Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed). Functions in dorsal root ganglion neurons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
657 Ala Thr Neurodevelopmentaldisorderwithimpairedlanguageandataxiaandwithorwithoutseizures(NEDLAS) -
660 Thr Lys Neurodevelopmentaldisorderwithimpairedlanguageandataxiaandwithorwithoutseizures(NEDLAS) -
660 Thr Arg Neurodevelopmentaldisorderwithimpairedlanguageandataxiaandwithorwithoutseizures(NEDLAS) -
668 Ile Thr Neurodevelopmentaldisorderwithimpairedlanguageandataxiaandwithorwithoutseizures(NEDLAS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIK2_HUMAN
GO:0005216 ion channel activity 46.4286 4 yes
GO:0015267 channel activity 46.4286 4 yes
GO:0005261 cation channel activity 42.8571 5 yes
GO:0008324 cation transmembrane transporter activity 42.8571 4 yes
GO:0022836 gated channel activity 42.8571 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 42.8571 4 yes
GO:0004970 ionotropic glutamate receptor activity 39.2857 5 yes
GO:0005230 extracellular ligand-gated ion channel activity 39.2857 6 yes
GO:0008066 glutamate receptor activity 39.2857 4 yes
GO:0015276 ligand-gated ion channel activity 39.2857 5 yes
GO:0022824 transmitter-gated ion channel activity 39.2857 5 yes
GO:0022834 ligand-gated channel activity 39.2857 6 yes
GO:0022835 transmitter-gated channel activity 39.2857 4 yes
GO:0046873 metal ion transmembrane transporter activity 35.7143 5 yes
GO:0099094 ligand-gated cation channel activity 35.7143 6 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 28.5714 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 28.5714 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 28.5714 6 yes
GO:0015079 potassium ion transmembrane transporter activity 25.0000 6 yes
GO:0030165 PDZ domain binding 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0005267 potassium channel activity 21.4286 6 yes
GO:0005272 sodium channel activity 21.4286 6 yes
GO:0015081 sodium ion transmembrane transporter activity 21.4286 6 yes
GO:0015277 kainate selective glutamate receptor activity 21.4286 6 yes
GO:0019901 protein kinase binding 21.4286 5 no
GO:0031625 ubiquitin protein ligase binding 17.8571 5 yes
GO:0044389 ubiquitin-like protein ligase binding 17.8571 4 yes
GO:0031624 ubiquitin conjugating enzyme binding 10.7143 5 yes
GO:0044390 ubiquitin-like protein conjugating enzyme binding 10.7143 4 yes
GO:0099507 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential 10.7143 6 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 7.1429 7 yes
GO:0005234 extracellularly glutamate-gated ion channel activity 7.1429 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRIK2_HUMAN
GO:0010646 regulation of cell communication 67.8571 4 yes
GO:0007268 chemical synaptic transmission 60.7143 6 yes
GO:0048522 positive regulation of cellular process 60.7143 4 yes
GO:0098916 anterograde trans-synaptic signaling 60.7143 5 yes
GO:0099537 trans-synaptic signaling 60.7143 4 yes
GO:0008104 protein localization 53.5714 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0072657 protein localization to membrane 42.8571 4 yes
GO:0009966 regulation of signal transduction 39.2857 4 yes
GO:0048523 negative regulation of cellular process 39.2857 4 yes
GO:0010647 positive regulation of cell communication 35.7143 5 yes
GO:0023056 positive regulation of signaling 35.7143 4 yes
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0051049 regulation of transport 35.7143 4 no
GO:0051171 regulation of nitrogen compound metabolic process 35.7143 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0060255 regulation of macromolecule metabolic process 35.7143 4 no
GO:0080090 regulation of primary metabolic process 35.7143 4 no
GO:0051128 regulation of cellular component organization 35.7143 4 no
GO:0007215 glutamate receptor signaling pathway 32.1429 4 yes
GO:0035249 synaptic transmission, glutamatergic 32.1429 7 yes
GO:0031323 regulation of cellular metabolic process 32.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 32.1429 5 no
GO:0051246 regulation of protein metabolic process 32.1429 5 no
GO:0051247 positive regulation of protein metabolic process 32.1429 6 no
GO:0010648 negative regulation of cell communication 28.5714 5 yes
GO:0023057 negative regulation of signaling 28.5714 4 yes
GO:0022607 cellular component assembly 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0010941 regulation of cell death 25.0000 4 yes
GO:0042981 regulation of apoptotic process 25.0000 6 yes
GO:0043067 regulation of programmed cell death 25.0000 5 yes
GO:0043113 receptor clustering 25.0000 5 yes
GO:0043408 regulation of MAPK cascade 25.0000 6 yes
GO:0080134 regulation of response to stress 25.0000 4 yes
GO:0080135 regulation of cellular response to stress 25.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 25.0000 5 yes
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0006996 organelle organization 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0032872 regulation of stress-activated MAPK cascade 21.4286 6 yes
GO:0043523 regulation of neuron apoptotic process 21.4286 6 yes
GO:0048878 chemical homeostasis 21.4286 4 yes
GO:0050805 negative regulation of synaptic transmission 21.4286 5 yes
GO:0060078 regulation of postsynaptic membrane potential 21.4286 4 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 21.4286 5 yes
GO:1901214 regulation of neuron death 21.4286 5 yes
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 7 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0010468 regulation of gene expression 21.4286 5 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0050890 cognition 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:1990778 protein localization to cell periphery 21.4286 5 no
GO:0010942 positive regulation of cell death 17.8571 5 yes
GO:0043065 positive regulation of apoptotic process 17.8571 7 yes
GO:0043068 positive regulation of programmed cell death 17.8571 6 yes
GO:0046328 regulation of JNK cascade 17.8571 7 yes
GO:0050801 ion homeostasis 17.8571 5 yes
GO:0050806 positive regulation of synaptic transmission 17.8571 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 17.8571 6 yes
GO:0055065 metal ion homeostasis 17.8571 7 yes
GO:0055080 cation homeostasis 17.8571 6 yes
GO:0098771 inorganic ion homeostasis 17.8571 6 yes
GO:0043066 negative regulation of apoptotic process 14.2857 7 yes
GO:0043069 negative regulation of programmed cell death 14.2857 6 yes
GO:0043525 positive regulation of neuron apoptotic process 14.2857 7 yes
GO:0060548 negative regulation of cell death 14.2857 5 yes
GO:0072507 divalent inorganic cation homeostasis 14.2857 7 yes
GO:1901215 negative regulation of neuron death 14.2857 6 yes
GO:1901216 positive regulation of neuron death 14.2857 6 yes
GO:0006873 cellular ion homeostasis 10.7143 4 yes
GO:0030003 cellular cation homeostasis 10.7143 5 yes
GO:0043524 negative regulation of neuron apoptotic process 10.7143 7 yes
GO:0048168 regulation of neuronal synaptic plasticity 10.7143 4 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 10.7143 5 yes
GO:0051967 negative regulation of synaptic transmission, glutamatergic 10.7143 6 yes
GO:0055074 calcium ion homeostasis 10.7143 8 yes
GO:0001508 action potential 7.1429 4 yes
GO:0001662 behavioral fear response 7.1429 4 yes
GO:0006874 cellular calcium ion homeostasis 7.1429 7 yes
GO:0006875 cellular metal ion homeostasis 7.1429 6 yes
GO:0006915 apoptotic process 7.1429 4 yes
GO:0016048 detection of temperature stimulus 7.1429 4 yes
GO:0019228 neuronal action potential 7.1429 5 yes
GO:0048172 regulation of short-term neuronal synaptic plasticity 7.1429 5 yes
GO:0050960 detection of temperature stimulus involved in thermoception 7.1429 5 yes
GO:0050961 detection of temperature stimulus involved in sensory perception 7.1429 4 yes
GO:0051402 neuron apoptotic process 7.1429 4 yes
GO:0060080 inhibitory postsynaptic potential 7.1429 5 yes
GO:0072503 cellular divalent inorganic cation homeostasis 7.1429 6 yes
GO:0120169 detection of cold stimulus involved in thermoception 7.1429 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in GRIK2_HUMAN
DOID:1289 neurodegenerative disease 7.1429 4 no
DOID:331 central nervous system disease 7.1429 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBC9_HUMAN [view interactions] Low throughput no yes
PIAS3_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO1_HUMAN [view interactions] Low throughput no yes
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K11_HUMAN [view interactions] Low throughput no yes
EGFLA_HUMAN [view interactions] Low throughput no no
SDCB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
KLH24_HUMAN [view interactions] Low throughput no no
GRIK4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK5_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
KLH17_HUMAN [view entry] [view interactions] Low throughput yes no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK3_HUMAN [view entry] [view interactions] Low throughput yes no
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NETO2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
ASF1A_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
CACO1_HUMAN [view entry] [view interactions] High throughput yes yes
WT1_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
GRIK1_HUMAN [view entry] [view interactions] Computational yes yes
KIF17_HUMAN [view interactions] Computational no no
S12A5_HUMAN [view entry] [view interactions] Computational yes yes
SYK_HUMAN [view interactions] Computational no yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
E41L1_HUMAN [view entry] [view interactions] Computational yes yes