BIP_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed, PubMed, PubMed). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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BIP_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [BIP_HUMAN]
Isoform [A0A7P0TAI0] alignment
Isoform [A0A7P0TB36] alignment
LOADING 86%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BIP_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 33.5586 | 4 | no |
| GO:0043168 | anion binding | 27.4775 | 4 | yes |
| GO:0000166 | nucleotide binding | 26.1261 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.6757 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.0991 | 4 | yes |
| GO:0043169 | cation binding | 20.0450 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.0450 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.3694 | 5 | yes |
| GO:0046872 | metal ion binding | 19.3694 | 5 | yes |
| GO:0005524 | ATP binding | 18.4685 | 5 | yes |
| GO:0045296 | cadherin binding | 18.2432 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 13.2883 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 13.0631 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 11.4865 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 11.4865 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 11.4865 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 6.0811 | 7 | yes |
| GO:0005509 | calcium ion binding | 5.6306 | 6 | yes |
| GO:0043022 | ribosome binding | 2.2523 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BIP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.3514 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.9459 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.0450 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.9189 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 42.1171 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.8378 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.3874 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.7117 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.7117 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.0360 | 4 | yes |
| GO:0010468 | regulation of gene expression | 35.3604 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 34.9099 | 4 | yes |
| GO:0006996 | organelle organization | 32.6577 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.2072 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.2072 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.6306 | 5 | yes |
| GO:0022607 | cellular component assembly | 30.4054 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.2793 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.1532 | 4 | no |
| GO:0008104 | protein localization | 27.7027 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.8018 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.6757 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.2252 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT7R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A1AT_HUMAN | [view interactions] | Low throughput | no | no |
| A2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | Low throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |