Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SPTN4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SPTN4_HUMAN
GO:0017076 purine nucleotide binding 28.1250 4 no
GO:0032555 purine ribonucleotide binding 28.1250 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.1250 4 no
GO:0003779 actin binding 21.8750 4 yes
GO:0019902 phosphatase binding 12.5000 4 yes
GO:0030506 ankyrin binding 9.3750 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SPTN4_HUMAN
GO:0048522 positive regulation of cellular process 68.7500 4 no
GO:0051128 regulation of cellular component organization 59.3750 4 yes
GO:0051049 regulation of transport 53.1250 4 yes
GO:0006996 organelle organization 50.0000 4 yes
GO:0010646 regulation of cell communication 46.8750 4 no
GO:0048523 negative regulation of cellular process 46.8750 4 yes
GO:0060255 regulation of macromolecule metabolic process 43.7500 4 yes
GO:0022607 cellular component assembly 43.7500 4 no
GO:0008104 protein localization 43.7500 4 yes
GO:0051050 positive regulation of transport 40.6250 4 no
GO:0007010 cytoskeleton organization 40.6250 5 yes
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 yes
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0043269 regulation of ion transport 37.5000 5 yes
GO:0044087 regulation of cellular component biogenesis 37.5000 4 yes
GO:0051240 positive regulation of multicellular organismal process 34.3750 4 yes
GO:0080090 regulation of primary metabolic process 34.3750 4 yes
GO:0031344 regulation of cell projection organization 34.3750 5 no
GO:0034762 regulation of transmembrane transport 34.3750 4 no
GO:0034765 regulation of ion transmembrane transport 34.3750 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.3750 6 no
GO:0031323 regulation of cellular metabolic process 34.3750 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 34.3750 4 yes
GO:0051246 regulation of protein metabolic process 31.2500 5 yes
GO:0051493 regulation of cytoskeleton organization 31.2500 6 yes
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010468 regulation of gene expression 31.2500 5 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0034330 cell junction organization 31.2500 4 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0120036 plasma membrane bounded cell projection organization 31.2500 5 no
GO:0016192 vesicle-mediated transport 31.2500 4 yes
GO:0051094 positive regulation of developmental process 31.2500 4 yes
GO:0072657 protein localization to membrane 28.1250 4 yes
GO:0023056 positive regulation of signaling 28.1250 4 no
GO:0032880 regulation of protein localization 28.1250 5 no
GO:0045595 regulation of cell differentiation 28.1250 4 no
GO:0060341 regulation of cellular localization 28.1250 4 no
GO:1903829 positive regulation of protein localization 28.1250 5 no
GO:0031399 regulation of protein modification process 28.1250 6 yes
GO:0044057 regulation of system process 28.1250 4 yes
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0050808 synapse organization 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 yes
GO:0032970 regulation of actin filament-based process 25.0000 4 yes
GO:0051129 negative regulation of cellular component organization 25.0000 5 yes
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 yes
GO:0061024 membrane organization 21.8750 4 yes
GO:0043270 positive regulation of ion transport 21.8750 5 no
GO:0050807 regulation of synapse organization 21.8750 5 no
GO:0065003 protein-containing complex assembly 21.8750 5 no
GO:2001257 regulation of cation channel activity 21.8750 6 no
GO:0001508 action potential 21.8750 4 no
GO:0034329 cell junction assembly 21.8750 5 no
GO:0009892 negative regulation of metabolic process 21.8750 4 no
GO:0031325 positive regulation of cellular metabolic process 21.8750 5 no
GO:0031346 positive regulation of cell projection organization 21.8750 6 no
GO:0045597 positive regulation of cell differentiation 21.8750 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.8750 5 no
GO:0051247 positive regulation of protein metabolic process 21.8750 6 no
GO:1902531 regulation of intracellular signal transduction 21.8750 5 no
GO:2000026 regulation of multicellular organismal development 21.8750 4 no
GO:0051222 positive regulation of protein transport 21.8750 5 no
GO:0051223 regulation of protein transport 21.8750 5 no
GO:1904951 positive regulation of establishment of protein localization 21.8750 6 no
GO:0010639 negative regulation of organelle organization 21.8750 6 yes
GO:0042325 regulation of phosphorylation 21.8750 7 yes
GO:0043254 regulation of protein-containing complex assembly 21.8750 5 yes
GO:0072659 protein localization to plasma membrane 18.7500 5 yes
GO:1902903 regulation of supramolecular fiber organization 18.7500 5 yes
GO:1990778 protein localization to cell periphery 18.7500 5 yes
GO:0001932 regulation of protein phosphorylation 18.7500 7 yes
GO:0010959 regulation of metal ion transport 18.7500 6 yes
GO:0032956 regulation of actin cytoskeleton organization 18.7500 5 yes
GO:0048638 regulation of developmental growth 18.7500 4 yes
GO:0110053 regulation of actin filament organization 15.6250 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 15.6250 6 yes
GO:0031333 negative regulation of protein-containing complex assembly 15.6250 6 yes
GO:0032271 regulation of protein polymerization 15.6250 6 yes
GO:0032535 regulation of cellular component size 15.6250 4 yes
GO:0032990 cell part morphogenesis 15.6250 4 yes
GO:0045927 positive regulation of growth 15.6250 4 yes
GO:0048812 neuron projection morphogenesis 15.6250 7 yes
GO:0048858 cell projection morphogenesis 15.6250 5 yes
GO:0051494 negative regulation of cytoskeleton organization 12.5000 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 12.5000 6 yes
GO:1903522 regulation of blood circulation 12.5000 5 yes
GO:0008016 regulation of heart contraction 12.5000 6 yes
GO:0008064 regulation of actin polymerization or depolymerization 12.5000 6 yes
GO:0030832 regulation of actin filament length 12.5000 5 yes
GO:0048639 positive regulation of developmental growth 12.5000 5 yes
GO:0051241 negative regulation of multicellular organismal process 9.3750 4 yes
GO:0051693 actin filament capping 9.3750 8 yes
GO:1901879 regulation of protein depolymerization 9.3750 6 yes
GO:1901880 negative regulation of protein depolymerization 9.3750 7 yes
GO:0002028 regulation of sodium ion transport 9.3750 7 yes
GO:0007409 axonogenesis 9.3750 8 yes
GO:0030833 regulation of actin filament polymerization 9.3750 7 yes
GO:0030834 regulation of actin filament depolymerization 9.3750 7 yes
GO:0030835 negative regulation of actin filament depolymerization 9.3750 7 yes
GO:0030837 negative regulation of actin filament polymerization 9.3750 7 yes
GO:0032272 negative regulation of protein polymerization 9.3750 7 yes
GO:0043242 negative regulation of protein-containing complex disassembly 9.3750 6 yes
GO:0043244 regulation of protein-containing complex disassembly 9.3750 5 yes
GO:0007600 sensory perception 6.2500 4 yes
GO:0008344 adult locomotory behavior 6.2500 4 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 6.2500 8 yes
GO:0045161 neuronal ion channel clustering 6.2500 5 yes
GO:0045162 clustering of voltage-gated sodium channels 6.2500 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in SPTN4_HUMAN
DOID:0050701 electroclinical syndrome 12.5000 6 no
DOID:0112202 developmental and epileptic encephalopathy 12.5000 7 no
DOID:1826 epilepsy 12.5000 5 no
DOID:331 central nervous system disease 12.5000 3 no
DOID:936 brain disease 12.5000 4 no
DOID:114 heart disease 9.3750 3 no
DOID:0050700 cardiomyopathy 6.2500 4 no
DOID:0060036 intrinsic cardiomyopathy 6.2500 5 no
DOID:0050703 infancy electroclinical syndrome 6.2500 7 no
DOID:0060169 benign familial infantile epilepsy 6.2500 8 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
ANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
PTPR2_HUMAN [view interactions] Low throughput no yes
PTPRN_HUMAN [view interactions] Low throughput no yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
PNPH_HUMAN [view interactions] High throughput no no
ETS1_HUMAN [view interactions] High throughput no no
ANTR2_HUMAN [view interactions] High throughput no no
TIMD4_HUMAN [view interactions] High throughput no no
TPPP_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
CELR3_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
GA45A_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
CENPU_HUMAN [view interactions] High throughput no no
NEK2_HUMAN [view interactions] High throughput no no
PFD1_HUMAN [view interactions] High throughput no yes
KS6A6_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view interactions] High throughput no yes
RA51D_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC3_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERR2_HUMAN [view interactions] High throughput no no
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
RSBN1_HUMAN [view interactions] High throughput no yes
PCDGK_HUMAN [view interactions] High throughput no yes
SPTA1_HUMAN [view interactions] High throughput no no
ANK1_HUMAN [view entry] [view interactions] Computational yes no
NRCAM_HUMAN [view entry] [view interactions] Computational yes no
SPTN2_HUMAN [view entry] [view interactions] Computational yes yes
SCN1A_HUMAN [view interactions] Computational no no
RASK_HUMAN [view entry] [view interactions] Computational yes no
SCN8A_HUMAN [view entry] [view interactions] Computational yes no
KCNQ3_HUMAN [view interactions] Computational no no
NFASC_HUMAN [view entry] [view interactions] Computational yes yes
SPTN5_HUMAN [view interactions] Computational no no
SRC_HUMAN [view entry] [view interactions] Computational yes no
SCN2A_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
RASN_HUMAN [view entry] [view interactions] Computational yes no
KCNQ2_HUMAN [view entry] [view interactions] Computational yes yes
E41L2_HUMAN [view entry] [view interactions] Computational yes yes