Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MYH6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Muscle contraction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
795 Arg Gln Cardiomyopathy,familialhypertrophic,14(CMH14) -
820 Ile Asn Atrialseptaldefect3(ASD3) -
830 Pro Leu Cardiomyopathy,dilated,1EE(CMD1EE) -
1004 Ala Ser Cardiomyopathy,dilated,1EE(CMD1EE) -
1065 Gln His Cardiomyopathy,familialhypertrophic,14(CMH14) -
1457 Glu Lys Cardiomyopathy,dilated,1EE(CMD1EE) -
721 Arg Trp Sicksinussyndrome3(SSS3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MYH6_HUMAN
GO:0043168 anion binding 40.0000 4 yes
GO:0000166 nucleotide binding 35.0000 4 yes
GO:0003779 actin binding 35.0000 4 yes
GO:0005524 ATP binding 35.0000 5 yes
GO:0017076 purine nucleotide binding 35.0000 5 yes
GO:0030554 adenyl nucleotide binding 35.0000 6 yes
GO:0032555 purine ribonucleotide binding 35.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 35.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.0000 4 yes
GO:0043169 cation binding 35.0000 4 no
GO:0046872 metal ion binding 35.0000 5 no
GO:0019900 kinase binding 30.0000 4 yes
GO:0019901 protein kinase binding 30.0000 5 yes
GO:0004722 protein serine/threonine phosphatase activity 15.0000 4 yes
GO:0016791 phosphatase activity 15.0000 5 yes
GO:0017018 myosin phosphatase activity 15.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 15.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MYH6_HUMAN
GO:0048522 positive regulation of cellular process 70.0000 4 no
GO:0048523 negative regulation of cellular process 55.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 45.0000 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 35.0000 4 yes
GO:0006996 organelle organization 35.0000 4 yes
GO:0009889 regulation of biosynthetic process 35.0000 4 no
GO:0009966 regulation of signal transduction 35.0000 4 no
GO:0010646 regulation of cell communication 35.0000 4 no
GO:0009894 regulation of catabolic process 35.0000 4 no
GO:0051128 regulation of cellular component organization 35.0000 4 no
GO:0008104 protein localization 35.0000 4 no
GO:0022607 cellular component assembly 30.0000 4 yes
GO:0010468 regulation of gene expression 30.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 no
GO:0071310 cellular response to organic substance 30.0000 4 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 no
GO:0006936 muscle contraction 25.0000 4 yes
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0006941 striated muscle contraction 20.0000 5 yes
GO:0007507 heart development 20.0000 4 yes
GO:0031032 actomyosin structure organization 20.0000 4 yes
GO:0044057 regulation of system process 20.0000 4 yes
GO:0045214 sarcomere organization 20.0000 5 yes
GO:0060048 cardiac muscle contraction 20.0000 6 yes
GO:0097435 supramolecular fiber organization 20.0000 4 yes
GO:0001701 in utero embryonic development 15.0000 6 yes
GO:0007512 adult heart development 15.0000 5 yes
GO:0008016 regulation of heart contraction 15.0000 6 yes
GO:0009792 embryo development ending in birth or egg hatching 15.0000 4 yes
GO:0030049 muscle filament sliding 15.0000 6 yes
GO:0033275 actin-myosin filament sliding 15.0000 5 yes
GO:0043009 chordate embryonic development 15.0000 5 yes
GO:0046620 regulation of organ growth 15.0000 4 yes
GO:0048638 regulation of developmental growth 15.0000 4 yes
GO:0055001 muscle cell development 15.0000 4 yes
GO:0055006 cardiac cell development 15.0000 4 yes
GO:0055008 cardiac muscle tissue morphogenesis 15.0000 5 yes
GO:0055010 ventricular cardiac muscle tissue morphogenesis 15.0000 6 yes
GO:0055013 cardiac muscle cell development 15.0000 5 yes
GO:0060415 muscle tissue morphogenesis 15.0000 4 yes
GO:0070252 actin-mediated cell contraction 15.0000 4 yes
GO:0070925 organelle assembly 15.0000 5 yes
GO:1903522 regulation of blood circulation 15.0000 5 yes
GO:2000026 regulation of multicellular organismal development 15.0000 4 yes
GO:0003300 cardiac muscle hypertrophy 10.0000 6 yes
GO:0006163 purine nucleotide metabolic process 10.0000 5 yes
GO:0006753 nucleoside phosphate metabolic process 10.0000 4 yes
GO:0007517 muscle organ development 10.0000 4 yes
GO:0007522 visceral muscle development 10.0000 5 yes
GO:0009117 nucleotide metabolic process 10.0000 5 yes
GO:0009141 nucleoside triphosphate metabolic process 10.0000 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 10.0000 6 yes
GO:0009150 purine ribonucleotide metabolic process 10.0000 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 10.0000 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 10.0000 7 yes
GO:0009259 ribonucleotide metabolic process 10.0000 5 yes
GO:0014887 cardiac muscle adaptation 10.0000 4 yes
GO:0014896 muscle hypertrophy 10.0000 4 yes
GO:0014897 striated muscle hypertrophy 10.0000 5 yes
GO:0014898 cardiac muscle hypertrophy in response to stress 10.0000 4 yes
GO:0019693 ribose phosphate metabolic process 10.0000 4 yes
GO:0030239 myofibril assembly 10.0000 4 yes
GO:0046034 ATP metabolic process 10.0000 7 yes
GO:0055009 atrial cardiac muscle tissue morphogenesis 10.0000 6 yes
GO:0060420 regulation of heart growth 10.0000 5 yes
GO:0072521 purine-containing compound metabolic process 10.0000 4 yes
GO:0140694 non-membrane-bounded organelle assembly 10.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYPC3_HUMAN [view interactions] Low throughput no no
LRC39_HUMAN [view interactions] Low throughput no no
PKHG5_HUMAN [view interactions] Low throughput no yes
MYH6_HUMAN [view entry] [view interactions] Low throughput yes no
OPTN_HUMAN [view interactions] Low throughput no yes
BAG3_HUMAN [view entry] [view interactions] Low throughput yes no
RPB1_HUMAN [view interactions] Low throughput no no
CACO2_HUMAN [view interactions] Low throughput no yes
CACO1_HUMAN [view entry] [view interactions] Low throughput yes yes
ESR1_HUMAN [view interactions] Low throughput no no
TRI63_HUMAN [view interactions] Low throughput no no
NEUL2_HUMAN [view interactions] Low throughput no yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
FBX31_HUMAN [view entry] [view interactions] High throughput yes yes
UBP24_HUMAN [view interactions] High throughput no yes
TYB4_HUMAN [view interactions] High throughput no yes
GANP_HUMAN [view interactions] High throughput no yes
SPICE_HUMAN [view interactions] High throughput no yes
DOCK6_HUMAN [view interactions] High throughput no yes
UMPS_HUMAN [view interactions] High throughput no no
PIGS_HUMAN [view interactions] High throughput no yes
COPE_HUMAN [view interactions] High throughput no yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
TRIPB_HUMAN [view interactions] High throughput no yes
T132A_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
SPT2_HUMAN [view interactions] High throughput no yes
IPIL2_HUMAN [view interactions] High throughput no no
HMGN1_HUMAN [view interactions] High throughput no yes
EDRF1_HUMAN [view interactions] High throughput no no
MBB1A_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
AAKG2_HUMAN [view interactions] High throughput no yes
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
SMYD2_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
MBP_HUMAN [view entry] [view interactions] High throughput yes no
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
ELOC_HUMAN [view interactions] High throughput no no
DCAF1_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
BDP1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
TRIM6_HUMAN [view interactions] High throughput no no
LZTR1_HUMAN [view interactions] High throughput no no
MYH3_HUMAN [view interactions] High throughput no no
ABTB2_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
FOXA1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
MSX2_HUMAN [view interactions] High throughput no no
CDK3_HUMAN [view interactions] High throughput no no
STK3_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
TNNI1_HUMAN [view interactions] High throughput no no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes