication 25.9259 5 no
GO:0023057 negative regulation of signaling 25.9259 4 no
GO:0071702 organic substance transport 25.9259 4 no
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 yes
GO:0141124 intracellular signaling cassette 25.0000 4 yes
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0031401 positive regulation of protein modification process 25.0000 7 yes
GO:0043408 regulation of MAPK cascade 25.0000 6 yes
GO:0071705 nitrogen compound transport 24.0741 4 no
GO:0032101 regulation of response to external stimulus 24.0741 4 yes
GO:0051094 positive regulation of developmental process 24.0741 4 yes
GO:0043085 positive regulation of catalytic activity 23.1481 4 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0015031 protein transport 21.2963 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.2963 5 no
GO:0051248 negative regulation of protein metabolic process 20.3704 6 no
GO:0045859 regulation of protein kinase activity 20.3704 6 no
GO:0002684 positive regulation of immune system process 20.3704 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 20.3704 6 yes
GO:0014070 response to organic cyclic compound 20.3704 4 yes
GO:0042327 positive regulation of phosphorylation 20.3704 8 yes
GO:0045937 positive regulation of phosphate metabolic process 20.3704 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.4444 6 yes
GO:2000026 regulation of multicellular organismal development 19.4444 4 yes
GO:2000145 regulation of cell motility 19.4444 4 yes
GO:0001934 positive regulation of protein phosphorylation 19.4444 8 yes
GO:0010628 positive regulation of gene expression 19.4444 7 yes
GO:0031344 regulation of cell projection organization 19.4444 5 yes
GO:0050776 regulation of immune response 19.4444 4 yes
GO:0006915 apoptotic process 18.5185 4 yes
GO:0016310 phosphorylation 18.5185 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 17.5926 4 yes
GO:0030334 regulation of cell migration 17.5926 5 yes
GO:0043410 positive regulation of MAPK cascade 17.5926 7 yes
GO:0045597 positive regulation of cell differentiation 17.5926 5 yes
GO:0060284 regulation of cell development 17.5926 5 yes
GO:0010243 response to organonitrogen compound 16.6667 4 yes
GO:0010638 positive regulation of organelle organization 16.6667 6 yes
GO:0080135 regulation of cellular response to stress 15.7407 4 yes
GO:0006468 protein phosphorylation 15.7407 5 yes
GO:0032103 positive regulation of response to external stimulus 15.7407 5 yes
GO:0050778 positive regulation of immune response 15.7407 5 yes
GO:0051050 positive regulation of transport 15.7407 4 yes
GO:0007010 cytoskeleton organization 14.8148 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 14.8148 4 yes
GO:0044089 positive regulation of cellular component biogenesis 14.8148 5 yes
GO:0051493 regulation of cytoskeleton organization 14.8148 6 yes
GO:0060627 regulation of vesicle-mediated transport 14.8148 4 yes
GO:0099177 regulation of trans-synaptic signaling 13.8889 4 yes
GO:0000165 MAPK cascade 13.8889 5 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 13.8889 5 yes
GO:0010975 regulation of neuron projection development 13.8889 7 yes
GO:0050804 modulation of chemical synaptic transmission 13.8889 5 yes
GO:0097435 supramolecular fiber organization 12.9630 4 yes
GO:0010038 response to metal ion 12.9630 4 yes
GO:0030155 regulation of cell adhesion 12.9630 4 yes
GO:0051051 negative regulation of transport 12.9630 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 12.9630 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 12.0370 8 yes
GO:0071363 cellular response to growth factor stimulus 11.1111 4 yes
GO:1902903 regulation of supramolecular fiber organization 11.1111 5 yes
GO:0031346 positive regulation of cell projection organization 11.1111 6 yes
GO:0032970 regulation of actin filament-based process 11.1111 4 yes
GO:1903530 regulation of secretion by cell 10.1852 4 yes
GO:0034762 regulation of transmembrane transport 10.1852 4 yes
GO:0038127 ERBB signaling pathway 10.1852 6 yes
GO:0043523 regulation of neuron apoptotic process 10.1852 6 yes
GO:0045785 positive regulation of cell adhesion 10.1852 5 yes
GO:0048732 gland development 10.1852 4 yes
GO:0051046 regulation of secretion 10.1852 5 yes
GO:1903034 regulation of response to wounding 9.2593 5 yes
GO:1903706 regulation of hemopoiesis 9.2593 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 9.2593 4 yes
GO:0010720 positive regulation of cell development 9.2593 6 yes
GO:0032956 regulation of actin cytoskeleton organization 9.2593 5 yes
GO:0051960 regulation of nervous system development 9.2593 5 yes
GO:0071241 cellular response to inorganic substance 8.3333 4 yes
GO:0071248 cellular response to metal ion 8.3333 5 yes
GO:0072657 protein localization to membrane 8.3333 4 yes
GO:0110053 regulation of actin filament organization 8.3333 6 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 8.3333 4 yes
GO:0009416 response to light stimulus 8.3333 4 yes
GO:0043434 response to peptide hormone 8.3333 4 yes
GO:0050767 regulation of neurogenesis 8.3333 6 yes
GO:0050865 regulation of cell activation 8.3333 4 yes
GO:0002694 regulation of leukocyte activation 7.4074 4 yes
GO:0017157 regulation of exocytosis 7.4074 5 yes
GO:0046903 secretion 7.4074 4 yes
GO:0048534 hematopoietic or lymphoid organ development 7.4074 4 yes
GO:0048538 thymus development 7.4074 5 yes
GO:0050863 regulation of T cell activation 7.4074 6 yes
GO:0050890 cognition 7.4074 4 yes
GO:0051249 regulation of lymphocyte activation 7.4074 5 yes
GO:1902105 regulation of leukocyte differentiation 6.4815 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 6.4815 6 yes
GO:0007015 actin filament organization 6.4815 5 yes
GO:0010810 regulation of cell-substrate adhesion 6.4815 5 yes
GO:0030878 thyroid gland development 6.4815 5 yes
GO:0043524 negative regulation of neuron apoptotic process 6.4815 7 yes
GO:0050770 regulation of axonogenesis 6.4815 5 yes
GO:0051495 positive regulation of cytoskeleton organization 6.4815 7 yes
GO:0090150 establishment of protein localization to membrane 5.5556 4 yes
GO:1903036 positive regulation of response to wounding 5.5556 5 yes
GO:1903305 regulation of regulated secretory pathway 5.5556 6 yes
GO:1903531 negative regulation of secretion by cell 5.5556 5 yes
GO:2000146 negative regulation of cell motility 5.5556 5 yes
GO:0007173 epidermal growth factor receptor signaling pathway 5.5556 7 yes
GO:0023061 signal release 5.5556 4 yes
GO:0030336 negative regulation of cell migration 5.5556 6 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 5.5556 8 yes
GO:0040013 negative regulation of locomotion 5.5556 4 yes
GO:0045920 negative regulation of exocytosis 5.5556 6 yes
GO:0046928 regulation of neurotransmitter secretion 5.5556 5 yes
GO:0050769 positive regulation of neurogenesis 5.5556 6 yes
GO:0051048 negative regulation of secretion 5.5556 5 yes
GO:0051588 regulation of neurotransmitter transport 5.5556 5 yes
GO:0051962 positive regulation of nervous system development 5.5556 5 yes
GO:0070371 ERK1 and ERK2 cascade 5.5556 6 yes
GO:0070570 regulation of neuron projection regeneration 4.6296 4 yes
GO:1903306 negative regulation of regulated secretory pathway 4.6296 7 yes
GO:1990089 response to nerve growth factor 4.6296 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 4.6296 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 4.6296 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 4.6296 6 yes
GO:0010976 positive regulation of neuron projection development 4.6296 7 yes
GO:0014074 response to purine-containing compound 4.6296 5 yes
GO:0032231 regulation of actin filament bundle assembly 4.6296 5 yes
GO:0045580 regulation of T cell differentiation 4.6296 7 yes
GO:0045619 regulation of lymphocyte differentiation 4.6296 6 yes
GO:0046683 response to organophosphorus 4.6296 4 yes
GO:0048679 regulation of axon regeneration 4.6296 5 yes
GO:0050772 positive regulation of axonogenesis 4.6296 6 yes
GO:0050806 positive regulation of synaptic transmission 4.6296 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 4.6296 5 yes
GO:0050852 T cell receptor signaling pathway 4.6296 6 yes
GO:0051017 actin filament bundle assembly 4.6296 5 yes
GO:0061572 actin filament bundle organization 4.6296 6 yes
GO:0110020 regulation of actomyosin structure organization 3.7037 6 yes
GO:1903131 mononuclear cell differentiation 3.7037 5 yes
GO:2000301 negative regulation of synaptic vesicle exocytosis 3.7037 7 yes
GO:0002521 leukocyte differentiation 3.7037 4 yes
GO:0007612 learning 3.7037 4 yes
GO:0010762 regulation of fibroblast migration 3.7037 6 yes
GO:0030038 contractile actin filament bundle assembly 3.7037 6 yes
GO:0031032 actomyosin structure organization 3.7037 4 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 3.7037 9 yes
GO:0034446 substrate adhesion-dependent cell spreading 3.7037 4 yes
GO:0034764 positive regulation of transmembrane transport 3.7037 5 yes
GO:0043149 stress fiber assembly 3.7037 5 yes
GO:0045055 regulated exocytosis 3.7037 4 yes
GO:0051492 regulation of stress fiber assembly 3.7037 6 yes
GO:0051591 response to cAMP 3.7037 4 yes
GO:0051592 response to calcium ion 3.7037 5 yes
GO:0070572 positive regulation of neuron projection regeneration 2.7778 5 yes
GO:0071277 cellular response to calcium ion 2.7778 6 yes
GO:0099643 signal release from synapse 2.7778 5 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 2.7778 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 2.7778 7 yes
GO:1904035 regulation of epithelial cell apoptotic process 2.7778 6 yes
GO:1904036 negative regulation of epithelial cell apoptotic process 2.7778 7 yes
GO:0002360 T cell lineage commitment 2.7778 4 yes
GO:0008306 associative learning 2.7778 5 yes
GO:0008542 visual learning 2.7778 4 yes
GO:0010827 regulation of glucose transmembrane transport 2.7778 5 yes
GO:0010828 positive regulation of glucose transmembrane transport 2.7778 6 yes
GO:0016079 synaptic vesicle exocytosis 2.7778 4 yes
GO:0032233 positive regulation of actin filament bundle assembly 2.7778 6 yes
GO:0042110 T cell activation 2.7778 4 yes
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 2.7778 5 yes
GO:0048680 positive regulation of axon regeneration 2.7778 6 yes
GO:0051496 positive regulation of stress fiber assembly 2.7778 7 yes
GO:0060291 long-term synaptic potentiation 2.7778 4 yes
GO:0070413 trehalose metabolism in response to stress 1.8519 7 yes
GO:0071466 cellular response to xenobiotic stimulus 1.8519 4 yes
GO:0072577 endothelial cell apoptotic process 1.8519 6 yes
GO:1904019 epithelial cell apoptotic process 1.8519 5 yes
GO:2000351 regulation of endothelial cell apoptotic process 1.8519 7 yes
GO:2000352 negative regulation of endothelial cell apoptotic process 1.8519 8 yes
GO:0002244 hematopoietic progenitor cell differentiation 1.8519 4 yes
GO:0002318 myeloid progenitor cell differentiation 1.8519 5 yes
GO:0005984 disaccharide metabolic process 1.8519 5 yes
GO:0005991 trehalose metabolic process 1.8519 6 yes
GO:0009311 oligosaccharide metabolic process 1.8519 4 yes
GO:0010764 negative regulation of fibroblast migration 1.8519 7 yes
GO:0030098 lymphocyte differentiation 1.8519 4 yes
GO:0030217 T cell differentiation 1.8519 5 yes
GO:0033077 T cell differentiation in thymus 1.8519 6 yes
GO:0035710 CD4-positive, alpha-beta T cell activation 1.8519 6 yes
GO:0043367 CD4-positive, alpha-beta T cell differentiation 1.8519 7 yes
GO:0046631 alpha-beta T cell activation 1.8519 5 yes
GO:0046632 alpha-beta T cell differentiation 1.8519 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSME3_HUMAN [view interactions] Low throughput no yes
STK3_HUMAN [view interactions] Low throughput no yes
VIGLN_HUMAN [view entry] [view interactions] Low throughput yes yes
SPOP_HUMAN [view interactions] Low throughput no no
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
BAD_HUMAN [view entry] [view interactions] Low throughput yes yes
PPP5_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
MP2K2_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS12_HUMAN [view entry] [view interactions] Low throughput yes no
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
ARAF_HUMAN [view interactions] Low throughput no yes
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
RASN_HUMAN [view entry] [view interactions] Low throughput yes no
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
CDC37_HUMAN [view interactions] Low throughput no yes
HS90B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6A2_HUMAN [view interactions] Low throughput no yes
M3K1_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B2_HUMAN [view interactions] Low throughput no yes
TYK2_HUMAN [view interactions] Low throughput no no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
RASM_HUMAN [view entry] [view interactions] Low throughput yes yes
RN149_HUMAN [view interactions] Low throughput no no
FBXW7_HUMAN [view interactions] Low throughput no yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
SPY2_HUMAN [view interactions] Low throughput no yes
TRAF2_HUMAN [view interactions] Low throughput no yes
NANOG_HUMAN [view interactions] Low throughput no no
ITCH_HUMAN [view interactions] Low throughput no yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
2ABA_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
CRBN_HUMAN [view interactions] Low throughput no yes
JTB_HUMAN [view interactions] High throughput no yes
S100P_HUMAN [view interactions] High throughput no no
UBP28_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
NOMO2_HUMAN [view interactions] High throughput no yes
NOMO3_HUMAN [view interactions] High throughput no yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
MUS81_HUMAN [view interactions] High throughput no no
FGFR2_HUMAN [view interactions] High throughput no yes
BRCA2_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
FNTA_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
LATS2_HUMAN [view interactions] High throughput no yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K6_HUMAN [view interactions] High throughput no yes
RASF1_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
TERT_HUMAN [view interactions] High throughput no no
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
MS18B_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
KSR2_HUMAN [view interactions] High throughput no yes
VPS4B_HUMAN [view interactions] High throughput no yes
FKBPL_HUMAN [view interactions] High throughput no yes
LIPF_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
DELE1_HUMAN [view interactions] High throughput no yes
RB3GP_HUMAN [view entry] [view interactions] High throughput yes yes
RPTOR_HUMAN [view interactions] High throughput no yes
ARMX3_HUMAN [view interactions] High throughput no no
SDF2L_HUMAN [view interactions] High throughput no yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN4_HUMAN [view entry] [view interactions] High throughput yes no
TMM33_HUMAN [view entry] [view interactions] High throughput yes yes
CATB_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3B_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
H90B3_HUMAN [view interactions] High throughput no no
DJB11_HUMAN [view interactions] High throughput no yes
FACR1_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
PRS6B_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
PDIA1_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
HEMO_HUMAN [view interactions] High throughput no no
TXD12_HUMAN [view interactions] High throughput no no
JAZF1_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
CATL2_HUMAN [view interactions] High throughput no yes
MAPK3_HUMAN [view interactions] High throughput no no
DHB3_HUMAN [view interactions] High throughput no no
ZN510_HUMAN [view interactions] High throughput no yes
ZN189_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
TERF1_HUMAN [view interactions] High throughput no no
GRDN_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KPBB_HUMAN [view interactions] High throughput no no
LIMK1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB38_HUMAN [view interactions] High throughput no no
BRAP_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
FNIP1_HUMAN [view interactions] High throughput no yes
FNIP2_HUMAN [view interactions] High throughput no yes
KCNC4_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
RRP5_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
VANG1_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
FKBP5_HUMAN [view interactions] High throughput no yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
DJC13_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AB_HUMAN [view interactions] High throughput no yes
DHI2_HUMAN [view interactions] High throughput no no
PLD2_HUMAN [view interactions] High throughput no yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
CPNE3_HUMAN [view interactions] High throughput no yes
MYOF_HUMAN [view interactions] High throughput no yes
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
UBCP1_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAD50_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP8_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
WDR26_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
IF5_HUMAN [view interactions] High throughput no yes
GRAM4_HUMAN [view interactions] High throughput no no
ECM29_HUMAN [view interactions] High throughput no no
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
DJB12_HUMAN [view interactions] High throughput no yes
PP1RA_HUMAN [view interactions] High throughput no yes
FMNL3_HUMAN [view entry] [view interactions] High throughput yes yes
MSHR_HUMAN [view interactions] High throughput no no
SGPL1_HUMAN [view interactions] High throughput no yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
PPP6_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SYEP_HUMAN [view interactions] High throughput no yes
REST_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
SMUF2_HUMAN [view interactions] High throughput no yes
WWP1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no