Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DYL2_HUMAN

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures . [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DYL2_HUMAN
GO:0043168 anion binding 29.5775 4 no
GO:0000166 nucleotide binding 26.7606 4 no
GO:0017076 purine nucleotide binding 26.7606 5 no
GO:0032555 purine ribonucleotide binding 25.3521 4 no
GO:0030554 adenyl nucleotide binding 23.9437 6 no
GO:0032559 adenyl ribonucleotide binding 22.5352 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.1268 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DYL2_HUMAN
GO:0048522 positive regulation of cellular process 45.0704 4 no
GO:0060255 regulation of macromolecule metabolic process 43.6620 4 no
GO:0031323 regulation of cellular metabolic process 42.2535 4 no
GO:0010646 regulation of cell communication 39.4366 4 no
GO:0051128 regulation of cellular component organization 39.4366 4 no
GO:0080090 regulation of primary metabolic process 39.4366 4 no
GO:0048523 negative regulation of cellular process 39.4366 4 no
GO:0006996 organelle organization 38.0282 4 no
GO:0009966 regulation of signal transduction 35.2113 4 no
GO:0022607 cellular component assembly 35.2113 4 no
GO:0009889 regulation of biosynthetic process 33.8028 4 no
GO:0010468 regulation of gene expression 32.3944 6 no
GO:0010556 regulation of macromolecule biosynthetic process 32.3944 5 no
GO:0031326 regulation of cellular biosynthetic process 32.3944 5 no
GO:0008104 protein localization 30.9859 4 no
GO:1902531 regulation of intracellular signal transduction 28.1690 5 no
GO:0010647 positive regulation of cell communication 26.7606 5 no
GO:0023056 positive regulation of signaling 26.7606 4 no
GO:0051246 regulation of protein metabolic process 26.7606 5 no
GO:0051049 regulation of transport 25.3521 4 no
GO:0007010 cytoskeleton organization 25.3521 5 no
GO:0010648 negative regulation of cell communication 25.3521 5 no
GO:0023057 negative regulation of signaling 25.3521 4 no
GO:0048585 negative regulation of response to stimulus 25.3521 4 no
GO:0009893 positive regulation of metabolic process 23.9437 4 no
GO:0051130 positive regulation of cellular component organization 23.9437 5 no
GO:0033043 regulation of organelle organization 23.9437 5 no
GO:0044087 regulation of cellular component biogenesis 23.9437 4 no
GO:0009968 negative regulation of signal transduction 23.9437 5 no
GO:0009892 negative regulation of metabolic process 23.9437 4 no
GO:0048584 positive regulation of response to stimulus 22.5352 4 no
GO:0043933 protein-containing complex organization 22.5352 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.5352 5 no
GO:0010604 positive regulation of macromolecule metabolic process 21.1268 5 no
GO:0019220 regulation of phosphate metabolic process 21.1268 6 no
GO:0031325 positive regulation of cellular metabolic process 21.1268 5 no
GO:0031399 regulation of protein modification process 21.1268 6 no
GO:0051174 regulation of phosphorus metabolic process 21.1268 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.1268 5 no
GO:0051252 regulation of RNA metabolic process 21.1268 5 no

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BMF_HUMAN [view interactions] Low throughput no yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
B2L11_HUMAN [view interactions] Low throughput no yes
MLF1_HUMAN [view entry] [view interactions] Low throughput yes yes
TPPP_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
DYL2_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
MORN3_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
DNAL4_HUMAN [view interactions] High throughput no yes
HMBX1_HUMAN [view interactions] High throughput no yes
RDIC1_HUMAN [view interactions] High throughput no no
GRP3_HUMAN [view interactions] High throughput no no
IHO1_HUMAN [view interactions] High throughput no no
SBP2L_HUMAN [view interactions] High throughput no yes
IPKG_HUMAN [view interactions] High throughput no yes
F117B_HUMAN [view interactions] High throughput no no
MCSP_HUMAN [view interactions] High throughput no no
IPKA_HUMAN [view interactions] High throughput no yes
OTU6A_HUMAN [view interactions] High throughput no no
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CN119_HUMAN [view interactions] High throughput no yes
DPPA3_HUMAN [view interactions] High throughput no no
SEPT4_HUMAN [view interactions] High throughput no no
ZAR1_HUMAN [view interactions] High throughput no no
THA10_HUMAN [view interactions] High throughput no no
XIAP_HUMAN [view interactions] High throughput no yes
GRIN2_HUMAN [view interactions] High throughput no yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
SPAG5_HUMAN [view interactions] High throughput no yes
NEK9_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
SMBT1_HUMAN [view interactions] High throughput no no
ZMYM4_HUMAN [view interactions] High throughput no yes
RN214_HUMAN [view interactions] High throughput no yes
DCAF7_HUMAN [view interactions] High throughput no yes
PAPD1_HUMAN [view interactions] High throughput no yes
EPN4_HUMAN [view interactions] High throughput no yes
MORC3_HUMAN [view interactions] High throughput no yes
NRF1_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
DDHD1_HUMAN [view interactions] High throughput no no
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
CIZ1_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
DC2I1_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
DC2I2_HUMAN [view interactions] High throughput no yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
SKP1_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
DZAN1_HUMAN [view interactions] High throughput no yes
LCA5_HUMAN [view interactions] High throughput no no
OFD1_HUMAN [view interactions] High throughput no yes
ZMY11_HUMAN [view interactions] High throughput no no
H2B1C_HUMAN [view interactions] High throughput no yes
ETS1_HUMAN [view interactions] High throughput no no
FOXL1_HUMAN [view interactions] High throughput no no
HNF4A_HUMAN [view interactions] High throughput no no
NFIA_HUMAN [view interactions] High throughput no yes
PAX6_HUMAN [view interactions] High throughput no no
TYY1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
SSNA1_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
FTM_HUMAN [view interactions] High throughput no yes
SKAP1_HUMAN [view interactions] High throughput no no
SPAG8_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] High throughput yes yes
STB5L_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH18_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
ODFP2_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
MT21E_HUMAN [view interactions] High throughput no no
RS30_HUMAN [view interactions] High throughput no yes
RM22_HUMAN [view interactions] High throughput no yes
HMMR_HUMAN [view interactions] High throughput no yes
AMOL2_HUMAN [view interactions] High throughput no no
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
STRP1_HUMAN [view interactions] High throughput no yes
ARB2A_HUMAN [view interactions] High throughput no yes
ZN608_HUMAN [view interactions] High throughput no yes
MPP9_HUMAN [view interactions] High throughput no yes
RNF41_HUMAN [view interactions] High throughput no yes
ANM3_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
NDE1_HUMAN [view interactions] High throughput no yes
WDR13_HUMAN [view interactions] High throughput no yes
BACH1_HUMAN [view interactions] High throughput no no
FBX38_HUMAN [view interactions] High throughput no yes
A20A2_HUMAN [view interactions] High throughput no no
ZMYM2_HUMAN [view interactions] High throughput no yes
TRPS1_HUMAN [view interactions] High throughput no no
LIPB1_HUMAN [view interactions] High throughput no yes
CC136_HUMAN [view interactions] High throughput no yes
MTCL1_HUMAN [view interactions] High throughput no yes
NOS1_HUMAN [view entry] [view interactions] High throughput yes yes
IFFO2_HUMAN [view interactions] High throughput no yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
BORA_HUMAN [view interactions] High throughput no yes
FA83D_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
PZRN3_HUMAN [view interactions] High throughput no yes
CDR2_HUMAN [view interactions] High throughput no yes
GOGB1_HUMAN [view entry] [view interactions] High throughput yes yes
GLCI1_HUMAN [view interactions] High throughput no yes
B2CL1_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP28_HUMAN [view interactions] High throughput no yes
BLT3B_HUMAN [view interactions] High throughput no yes
CCSE2_HUMAN [view interactions] High throughput no yes
RSBNL_HUMAN [view interactions] High throughput no yes
DEDD_HUMAN [view interactions] High throughput no yes
C170B_HUMAN [view interactions] High throughput no yes
CDR2L_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
RCOR2_HUMAN [view interactions] High throughput no no
STRP2_HUMAN [view interactions] High throughput no yes
KDM6A_HUMAN [view interactions] High throughput no yes
A20A1_HUMAN [view interactions] High throughput no no
TTC3_HUMAN [view interactions] High throughput no yes
KCNQ5_HUMAN [view entry] [view interactions] High throughput yes yes
CDAC1_HUMAN [view interactions] High throughput no no
AMOL1_HUMAN [view interactions] High throughput no no
RCOR3_HUMAN [view interactions] High throughput no yes
ADNP_HUMAN [view interactions] High throughput no yes
FBX30_HUMAN [view interactions] High throughput no yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
ZN609_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
BSN_HUMAN [view entry] [view interactions] High throughput yes yes
KANK1_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
CT2NL_HUMAN [view interactions] High throughput no yes
CTTB2_HUMAN [view entry] [view interactions] High throughput yes yes
JCAD_HUMAN [view interactions] High throughput no yes
AGGF1_HUMAN [view interactions] High throughput no no
NCOA6_HUMAN [view interactions] High throughput no yes
NHSL1_HUMAN [view interactions] High throughput no yes
MTCL2_HUMAN [view interactions] High throughput no yes
ATMIN_HUMAN [view interactions] High throughput no yes
EMAL3_HUMAN [view interactions] High throughput no no
IFFO1_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
KAPCG_HUMAN [view interactions] High throughput no no
SCML1_HUMAN [view interactions] High throughput no no
F1711_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
ZN710_HUMAN [view interactions] High throughput no yes
XRCC4_HUMAN [view interactions] High throughput no yes
STXB4_HUMAN [view interactions] High throughput no yes
MCL1_HUMAN [view interactions] High throughput no yes
MRCKG_HUMAN [view interactions] High throughput no no
RELCH_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
ELL_HUMAN [view interactions] High throughput no no
ZMYM3_HUMAN [view interactions] High throughput no yes
ZMYM6_HUMAN [view interactions] High throughput no yes
MIGA1_HUMAN [view interactions] High throughput no yes
RSBN1_HUMAN [view interactions] High throughput no yes
KMT2C_HUMAN [view interactions] High throughput no no
STRN3_HUMAN [view entry] [view interactions] High throughput yes yes
SKAP_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
WWC2_HUMAN [view interactions] High throughput no yes
UBP25_HUMAN [view interactions] High throughput no yes
F117A_HUMAN [view interactions] High throughput no yes
ZSA5A_HUMAN [view interactions] High throughput no no
PALD_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
N4BP2_HUMAN [view interactions] High throughput no yes
TRAK1_HUMAN [view interactions] High throughput no yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
OPTN_HUMAN [view interactions] High throughput no yes
DYT2B_HUMAN [view interactions] High throughput no no
CEP20_HUMAN [view interactions] High throughput no yes
FBX40_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
PKHH2_HUMAN [view interactions] High throughput no no
CISD2_HUMAN [view interactions] High throughput no yes
DYHC2_HUMAN [view interactions] High throughput no yes
POGZ_HUMAN [view interactions] High throughput no yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
PP2AB_HUMAN [view interactions] High throughput no yes
PTN12_HUMAN [view interactions] High throughput no yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
CHD4_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL4_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
DC2L1_HUMAN [view interactions] High throughput no no
NDEL1_HUMAN [view entry] [view interactions] High throughput yes yes
DDA1_HUMAN [view interactions] High throughput no yes
ELOC_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCBP_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
ELOB_HUMAN [view interactions] High throughput no no
EMAL4_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
A20A4_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
CCD66_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
2AAB_HUMAN [view interactions] High throughput no yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
CO3_HUMAN [view entry] [view interactions] High throughput yes no
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
KIBRA_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
NEK1_HUMAN [view interactions] High throughput no yes
SDS3_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
HMGA2_HUMAN [view interactions] High throughput no yes
TLK2_HUMAN [view interactions] High throughput no no
TLK1_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
PTBP3_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes