Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPPP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed, PubMed). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed, PubMed, PubMed, PubMed). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed, PubMed). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TPPP_HUMAN
GO:0043169 cation binding 50.0000 4 yes
GO:0046872 metal ion binding 43.7500 5 yes
GO:0003779 actin binding 31.2500 4 no
GO:0003924 GTPase activity 25.0000 7 yes
GO:0015631 tubulin binding 25.0000 4 yes
GO:0016462 pyrophosphatase activity 25.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019902 phosphatase binding 25.0000 4 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0000287 magnesium ion binding 18.7500 6 yes
GO:0008017 microtubule binding 18.7500 5 yes
GO:0042803 protein homodimerization activity 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPPP_HUMAN
GO:0080090 regulation of primary metabolic process 75.0000 4 yes
GO:0051128 regulation of cellular component organization 68.7500 4 yes
GO:0060255 regulation of macromolecule metabolic process 68.7500 4 yes
GO:0044087 regulation of cellular component biogenesis 62.5000 4 yes
GO:0051246 regulation of protein metabolic process 62.5000 5 yes
GO:0031323 regulation of cellular metabolic process 56.2500 4 no
GO:0006996 organelle organization 56.2500 4 yes
GO:0022607 cellular component assembly 56.2500 4 yes
GO:0031399 regulation of protein modification process 56.2500 6 yes
GO:0048522 positive regulation of cellular process 56.2500 4 yes
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0051493 regulation of cytoskeleton organization 50.0000 6 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0042325 regulation of phosphorylation 43.7500 7 no
GO:0009892 negative regulation of metabolic process 43.7500 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 yes
GO:0043254 regulation of protein-containing complex assembly 43.7500 5 yes
GO:0043933 protein-containing complex organization 43.7500 4 yes
GO:0051049 regulation of transport 43.7500 4 no
GO:0030030 cell projection organization 43.7500 4 no
GO:0051129 negative regulation of cellular component organization 43.7500 5 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0031329 regulation of cellular catabolic process 37.5000 5 no
GO:0031400 negative regulation of protein modification process 37.5000 7 yes
GO:0032271 regulation of protein polymerization 37.5000 6 yes
GO:0032886 regulation of microtubule-based process 37.5000 4 yes
GO:0044057 regulation of system process 37.5000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 37.5000 5 yes
GO:0051248 negative regulation of protein metabolic process 37.5000 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 37.5000 5 yes
GO:0097435 supramolecular fiber organization 37.5000 4 yes
GO:0031175 neuron projection development 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:1902903 regulation of supramolecular fiber organization 37.5000 5 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0010506 regulation of autophagy 31.2500 6 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0048638 regulation of developmental growth 31.2500 4 no
GO:0051338 regulation of transferase activity 31.2500 4 no
GO:1902531 regulation of intracellular signal transduction 31.2500 5 no
GO:0010243 response to organonitrogen compound 31.2500 4 no
GO:0007010 cytoskeleton organization 31.2500 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 31.2500 6 yes
GO:0065003 protein-containing complex assembly 31.2500 5 yes
GO:2000026 regulation of multicellular organismal development 31.2500 4 yes
GO:0034330 cell junction organization 31.2500 4 no
GO:0045595 regulation of cell differentiation 31.2500 4 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0050808 synapse organization 31.2500 5 no
GO:0051094 positive regulation of developmental process 31.2500 4 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:0031333 negative regulation of protein-containing complex assembly 25.0000 6 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0031644 regulation of nervous system process 25.0000 5 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0008104 protein localization 25.0000 4 no
GO:0010639 negative regulation of organelle organization 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 5 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 4 no
GO:0007005 mitochondrion organization 25.0000 5 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0021782 glial cell development 18.7500 4 yes
GO:0031109 microtubule polymerization or depolymerization 18.7500 4 yes
GO:0031122 cytoplasmic microtubule organization 18.7500 4 yes
GO:0032273 positive regulation of protein polymerization 18.7500 7 yes
GO:0046785 microtubule polymerization 18.7500 5 yes
GO:0051258 protein polymerization 18.7500 6 yes
GO:0090043 regulation of tubulin deacetylation 18.7500 8 yes
GO:0090311 regulation of protein deacetylation 18.7500 7 yes
GO:1904428 negative regulation of tubulin deacetylation 18.7500 8 yes
GO:0001578 microtubule bundle formation 12.5000 4 yes
GO:0007020 microtubule nucleation 12.5000 4 yes
GO:0010001 glial cell differentiation 12.5000 4 yes
GO:0014003 oligodendrocyte development 12.5000 5 yes
GO:0030953 astral microtubule organization 12.5000 4 yes
GO:0031641 regulation of myelination 12.5000 4 yes
GO:0031643 positive regulation of myelination 12.5000 5 yes
GO:0031646 positive regulation of nervous system process 12.5000 5 yes
GO:0032288 myelin assembly 12.5000 4 yes
GO:0048709 oligodendrocyte differentiation 12.5000 5 yes
GO:0051418 microtubule nucleation by microtubule organizing center 12.5000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
TPPP_HUMAN [view entry] [view interactions] Low throughput yes yes
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
TBB5_HUMAN [view interactions] Low throughput no yes
DYL2_HUMAN [view entry] [view interactions] Low throughput yes no
MLP3B_HUMAN [view interactions] Low throughput no yes
ROCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD11B_HUMAN [view interactions] High throughput no yes
CB27B_HUMAN [view interactions] High throughput no no
H11_HUMAN [view interactions] High throughput no no
FADD_HUMAN [view interactions] High throughput no yes
GRPE1_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
H15_HUMAN [view interactions] High throughput no no
HMGN2_HUMAN [view interactions] High throughput no no
DDB2_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ZN114_HUMAN [view interactions] High throughput no no
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
MAGB6_HUMAN [view interactions] High throughput no no
CB27A_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
INS_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
CHST5_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
MA2C1_HUMAN [view interactions] High throughput no no
KLH24_HUMAN [view interactions] High throughput no no
DCA10_HUMAN [view interactions] High throughput no no
SEMG1_HUMAN [view interactions] High throughput no no
SEMG2_HUMAN [view interactions] High throughput no no
PPCT_HUMAN [view interactions] High throughput no yes
PPAP_HUMAN [view interactions] High throughput no no
SPTN4_HUMAN [view entry] [view interactions] High throughput yes no
LN28A_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
IFT74_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes