PIAS3_HUMAN
Evidence for PS localization
Functions
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed, PubMed). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002800 | LIG_SUMO_SIM_par_1 | LIG | 446 | 451 | - |
| ELMI002800 | LIG_SUMO_SIM_par_1 | LIG | 446 | 451 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PIAS3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 34.2857 | 4 | yes |
| GO:0046872 | metal ion binding | 34.2857 | 5 | yes |
| GO:0003723 | RNA binding | 31.4286 | 4 | no |
| GO:0043168 | anion binding | 25.7143 | 4 | no |
| GO:0019900 | kinase binding | 22.8571 | 4 | no |
| GO:0019901 | protein kinase binding | 22.8571 | 5 | no |
| GO:0008270 | zinc ion binding | 14.2857 | 7 | yes |
| GO:0046914 | transition metal ion binding | 14.2857 | 6 | yes |
| GO:0016755 | aminoacyltransferase activity | 11.4286 | 4 | yes |
| GO:0019789 | SUMO transferase activity | 8.5714 | 4 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 5.7143 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PIAS3_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 68.5714 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 68.5714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 68.5714 | 4 | yes |
| GO:0010468 | regulation of gene expression | 65.7143 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 65.7143 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 65.7143 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 65.7143 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 65.7143 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 62.8571 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 54.2857 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 54.2857 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 54.2857 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 54.2857 | 5 | yes |
| GO:0010646 | regulation of cell communication | 54.2857 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 48.5714 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 48.5714 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 48.5714 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 45.7143 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 45.7143 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 45.7143 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 45.7143 | 7 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 42.8571 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 42.8571 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 42.8571 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 42.8571 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 42.8571 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 42.8571 | 5 | yes |
| GO:0036211 | protein modification process | 40.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 37.1429 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 37.1429 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 34.2857 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 34.2857 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.2857 | 4 | no |
| GO:0022607 | cellular component assembly | 34.2857 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 31.4286 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 31.4286 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 31.4286 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.4286 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 31.4286 | 4 | no |
| GO:0006996 | organelle organization | 31.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.4286 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 31.4286 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.4286 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 31.4286 | 8 | yes |
| GO:0043687 | post-translational protein modification | 28.5714 | 5 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 28.5714 | 8 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 28.5714 | 7 | yes |
| GO:0008104 | protein localization | 28.5714 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 28.5714 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.5714 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 28.5714 | 6 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 28.5714 | 7 | no |
| GO:0018193 | peptidyl-amino acid modification | 25.7143 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 25.7143 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 25.7143 | 7 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 25.7143 | 4 | yes |
| GO:0060284 | regulation of cell development | 25.7143 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 25.7143 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 25.7143 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.7143 | 4 | no |
| GO:0030162 | regulation of proteolysis | 25.7143 | 6 | no |
| GO:0030334 | regulation of cell migration | 25.7143 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.7143 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.7143 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.7143 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.7143 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.7143 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.7143 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 22.8571 | 7 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.8571 | 5 | no |
| GO:0045862 | positive regulation of proteolysis | 22.8571 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 22.8571 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.8571 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.8571 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.8571 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.8571 | 4 | no |
| GO:0051049 | regulation of transport | 22.8571 | 4 | no |
| GO:0016925 | protein sumoylation | 20.0000 | 7 | yes |
| GO:0018205 | peptidyl-lysine modification | 20.0000 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 20.0000 | 4 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 20.0000 | 9 | yes |
| GO:0045596 | negative regulation of cell differentiation | 17.1429 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 17.1429 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 14.2857 | 7 | yes |
| GO:0010721 | negative regulation of cell development | 11.4286 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 11.4286 | 7 | yes |
| GO:1901873 | regulation of post-translational protein modification | 11.4286 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 11.4286 | 8 | yes |
| GO:1903706 | regulation of hemopoiesis | 11.4286 | 4 | yes |
| GO:0033233 | regulation of protein sumoylation | 8.5714 | 9 | yes |
| GO:0045637 | regulation of myeloid cell differentiation | 8.5714 | 5 | yes |
| GO:1902105 | regulation of leukocyte differentiation | 8.5714 | 5 | yes |
| GO:0033234 | negative regulation of protein sumoylation | 5.7143 | 10 | yes |
| GO:1901874 | negative regulation of post-translational protein modification | 5.7143 | 8 | yes |
| GO:1901875 | positive regulation of post-translational protein modification | 5.7143 | 8 | yes |
| GO:1902106 | negative regulation of leukocyte differentiation | 5.7143 | 6 | yes |
| GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 5.7143 | 9 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 5.7143 | 9 | yes |
| GO:1903707 | negative regulation of hemopoiesis | 5.7143 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 5.7143 | 4 | yes |
| GO:0002761 | regulation of myeloid leukocyte differentiation | 5.7143 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBD1_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GFI1_HUMAN | [view interactions] | Low throughput | no | yes |
| SATB1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKZF1_HUMAN | [view interactions] | Low throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MITF_HUMAN | [view interactions] | Low throughput | no | no |
| TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| HMGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZMIZ2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZMIZ1_HUMAN | [view interactions] | Low throughput | no | no |
| TRI27_HUMAN | [view interactions] | Low throughput | no | yes |
| GRM8_HUMAN | [view interactions] | Low throughput | no | no |
| IRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SERB1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZFHX3_HUMAN | [view interactions] | Low throughput | no | yes |
| TBP_HUMAN | [view interactions] | Low throughput | no | yes |
| NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
| CBS_HUMAN | [view interactions] | Low throughput | no | yes |
| SENP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIM8_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| BC11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMUF2_HUMAN | [view interactions] | Low throughput | no | yes |
| PIM1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD6_HUMAN | [view interactions] | Low throughput | no | no |
| NR4A1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK_HUMAN | [view interactions] | Low throughput | no | yes |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MUS81_HUMAN | [view interactions] | Low throughput | no | no |
| TRI32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIAH2_HUMAN | [view interactions] | Low throughput | no | no |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| SNAI2_HUMAN | [view interactions] | Low throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | Low throughput | no | no |
| HIC1_HUMAN | [view interactions] | Low throughput | no | no |
| SKIL_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| MCAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| GEMI4_HUMAN | [view interactions] | High throughput | no | yes |
| ZPI_HUMAN | [view interactions] | High throughput | no | no |
| REX1B_HUMAN | [view interactions] | High throughput | no | no |
| CHSP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP2_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| OTUB2_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| GRM4_HUMAN | [view interactions] | High throughput | no | no |
| GRM6_HUMAN | [view interactions] | High throughput | no | no |
| GRM7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| GLI1_HUMAN | [view interactions] | High throughput | no | no |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL7_HUMAN | [view interactions] | High throughput | no | yes |
| KMT5B_HUMAN | [view interactions] | High throughput | no | no |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |