Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SPTN4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SPTN4_HUMAN
GO:0043169 cation binding 36.3636 4 no
GO:0046872 metal ion binding 36.3636 5 no
GO:0019900 kinase binding 31.8182 4 no
GO:0019901 protein kinase binding 31.8182 5 no
GO:0043168 anion binding 27.2727 4 no
GO:0003779 actin binding 22.7273 4 yes
GO:0000166 nucleotide binding 22.7273 4 no
GO:0005524 ATP binding 22.7273 5 no
GO:0016301 kinase activity 22.7273 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.7273 4 no
GO:0017076 purine nucleotide binding 22.7273 5 no
GO:0030554 adenyl nucleotide binding 22.7273 6 no
GO:0032555 purine ribonucleotide binding 22.7273 4 no
GO:0032559 adenyl ribonucleotide binding 22.7273 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.7273 4 no
GO:0019902 phosphatase binding 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SPTN4_HUMAN
GO:0048522 positive regulation of cellular process 77.2727 4 no
GO:0051128 regulation of cellular component organization 68.1818 4 yes
GO:0010646 regulation of cell communication 63.6364 4 no
GO:0008104 protein localization 59.0909 4 yes
GO:0022607 cellular component assembly 59.0909 4 yes
GO:0051049 regulation of transport 54.5455 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0006996 organelle organization 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 45.4545 4 yes
GO:0051240 positive regulation of multicellular organismal process 45.4545 4 yes
GO:0051050 positive regulation of transport 45.4545 4 no
GO:0030030 cell projection organization 45.4545 4 yes
GO:0051094 positive regulation of developmental process 40.9091 4 yes
GO:0072657 protein localization to membrane 40.9091 4 yes
GO:0080090 regulation of primary metabolic process 40.9091 4 yes
GO:0031344 regulation of cell projection organization 40.9091 5 no
GO:0051130 positive regulation of cellular component organization 40.9091 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.9091 6 no
GO:0009966 regulation of signal transduction 40.9091 4 no
GO:0050804 modulation of chemical synaptic transmission 40.9091 5 no
GO:0099177 regulation of trans-synaptic signaling 40.9091 4 no
GO:0033043 regulation of organelle organization 40.9091 5 yes
GO:0043933 protein-containing complex organization 36.3636 4 yes
GO:0051246 regulation of protein metabolic process 36.3636 5 yes
GO:0051493 regulation of cytoskeleton organization 36.3636 6 yes
GO:0010975 regulation of neuron projection development 36.3636 7 no
GO:0034762 regulation of transmembrane transport 36.3636 4 no
GO:0045595 regulation of cell differentiation 36.3636 4 no
GO:0120036 plasma membrane bounded cell projection organization 36.3636 5 no
GO:0009889 regulation of biosynthetic process 36.3636 4 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0010468 regulation of gene expression 36.3636 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0022603 regulation of anatomical structure morphogenesis 36.3636 4 no
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:2000026 regulation of multicellular organismal development 36.3636 4 no
GO:0043269 regulation of monoatomic ion transport 31.8182 5 yes
GO:0044057 regulation of system process 31.8182 4 yes
GO:0065003 protein-containing complex assembly 31.8182 5 yes
GO:0022898 regulation of transmembrane transporter activity 31.8182 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 31.8182 5 no
GO:0045597 positive regulation of cell differentiation 31.8182 5 no
GO:0031325 positive regulation of cellular metabolic process 31.8182 5 no
GO:0060284 regulation of cell development 31.8182 5 no
GO:0023056 positive regulation of signaling 31.8182 4 no
GO:0051960 regulation of nervous system development 31.8182 5 no
GO:0007010 cytoskeleton organization 31.8182 5 yes
GO:0031399 regulation of protein modification process 31.8182 6 yes
GO:0034330 cell junction organization 31.8182 4 yes
GO:0050808 synapse organization 27.2727 5 yes
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 yes
GO:0061024 membrane organization 27.2727 4 yes
GO:0031346 positive regulation of cell projection organization 27.2727 6 no
GO:0034764 positive regulation of transmembrane transport 27.2727 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 27.2727 5 no
GO:0043270 positive regulation of monoatomic ion transport 27.2727 5 no
GO:0141124 intracellular signaling cassette 27.2727 4 no
GO:0009891 positive regulation of biosynthetic process 27.2727 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.2727 6 no
GO:0010628 positive regulation of gene expression 27.2727 7 no
GO:0031175 neuron projection development 27.2727 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.2727 6 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0070201 regulation of establishment of protein localization 27.2727 6 no
GO:1903829 positive regulation of protein localization 27.2727 5 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0050807 regulation of synapse organization 27.2727 5 no
GO:0051962 positive regulation of nervous system development 27.2727 5 no
GO:0010038 response to metal ion 27.2727 4 no
GO:0010959 regulation of metal ion transport 27.2727 6 yes
GO:0019220 regulation of phosphate metabolic process 27.2727 6 yes
GO:0032970 regulation of actin filament-based process 27.2727 4 yes
GO:0042325 regulation of phosphorylation 22.7273 7 yes
GO:0043254 regulation of protein-containing complex assembly 22.7273 5 yes
GO:0045927 positive regulation of growth 22.7273 4 yes
GO:0048638 regulation of developmental growth 22.7273 4 yes
GO:0051129 negative regulation of cellular component organization 22.7273 5 yes
GO:1902903 regulation of supramolecular fiber organization 22.7273 5 yes
GO:1990778 protein localization to cell periphery 22.7273 5 yes
GO:0032411 positive regulation of transporter activity 22.7273 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 22.7273 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 22.7273 6 no
GO:0070925 organelle assembly 22.7273 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 22.7273 6 no
GO:0001558 regulation of cell growth 22.7273 4 no
GO:0006796 phosphate-containing compound metabolic process 22.7273 4 no
GO:0016310 phosphorylation 22.7273 5 no
GO:0030155 regulation of cell adhesion 22.7273 4 no
GO:0032886 regulation of microtubule-based process 22.7273 4 no
GO:0036211 protein modification process 22.7273 4 no
GO:0043412 macromolecule modification 22.7273 4 no
GO:0044089 positive regulation of cellular component biogenesis 22.7273 5 no
GO:0045785 positive regulation of cell adhesion 22.7273 5 no
GO:0050770 regulation of axonogenesis 22.7273 5 no
GO:0051247 positive regulation of protein metabolic process 22.7273 6 no
GO:1902531 regulation of intracellular signal transduction 22.7273 5 no
GO:1904951 positive regulation of establishment of protein localization 22.7273 6 no
GO:0010720 positive regulation of cell development 22.7273 6 no
GO:0033365 protein localization to organelle 22.7273 5 no
GO:0050767 regulation of neurogenesis 22.7273 6 no
GO:0050769 positive regulation of neurogenesis 22.7273 6 no
GO:0099175 regulation of postsynapse organization 22.7273 6 no
GO:0048639 positive regulation of developmental growth 18.1818 5 yes
GO:0048812 neuron projection morphogenesis 18.1818 5 yes
GO:0072659 protein localization to plasma membrane 18.1818 5 yes
GO:0110053 regulation of actin filament organization 18.1818 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 18.1818 4 yes
GO:1903522 regulation of blood circulation 18.1818 5 yes
GO:0001932 regulation of protein phosphorylation 18.1818 7 yes
GO:0008016 regulation of heart contraction 18.1818 6 yes
GO:0010639 negative regulation of organelle organization 18.1818 6 yes
GO:0032271 regulation of protein polymerization 18.1818 6 yes
GO:0032956 regulation of actin cytoskeleton organization 18.1818 5 yes
GO:0051241 negative regulation of multicellular organismal process 13.6364 4 yes
GO:0051494 negative regulation of cytoskeleton organization 13.6364 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 13.6364 6 yes
GO:0002028 regulation of sodium ion transport 13.6364 7 yes
GO:0007528 neuromuscular junction development 13.6364 6 yes
GO:0031333 negative regulation of protein-containing complex assembly 13.6364 6 yes
GO:0032535 regulation of cellular component size 13.6364 4 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 13.6364 8 yes
GO:0043242 negative regulation of protein-containing complex disassembly 9.0909 6 yes
GO:0043244 regulation of protein-containing complex disassembly 9.0909 5 yes
GO:0050905 neuromuscular process 9.0909 4 yes
GO:0051693 actin filament capping 9.0909 8 yes
GO:0061337 cardiac conduction 9.0909 7 yes
GO:1901879 regulation of protein depolymerization 9.0909 6 yes
GO:1901880 negative regulation of protein depolymerization 9.0909 7 yes
GO:0007409 axonogenesis 9.0909 6 yes
GO:0007600 sensory perception 9.0909 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 9.0909 6 yes
GO:0008344 adult locomotory behavior 9.0909 4 yes
GO:0030832 regulation of actin filament length 9.0909 5 yes
GO:0030833 regulation of actin filament polymerization 9.0909 7 yes
GO:0030834 regulation of actin filament depolymerization 9.0909 7 yes
GO:0030835 negative regulation of actin filament depolymerization 9.0909 7 yes
GO:0030837 negative regulation of actin filament polymerization 9.0909 7 yes
GO:0032272 negative regulation of protein polymerization 9.0909 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
ANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRN_HUMAN [view interactions] Low throughput no yes
PTPR2_HUMAN [view interactions] Low throughput no yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC3_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
CF298_HUMAN [view interactions] High throughput no yes
MORC3_HUMAN [view interactions] High throughput no yes
ERR2_HUMAN [view interactions] High throughput no no
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
RSBN1_HUMAN [view interactions] High throughput no yes
PCDGK_HUMAN [view interactions] High throughput no yes
SPTA1_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
PNPH_HUMAN [view interactions] High throughput no no
ETS1_HUMAN [view interactions] High throughput no no
ANTR2_HUMAN [view interactions] High throughput no no
TIMD4_HUMAN [view interactions] High throughput no no
TPPP_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
TLE3_HUMAN [view interactions] High throughput no yes
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
CELR3_HUMAN [view entry] [view interactions] High throughput yes no
CDC37_HUMAN [view interactions] High throughput no yes
GA45A_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
CENPU_HUMAN [view interactions] High throughput no no
NEK2_HUMAN [view interactions] High throughput no no
PFD1_HUMAN [view interactions] High throughput no yes
KS6A6_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
RA51D_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no