TPPP_HUMAN
Evidence for PS localization
Functions
Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed, PubMed). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed, PubMed, PubMed, PubMed). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed, PubMed). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TPPP_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 40.0000 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 35.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.0000 | 6 | yes |
| GO:0003924 | GTPase activity | 30.0000 | 7 | yes |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
| GO:0015631 | tubulin binding | 25.0000 | 4 | yes |
| GO:0003779 | actin binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0008017 | microtubule binding | 20.0000 | 5 | yes |
| GO:0000287 | magnesium ion binding | 15.0000 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 15.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TPPP_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 75.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 75.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 70.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 65.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 65.0000 | 4 | no |
| GO:0006996 | organelle organization | 60.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 55.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 50.0000 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 45.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 45.0000 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 45.0000 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 45.0000 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 45.0000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 45.0000 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 45.0000 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 45.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 45.0000 | 5 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 40.0000 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 40.0000 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 40.0000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
| GO:0030030 | cell projection organization | 40.0000 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 40.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 40.0000 | 7 | no |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 35.0000 | 5 | yes |
| GO:0031400 | negative regulation of protein modification process | 35.0000 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 35.0000 | 4 | yes |
| GO:0010506 | regulation of autophagy | 35.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 35.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.0000 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 35.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 35.0000 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 35.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 35.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 35.0000 | 5 | no |
| GO:0032271 | regulation of protein polymerization | 30.0000 | 6 | yes |
| GO:0032886 | regulation of microtubule-based process | 30.0000 | 4 | yes |
| GO:0044057 | regulation of system process | 30.0000 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 30.0000 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 30.0000 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 30.0000 | 4 | yes |
| GO:0030162 | regulation of proteolysis | 30.0000 | 6 | no |
| GO:0031175 | neuron projection development | 30.0000 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 30.0000 | 4 | no |
| GO:0043086 | negative regulation of catalytic activity | 30.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 30.0000 | 4 | no |
| GO:0070848 | response to growth factor | 30.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 30.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 30.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0060548 | negative regulation of cell death | 30.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0031334 | positive regulation of protein-containing complex assembly | 25.0000 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | yes |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 25.0000 | 6 | no |
| GO:0010639 | negative regulation of organelle organization | 25.0000 | 6 | no |
| GO:0010942 | positive regulation of cell death | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0048638 | regulation of developmental growth | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051345 | positive regulation of hydrolase activity | 25.0000 | 5 | no |
| GO:0071363 | cellular response to growth factor stimulus | 25.0000 | 5 | no |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:1901214 | regulation of neuron death | 25.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051346 | negative regulation of hydrolase activity | 25.0000 | 5 | no |
| GO:0034097 | response to cytokine | 25.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031333 | negative regulation of protein-containing complex assembly | 25.0000 | 6 | no |
| GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | no |
| GO:0031644 | regulation of nervous system process | 20.0000 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 20.0000 | 5 | yes |
| GO:0021782 | glial cell development | 15.0000 | 4 | yes |
| GO:0031109 | microtubule polymerization or depolymerization | 15.0000 | 4 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 15.0000 | 4 | yes |
| GO:0032273 | positive regulation of protein polymerization | 15.0000 | 7 | yes |
| GO:0046785 | microtubule polymerization | 15.0000 | 5 | yes |
| GO:0051258 | protein polymerization | 15.0000 | 6 | yes |
| GO:0090043 | regulation of tubulin deacetylation | 15.0000 | 8 | yes |
| GO:0090311 | regulation of protein deacetylation | 15.0000 | 7 | yes |
| GO:1904428 | negative regulation of tubulin deacetylation | 15.0000 | 8 | yes |
| GO:0001578 | microtubule bundle formation | 10.0000 | 4 | yes |
| GO:0007020 | microtubule nucleation | 10.0000 | 4 | yes |
| GO:0010001 | glial cell differentiation | 10.0000 | 4 | yes |
| GO:0014003 | oligodendrocyte development | 10.0000 | 5 | yes |
| GO:0030953 | astral microtubule organization | 10.0000 | 4 | yes |
| GO:0031641 | regulation of myelination | 10.0000 | 4 | yes |
| GO:0031643 | positive regulation of myelination | 10.0000 | 5 | yes |
| GO:0031646 | positive regulation of nervous system process | 10.0000 | 5 | yes |
| GO:0032288 | myelin assembly | 10.0000 | 4 | yes |
| GO:0048709 | oligodendrocyte differentiation | 10.0000 | 5 | yes |
| GO:0051418 | microtubule nucleation by microtubule organizing center | 10.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TPPP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| ROCK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD11B_HUMAN | [view interactions] | High throughput | no | yes |
| CB27B_HUMAN | [view interactions] | High throughput | no | no |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| FADD_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| DDB2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN114_HUMAN | [view interactions] | High throughput | no | no |
| MAGB6_HUMAN | [view interactions] | High throughput | no | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CB27A_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| CHST5_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA2C1_HUMAN | [view interactions] | High throughput | no | no |
| KLH24_HUMAN | [view interactions] | High throughput | no | no |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| SEMG1_HUMAN | [view interactions] | High throughput | no | no |
| SEMG2_HUMAN | [view interactions] | High throughput | no | no |
| PPCT_HUMAN | [view interactions] | High throughput | no | yes |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| SPTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| G3PT_HUMAN | [view interactions] | Computational | no | no |
| BIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYUB_HUMAN | [view interactions] | Computational | no | yes |