Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KPCA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at Ser-52 facilitating its ubiquitination and proteosomal degradation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KPCA_HUMAN
GO:0043168 anion binding 38.6364 4 yes
GO:0019900 kinase binding 35.6061 4 no
GO:0000166 nucleotide binding 34.0909 4 yes
GO:0017076 purine nucleotide binding 34.0909 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0030554 adenyl nucleotide binding 32.5758 6 yes
GO:0019901 protein kinase binding 32.5758 5 no
GO:0032559 adenyl ribonucleotide binding 31.8182 5 yes
GO:0043169 cation binding 31.0606 4 yes
GO:0046872 metal ion binding 30.3030 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.5455 4 yes
GO:0005524 ATP binding 28.0303 5 yes
GO:0003723 RNA binding 21.2121 4 no
GO:0016301 kinase activity 16.6667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 15.9091 4 yes
GO:0004674 protein serine/threonine kinase activity 14.3939 4 yes
GO:0106310 protein serine kinase activity 14.3939 4 yes
GO:0046914 transition metal ion binding 8.3333 6 yes
GO:0008270 zinc ion binding 7.5758 7 yes
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6.0606 5 yes
GO:0035173 histone kinase activity 3.0303 4 yes
GO:0140996 histone H3 kinase activity 3.0303 5 yes
GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2.2727 6 yes
GO:0009931 calcium-dependent protein serine/threonine kinase activity 2.2727 5 yes
GO:0010857 calcium-dependent protein kinase activity 2.2727 4 yes
GO:0035403 histone H3T6 kinase activity 2.2727 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KPCA_HUMAN
GO:0048522 positive regulation of cellular process 65.1515 4 yes
GO:0048523 negative regulation of cellular process 61.3636 4 yes
GO:0060255 regulation of macromolecule metabolic process 61.3636 4 yes
GO:0031323 regulation of cellular metabolic process 59.0909 4 yes
GO:0010646 regulation of cell communication 56.0606 4 yes
GO:0080090 regulation of primary metabolic process 56.0606 4 yes
GO:0009966 regulation of signal transduction 46.9697 4 yes
GO:0051246 regulation of protein metabolic process 46.2121 5 no
GO:0051049 regulation of transport 43.9394 4 no
GO:0009889 regulation of biosynthetic process 43.1818 4 yes
GO:0031326 regulation of cellular biosynthetic process 42.4242 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 41.6667 5 yes
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0009893 positive regulation of metabolic process 40.9091 4 no
GO:0010468 regulation of gene expression 40.1515 6 yes
GO:0023056 positive regulation of signaling 40.1515 4 yes
GO:0010647 positive regulation of cell communication 39.3939 5 yes
GO:0048584 positive regulation of response to stimulus 39.3939 4 yes
GO:0009892 negative regulation of metabolic process 38.6364 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.6364 5 no
GO:0006996 organelle organization 38.6364 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.1212 5 no
GO:0031325 positive regulation of cellular metabolic process 37.1212 5 no
GO:0022607 cellular component assembly 35.6061 4 yes
GO:1902531 regulation of intracellular signal transduction 34.8485 5 yes
GO:0031399 regulation of protein modification process 34.8485 6 no
GO:0008104 protein localization 34.8485 4 no
GO:0071310 cellular response to organic substance 34.0909 4 no
GO:0031324 negative regulation of cellular metabolic process 32.5758 5 no
GO:0009967 positive regulation of signal transduction 31.0606 5 yes
GO:0019220 regulation of phosphate metabolic process 31.0606 6 no
GO:0051174 regulation of phosphorus metabolic process 31.0606 5 no
GO:0051240 positive regulation of multicellular organismal process 30.3030 4 yes
GO:0060341 regulation of cellular localization 29.5455 4 no
GO:0042325 regulation of phosphorylation 29.5455 7 no
GO:0042981 regulation of apoptotic process 28.7879 5 yes
GO:0043067 regulation of programmed cell death 28.7879 4 yes
GO:0051247 positive regulation of protein metabolic process 28.7879 6 no
GO:0050804 modulation of chemical synaptic transmission 28.0303 5 no
GO:0099177 regulation of trans-synaptic signaling 28.0303 4 no
GO:0001932 regulation of protein phosphorylation 28.0303 7 no
GO:0006796 phosphate-containing compound metabolic process 26.5152 4 yes
GO:0051094 positive regulation of developmental process 26.5152 4 yes
GO:0051248 negative regulation of protein metabolic process 26.5152 6 no
GO:0032880 regulation of protein localization 26.5152 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.7576 5 yes
GO:0010243 response to organonitrogen compound 25.7576 4 no
GO:0009891 positive regulation of biosynthetic process 25.7576 5 no
GO:0033043 regulation of organelle organization 25.7576 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0036211 protein modification process 24.2424 4 yes
GO:0043412 macromolecule modification 24.2424 4 yes
GO:0051050 positive regulation of transport 24.2424 4 no
GO:0045595 regulation of cell differentiation 23.4848 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 23.4848 6 no
GO:0043933 protein-containing complex organization 23.4848 4 no
GO:0051130 positive regulation of cellular component organization 23.4848 5 no
GO:0051338 regulation of transferase activity 23.4848 4 no
GO:0007010 cytoskeleton organization 23.4848 5 no
GO:0009894 regulation of catabolic process 22.7273 4 yes
GO:0043066 negative regulation of apoptotic process 22.7273 6 yes
GO:0043069 negative regulation of programmed cell death 22.7273 5 yes
GO:0010648 negative regulation of cell communication 22.7273 5 no
GO:0023057 negative regulation of signaling 22.7273 4 no
GO:0043085 positive regulation of catalytic activity 22.7273 4 no
GO:0051252 regulation of RNA metabolic process 21.9697 5 yes
GO:0009890 negative regulation of biosynthetic process 21.9697 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.9697 6 no
GO:1901701 cellular response to oxygen-containing compound 21.9697 4 no
GO:2000026 regulation of multicellular organismal development 21.2121 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 21.2121 6 no
GO:0071702 organic substance transport 21.2121 4 no
GO:0042127 regulation of cell population proliferation 20.4545 4 yes
GO:0014070 response to organic cyclic compound 20.4545 4 no
GO:0080134 regulation of response to stress 20.4545 4 no
GO:0048585 negative regulation of response to stimulus 20.4545 4 no
GO:0043549 regulation of kinase activity 20.4545 5 no
GO:0045597 positive regulation of cell differentiation 19.6970 5 yes
GO:0002684 positive regulation of immune system process 18.9394 4 yes
GO:0016310 phosphorylation 18.9394 5 yes
GO:0030334 regulation of cell migration 18.9394 5 yes
GO:1902533 positive regulation of intracellular signal transduction 18.9394 6 yes
GO:2000145 regulation of cell motility 18.9394 4 yes
GO:0060284 regulation of cell development 18.1818 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 17.4242 4 yes
GO:0044057 regulation of system process 17.4242 4 yes
GO:0043408 regulation of MAPK cascade 16.6667 6 yes
GO:0006468 protein phosphorylation 15.9091 5 yes
GO:0030155 regulation of cell adhesion 15.9091 4 yes
GO:0032101 regulation of response to external stimulus 15.9091 4 yes
GO:0034330 cell junction organization 15.9091 4 yes
GO:0010720 positive regulation of cell development 15.1515 6 yes
GO:0044089 positive regulation of cellular component biogenesis 14.3939 5 yes
GO:0061024 membrane organization 14.3939 4 yes
GO:0030335 positive regulation of cell migration 13.6364 6 yes
GO:0034097 response to cytokine 13.6364 4 yes
GO:0040017 positive regulation of locomotion 13.6364 4 yes
GO:0051726 regulation of cell cycle 13.6364 4 yes
GO:2000147 positive regulation of cell motility 13.6364 5 yes
GO:0008284 positive regulation of cell population proliferation 12.8788 5 yes
GO:0050865 regulation of cell activation 12.1212 4 yes
GO:0032103 positive regulation of response to external stimulus 11.3636 5 yes
GO:0034329 cell junction assembly 11.3636 5 yes
GO:0043410 positive regulation of MAPK cascade 10.6061 7 yes
GO:0045785 positive regulation of cell adhesion 10.6061 5 yes
GO:0010608 post-transcriptional regulation of gene expression 9.8485 7 yes
GO:0018193 peptidyl-amino acid modification 9.8485 5 yes
GO:0022407 regulation of cell-cell adhesion 9.8485 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 9.8485 7 yes
GO:0090257 regulation of muscle system process 9.0909 5 yes
GO:0002831 regulation of response to biotic stimulus 8.3333 4 yes
GO:0043687 post-translational protein modification 8.3333 5 yes
GO:0045216 cell-cell junction organization 8.3333 5 yes
GO:1903706 regulation of hemopoiesis 8.3333 4 yes
GO:0018105 peptidyl-serine phosphorylation 7.5758 6 yes
GO:0018209 peptidyl-serine modification 7.5758 6 yes
GO:0022411 cellular component disassembly 6.8182 4 yes
GO:1902105 regulation of leukocyte differentiation 6.8182 5 yes
GO:0007043 cell-cell junction assembly 6.0606 6 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 6.0606 8 yes
GO:0002833 positive regulation of response to biotic stimulus 5.3030 5 yes
GO:0007346 regulation of mitotic cell cycle 5.3030 5 yes
GO:0010632 regulation of epithelial cell migration 5.3030 4 yes
GO:0010634 positive regulation of epithelial cell migration 5.3030 5 yes
GO:0045637 regulation of myeloid cell differentiation 5.3030 5 yes
GO:0045765 regulation of angiogenesis 5.3030 5 yes
GO:0045787 positive regulation of cell cycle 5.3030 5 yes
GO:1901342 regulation of vasculature development 5.3030 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 4.5455 5 yes
GO:0010543 regulation of platelet activation 4.5455 5 yes
GO:0045766 positive regulation of angiogenesis 4.5455 6 yes
GO:0050678 regulation of epithelial cell proliferation 4.5455 5 yes
GO:1903311 regulation of mRNA metabolic process 4.5455 6 yes
GO:1904018 positive regulation of vasculature development 4.5455 5 yes
GO:0002761 regulation of myeloid leukocyte differentiation 3.7879 6 yes
GO:0010594 regulation of endothelial cell migration 3.7879 5 yes
GO:0010595 positive regulation of endothelial cell migration 3.7879 6 yes
GO:0018107 peptidyl-threonine phosphorylation 3.7879 6 yes
GO:0018210 peptidyl-threonine modification 3.7879 6 yes
GO:0034110 regulation of homotypic cell-cell adhesion 3.7879 6 yes
GO:0034350 regulation of glial cell apoptotic process 3.7879 6 yes
GO:0043488 regulation of mRNA stability 3.7879 4 yes
GO:0050679 positive regulation of epithelial cell proliferation 3.7879 6 yes
GO:0061013 regulation of mRNA catabolic process 3.7879 5 yes
GO:0070555 response to interleukin-1 3.7879 5 yes
GO:0090330 regulation of platelet aggregation 3.7879 6 yes
GO:1902107 positive regulation of leukocyte differentiation 3.7879 6 yes
GO:1903708 positive regulation of hemopoiesis 3.7879 5 yes
GO:0034103 regulation of tissue remodeling 3.0303 4 yes
GO:0034351 negative regulation of glial cell apoptotic process 3.0303 7 yes
GO:0045639 positive regulation of myeloid cell differentiation 3.0303 6 yes
GO:0045931 positive regulation of mitotic cell cycle 3.0303 6 yes
GO:0046850 regulation of bone remodeling 3.0303 5 yes
GO:0001936 regulation of endothelial cell proliferation 2.2727 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 2.2727 7 yes
GO:0002934 desmosome organization 2.2727 6 yes
GO:0007077 mitotic nuclear membrane disassembly 2.2727 4 yes
GO:0010611 regulation of cardiac muscle hypertrophy 2.2727 5 yes
GO:0014743 regulation of muscle hypertrophy 2.2727 6 yes
GO:0030397 membrane disassembly 2.2727 5 yes
GO:0043502 regulation of muscle adaptation 2.2727 4 yes
GO:0043535 regulation of blood vessel endothelial cell migration 2.2727 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 2.2727 7 yes
GO:0045124 regulation of bone resorption 2.2727 6 yes
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 2.2727 6 yes
GO:0045780 positive regulation of bone resorption 2.2727 5 yes
GO:0051081 nuclear membrane disassembly 2.2727 6 yes
GO:0071763 nuclear membrane organization 2.2727 5 yes
GO:0002159 desmosome assembly 1.5152 7 yes
GO:0002763 positive regulation of myeloid leukocyte differentiation 1.5152 7 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 1.5152 6 yes
GO:0014742 positive regulation of muscle hypertrophy 1.5152 5 yes
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 1.5152 5 yes
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway 1.5152 6 yes
GO:0045649 regulation of macrophage differentiation 1.5152 7 yes
GO:0045651 positive regulation of macrophage differentiation 1.5152 8 yes
GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1.5152 6 yes
GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1.5152 7 yes
GO:0110061 regulation of angiotensin-activated signaling pathway 1.5152 6 yes
GO:0110063 positive regulation of angiotensin-activated signaling pathway 1.5152 7 yes
GO:2000705 regulation of dense core granule biogenesis 1.5152 5 yes
GO:2000707 positive regulation of dense core granule biogenesis 1.5152 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TEP1_HUMAN [view interactions] Low throughput no no
TERT_HUMAN [view interactions] Low throughput no no
APLP2_HUMAN [view interactions] Low throughput no yes
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
STMN1_HUMAN [view interactions] Low throughput no yes
LMNA_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA6_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
CD151_HUMAN [view interactions] Low throughput no no
PPARG_HUMAN [view interactions] Low throughput no yes
SIN1_HUMAN [view interactions] Low throughput no yes
FSCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EAA3_HUMAN [view entry] [view interactions] Low throughput yes yes
PLD1_HUMAN [view interactions] Low throughput no no
PLD2_HUMAN [view interactions] Low throughput no yes
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
V1AR_HUMAN [view interactions] Low throughput no no
V1BR_HUMAN [view interactions] Low throughput no no
OGG1_HUMAN [view interactions] Low throughput no yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
RACK1_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
CD53_HUMAN [view interactions] Low throughput no yes
CD9_HUMAN [view entry] [view interactions] Low throughput yes no
IKKB_HUMAN [view interactions] Low throughput no yes
IKKA_HUMAN [view interactions] Low throughput no yes
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
RIGI_HUMAN [view interactions] Low throughput no yes
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
ELAV1_HUMAN [view entry] [view interactions] Low throughput yes yes
LNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
LNX2_HUMAN [view interactions] Low throughput no yes
IBTK_HUMAN [view interactions] Low throughput no yes
AKP13_HUMAN [view interactions] Low throughput no yes
LYAM1_HUMAN [view interactions] Low throughput no no
CISH_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
PLCG2_HUMAN [view interactions] Low throughput no yes
HOIL1_HUMAN [view interactions] Low throughput no no
PA24A_HUMAN [view entry] [view interactions] Low throughput yes yes
EP300_HUMAN [view interactions] Low throughput no yes
PAR6A_HUMAN [view interactions] Low throughput no yes
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH5_HUMAN [view interactions] Low throughput no yes
ENPL_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIB3_HUMAN [view interactions] Low throughput no yes
NUMB_HUMAN [view entry] [view interactions] Low throughput yes yes
ATM_HUMAN [view interactions] Low throughput no yes
SDC4_HUMAN [view interactions] Low throughput no yes
LDB3_HUMAN [view interactions] Low throughput no no
GRM7_HUMAN [view entry] [view interactions] Low throughput yes no
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
RICTR_HUMAN [view interactions] Low throughput no yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAP1_HUMAN [view interactions] Low throughput no yes
HDAC6_HUMAN [view interactions] Low throughput no yes
LMNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP14A_HUMAN [view interactions] Low throughput no yes
NHRF1_HUMAN [view interactions] Low throughput no no
NHRF2_HUMAN [view interactions] Low throughput no no
FCG2B_HUMAN [view interactions] Low throughput no no
LIMK1_HUMAN [view entry] [view interactions] Low throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] Low throughput yes no
HABP4_HUMAN [view interactions] Low throughput no yes
HAND1_HUMAN [view interactions] Low throughput no yes
HAND2_HUMAN [view interactions] Low throughput no yes
KLF5_HUMAN [view interactions] Low throughput no yes
MGMT_HUMAN [view interactions] Low throughput no no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS2_HUMAN [view interactions] Low throughput no no
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HMGA1_HUMAN [view interactions] Low throughput no yes
HMGA2_HUMAN [view interactions] Low throughput no yes
STP1_HUMAN [view interactions] Low throughput no no
STP2_HUMAN [view interactions] Low throughput no no
AKA12_HUMAN [view entry] [view interactions] Low throughput yes no
H31_HUMAN [view interactions] Low throughput no yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPV6_HUMAN [view interactions] Low throughput no no
H11_HUMAN [view interactions] Low throughput no no
H15_HUMAN [view interactions] Low throughput no no
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
NR1H2_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
H31T_HUMAN [view interactions] Low throughput no yes
TRI41_HUMAN [view interactions] Low throughput no yes
GLI3_HUMAN [view interactions] Low throughput no yes
PDLI7_HUMAN [view entry] [view interactions] Low throughput yes no
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
TOP2A_HUMAN [view interactions] Low throughput no no
F261_HUMAN [view interactions] Low throughput no no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
VTNC_HUMAN [view interactions] Low throughput no no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
MARCS_HUMAN [view entry] [view interactions] Low throughput yes yes
INADL_HUMAN [view interactions] Low throughput no no
SDC2_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3A_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
KS6A2_HUMAN [view interactions] Low throughput no yes
CASR_HUMAN [view interactions] Low throughput no no
TYK2_HUMAN [view interactions] Low throughput no no
NOXA1_HUMAN [view interactions] Low throughput no yes
IF2A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAD_HUMAN [view interactions] Low throughput no yes
JAK1_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
CLOCK_HUMAN [view interactions] Low throughput no yes
HMGN1_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
HMGN2_HUMAN [view interactions] Low throughput no no
PI2R_HUMAN [view interactions] Low throughput no no
TA2R_HUMAN [view interactions] Low throughput no no
CP3A4_HUMAN [view interactions] Low throughput no no
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
RNF31_HUMAN [view interactions] Low throughput no yes
RBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NFKB1_HUMAN [view interactions] Low throughput no yes
SPAG1_HUMAN [view interactions] Low throughput no no
NCF1_HUMAN [view interactions] Low throughput no no
BTG2_HUMAN [view interactions] Low throughput no yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NF2L2_HUMAN [view interactions] Low throughput no yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
CYBP_HUMAN [view entry] [view interactions] Low throughput yes yes
MERL_HUMAN [view interactions] Low throughput no yes
HAIR_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
PPM1A_HUMAN [view interactions] Low throughput no yes
KC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
EGLN2_HUMAN [view interactions] Low throughput no no
FCG3A_HUMAN [view interactions] Low throughput no no
PHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ADDA_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE3_HUMAN [view entry] [view interactions] Low throughput yes no
IL3RA_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
LUM_HUMAN [view interactions] High throughput no no
M3K9_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
MK11_HUMAN [view interactions] High throughput no yes
PROS_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
C560_HUMAN [view interactions] High throughput no no
ACINU_HUMAN [view interactions] High throughput no yes
SOX10_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
ITF2_HUMAN [view interactions] High throughput no yes
F262_HUMAN [view interactions] High throughput no no
ZSC9_HUMAN [view interactions] High throughput no yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
VNN2_HUMAN [view interactions] High throughput no no
STXB3_HUMAN [view entry] [view interactions] High throughput yes yes
SNG3_HUMAN [view entry] [view interactions] High throughput yes no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
ACAP1_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
RHBT1_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS3_HUMAN [view entry] [view interactions] High throughput yes yes
CYH2_HUMAN [view entry] [view interactions] High throughput yes yes
HXB13_HUMAN [view interactions] High throughput no no
NEUG_HUMAN [view entry] [view interactions] High throughput yes yes
DNPH1_HUMAN [view interactions] High throughput no yes
TIAM2_HUMAN [view interactions] High throughput no yes
POLI_HUMAN [view interactions] High throughput no yes
CLU_HUMAN [view interactions] High throughput no yes
SEPT6_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
FSCN2_HUMAN [view interactions] High throughput no no
ERF3A_HUMAN [view interactions] High throughput no yes
TMT1A_HUMAN [view interactions] High throughput no no
GNS_HUMAN [view interactions] High throughput no yes
GP160_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
T176B_HUMAN [view interactions] High throughput no yes
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
MAGH1_HUMAN [view interactions] High throughput no yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
SNX10_HUMAN [view interactions] High throughput no yes
SRSF9_HUMAN [view interactions] High throughput no yes
LIPT_HUMAN [view interactions] High throughput no no
PSB7_HUMAN [view interactions] High throughput no yes
PELO_HUMAN [view interactions] High throughput no yes
HTAI2_HUMAN [view interactions] High throughput no yes
CCD47_HUMAN [view interactions] High throughput no yes
RPA49_HUMAN [view interactions] High throughput no yes
ZFY21_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
KRA31_HUMAN [view interactions] High throughput no no
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
UBP38_HUMAN [view interactions] High throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
DEXI_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PER2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
IMP2L_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
T185A_HUMAN [view interactions] High throughput no no
JSPR1_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
VPS4B_HUMAN [view interactions] High throughput no yes
QCR7_HUMAN [view entry] [view interactions] High throughput yes yes
WWC2_HUMAN [view interactions] High throughput no yes
WWC3_HUMAN [view interactions] High throughput no yes
KIBRA_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
BIG3_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
BAD_HUMAN [view entry] [view interactions] High throughput yes yes
MK07_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
ARMS2_HUMAN [view interactions] High throughput no no
PIPNB_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
TFAP4_HUMAN [view interactions] High throughput no yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
F133A_HUMAN [view interactions] High throughput no no
INSRR_HUMAN [view interactions] High throughput no no
SERB1_HUMAN [view interactions] High throughput no yes
FHR3_HUMAN [view interactions] High throughput no no
TFDP2_HUMAN [view interactions] High throughput no yes
TACAN_HUMAN [view interactions] High throughput no no
TRNT1_HUMAN [view interactions] High throughput no yes
DPPA3_HUMAN [view interactions] High throughput no no
PAHO_HUMAN [view interactions] High throughput no no
TMM53_HUMAN [view interactions] High throughput no yes
T2EB_HUMAN [view interactions] High throughput no yes
P20L1_HUMAN [view interactions] High throughput no yes
RDH11_HUMAN [view interactions] High throughput no no
ISOC1_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
UBA5_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
GPI8_HUMAN [view entry] [view interactions] High throughput yes no
CCR3_HUMAN [view interactions] High throughput no yes
T2R20_HUMAN [view interactions] High throughput no no
BPHL_HUMAN [view interactions] High throughput no no
TBD_HUMAN [view interactions] High throughput no yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
CLD10_HUMAN [view interactions] High throughput no no
PEX3_HUMAN [view interactions] High throughput no yes
IL23R_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
MUS81_HUMAN [view interactions] High throughput no no
PDE7A_HUMAN [view interactions] High throughput no yes
SCP2_HUMAN [view interactions] High throughput no no
FACC1_HUMAN [view interactions] High throughput no no
SEPT9_HUMAN [view interactions] High throughput no no
AMFR_HUMAN [view interactions] High throughput no yes
ERCC8_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
AKA11_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
PLAK2_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
RRP1B_HUMAN [view interactions] High throughput no yes
AXIN2_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
RON_HUMAN [view interactions] High throughput no yes
FN3K_HUMAN [view entry] [view interactions] High throughput yes no
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
KPCT_HUMAN [view interactions] High throughput no no
KIF11_HUMAN [view interactions] High throughput no yes
SPF27_HUMAN [view interactions] High throughput no yes
CTBL1_HUMAN [view interactions] High throughput no yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
CAVN1_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
CAVN2_HUMAN [view interactions] High throughput no no
DUS11_HUMAN [view interactions] High throughput no no
FBX21_HUMAN [view interactions] High throughput no yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
KPCL_HUMAN [view interactions] High throughput no yes
GSH0_HUMAN [view interactions] High throughput no yes
SHCBP_HUMAN [view interactions] High throughput no no
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
STAR7_HUMAN [view interactions] High throughput no yes
TA2R7_HUMAN [view interactions] High throughput no no
NS1BP_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
KPRA_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
SYVC_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
PRPS2_HUMAN [view interactions] High throughput no no
H13_HUMAN [view interactions] High throughput no no
KPRB_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
H1T_HUMAN [view interactions] High throughput no no
HYOU1_HUMAN [view interactions] High throughput no yes
4EBP1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
MBP_HUMAN [view entry] [view interactions] High throughput yes no
MB212_HUMAN [view interactions] High throughput no no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
GLYG_HUMAN [view interactions] High throughput no yes
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX25_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDN2A_HUMAN [view interactions] High throughput no yes
PSB4_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
BAGE1_HUMAN [view interactions] High throughput no no
CBPN_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
CATO_HUMAN [view interactions] High throughput no yes
DRD1_HUMAN [view entry] [view interactions] High throughput yes no
HNRPF_HUMAN [view interactions] High throughput no yes
ID2_HUMAN [view interactions] High throughput no no
IBP3_HUMAN [view interactions] High throughput no no