Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NMD3B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NMD3B_HUMAN
GO:0005216 ion channel activity 71.4286 4 yes
GO:0005261 cation channel activity 71.4286 5 yes
GO:0008324 cation transmembrane transporter activity 71.4286 4 yes
GO:0015267 channel activity 71.4286 4 yes
GO:0022836 gated channel activity 71.4286 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 71.4286 4 yes
GO:0005262 calcium channel activity 64.2857 6 yes
GO:0015085 calcium ion transmembrane transporter activity 64.2857 6 yes
GO:0046873 metal ion transmembrane transporter activity 64.2857 5 yes
GO:0004970 ionotropic glutamate receptor activity 57.1429 5 yes
GO:0005230 extracellular ligand-gated ion channel activity 57.1429 6 yes
GO:0008066 glutamate receptor activity 57.1429 4 yes
GO:0015276 ligand-gated ion channel activity 57.1429 5 yes
GO:0022824 transmitter-gated ion channel activity 57.1429 5 yes
GO:0022834 ligand-gated channel activity 57.1429 6 yes
GO:0022835 transmitter-gated channel activity 57.1429 4 yes
GO:0005244 voltage-gated ion channel activity 57.1429 4 no
GO:0022832 voltage-gated channel activity 57.1429 6 no
GO:0022843 voltage-gated cation channel activity 57.1429 5 no
GO:0099094 ligand-gated cation channel activity 50.0000 6 no
GO:0004972 NMDA glutamate receptor activity 42.8571 6 no
GO:0016597 amino acid binding 35.7143 4 yes
GO:0031406 carboxylic acid binding 35.7143 4 yes
GO:0022849 glutamate-gated calcium ion channel activity 35.7143 6 no
GO:0046872 metal ion binding 35.7143 4 no
GO:0099604 ligand-gated calcium channel activity 35.7143 7 no
GO:0016594 glycine binding 28.5714 4 yes
GO:0001540 amyloid-beta binding 28.5714 4 no
GO:0005509 calcium ion binding 21.4286 5 no
GO:0016595 glutamate binding 21.4286 5 no
GO:0098960 postsynaptic neurotransmitter receptor activity 21.4286 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 21.4286 5 no
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 21.4286 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in NMD3B_HUMAN
GO:0010646 regulation of cell communication 78.5714 4 no
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0010647 positive regulation of cell communication 57.1429 5 no
GO:0023056 positive regulation of signaling 57.1429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0050804 modulation of chemical synaptic transmission 57.1429 5 no
GO:0099177 regulation of trans-synaptic signaling 57.1429 4 no
GO:0007215 glutamate receptor signaling pathway 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0006811 ion transport 50.0000 4 no
GO:0006812 cation transport 50.0000 5 no
GO:0006816 calcium ion transport 50.0000 7 no
GO:0030001 metal ion transport 50.0000 6 no
GO:0007420 brain development 42.8571 4 no
GO:0050806 positive regulation of synaptic transmission 42.8571 5 no
GO:0043269 regulation of ion transport 35.7143 5 yes
GO:0072657 protein localization to membrane 35.7143 4 yes
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0010941 regulation of cell death 35.7143 4 no
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0007268 chemical synaptic transmission 35.7143 6 no
GO:0060078 regulation of postsynaptic membrane potential 35.7143 4 no
GO:0060079 excitatory postsynaptic potential 35.7143 5 no
GO:0070588 calcium ion transmembrane transport 35.7143 6 no
GO:0097553 calcium ion transmembrane import into cytosol 35.7143 7 no
GO:0098655 cation transmembrane transport 35.7143 4 no
GO:0098660 inorganic ion transmembrane transport 35.7143 4 no
GO:0098662 inorganic cation transmembrane transport 35.7143 5 no
GO:0098916 anterograde trans-synaptic signaling 35.7143 5 no
GO:0098976 excitatory chemical synaptic transmission 35.7143 7 no
GO:0099537 trans-synaptic signaling 35.7143 4 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0034765 regulation of ion transmembrane transport 28.5714 5 no
GO:0045471 response to ethanol 28.5714 5 no
GO:0097305 response to alcohol 28.5714 4 no
GO:1904062 regulation of cation transmembrane transport 28.5714 6 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0060291 long-term synaptic potentiation 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0035418 protein localization to synapse 28.5714 6 no
GO:0062237 protein localization to postsynapse 28.5714 7 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:1902414 protein localization to cell junction 28.5714 5 no
GO:1903539 protein localization to postsynaptic membrane 28.5714 5 no
GO:1990778 protein localization to cell periphery 28.5714 5 no
GO:0035235 ionotropic glutamate receptor signaling pathway 21.4286 4 yes
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0010942 positive regulation of cell death 21.4286 5 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0010950 positive regulation of endopeptidase activity 21.4286 7 no
GO:0010952 positive regulation of peptidase activity 21.4286 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0030162 regulation of proteolysis 21.4286 6 no
GO:0045862 positive regulation of proteolysis 21.4286 7 no
GO:0050890 cognition 21.4286 4 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0051336 regulation of hydrolase activity 21.4286 4 no
GO:0051345 positive regulation of hydrolase activity 21.4286 5 no
GO:0052547 regulation of peptidase activity 21.4286 5 no
GO:0052548 regulation of endopeptidase activity 21.4286 6 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:2000116 regulation of cysteine-type endopeptidase activity 21.4286 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 21.4286 8 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0050905 neuromuscular process 21.4286 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.4286 6 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 21.4286 6 no
GO:0006886 intracellular protein transport 21.4286 4 no
GO:0006897 endocytosis 21.4286 5 no
GO:0006898 receptor-mediated endocytosis 21.4286 6 no
GO:0016192 vesicle-mediated transport 21.4286 4 no
GO:0006508 proteolysis 21.4286 4 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0010959 regulation of metal ion transport 14.2857 6 yes
GO:0051924 regulation of calcium ion transport 14.2857 7 yes
GO:0090150 establishment of protein localization to membrane 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
CS044_HUMAN [view interactions] High throughput no no
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
BBLN_HUMAN [view interactions] High throughput no yes
EDEM2_HUMAN [view interactions] High throughput no yes
ABCB9_HUMAN [view interactions] High throughput no yes
DAPK3_HUMAN [view interactions] High throughput no yes
MXRA7_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CGRF1_HUMAN [view interactions] High throughput no yes
NMD3A_HUMAN [view entry] [view interactions] High throughput yes no
ATF1_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
CIB1_HUMAN [view interactions] High throughput no no
PKD2_HUMAN [view interactions] High throughput no yes
TPD54_HUMAN [view interactions] High throughput no yes
TPD52_HUMAN [view interactions] High throughput no yes
SPCS1_HUMAN [view interactions] High throughput no yes
GCYB1_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
DRB1_HUMAN [view interactions] High throughput no no
LRRF2_HUMAN [view interactions] High throughput no yes
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
TXD11_HUMAN [view interactions] High throughput no yes
NEST_HUMAN [view interactions] High throughput no no
CCG7_HUMAN [view entry] [view interactions] Computational yes no
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
MBRL_HUMAN [view interactions] Computational no yes
PDYN_HUMAN [view interactions] Computational no yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
CCG2_HUMAN [view entry] [view interactions] Computational yes no