NMD3B_HUMAN
Evidence for PS localization
Functions
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NMD3B_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 75.0000 | 4 | yes |
| GO:0004970 | glutamate-gated receptor activity | 50.0000 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 50.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 6 | yes |
| GO:0005261 | monoatomic cation channel activity | 50.0000 | 5 | yes |
| GO:0005262 | calcium channel activity | 50.0000 | 6 | yes |
| GO:0008066 | glutamate receptor activity | 50.0000 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 50.0000 | 6 | yes |
| GO:0015267 | channel activity | 50.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0043168 | anion binding | 50.0000 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 50.0000 | 5 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 5 | no |
| GO:0031406 | carboxylic acid binding | 37.5000 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 37.5000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 37.5000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 37.5000 | 6 | yes |
| GO:0005509 | calcium ion binding | 37.5000 | 6 | no |
| GO:0004972 | NMDA glutamate receptor activity | 37.5000 | 5 | no |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 37.5000 | 5 | no |
| GO:0022832 | voltage-gated channel activity | 37.5000 | 6 | no |
| GO:0022849 | glutamate-gated calcium ion channel activity | 25.0000 | 5 | no |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 25.0000 | 6 | no |
| GO:0099604 | ligand-gated calcium channel activity | 25.0000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NMD3B_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 87.5000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 62.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 62.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 62.5000 | 4 | no |
| GO:0007215 | glutamate receptor signaling pathway | 50.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 7 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | yes |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 50.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0099536 | synaptic signaling | 50.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
| GO:0035249 | synaptic transmission, glutamatergic | 37.5000 | 8 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 37.5000 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 37.5000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 37.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 37.5000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 37.5000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.5000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 37.5000 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 37.5000 | 4 | no |
| GO:0006811 | monoatomic ion transport | 37.5000 | 4 | no |
| GO:0006812 | monoatomic cation transport | 37.5000 | 5 | no |
| GO:0006816 | calcium ion transport | 37.5000 | 7 | no |
| GO:0007420 | brain development | 37.5000 | 4 | no |
| GO:0030001 | metal ion transport | 37.5000 | 6 | no |
| GO:0045471 | response to ethanol | 37.5000 | 5 | no |
| GO:0097305 | response to alcohol | 37.5000 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 25.0000 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 25.0000 | 7 | yes |
| GO:0072657 | protein localization to membrane | 25.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0043065 | positive regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043068 | positive regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0007612 | learning | 25.0000 | 4 | no |
| GO:0008306 | associative learning | 25.0000 | 5 | no |
| GO:0008542 | visual learning | 25.0000 | 4 | no |
| GO:0009416 | response to light stimulus | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031644 | regulation of nervous system process | 25.0000 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 25.0000 | 5 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 25.0000 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 25.0000 | 5 | no |
| GO:0050890 | cognition | 25.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
| GO:0060078 | regulation of postsynaptic membrane potential | 25.0000 | 4 | no |
| GO:0060079 | excitatory postsynaptic potential | 25.0000 | 5 | no |
| GO:0070588 | calcium ion transmembrane transport | 25.0000 | 5 | no |
| GO:0097553 | calcium ion transmembrane import into cytosol | 25.0000 | 6 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 25.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 4 | no |
| GO:0098815 | modulation of excitatory postsynaptic potential | 25.0000 | 4 | no |
| GO:0098976 | excitatory chemical synaptic transmission | 25.0000 | 8 | no |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 25.0000 | 6 | no |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 25.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0031175 | neuron projection development | 25.0000 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| CS044_HUMAN | [view interactions] | High throughput | no | no |
| TPD53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB9_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| MXRA7_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| NMD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATF1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIB1_HUMAN | [view interactions] | High throughput | no | no |
| PKD2_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| TPD52_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |