Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NMD3A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NMD3A_HUMAN
GO:0043168 anion binding 50.0000 4 yes
GO:0043169 cation binding 50.0000 4 yes
GO:0004970 glutamate-gated receptor activity 42.8571 4 yes
GO:0005216 monoatomic ion channel activity 42.8571 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 42.8571 6 yes
GO:0005261 monoatomic cation channel activity 42.8571 5 yes
GO:0005262 calcium channel activity 42.8571 6 yes
GO:0008066 glutamate receptor activity 42.8571 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 42.8571 4 yes
GO:0015085 calcium ion transmembrane transporter activity 42.8571 6 yes
GO:0015267 channel activity 42.8571 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 42.8571 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 42.8571 5 yes
GO:0022834 ligand-gated channel activity 42.8571 6 yes
GO:0022835 transmitter-gated channel activity 42.8571 4 yes
GO:0022836 gated channel activity 42.8571 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 42.8571 4 yes
GO:0046873 metal ion transmembrane transporter activity 42.8571 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 42.8571 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 35.7143 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 35.7143 6 yes
GO:0004972 NMDA glutamate receptor activity 35.7143 5 yes
GO:0005244 voltage-gated monoatomic ion channel activity 35.7143 5 yes
GO:0022832 voltage-gated channel activity 35.7143 6 yes
GO:0031406 carboxylic acid binding 35.7143 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 35.7143 4 yes
GO:0046872 metal ion binding 28.5714 5 no
GO:0022849 glutamate-gated calcium ion channel activity 21.4286 5 no
GO:0099094 ligand-gated monoatomic cation channel activity 21.4286 6 no
GO:0099604 ligand-gated calcium channel activity 21.4286 7 no
GO:0019902 phosphatase binding 14.2857 4 yes
GO:0019903 protein phosphatase binding 14.2857 5 yes
GO:0051721 protein phosphatase 2A binding 14.2857 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NMD3A_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0050804 modulation of chemical synaptic transmission 57.1429 5 yes
GO:0099177 regulation of trans-synaptic signaling 57.1429 4 yes
GO:0051049 regulation of transport 57.1429 4 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0007215 glutamate receptor signaling pathway 42.8571 4 yes
GO:0007268 chemical synaptic transmission 42.8571 7 yes
GO:0035235 ionotropic glutamate receptor signaling pathway 42.8571 4 yes
GO:0098916 anterograde trans-synaptic signaling 42.8571 6 yes
GO:0099536 synaptic signaling 42.8571 4 yes
GO:0099537 trans-synaptic signaling 42.8571 5 yes
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0008104 protein localization 42.8571 4 no
GO:0006996 organelle organization 42.8571 4 no
GO:0006811 monoatomic ion transport 35.7143 4 yes
GO:0006812 monoatomic cation transport 35.7143 5 yes
GO:0006816 calcium ion transport 35.7143 7 yes
GO:0030001 metal ion transport 35.7143 6 yes
GO:0030030 cell projection organization 35.7143 4 yes
GO:0035249 synaptic transmission, glutamatergic 35.7143 8 yes
GO:0045471 response to ethanol 35.7143 5 yes
GO:0097305 response to alcohol 35.7143 4 yes
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0060255 regulation of macromolecule metabolic process 35.7143 4 no
GO:0080090 regulation of primary metabolic process 35.7143 4 no
GO:0098657 import into cell 35.7143 4 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 yes
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0043269 regulation of monoatomic ion transport 28.5714 5 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0031175 neuron projection development 21.4286 6 yes
GO:0048585 negative regulation of response to stimulus 21.4286 4 yes
GO:0051093 negative regulation of developmental process 21.4286 4 yes
GO:0007420 brain development 21.4286 4 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0031644 regulation of nervous system process 21.4286 5 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.4286 5 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0048168 regulation of neuronal synaptic plasticity 21.4286 4 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0050806 positive regulation of synaptic transmission 21.4286 5 no
GO:0050890 cognition 21.4286 4 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0051259 protein complex oligomerization 21.4286 6 no
GO:0051262 protein tetramerization 21.4286 7 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.4286 6 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 21.4286 6 no
GO:0060078 regulation of postsynaptic membrane potential 21.4286 4 no
GO:0060079 excitatory postsynaptic potential 21.4286 5 no
GO:0070588 calcium ion transmembrane transport 21.4286 5 no
GO:0097553 calcium ion transmembrane import into cytosol 21.4286 6 no
GO:0098655 monoatomic cation transmembrane transport 21.4286 4 no
GO:0098662 inorganic cation transmembrane transport 21.4286 4 no
GO:0098815 modulation of excitatory postsynaptic potential 21.4286 4 no
GO:0098976 excitatory chemical synaptic transmission 21.4286 8 no
GO:1904062 regulation of monoatomic cation transmembrane transport 21.4286 6 no
GO:2000463 positive regulation of excitatory postsynaptic potential 21.4286 5 no
GO:0006886 intracellular protein transport 21.4286 4 no
GO:0006898 receptor-mediated endocytosis 21.4286 4 no
GO:0015031 protein transport 21.4286 4 no
GO:0031623 receptor internalization 21.4286 5 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:0010970 transport along microtubule 21.4286 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 21.4286 4 no
GO:0031346 positive regulation of cell projection organization 21.4286 6 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0099111 microtubule-based transport 21.4286 4 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0048488 synaptic vesicle endocytosis 21.4286 5 no
GO:0061024 membrane organization 21.4286 4 no
GO:0140238 presynaptic endocytosis 21.4286 4 no
GO:0032101 regulation of response to external stimulus 14.2857 4 yes
GO:0032102 negative regulation of response to external stimulus 14.2857 5 yes
GO:0060134 prepulse inhibition 14.2857 6 yes
GO:0060998 regulation of dendritic spine development 14.2857 4 yes
GO:0061000 negative regulation of dendritic spine development 14.2857 5 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 14.2857 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAB1A_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3A_HUMAN [view entry] [view interactions] Low throughput yes no
PTPA_HUMAN [view interactions] Low throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
PACN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1S_HUMAN [view interactions] Low throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
INSR_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
NMD3B_HUMAN [view entry] [view interactions] High throughput yes no
SPPL3_HUMAN [view interactions] High throughput no no