Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KPCE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002989 LIG_14-3-3_CanoR_1 LIG 343 348 -
ELMI003043 LIG_14-3-3_CanoR_1 LIG 364 370 -
ELMI002989 LIG_14-3-3_CanoR_1 LIG 343 348 -
ELMI003043 LIG_14-3-3_CanoR_1 LIG 364 370 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KPCE_HUMAN
GO:0043168 anion binding 37.5000 4 yes
GO:0000166 nucleotide binding 34.1667 4 yes
GO:0017076 purine nucleotide binding 34.1667 5 yes
GO:0003723 RNA binding 32.5000 4 no
GO:0030554 adenyl nucleotide binding 31.6667 6 yes
GO:0032555 purine ribonucleotide binding 30.8333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 yes
GO:0043169 cation binding 30.0000 4 yes
GO:0046872 metal ion binding 29.1667 5 yes
GO:0032559 adenyl ribonucleotide binding 28.3333 5 yes
GO:0019900 kinase binding 28.3333 4 no
GO:0005524 ATP binding 27.5000 5 yes
GO:0019901 protein kinase binding 27.5000 5 no
GO:0016301 kinase activity 17.5000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.5000 4 yes
GO:0003779 actin binding 15.8333 4 yes
GO:0004674 protein serine/threonine kinase activity 15.0000 4 yes
GO:0106310 protein serine kinase activity 14.1667 4 yes
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6.6667 5 yes
GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2.5000 6 yes
GO:0003785 actin monomer binding 1.6667 5 yes
GO:0035276 ethanol binding 1.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KPCE_HUMAN
GO:0048523 negative regulation of cellular process 61.6667 4 yes
GO:0048522 positive regulation of cellular process 60.8333 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.6667 4 yes
GO:0031323 regulation of cellular metabolic process 56.6667 4 yes
GO:0080090 regulation of primary metabolic process 55.0000 4 yes
GO:0051128 regulation of cellular component organization 53.3333 4 yes
GO:0006996 organelle organization 47.5000 4 no
GO:0009893 positive regulation of metabolic process 45.8333 4 yes
GO:0010646 regulation of cell communication 45.0000 4 yes
GO:0051246 regulation of protein metabolic process 43.3333 5 yes
GO:0009889 regulation of biosynthetic process 43.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 43.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 43.3333 5 no
GO:0009966 regulation of signal transduction 43.3333 4 yes
GO:0010468 regulation of gene expression 40.8333 6 no
GO:0031325 positive regulation of cellular metabolic process 40.8333 5 yes
GO:0048584 positive regulation of response to stimulus 40.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0051049 regulation of transport 39.1667 4 yes
GO:0009892 negative regulation of metabolic process 39.1667 4 yes
GO:0022607 cellular component assembly 37.5000 4 no
GO:0042981 regulation of apoptotic process 36.6667 5 no
GO:0043067 regulation of programmed cell death 36.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.8333 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 34.1667 4 yes
GO:0033043 regulation of organelle organization 32.5000 5 yes
GO:1902531 regulation of intracellular signal transduction 31.6667 5 yes
GO:0009891 positive regulation of biosynthetic process 31.6667 5 no
GO:0031328 positive regulation of cellular biosynthetic process 31.6667 6 no
GO:0008104 protein localization 31.6667 4 yes
GO:0023056 positive regulation of signaling 31.6667 4 yes
GO:0010647 positive regulation of cell communication 30.8333 5 yes
GO:0080134 regulation of response to stress 30.0000 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 30.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 yes
GO:0031399 regulation of protein modification process 30.0000 6 yes
GO:0071310 cellular response to organic substance 29.1667 4 yes
GO:0051252 regulation of RNA metabolic process 29.1667 5 no
GO:0051130 positive regulation of cellular component organization 28.3333 5 yes
GO:0060341 regulation of cellular localization 28.3333 4 yes
GO:0051247 positive regulation of protein metabolic process 28.3333 6 no
GO:0009967 positive regulation of signal transduction 28.3333 5 yes
GO:0043412 macromolecule modification 27.5000 4 yes
GO:0044087 regulation of cellular component biogenesis 27.5000 4 yes
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 yes
GO:0007010 cytoskeleton organization 26.6667 5 no
GO:0043066 negative regulation of apoptotic process 26.6667 6 no
GO:0043069 negative regulation of programmed cell death 26.6667 5 no
GO:0019220 regulation of phosphate metabolic process 26.6667 6 yes
GO:0036211 protein modification process 26.6667 4 yes
GO:0045595 regulation of cell differentiation 25.8333 4 no
GO:0048585 negative regulation of response to stimulus 25.8333 4 no
GO:0009894 regulation of catabolic process 25.8333 4 yes
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 24.1667 6 yes
GO:0010648 negative regulation of cell communication 24.1667 5 no
GO:0002684 positive regulation of immune system process 24.1667 4 yes
GO:0023057 negative regulation of signaling 24.1667 4 no
GO:0043085 positive regulation of catalytic activity 24.1667 4 no
GO:0042325 regulation of phosphorylation 24.1667 7 yes
GO:0043933 protein-containing complex organization 23.3333 4 no
GO:0010628 positive regulation of gene expression 23.3333 7 no
GO:0051338 regulation of transferase activity 23.3333 4 no
GO:0032101 regulation of response to external stimulus 23.3333 4 yes
GO:0032880 regulation of protein localization 23.3333 5 yes
GO:0071702 organic substance transport 22.5000 4 yes
GO:0001932 regulation of protein phosphorylation 22.5000 7 yes
GO:0009968 negative regulation of signal transduction 22.5000 5 no
GO:0051129 negative regulation of cellular component organization 22.5000 5 no
GO:0051050 positive regulation of transport 21.6667 4 yes
GO:0071705 nitrogen compound transport 21.6667 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 21.6667 4 no
GO:0010243 response to organonitrogen compound 21.6667 4 yes
GO:1901701 cellular response to oxygen-containing compound 20.8333 4 yes
GO:0010638 positive regulation of organelle organization 20.8333 6 yes
GO:0050776 regulation of immune response 20.0000 4 yes
GO:0051493 regulation of cytoskeleton organization 20.0000 6 yes
GO:1902533 positive regulation of intracellular signal transduction 20.0000 6 yes
GO:2000145 regulation of cell motility 20.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 19.1667 5 yes
GO:0099177 regulation of trans-synaptic signaling 19.1667 4 yes
GO:0141124 intracellular signaling cassette 19.1667 4 yes
GO:1902903 regulation of supramolecular fiber organization 19.1667 5 yes
GO:0006468 protein phosphorylation 19.1667 5 yes
GO:0016310 phosphorylation 19.1667 5 yes
GO:0030334 regulation of cell migration 19.1667 5 yes
GO:0034762 regulation of transmembrane transport 19.1667 4 yes
GO:0006915 apoptotic process 18.3333 4 yes
GO:0043254 regulation of protein-containing complex assembly 17.5000 5 yes
GO:0043408 regulation of MAPK cascade 17.5000 6 yes
GO:0050778 positive regulation of immune response 17.5000 5 yes
GO:0014070 response to organic cyclic compound 17.5000 4 yes
GO:0031400 negative regulation of protein modification process 17.5000 7 yes
GO:0031347 regulation of defense response 16.6667 5 yes
GO:0032103 positive regulation of response to external stimulus 16.6667 5 yes
GO:0015031 protein transport 15.8333 4 yes
GO:1903829 positive regulation of protein localization 15.0000 5 yes
GO:0030155 regulation of cell adhesion 15.0000 4 yes
GO:0043269 regulation of monoatomic ion transport 14.1667 5 yes
GO:0051051 negative regulation of transport 14.1667 4 yes
GO:2000147 positive regulation of cell motility 14.1667 5 yes
GO:0002831 regulation of response to biotic stimulus 14.1667 4 yes
GO:0009896 positive regulation of catabolic process 14.1667 5 yes
GO:0030335 positive regulation of cell migration 14.1667 6 yes
GO:0032970 regulation of actin filament-based process 14.1667 4 yes
GO:0033993 response to lipid 14.1667 4 yes
GO:0040017 positive regulation of locomotion 14.1667 4 yes
GO:0044089 positive regulation of cellular component biogenesis 13.3333 5 yes
GO:0045785 positive regulation of cell adhesion 13.3333 5 yes
GO:0018193 peptidyl-amino acid modification 13.3333 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 13.3333 5 yes
GO:0070201 regulation of establishment of protein localization 12.5000 6 yes
GO:0032271 regulation of protein polymerization 12.5000 6 yes
GO:0032956 regulation of actin cytoskeleton organization 12.5000 5 yes
GO:0043410 positive regulation of MAPK cascade 11.6667 7 yes
GO:0045088 regulation of innate immune response 11.6667 5 yes
GO:0051223 regulation of protein transport 11.6667 5 yes
GO:0110053 regulation of actin filament organization 11.6667 6 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 11.6667 6 yes
GO:0032870 cellular response to hormone stimulus 11.6667 4 yes
GO:0050806 positive regulation of synaptic transmission 10.8333 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 10.8333 6 yes
GO:0010959 regulation of metal ion transport 10.8333 6 yes
GO:0031349 positive regulation of defense response 10.8333 5 yes
GO:0051046 regulation of secretion 10.0000 5 yes
GO:0051495 positive regulation of cytoskeleton organization 10.0000 7 yes
GO:0051726 regulation of cell cycle 10.0000 4 yes
GO:0071396 cellular response to lipid 10.0000 5 yes
GO:0098916 anterograde trans-synaptic signaling 10.0000 6 yes
GO:0099536 synaptic signaling 10.0000 4 yes
GO:0099537 trans-synaptic signaling 10.0000 5 yes
GO:1901873 regulation of post-translational protein modification 10.0000 7 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 10.0000 8 yes
GO:1903530 regulation of secretion by cell 10.0000 4 yes
GO:0007268 chemical synaptic transmission 10.0000 7 yes
GO:0022898 regulation of transmembrane transporter activity 10.0000 4 yes
GO:0031396 regulation of protein ubiquitination 10.0000 9 yes
GO:0097305 response to alcohol 9.1667 4 yes
GO:0000165 MAPK cascade 9.1667 5 yes
GO:0002833 positive regulation of response to biotic stimulus 9.1667 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 9.1667 6 yes
GO:0032535 regulation of cellular component size 9.1667 4 yes
GO:0045089 positive regulation of innate immune response 8.3333 6 yes
GO:0046903 secretion 8.3333 4 yes
GO:0051222 positive regulation of protein transport 8.3333 5 yes
GO:0051924 regulation of calcium ion transport 8.3333 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 8.3333 7 yes
GO:1904375 regulation of protein localization to cell periphery 8.3333 6 yes
GO:1904951 positive regulation of establishment of protein localization 8.3333 6 yes
GO:1905475 regulation of protein localization to membrane 8.3333 6 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 8.3333 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 8.3333 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 8.3333 5 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 7.5000 6 yes
GO:0062012 regulation of small molecule metabolic process 7.5000 4 yes
GO:1901874 negative regulation of post-translational protein modification 7.5000 8 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 7.5000 9 yes
GO:0008064 regulation of actin polymerization or depolymerization 7.5000 6 yes
GO:0010632 regulation of epithelial cell migration 7.5000 4 yes
GO:0010634 positive regulation of epithelial cell migration 7.5000 5 yes
GO:0018105 peptidyl-serine phosphorylation 7.5000 6 yes
GO:0018209 peptidyl-serine modification 7.5000 6 yes
GO:0030832 regulation of actin filament length 7.5000 5 yes
GO:0031397 negative regulation of protein ubiquitination 7.5000 10 yes
GO:0045471 response to ethanol 6.6667 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 6.6667 8 yes
GO:1903076 regulation of protein localization to plasma membrane 6.6667 7 yes
GO:0006109 regulation of carbohydrate metabolic process 6.6667 5 yes
GO:0010810 regulation of cell-substrate adhesion 6.6667 5 yes
GO:0030833 regulation of actin filament polymerization 6.6667 7 yes
GO:0032273 positive regulation of protein polymerization 6.6667 7 yes
GO:0034763 negative regulation of transmembrane transport 6.6667 5 yes
GO:0036293 response to decreased oxygen levels 6.6667 4 yes
GO:0043271 negative regulation of monoatomic ion transport 5.8333 5 yes
GO:0043279 response to alkaloid 5.8333 5 yes
GO:0046883 regulation of hormone secretion 5.8333 4 yes
GO:0051282 regulation of sequestering of calcium ion 5.8333 4 yes
GO:0062013 positive regulation of small molecule metabolic process 5.8333 5 yes
GO:1903034 regulation of response to wounding 5.8333 5 yes
GO:1904377 positive regulation of protein localization to cell periphery 5.8333 6 yes
GO:1905477 positive regulation of protein localization to membrane 5.8333 6 yes
GO:0010564 regulation of cell cycle process 5.8333 5 yes
GO:0010762 regulation of fibroblast migration 5.8333 6 yes
GO:0038093 Fc receptor signaling pathway 5.8333 5 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 5.0000 7 yes
GO:0045913 positive regulation of carbohydrate metabolic process 5.0000 5 yes
GO:0050708 regulation of protein secretion 5.0000 5 yes
GO:0050796 regulation of insulin secretion 5.0000 6 yes
GO:0051047 positive regulation of secretion 5.0000 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 5.0000 5 yes
GO:0071453 cellular response to oxygen levels 5.0000 4 yes
GO:0090087 regulation of peptide transport 5.0000 5 yes
GO:0090276 regulation of peptide hormone secretion 5.0000 5 yes
GO:1901654 response to ketone 5.0000 4 yes
GO:1903078 positive regulation of protein localization to plasma membrane 5.0000 7 yes
GO:1903532 positive regulation of secretion by cell 5.0000 5 yes
GO:0002758 innate immune response-activating signaling pathway 5.0000 4 yes
GO:0002791 regulation of peptide secretion 5.0000 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 5.0000 6 yes
GO:0019216 regulation of lipid metabolic process 5.0000 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 5.0000 6 yes
GO:0036294 cellular response to decreased oxygen levels 5.0000 5 yes
GO:0038094 Fc-gamma receptor signaling pathway 5.0000 6 yes
GO:0042116 macrophage activation 5.0000 4 yes
GO:0045787 positive regulation of cell cycle 4.1667 5 yes
GO:0045834 positive regulation of lipid metabolic process 4.1667 5 yes
GO:0061041 regulation of wound healing 4.1667 6 yes
GO:0071456 cellular response to hypoxia 4.1667 4 yes
GO:1904063 negative regulation of cation transmembrane transport 4.1667 7 yes
GO:0002221 pattern recognition receptor signaling pathway 4.1667 5 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 4.1667 5 yes
GO:0010763 positive regulation of fibroblast migration 4.1667 7 yes
GO:0023061 signal release 4.1667 4 yes
GO:0031663 lipopolysaccharide-mediated signaling pathway 4.1667 4 yes
GO:0032410 negative regulation of transporter activity 4.1667 4 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 4.1667 4 yes
GO:0046887 positive regulation of hormone secretion 3.3333 5 yes
GO:0050714 positive regulation of protein secretion 3.3333 6 yes
GO:0050994 regulation of lipid catabolic process 3.3333 5 yes
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 3.3333 7 yes
GO:0071692 protein localization to extracellular region 3.3333 5 yes
GO:0090068 positive regulation of cell cycle process 3.3333 6 yes
GO:0090277 positive regulation of peptide hormone secretion 3.3333 6 yes
GO:1901655 cellular response to ketone 3.3333 5 yes
GO:1903036 positive regulation of response to wounding 3.3333 5 yes
GO:0002793 positive regulation of peptide secretion 3.3333 6 yes
GO:0007589 body fluid secretion 3.3333 4 yes
GO:0009306 protein secretion 3.3333 4 yes
GO:0010565 regulation of cellular ketone metabolic process 3.3333 5 yes
GO:0032024 positive regulation of insulin secretion 3.3333 7 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 3.3333 5 yes
GO:0035592 establishment of protein localization to extracellular region 3.3333 4 yes
GO:0035641 locomotory exploration behavior 3.3333 4 yes
GO:0042886 amide transport 2.5000 5 yes
GO:0043278 response to morphine 2.5000 6 yes
GO:0046879 hormone secretion 2.5000 5 yes
GO:0050996 positive regulation of lipid catabolic process 2.5000 6 yes
GO:0051302 regulation of cell division 2.5000 4 yes
GO:0071379 cellular response to prostaglandin stimulus 2.5000 5 yes
GO:0071380 cellular response to prostaglandin E stimulus 2.5000 6 yes
GO:0090303 positive regulation of wound healing 2.5000 6 yes
GO:0097306 cellular response to alcohol 2.5000 5 yes
GO:0002028 regulation of sodium ion transport 2.5000 7 yes
GO:0002220 innate immune response activating cell surface receptor signaling pathway 2.5000 5 yes
GO:0002224 toll-like receptor signaling pathway 2.5000 6 yes
GO:0002790 peptide secretion 2.5000 5 yes
GO:0009914 hormone transport 2.5000 4 yes
GO:0014072 response to isoquinoline alkaloid 2.5000 5 yes
GO:0015833 peptide transport 2.5000 5 yes
GO:0030072 peptide hormone secretion 2.5000 6 yes
GO:0030073 insulin secretion 2.5000 5 yes
GO:0030838 positive regulation of actin filament polymerization 2.5000 7 yes
GO:0034694 response to prostaglandin 2.5000 4 yes
GO:0034695 response to prostaglandin E 2.5000 5 yes
GO:0051781 positive regulation of cell division 1.6667 5 yes
GO:0051932 synaptic transmission, GABAergic 1.6667 8 yes
GO:0070255 regulation of mucus secretion 1.6667 4 yes
GO:0070257 positive regulation of mucus secretion 1.6667 5 yes
GO:0071361 cellular response to ethanol 1.6667 6 yes
GO:0140895 cell surface toll-like receptor signaling pathway 1.6667 7 yes
GO:1902305 regulation of sodium ion transmembrane transport 1.6667 7 yes
GO:1902306 negative regulation of sodium ion transmembrane transport 1.6667 7 yes
GO:2000649 regulation of sodium ion transmembrane transporter activity 1.6667 6 yes
GO:2000650 negative regulation of sodium ion transmembrane transporter activity 1.6667 6 yes
GO:2001029 regulation of cellular glucuronidation 1.6667 6 yes
GO:2001031 positive regulation of cellular glucuronidation 1.6667 6 yes
GO:0002281 macrophage activation involved in immune response 1.6667 4 yes
GO:0002752 cell surface pattern recognition receptor signaling pathway 1.6667 6 yes
GO:0002756 MyD88-independent toll-like receptor signaling pathway 1.6667 7 yes
GO:0010766 negative regulation of sodium ion transport 1.6667 6 yes
GO:0032228 regulation of synaptic transmission, GABAergic 1.6667 6 yes
GO:0032230 positive regulation of synaptic transmission, GABAergic 1.6667 6 yes
GO:0032465 regulation of cytokinesis 1.6667 5 yes
GO:0032467 positive regulation of cytokinesis 1.6667 6 yes
GO:0034142 toll-like receptor 4 signaling pathway 1.6667 8 yes
GO:0035668 TRAM-dependent toll-like receptor signaling pathway 1.6667 8 yes
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway 1.6667 9 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6A2_HUMAN [view interactions] Low throughput no yes
BAX_HUMAN [view interactions] Low throughput no yes
CASR_HUMAN [view interactions] Low throughput no no
KS6B2_HUMAN [view interactions] Low throughput no yes
TYK2_HUMAN [view interactions] Low throughput no no
PECA1_HUMAN [view interactions] Low throughput no no
ATF2_HUMAN [view interactions] Low throughput no yes
UD17_HUMAN [view interactions] Low throughput no no
TCAM2_HUMAN [view interactions] Low throughput no no
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD1_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
HXK2_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
CFTR_HUMAN [view interactions] Low throughput no no
RACK1_HUMAN [view interactions] Low throughput no yes
MYH9_HUMAN [view entry] [view interactions] Low throughput yes no
COPB2_HUMAN [view entry] [view interactions] Low throughput yes yes
K2C1_HUMAN [view interactions] Low throughput no no
ACTS_HUMAN [view interactions] Low throughput no no
PK3CB_HUMAN [view interactions] Low throughput no yes
K2C8_HUMAN [view interactions] Low throughput no no
K1C18_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
KAT5_HUMAN [view interactions] Low throughput no yes
IBTK_HUMAN [view interactions] Low throughput no yes
IRAK1_HUMAN [view interactions] Low throughput no yes
IKKB_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
IL32_HUMAN [view interactions] Low throughput no no
ZBT16_HUMAN [view interactions] Low throughput no yes
BAD_HUMAN [view entry] [view interactions] Low throughput yes yes
BCL6_HUMAN [view interactions] Low throughput no no
TOM20_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAD9A_HUMAN [view interactions] Low throughput no yes
KCNC4_HUMAN [view entry] [view interactions] Low throughput yes no
KPCI_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAP1_HUMAN [view interactions] Low throughput no yes
PP14A_HUMAN [view interactions] Low throughput no yes
GRP3_HUMAN [view interactions] Low throughput no no
DCE2_HUMAN [view interactions] Low throughput no yes
DCE1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADAP1_HUMAN [view interactions] Low throughput no yes
GNA12_HUMAN [view interactions] Low throughput no no
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
H11_HUMAN [view interactions] Low throughput no no
MARK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
MARCS_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
ELAV1_HUMAN [view entry] [view interactions] Low throughput yes yes
NUMB_HUMAN [view entry] [view interactions] Low throughput yes yes
NANOG_HUMAN [view interactions] Low throughput no no
PDLI5_HUMAN [view entry] [view interactions] Low throughput yes no
LDB3_HUMAN [view interactions] Low throughput no no
LIMK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SIN1_HUMAN [view interactions] Low throughput no yes
PDPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
TRFE_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
RGAP1_HUMAN [view interactions] Low throughput no no
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
ADT1_HUMAN [view entry] [view interactions] Low throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
ROAA_HUMAN [view entry] [view interactions] High throughput yes yes
MYH7_HUMAN [view interactions] High throughput no no
HNRDL_HUMAN [view interactions] High throughput no yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
TIAR_HUMAN [view interactions] High throughput no no
CRIP2_HUMAN [view entry] [view interactions] High throughput yes no
C1QA_HUMAN [view entry] [view interactions] High throughput yes no
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
ACO13_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
BPIA2_HUMAN [view interactions] High throughput no no
CYTT_HUMAN [view interactions] High throughput no no
CYTS_HUMAN [view interactions] High throughput no no
PCBP3_HUMAN [view interactions] High throughput no yes
KPCL_HUMAN [view interactions] High throughput no yes
T10B_HUMAN [view interactions] High throughput no yes
AMY1B_HUMAN [view interactions] High throughput no no
AMY1A_HUMAN [view interactions] High throughput no no
AMY1C_HUMAN [view interactions] High throughput no no
PAPOG_HUMAN [view interactions] High throughput no yes
PAUF_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
KPCT_HUMAN [view interactions] High throughput no no
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
TIAM2_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PR15A_HUMAN [view interactions] High throughput no yes
SERC_HUMAN [view interactions] High throughput no yes
TR150_HUMAN [view interactions] High throughput no yes
BCLF1_HUMAN [view interactions] High throughput no yes
NTM1A_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
H90B2_HUMAN [view interactions] High throughput no no
TBB8_HUMAN [view interactions] High throughput no no
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
RCN2_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
DHSO_HUMAN [view interactions] High throughput no no
S25A3_HUMAN [view entry] [view interactions] High throughput yes no
TBB4B_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ILEU_HUMAN [view interactions] High throughput no no
SPI2_HUMAN [view interactions] High throughput no no
SPB8_HUMAN [view interactions] High throughput no no
SPB9_HUMAN [view interactions] High throughput no no
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
PUR9_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
KPRB_HUMAN [view interactions] High throughput no yes
DPP2_HUMAN [view interactions] High throughput no yes
PCKGM_HUMAN [view interactions] High throughput no no
ECH1_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
AMPL_HUMAN [view entry] [view interactions] High throughput yes no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
PAPS1_HUMAN [view interactions] High throughput no yes
ALDR_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
FAK2_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
LAP2A_HUMAN [view interactions] High throughput no yes
DESM_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
MLRV_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
BMX_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
MK14_HUMAN [view interactions] High throughput no yes
MAPK2_HUMAN [view interactions] High throughput no yes
MK08_HUMAN [view interactions] High throughput no yes
MK09_HUMAN [view interactions] High throughput no yes
P3C2A_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
NOS2_HUMAN [view interactions] High throughput no yes
PGH2_HUMAN [view interactions] High throughput no no
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1A_HUMAN [view interactions] High throughput no no
HMOX1_HUMAN [view interactions] High throughput no no
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
NOS3_HUMAN [view interactions] High throughput no no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
IKKA_HUMAN [view interactions] High throughput no yes
SRP54_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
OGFR_HUMAN [view interactions] High throughput no yes
VRK3_HUMAN [view interactions] High throughput no yes
ST32A_HUMAN [view interactions] High throughput no no
TSSK1_HUMAN [view interactions] High throughput no no
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
TNNC1_HUMAN [view interactions] High throughput no no
TNNI3_HUMAN [view interactions] High throughput no no
PCD12_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
CSRP3_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
MYOZ2_HUMAN [view interactions] High throughput no no
FHL2_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
KCRM_HUMAN [view interactions] High throughput no no
DECR_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
SDHB_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
H13_HUMAN [view interactions] High throughput no no