Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MYH6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Muscle contraction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
795 Arg Gln Cardiomyopathy,familialhypertrophic14(CMH14) -
820 Ile Asn Atrialseptaldefect3(ASD3) -
830 Pro Leu Cardiomyopathy,dilated1EE(CMD1EE) -
1004 Ala Ser Cardiomyopathy,dilated1EE(CMD1EE) -
1065 Gln His Cardiomyopathy,familialhypertrophic14(CMH14) -
1457 Glu Lys Cardiomyopathy,dilated1EE(CMD1EE) -
721 Arg Trp Sicksinussyndrome3(SSS3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MYH6_HUMAN
GO:0003779 actin binding 45.4545 4 yes
GO:0017076 purine nucleotide binding 40.9091 4 yes
GO:0030554 adenyl nucleotide binding 40.9091 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.3636 4 yes
GO:0046872 metal ion binding 36.3636 4 no
GO:0005524 ATP binding 36.3636 5 yes
GO:0032555 purine ribonucleotide binding 36.3636 4 yes
GO:0032559 adenyl ribonucleotide binding 36.3636 5 yes
GO:0019900 kinase binding 18.1818 4 yes
GO:0019901 protein kinase binding 18.1818 5 yes
GO:0042578 phosphoric ester hydrolase activity 13.6364 4 yes
GO:0004722 protein serine/threonine phosphatase activity 13.6364 4 yes
GO:0016791 phosphatase activity 13.6364 5 yes
GO:0017018 myosin phosphatase activity 9.0909 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MYH6_HUMAN
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.4545 4 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0009893 positive regulation of metabolic process 40.9091 4 no
GO:0006936 muscle contraction 36.3636 4 yes
GO:0051246 regulation of protein metabolic process 36.3636 5 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0006996 organelle organization 31.8182 4 yes
GO:0010468 regulation of gene expression 31.8182 5 no
GO:0031325 positive regulation of cellular metabolic process 31.8182 5 no
GO:0051049 regulation of transport 31.8182 4 no
GO:0022603 regulation of anatomical structure morphogenesis 31.8182 4 no
GO:0007010 cytoskeleton organization 27.2727 5 yes
GO:0022607 cellular component assembly 27.2727 4 yes
GO:0031032 actomyosin structure organization 27.2727 4 yes
GO:0008104 protein localization 27.2727 4 no
GO:0009894 regulation of catabolic process 27.2727 4 no
GO:0071310 cellular response to organic substance 27.2727 4 no
GO:0006796 phosphate-containing compound metabolic process 22.7273 4 yes
GO:0006941 striated muscle contraction 22.7273 5 yes
GO:0060048 cardiac muscle contraction 22.7273 6 yes
GO:0009966 regulation of signal transduction 22.7273 4 no
GO:0010646 regulation of cell communication 22.7273 4 no
GO:0009889 regulation of biosynthetic process 22.7273 4 no
GO:0015031 protein transport 22.7273 4 no
GO:0023056 positive regulation of signaling 22.7273 4 no
GO:0031326 regulation of cellular biosynthetic process 22.7273 5 no
GO:0071702 organic substance transport 22.7273 4 no
GO:0071705 nitrogen compound transport 22.7273 4 no
GO:0022604 regulation of cell morphogenesis 22.7273 5 no
GO:0051130 positive regulation of cellular component organization 22.7273 5 no
GO:0051240 positive regulation of multicellular organismal process 22.7273 4 no
GO:0030030 cell projection organization 22.7273 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.7273 5 no
GO:0010604 positive regulation of macromolecule metabolic process 22.7273 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.7273 5 no
GO:0008016 regulation of heart contraction 18.1818 6 yes
GO:0030049 muscle filament sliding 18.1818 6 yes
GO:0033275 actin-myosin filament sliding 18.1818 5 yes
GO:0044057 regulation of system process 18.1818 4 yes
GO:0045214 sarcomere organization 18.1818 5 yes
GO:0070252 actin-mediated cell contraction 18.1818 4 yes
GO:0097435 supramolecular fiber organization 18.1818 4 yes
GO:1903522 regulation of blood circulation 18.1818 5 yes
GO:2000026 regulation of multicellular organismal development 18.1818 4 yes
GO:0001701 in utero embryonic development 13.6364 6 yes
GO:0007507 heart development 13.6364 4 yes
GO:0009792 embryo development ending in birth or egg hatching 13.6364 4 yes
GO:0043009 chordate embryonic development 13.6364 5 yes
GO:0055001 muscle cell development 13.6364 4 yes
GO:0055006 cardiac cell development 13.6364 4 yes
GO:0055008 cardiac muscle tissue morphogenesis 13.6364 5 yes
GO:0055010 ventricular cardiac muscle tissue morphogenesis 13.6364 6 yes
GO:0055013 cardiac muscle cell development 13.6364 5 yes
GO:0060415 muscle tissue morphogenesis 13.6364 4 yes
GO:0070925 organelle assembly 13.6364 5 yes
GO:0003300 cardiac muscle hypertrophy 9.0909 6 yes
GO:0006163 purine nucleotide metabolic process 9.0909 5 yes
GO:0006753 nucleoside phosphate metabolic process 9.0909 4 yes
GO:0007512 adult heart development 9.0909 5 yes
GO:0007517 muscle organ development 9.0909 4 yes
GO:0007522 visceral muscle development 9.0909 5 yes
GO:0009117 nucleotide metabolic process 9.0909 5 yes
GO:0009141 nucleoside triphosphate metabolic process 9.0909 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 9.0909 6 yes
GO:0009150 purine ribonucleotide metabolic process 9.0909 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 9.0909 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 9.0909 7 yes
GO:0009259 ribonucleotide metabolic process 9.0909 5 yes
GO:0014887 cardiac muscle adaptation 9.0909 4 yes
GO:0014896 muscle hypertrophy 9.0909 4 yes
GO:0014897 striated muscle hypertrophy 9.0909 5 yes
GO:0014898 cardiac muscle hypertrophy in response to stress 9.0909 4 yes
GO:0019693 ribose phosphate metabolic process 9.0909 4 yes
GO:0030239 myofibril assembly 9.0909 4 yes
GO:0046034 ATP metabolic process 9.0909 7 yes
GO:0046620 regulation of organ growth 9.0909 4 yes
GO:0048638 regulation of developmental growth 9.0909 4 yes
GO:0055009 atrial cardiac muscle tissue morphogenesis 9.0909 6 yes
GO:0060420 regulation of heart growth 9.0909 5 yes
GO:0072521 purine-containing compound metabolic process 9.0909 4 yes
GO:0140694 non-membrane-bounded organelle assembly 9.0909 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in MYH6_HUMAN
DOID:0050700 cardiomyopathy 22.7273 4 yes
DOID:0060036 intrinsic cardiomyopathy 22.7273 5 yes
DOID:114 heart disease 22.7273 3 yes
DOID:12930 dilated cardiomyopathy 22.7273 6 yes
DOID:0080326 familial hypertrophic cardiomyopathy 13.6364 7 yes
DOID:11984 hypertrophic cardiomyopathy 13.6364 6 yes
DOID:0110108 atrial heart septal defect 3 9.0909 7 yes
DOID:0110320 hypertrophic cardiomyopathy 14 9.0909 8 yes
DOID:0110453 dilated cardiomyopathy 1EE 9.0909 7 yes
DOID:1681 heart septal defect 9.0909 5 yes
DOID:1682 congenital heart disease 9.0909 4 yes
DOID:1882 atrial heart septal defect 9.0909 6 yes
DOID:0080000 muscular disease 9.0909 3 no
DOID:423 myopathy 9.0909 5 no
DOID:66 muscle tissue disease 9.0909 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYPC3_HUMAN [view interactions] Low throughput no no
LRC39_HUMAN [view interactions] Low throughput no no
PKHG5_HUMAN [view interactions] Low throughput no yes
MYH6_HUMAN [view entry] [view interactions] Low throughput yes no
OPTN_HUMAN [view interactions] Low throughput no yes
BAG3_HUMAN [view entry] [view interactions] Low throughput yes no
RPB1_HUMAN [view interactions] Low throughput no no
CACO2_HUMAN [view interactions] Low throughput no yes
CACO1_HUMAN [view entry] [view interactions] Low throughput yes yes
ESR1_HUMAN [view interactions] Low throughput no no
TRI63_HUMAN [view interactions] Low throughput no no
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
TRIPB_HUMAN [view interactions] High throughput no yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
COPE_HUMAN [view interactions] High throughput no yes
PIGS_HUMAN [view interactions] High throughput no yes
UMPS_HUMAN [view interactions] High throughput no no
DOCK6_HUMAN [view interactions] High throughput no yes
SPICE_HUMAN [view interactions] High throughput no yes
GANP_HUMAN [view interactions] High throughput no yes
TYB4_HUMAN [view interactions] High throughput no yes
UBP24_HUMAN [view interactions] High throughput no yes
FBX31_HUMAN [view entry] [view interactions] High throughput yes yes
T132A_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
MBB1A_HUMAN [view interactions] High throughput no yes
EDRF1_HUMAN [view interactions] High throughput no no
HMGN1_HUMAN [view interactions] High throughput no yes
IPIL2_HUMAN [view interactions] High throughput no no
SPT2_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
AAKG2_HUMAN [view interactions] High throughput no yes
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
SMYD2_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
FBX32_HUMAN [view interactions] High throughput no no
MBP_HUMAN [view entry] [view interactions] High throughput yes no
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
ELOC_HUMAN [view interactions] High throughput no no
DCAF1_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
BDP1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
TRIM6_HUMAN [view interactions] High throughput no no
LZTR1_HUMAN [view interactions] High throughput no no
MYH3_HUMAN [view interactions] High throughput no no
ABTB2_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
TNNI1_HUMAN [view interactions] High throughput no no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
ANF_HUMAN [view interactions] Computational no no
MYL5_HUMAN [view interactions] Computational no no
MYOG_HUMAN [view interactions] Computational no no
MYH10_HUMAN [view entry] [view interactions] Computational yes yes
ML12A_HUMAN [view interactions] Computational no no
MYH9_HUMAN [view entry] [view interactions] Computational yes no
MLRA_HUMAN [view interactions] Computational no no
TELT_HUMAN [view interactions] Computational no no
TNNI2_HUMAN [view interactions] Computational no no
MYH7_HUMAN [view interactions] Computational no no
MYL6B_HUMAN [view entry] [view interactions] Computational yes no
TNNC1_HUMAN [view interactions] Computational no no
TNNT3_HUMAN [view interactions] Computational no no
ACTS_HUMAN [view interactions] Computational no no
MYL9_HUMAN [view interactions] Computational no no
GATA4_HUMAN [view interactions] Computational no no
MLRS_HUMAN [view interactions] Computational no no
ACTC_HUMAN [view interactions] Computational no no
ML12B_HUMAN [view interactions] Computational no no
TNNT1_HUMAN [view interactions] Computational no no
TNNI3_HUMAN [view interactions] Computational no no
MYL1_HUMAN [view interactions] Computational no no
MYH2_HUMAN [view interactions] Computational no yes
NKX25_HUMAN [view interactions] Computational no no
MLRV_HUMAN [view interactions] Computational no no
TNNT2_HUMAN [view interactions] Computational no no
MYL4_HUMAN [view entry] [view interactions] Computational yes no
TNNC2_HUMAN [view interactions] Computational no no
MYL3_HUMAN [view interactions] Computational no no
MYOD1_HUMAN [view interactions] Computational no no
MYH8_HUMAN [view interactions] Computational no no
MYH1_HUMAN [view interactions] Computational no no
MYH13_HUMAN [view interactions] Computational no no