NMDE1_HUMAN
Evidence for PS localization
Functions
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed, PubMed, PubMed, PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed, PubMed). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning . [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [NMDE1_HUMAN]
Isoform [A0A6Q8PGD2] alignment
Isoform [A0A6Q8PHM7] alignment
Isoform [A0A1B0GUT1] alignment
Isoform [A0A1B0GU35] alignment
Isoform [A0A1B0GVW1] alignment
Isoform [Q12879-2] alignment
Isoform [F5GZ52] alignment
LOADING 59%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NMDE1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 35.1351 | 4 | yes |
| GO:0046872 | metal ion binding | 31.0811 | 5 | yes |
| GO:0043168 | anion binding | 31.0811 | 4 | no |
| GO:0000166 | nucleotide binding | 24.3243 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.3243 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.3243 | 6 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 21.6216 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.6216 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.6216 | 5 | no |
| GO:0005216 | monoatomic ion channel activity | 20.2703 | 4 | yes |
| GO:0015267 | channel activity | 20.2703 | 4 | yes |
| GO:0005524 | ATP binding | 20.2703 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.2703 | 4 | no |
| GO:0019900 | kinase binding | 20.2703 | 4 | no |
| GO:0008066 | glutamate receptor activity | 17.5676 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 17.5676 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 17.5676 | 5 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 17.5676 | 4 | yes |
| GO:0004970 | glutamate-gated receptor activity | 16.2162 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 16.2162 | 6 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 16.2162 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 16.2162 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 16.2162 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 16.2162 | 4 | yes |
| GO:0022836 | gated channel activity | 16.2162 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NMDE1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 74.3243 | 4 | yes |
| GO:0010646 | regulation of cell communication | 70.2703 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.4595 | 4 | no |
| GO:0009966 | regulation of signal transduction | 55.4054 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.0541 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.6486 | 4 | no |
| GO:0008104 | protein localization | 47.2973 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 45.9459 | 4 | yes |
| GO:0051049 | regulation of transport | 45.9459 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 44.5946 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 43.2432 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.5405 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.5405 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 40.5405 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 40.5405 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.5405 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.8378 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 36.4865 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 35.1351 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.7838 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.4324 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.4324 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.4324 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 2A5B_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABCB9_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD4_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT5G1_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| CHIN_HUMAN | [view interactions] | Low throughput | no | no |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |