Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NMDE1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed, PubMed, PubMed, PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed, PubMed). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NMDE1_HUMAN
GO:0046872 metal ion binding 31.5789 4 yes
GO:0008324 cation transmembrane transporter activity 27.3684 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 27.3684 4 yes
GO:0005216 ion channel activity 24.2105 4 yes
GO:0015267 channel activity 24.2105 4 yes
GO:0017076 purine nucleotide binding 24.2105 4 no
GO:0030554 adenyl nucleotide binding 24.2105 5 no
GO:0032555 purine ribonucleotide binding 24.2105 4 no
GO:0032559 adenyl ribonucleotide binding 24.2105 5 no
GO:0005261 cation channel activity 23.1579 5 yes
GO:0005524 ATP binding 23.1579 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.1579 4 no
GO:0022836 gated channel activity 22.1053 5 yes
GO:0046873 metal ion transmembrane transporter activity 20.0000 5 yes
GO:0005230 extracellular ligand-gated ion channel activity 17.8947 6 yes
GO:0008066 glutamate receptor activity 17.8947 4 yes
GO:0015276 ligand-gated ion channel activity 17.8947 5 yes
GO:0022834 ligand-gated channel activity 17.8947 6 yes
GO:0099094 ligand-gated cation channel activity 16.8421 6 yes
GO:0015085 calcium ion transmembrane transporter activity 15.7895 6 yes
GO:0004970 ionotropic glutamate receptor activity 14.7368 5 yes
GO:0005262 calcium channel activity 14.7368 6 yes
GO:0022824 transmitter-gated ion channel activity 14.7368 5 yes
GO:0022835 transmitter-gated channel activity 14.7368 4 yes
GO:0005244 voltage-gated ion channel activity 12.6316 4 yes
GO:0022832 voltage-gated channel activity 12.6316 6 yes
GO:0022843 voltage-gated cation channel activity 12.6316 5 yes
GO:0001540 amyloid-beta binding 10.5263 4 yes
GO:0046914 transition metal ion binding 10.5263 5 yes
GO:0004972 NMDA glutamate receptor activity 8.4211 6 yes
GO:0008270 zinc ion binding 7.3684 6 yes
GO:0099604 ligand-gated calcium channel activity 7.3684 7 yes
GO:0022849 glutamate-gated calcium ion channel activity 6.3158 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NMDE1_HUMAN
GO:0010646 regulation of cell communication 72.6316 4 yes
GO:0048522 positive regulation of cellular process 68.4211 4 yes
GO:0009966 regulation of signal transduction 54.7368 4 no
GO:0060255 regulation of macromolecule metabolic process 53.6842 4 yes
GO:0048523 negative regulation of cellular process 51.5789 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.5263 4 yes
GO:0080090 regulation of primary metabolic process 50.5263 4 yes
GO:0051049 regulation of transport 49.4737 4 no
GO:0050804 modulation of chemical synaptic transmission 47.3684 5 yes
GO:0051246 regulation of protein metabolic process 47.3684 5 yes
GO:0099177 regulation of trans-synaptic signaling 47.3684 4 yes
GO:0031323 regulation of cellular metabolic process 46.3158 4 no
GO:0009893 positive regulation of metabolic process 42.1053 4 yes
GO:0010647 positive regulation of cell communication 42.1053 5 yes
GO:0023056 positive regulation of signaling 42.1053 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.0526 5 yes
GO:0051128 regulation of cellular component organization 41.0526 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.9474 5 yes
GO:0051247 positive regulation of protein metabolic process 37.8947 6 yes
GO:0008104 protein localization 36.8421 4 yes
GO:0010468 regulation of gene expression 34.7368 5 no
GO:0043269 regulation of ion transport 34.7368 5 no
GO:0031399 regulation of protein modification process 33.6842 6 no
GO:0036211 protein modification process 32.6316 4 no
GO:0043412 macromolecule modification 32.6316 4 no
GO:0019220 regulation of phosphate metabolic process 31.5789 6 no
GO:0051174 regulation of phosphorus metabolic process 31.5789 5 no
GO:0022607 cellular component assembly 31.5789 4 no
GO:0043085 positive regulation of catalytic activity 30.5263 4 yes
GO:0010941 regulation of cell death 29.4737 4 yes
GO:0006796 phosphate-containing compound metabolic process 29.4737 4 no
GO:0031325 positive regulation of cellular metabolic process 29.4737 5 no
GO:0042325 regulation of phosphorylation 29.4737 7 no
GO:0001932 regulation of protein phosphorylation 28.4211 7 no
GO:0031401 positive regulation of protein modification process 28.4211 7 no
GO:1902531 regulation of intracellular signal transduction 28.4211 5 no
GO:0034762 regulation of transmembrane transport 28.4211 4 no
GO:0009967 positive regulation of signal transduction 28.4211 5 no
GO:0048584 positive regulation of response to stimulus 28.4211 4 no
GO:0009889 regulation of biosynthetic process 27.3684 4 no
GO:0010648 negative regulation of cell communication 27.3684 5 no
GO:0023057 negative regulation of signaling 27.3684 4 no
GO:0031326 regulation of cellular biosynthetic process 27.3684 5 no
GO:0034765 regulation of ion transmembrane transport 27.3684 5 no
GO:0051050 positive regulation of transport 27.3684 4 no
GO:0060341 regulation of cellular localization 27.3684 4 no
GO:0042981 regulation of apoptotic process 26.3158 6 yes
GO:0043067 regulation of programmed cell death 26.3158 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0099537 trans-synaptic signaling 25.2632 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.2632 5 no
GO:1904062 regulation of cation transmembrane transport 25.2632 6 no
GO:0007268 chemical synaptic transmission 24.2105 6 yes
GO:0010243 response to organonitrogen compound 24.2105 4 yes
GO:0098916 anterograde trans-synaptic signaling 24.2105 5 yes
GO:0001934 positive regulation of protein phosphorylation 24.2105 8 no
GO:0042327 positive regulation of phosphorylation 24.2105 8 no
GO:0048585 negative regulation of response to stimulus 24.2105 4 no
GO:0044057 regulation of system process 24.2105 4 no
GO:0006996 organelle organization 24.2105 4 no
GO:0009892 negative regulation of metabolic process 23.1579 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.1579 5 no
GO:0071310 cellular response to organic substance 23.1579 4 no
GO:0006811 ion transport 22.1053 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 22.1053 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 22.1053 5 yes
GO:0051336 regulation of hydrolase activity 22.1053 4 yes
GO:0045595 regulation of cell differentiation 22.1053 4 no
GO:0051252 regulation of RNA metabolic process 22.1053 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.1053 4 no
GO:0071702 organic substance transport 22.1053 4 no
GO:0071705 nitrogen compound transport 22.1053 4 no
GO:0006812 cation transport 21.0526 5 yes
GO:0009894 regulation of catabolic process 21.0526 4 yes
GO:0006355 regulation of DNA-templated transcription 21.0526 6 no
GO:0009968 negative regulation of signal transduction 21.0526 5 no
GO:0051338 regulation of transferase activity 21.0526 4 no
GO:1903506 regulation of nucleic acid-templated transcription 21.0526 7 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0031344 regulation of cell projection organization 21.0526 5 no
GO:0051130 positive regulation of cellular component organization 21.0526 5 no
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 no
GO:0016192 vesicle-mediated transport 21.0526 4 no
GO:0050806 positive regulation of synaptic transmission 20.0000 5 yes
GO:0007215 glutamate receptor signaling pathway 18.9474 4 yes
GO:0030001 metal ion transport 18.9474 6 yes
GO:0030162 regulation of proteolysis 18.9474 6 yes
GO:0050890 cognition 18.9474 4 yes
GO:0051248 negative regulation of protein metabolic process 18.9474 6 yes
GO:0072657 protein localization to membrane 18.9474 4 yes
GO:0006816 calcium ion transport 16.8421 7 yes
GO:0010942 positive regulation of cell death 15.7895 5 yes
GO:0042176 regulation of protein catabolic process 14.7368 5 yes
GO:0045862 positive regulation of proteolysis 13.6842 7 yes
GO:0007612 learning 12.6316 4 yes
GO:0009416 response to light stimulus 12.6316 4 yes
GO:0043065 positive regulation of apoptotic process 12.6316 7 yes
GO:0043068 positive regulation of programmed cell death 12.6316 6 yes
GO:0051345 positive regulation of hydrolase activity 12.6316 5 yes
GO:0052547 regulation of peptidase activity 12.6316 5 yes
GO:0007613 memory 11.5789 4 yes
GO:0052548 regulation of endopeptidase activity 11.5789 6 yes
GO:0097305 response to alcohol 11.5789 4 yes
GO:1902414 protein localization to cell junction 11.5789 5 yes
GO:1990778 protein localization to cell periphery 11.5789 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 11.5789 7 yes
GO:0009895 negative regulation of catabolic process 10.5263 5 yes
GO:0035418 protein localization to synapse 10.5263 6 yes
GO:0098655 cation transmembrane transport 10.5263 4 yes
GO:0098660 inorganic ion transmembrane transport 10.5263 4 yes
GO:0098662 inorganic cation transmembrane transport 10.5263 5 yes
GO:0007420 brain development 9.4737 4 yes
GO:0060291 long-term synaptic potentiation 9.4737 4 yes
GO:0006508 proteolysis 8.4211 4 yes
GO:0008306 associative learning 8.4211 5 yes
GO:0010950 positive regulation of endopeptidase activity 8.4211 7 yes
GO:0010952 positive regulation of peptidase activity 8.4211 6 yes
GO:0060078 regulation of postsynaptic membrane potential 8.4211 4 yes
GO:0062237 protein localization to postsynapse 8.4211 7 yes
GO:1903539 protein localization to postsynaptic membrane 8.4211 5 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 8.4211 8 yes
GO:0007600 sensory perception 7.3684 4 yes
GO:0008542 visual learning 7.3684 4 yes
GO:0045471 response to ethanol 7.3684 5 yes
GO:0060079 excitatory postsynaptic potential 7.3684 5 yes
GO:0070588 calcium ion transmembrane transport 7.3684 6 yes
GO:0042177 negative regulation of protein catabolic process 6.3158 6 yes
GO:0050905 neuromuscular process 6.3158 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 6.3158 7 yes
GO:0098976 excitatory chemical synaptic transmission 6.3158 7 yes
GO:0019233 sensory perception of pain 5.2632 5 yes
GO:0001975 response to amphetamine 4.2105 6 yes
GO:0006576 cellular biogenic amine metabolic process 4.2105 5 yes
GO:0006584 catecholamine metabolic process 4.2105 6 yes
GO:0009308 amine metabolic process 4.2105 4 yes
GO:0009712 catechol-containing compound metabolic process 4.2105 5 yes
GO:0014075 response to amine 4.2105 5 yes
GO:0018958 phenol-containing compound metabolic process 4.2105 4 yes
GO:0042417 dopamine metabolic process 4.2105 7 yes
GO:0044106 cellular amine metabolic process 4.2105 4 yes
GO:0016485 protein processing 3.1579 5 yes
GO:0022008 neurogenesis 3.1579 4 yes
GO:0051604 protein maturation 3.1579 4 yes
GO:0031638 zymogen activation 2.1053 6 yes
GO:0042428 serotonin metabolic process 2.1053 4 yes
GO:0042430 indole-containing compound metabolic process 2.1053 4 yes
GO:0097202 activation of cysteine-type endopeptidase activity 2.1053 7 yes
GO:1901160 primary amino compound metabolic process 2.1053 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in NMDE1_HUMAN
DOID:1289 neurodegenerative disease 2.1053 4 no
DOID:331 central nervous system disease 2.1053 3 no
DOID:0050686 organ system cancer 2.1053 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
INADL_HUMAN [view interactions] Low throughput no no
PTN4_HUMAN [view interactions] Low throughput no no
NETO1_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
IL16_HUMAN [view interactions] Low throughput no no
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
APC_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] Low throughput yes no
CHIN_HUMAN [view interactions] Low throughput no no
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1M1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3B_HUMAN [view entry] [view interactions] Low throughput yes no
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS8_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN5_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE10_HUMAN [view entry] [view interactions] Low throughput yes no
APLP1_HUMAN [view interactions] Low throughput no yes
APLP2_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
P2RY1_HUMAN [view entry] [view interactions] Low throughput yes yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3A_HUMAN [view entry] [view interactions] Low throughput yes no
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
SQSTM_HUMAN [view interactions] Low throughput no yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK22_HUMAN [view entry] [view interactions] Low throughput yes no
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
CTND2_HUMAN [view entry] [view interactions] Low throughput yes no
IQEC1_HUMAN [view entry] [view interactions] Low throughput yes yes
IQEC2_HUMAN [view entry] [view interactions] Low throughput yes no
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BC_HUMAN [view interactions] Low throughput no yes
AT2B2_HUMAN [view entry] [view interactions] Low throughput yes yes
ZNT1_HUMAN [view entry] [view interactions] Low throughput yes no
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KIF3B_HUMAN [view interactions] High throughput no no
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
CBAR1_HUMAN [view interactions] High throughput no no
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TTC28_HUMAN [view interactions] High throughput no no
PDE3B_HUMAN [view interactions] High throughput no no
2A5D_HUMAN [view entry] [view interactions] High throughput yes yes
2A5E_HUMAN [view interactions] High throughput no yes
2A5B_HUMAN [view interactions] High throughput no yes
HIG2A_HUMAN [view interactions] High throughput no yes
AT2A3_HUMAN [view interactions] High throughput no yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
ABCD4_HUMAN [view interactions] High throughput no yes
AT5G1_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
LY6D_HUMAN [view interactions] High throughput no no
ST7_HUMAN [view interactions] High throughput no yes
NSMA_HUMAN [view interactions] High throughput no yes
UFSP2_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
LRP6_HUMAN [view interactions] High throughput no yes
CISD2_HUMAN [view interactions] High throughput no yes
PIGA_HUMAN [view interactions] High throughput no yes
DJC18_HUMAN [view interactions] High throughput no yes
ABCB9_HUMAN [view interactions] High throughput no yes
NXNL2_HUMAN [view interactions] High throughput no no
METL9_HUMAN [view interactions] High throughput no yes
LMF2_HUMAN [view interactions] High throughput no yes
UBP33_HUMAN [view interactions] High throughput no yes
TAP2_HUMAN [view interactions] High throughput no no
2AAB_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
S27A3_HUMAN [view interactions] High throughput no no
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
NEUL4_HUMAN [view interactions] High throughput no yes
P2RX4_HUMAN [view entry] [view interactions] Computational yes yes
PP1G_HUMAN [view entry] [view interactions] Computational yes yes
P2RX7_HUMAN [view interactions] Computational no yes
GRM3_HUMAN [view entry] [view interactions] Computational yes no
PP1B_HUMAN [view entry] [view interactions] Computational yes yes
CCG7_HUMAN [view entry] [view interactions] Computational yes no
P2RX6_HUMAN [view entry] [view interactions] Computational yes no
P2RX5_HUMAN [view interactions] Computational no no
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
ERBB4_HUMAN [view entry] [view interactions] Computational yes yes
NRG1_HUMAN [view entry] [view interactions] Computational yes no
P2RX1_HUMAN [view entry] [view interactions] Computational yes no
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
RGRF1_HUMAN [view interactions] Computational no yes
PDYN_HUMAN [view interactions] Computational no yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
RELN_HUMAN [view interactions] Computational no no
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
CCG3_HUMAN [view entry] [view interactions] Computational yes no
KAPCG_HUMAN [view interactions] Computational no no
MECP2_HUMAN [view interactions] Computational no yes
KIF17_HUMAN [view interactions] Computational no no
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
CCG8_HUMAN [view entry] [view interactions] Computational yes no
LRP8_HUMAN [view entry] [view interactions] Computational yes no
RGRF2_HUMAN [view entry] [view interactions] Computational yes yes
CNIH2_HUMAN [view entry] [view interactions] Computational yes no
PP1A_HUMAN [view entry] [view interactions] Computational yes yes
LRFN2_HUMAN [view entry] [view interactions] Computational yes yes
P2RX3_HUMAN [view interactions] Computational no no
GRM1_HUMAN [view entry] [view interactions] Computational yes yes
DAB1_HUMAN [view interactions] Computational no yes