Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KAPCB_HUMAN

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed, PubMed). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KAPCB_HUMAN
GO:0043168 anion binding 36.0000 4 yes
GO:0000166 nucleotide binding 34.6667 4 yes
GO:0017076 purine nucleotide binding 34.6667 5 yes
GO:0032555 purine ribonucleotide binding 34.6667 4 yes
GO:0019900 kinase binding 34.6667 4 no
GO:0019901 protein kinase binding 32.0000 5 no
GO:0030554 adenyl nucleotide binding 30.6667 6 yes
GO:0032559 adenyl ribonucleotide binding 30.6667 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.0000 4 yes
GO:0003723 RNA binding 28.0000 4 no
GO:0043169 cation binding 26.6667 4 yes
GO:0046872 metal ion binding 26.6667 5 yes
GO:0005524 ATP binding 24.0000 5 yes
GO:0031625 ubiquitin protein ligase binding 18.6667 5 yes
GO:0044389 ubiquitin-like protein ligase binding 18.6667 4 yes
GO:0016301 kinase activity 13.3333 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 13.3333 4 yes
GO:0004674 protein serine/threonine kinase activity 10.6667 4 yes
GO:0106310 protein serine kinase activity 10.6667 4 yes
GO:0000287 magnesium ion binding 5.3333 6 yes
GO:0004679 AMP-activated protein kinase activity 2.6667 5 yes
GO:0004690 cyclic nucleotide-dependent protein kinase activity 2.6667 5 yes
GO:0004691 cAMP-dependent protein kinase activity 2.6667 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KAPCB_HUMAN
GO:0048522 positive regulation of cellular process 64.0000 4 no
GO:0031323 regulation of cellular metabolic process 57.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.0000 4 yes
GO:0080090 regulation of primary metabolic process 53.3333 4 yes
GO:0048523 negative regulation of cellular process 52.0000 4 yes
GO:0010646 regulation of cell communication 50.6667 4 yes
GO:0009889 regulation of biosynthetic process 44.0000 4 yes
GO:0009966 regulation of signal transduction 42.6667 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.6667 5 yes
GO:0031326 regulation of cellular biosynthetic process 42.6667 5 yes
GO:0010468 regulation of gene expression 41.3333 6 yes
GO:0051128 regulation of cellular component organization 41.3333 4 no
GO:0022607 cellular component assembly 40.0000 4 yes
GO:0051246 regulation of protein metabolic process 40.0000 5 yes
GO:0006996 organelle organization 40.0000 4 no
GO:0051049 regulation of transport 38.6667 4 no
GO:0008104 protein localization 37.3333 4 no
GO:0009892 negative regulation of metabolic process 36.0000 4 no
GO:0048584 positive regulation of response to stimulus 34.6667 4 no
GO:0032880 regulation of protein localization 34.6667 5 no
GO:0060341 regulation of cellular localization 34.6667 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 32.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 32.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 32.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.6667 5 no
GO:0031325 positive regulation of cellular metabolic process 30.6667 5 no
GO:0010647 positive regulation of cell communication 30.6667 5 no
GO:0023056 positive regulation of signaling 30.6667 4 no
GO:0043933 protein-containing complex organization 29.3333 4 yes
GO:0071310 cellular response to organic substance 29.3333 4 no
GO:0042981 regulation of apoptotic process 29.3333 5 no
GO:0043067 regulation of programmed cell death 29.3333 4 no
GO:0019220 regulation of phosphate metabolic process 29.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 29.3333 5 no
GO:0036211 protein modification process 28.0000 4 yes
GO:0043412 macromolecule modification 28.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 28.0000 5 yes
GO:0051130 positive regulation of cellular component organization 26.6667 5 no
GO:0009967 positive regulation of signal transduction 26.6667 5 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0006796 phosphate-containing compound metabolic process 25.3333 4 yes
GO:0006355 regulation of DNA-templated transcription 25.3333 7 no
GO:0030030 cell projection organization 25.3333 4 no
GO:0051252 regulation of RNA metabolic process 25.3333 5 no
GO:0080134 regulation of response to stress 25.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 25.3333 6 no
GO:0031399 regulation of protein modification process 25.3333 6 no
GO:1903829 positive regulation of protein localization 25.3333 5 no
GO:0044087 regulation of cellular component biogenesis 24.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 24.0000 5 no
GO:0009890 negative regulation of biosynthetic process 24.0000 5 no
GO:0051050 positive regulation of transport 24.0000 4 no
GO:0070201 regulation of establishment of protein localization 24.0000 6 no
GO:0071702 organic substance transport 24.0000 4 no
GO:0065003 protein-containing complex assembly 22.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 22.6667 6 no
GO:0001932 regulation of protein phosphorylation 22.6667 7 no
GO:0071705 nitrogen compound transport 22.6667 4 no
GO:0009891 positive regulation of biosynthetic process 21.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.3333 6 no
GO:0097435 supramolecular fiber organization 21.3333 4 no
GO:0009894 regulation of catabolic process 21.3333 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.3333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.3333 6 no
GO:0090304 nucleic acid metabolic process 21.3333 4 no
GO:0010243 response to organonitrogen compound 21.3333 4 no
GO:0051240 positive regulation of multicellular organismal process 21.3333 4 no
GO:0010648 negative regulation of cell communication 20.0000 5 yes
GO:0023057 negative regulation of signaling 20.0000 4 yes
GO:0006468 protein phosphorylation 17.3333 5 yes
GO:0009968 negative regulation of signal transduction 17.3333 5 yes
GO:0016310 phosphorylation 17.3333 5 yes
GO:0030162 regulation of proteolysis 17.3333 6 yes
GO:0048585 negative regulation of response to stimulus 17.3333 4 yes
GO:1902532 negative regulation of intracellular signal transduction 9.3333 6 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 6.6667 4 yes
GO:0001843 neural tube closure 4.0000 5 yes
GO:0032006 regulation of TOR signaling 4.0000 6 yes
GO:0032007 negative regulation of TOR signaling 4.0000 7 yes
GO:0060606 tube closure 4.0000 4 yes
GO:1903432 regulation of TORC1 signaling 4.0000 7 yes
GO:1904262 negative regulation of TORC1 signaling 4.0000 8 yes
GO:0003091 renal water homeostasis 2.6667 4 yes
GO:0008589 regulation of smoothened signaling pathway 2.6667 5 yes
GO:0010737 protein kinase A signaling 2.6667 4 yes
GO:0034380 high-density lipoprotein particle assembly 2.6667 4 yes
GO:0045879 negative regulation of smoothened signaling pathway 2.6667 6 yes
GO:0050891 multicellular organismal-level water homeostasis 2.6667 4 yes
GO:0065005 protein-lipid complex assembly 2.6667 6 yes
GO:0070613 regulation of protein processing 2.6667 7 yes
GO:0071825 protein-lipid complex organization 2.6667 5 yes
GO:1903317 regulation of protein maturation 2.6667 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RN216_HUMAN [view entry] [view interactions] Low throughput yes yes
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
STP1_HUMAN [view interactions] Low throughput no no
STP2_HUMAN [view interactions] Low throughput no no
KAP0_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
RCAN1_HUMAN [view interactions] Low throughput no yes
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
P73_HUMAN [view interactions] Low throughput no no
MAVS_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
RA51B_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
SULF2_HUMAN [view interactions] High throughput no yes
ZN641_HUMAN [view interactions] High throughput no yes
CEP57_HUMAN [view interactions] High throughput no yes
CARF_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
COR1A_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
NHEJ1_HUMAN [view interactions] High throughput no yes
AKAP8_HUMAN [view interactions] High throughput no yes
AKP8L_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
DDX23_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
DDX56_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
NOP53_HUMAN [view interactions] High throughput no yes
H2AV_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
H2A1A_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
H2B1A_HUMAN [view interactions] High throughput no no
H2B1B_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
H2A2A_HUMAN [view interactions] High throughput no yes
H32_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
MD1L1_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
NONO_HUMAN [view interactions] High throughput no yes
RPB2_HUMAN [view interactions] High throughput no yes
RPB3_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
RBP2_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
TOP1_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
RRP1B_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
KBP_HUMAN [view interactions] High throughput no yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ARC1B_HUMAN [view interactions] High throughput no no
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
PFD1_HUMAN [view interactions] High throughput no yes
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
PRPK_HUMAN [view interactions] High throughput no yes
TPRKB_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
RPE_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
NIN_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
IQCB1_HUMAN [view interactions] High throughput no no
CEP43_HUMAN [view interactions] High throughput no no
C170L_HUMAN [view entry] [view interactions] High throughput yes no
AKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
SMN_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
SCO2_HUMAN [view interactions] High throughput no no
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
FGOP2_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
PRKX_HUMAN [view interactions] High throughput no yes
CEP68_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA3_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MOONR_HUMAN [view interactions] High throughput no yes
CEP72_HUMAN [view interactions] High throughput no yes
AKA11_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
OFD1_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
CCD77_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSPP1_HUMAN [view interactions] High throughput no no
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS1_HUMAN [view interactions] High throughput no yes
BAD_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
H2B1H_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
NUAK1_HUMAN [view interactions] High throughput no no
MYL1_HUMAN [view interactions] High throughput no no
MYH1_HUMAN [view interactions] High throughput no no
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
GP161_HUMAN [view interactions] High throughput no yes
DDX11_HUMAN [view interactions] High throughput no yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
SMAKA_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
AKA7G_HUMAN [view interactions] High throughput no yes
MYH2_HUMAN [view interactions] High throughput no yes
IPKG_HUMAN [view interactions] High throughput no yes
PLAK2_HUMAN [view interactions] High throughput no no
MYH4_HUMAN [view interactions] High throughput no no
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
ARFG1_HUMAN [view interactions] High throughput no no
ACV1B_HUMAN [view interactions] High throughput no no
APBP2_HUMAN [view interactions] High throughput no yes
AVPI1_HUMAN [view entry] [view interactions] High throughput yes yes
IPKA_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
PITX2_HUMAN [view interactions] High throughput no no
PEBB_HUMAN [view interactions] High throughput no no
OSTP_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
PER1_HUMAN [view interactions] High throughput no no
TALDO_HUMAN [view entry] [view interactions] High throughput yes no
PGTB2_HUMAN [view interactions] High throughput no yes
CSTP1_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
DCR1C_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
AKA28_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
AKP13_HUMAN [view interactions] High throughput no yes
CP131_HUMAN [view interactions] High throughput no no
TBC31_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
FKBP5_HUMAN [view interactions] High throughput no yes
BMP1_HUMAN [view interactions] High throughput no yes
RT15_HUMAN [view interactions] High throughput no yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
NPAS1_HUMAN [view interactions] High throughput no no
DFFB_HUMAN [view interactions] High throughput no yes
RPGF5_HUMAN [view interactions] High throughput no yes
KLH28_HUMAN [view interactions] High throughput no no
DNA2_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
RHG36_HUMAN [view interactions] High throughput no yes
HPT_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
H12_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
MAP10_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
NAA11_HUMAN [view interactions] High throughput no no
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
CCD96_HUMAN [view interactions] High throughput no no
TIMP3_HUMAN [view interactions] High throughput no no
CR3L3_HUMAN [view interactions] High throughput no no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
FGF14_HUMAN [view interactions] High throughput no no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes