ACTN1_HUMAN

G2C

SynGO

SynaptomeDB

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

LOADING 91%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

ACTN1_HUMAN

KCC2A_HUMAN

LOADING 67%

ACTN1_HUMAN

LOADING 67%

ACTN1_HUMAN

SYNPO_HUMAN

LOADING 67%

ACTN1_HUMAN

SRC_HUMAN

LOADING 67%

ACTN1_HUMAN

FMR1_HUMAN

LOADING 67%

ACTN1_HUMAN

STXB1_HUMAN

LOADING 67%

ACTN1_HUMAN has binary interactions with 50 proteins

Download full PS network for entry.

Interacting regions

Canonical [ACTN1_HUMAN]

Isoform [H0YJW3] alignment

Isoform [H0YJW3] sequence

Isoform [H0YJ11] alignment

Isoform [H0YJ11] sequence

Isoform [G3V5M4] alignment

Isoform [G3V5M4] sequence

Isoform [G3V2N5] alignment

Isoform [G3V2N5] sequence

Isoform [G3V2W4] alignment

Isoform [G3V2W4] sequence

Isoform [G3V2X9] alignment

Isoform [G3V2X9] sequence

Isoform [G3V380] alignment

Isoform [G3V380] sequence

Isoform [G3V2E8] alignment

Isoform [G3V2E8] sequence

Isoform [A0A804HIN7] alignment

Isoform [A0A804HIN7] sequence

Isoform [A0A804HIY0] alignment

Isoform [A0A804HIY0] sequence

Isoform [A0A804HII9] alignment

Isoform [A0A804HII9] sequence

Isoform [P12814-2] alignment

Isoform [P12814-2] sequence

Isoform [P12814-3] alignment

Isoform [P12814-3] sequence

Isoform [P12814-4] alignment

Isoform [P12814-4] sequence

Isoform [A0A804HLF4] alignment

Isoform [A0A804HLF4] sequence

Isoform [A0A804HLD0] alignment

Isoform [A0A804HLD0] sequence

Isoform [A0A804HJU8] alignment

Isoform [A0A804HJU8] sequence

Isoform [A0A804HK61] alignment

Isoform [A0A804HK61] sequence

Isoform [A0A804HJN7] alignment

Isoform [A0A804HJN7] sequence

Isoform [A0A804HJQ9] alignment

Isoform [A0A804HJQ9] sequence

Isoform [A0A804HL31] alignment

Isoform [A0A804HL31] sequence

Isoform [A0A804HKE2] alignment

Isoform [A0A804HKE2] sequence

Isoform [H7C5W8] alignment

Isoform [H7C5W8] sequence

Isoform [H9KV75] alignment

Isoform [H9KV75] sequence

Isoform [A0A7I2V4Y4] alignment

Isoform [A0A7I2V4Y4] sequence

LOADING 21%

Position	Amino acid	Mutation	Disease	Overlap with binding region
32	Gln	Lys	Bleedingdisorder,platelet-type,15(BDPLT15)	-
46	Arg	Gln	Bleedingdisorder,platelet-type,15(BDPLT15)	-
105	Val	Ile	Bleedingdisorder,platelet-type,15(BDPLT15)	-
225	Glu	Lys	Bleedingdisorder,platelet-type,15(BDPLT15)	-
738	Arg	Trp	Bleedingdisorder,platelet-type,15(BDPLT15)	-
752	Arg	Gln	Bleedingdisorder,platelet-type,15(BDPLT15)	-

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Show entries

Search:

Term	Name	%	Distance from the top of the tree	Annotated in ACTN1_HUMAN
GO:0043169	cation binding	33.0986	4	yes
GO:0046872	metal ion binding	31.6901	5	yes
GO:0019900	kinase binding	29.5775	4	no
GO:0019901	protein kinase binding	26.7606	5	no
GO:0003723	RNA binding	25.3521	4	yes
GO:0003779	actin binding	25.3521	4	yes
GO:0043168	anion binding	23.9437	4	no
GO:0045296	cadherin binding	23.2394	4	no
GO:0000166	nucleotide binding	21.1268	4	no
GO:0042803	protein homodimerization activity	15.4930	4	yes
GO:0005509	calcium ion binding	11.9718	6	yes
GO:0003725	double-stranded RNA binding	4.2254	5	yes
GO:0017166	vinculin binding	3.5211	4	yes
GO:0030374	nuclear receptor coactivator activity	3.5211	4	yes

Showing 1 to 14 of 14 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in ACTN1_HUMAN
GO:0048522	positive regulation of cellular process	59.1549	4	no
GO:0048523	negative regulation of cellular process	58.4507	4	no
GO:0060255	regulation of macromolecule metabolic process	55.6338	4	no
GO:0031323	regulation of cellular metabolic process	54.9296	4	no
GO:0080090	regulation of primary metabolic process	52.8169	4	no
GO:0051128	regulation of cellular component organization	51.4085	4	no
GO:0010646	regulation of cell communication	47.1831	4	no
GO:0006996	organelle organization	46.4789	4	yes
GO:0009889	regulation of biosynthetic process	45.7746	4	no
GO:0031326	regulation of cellular biosynthetic process	44.3662	5	no
GO:0010556	regulation of macromolecule biosynthetic process	43.6620	5	no
GO:0010468	regulation of gene expression	42.2535	6	no
GO:0009966	regulation of signal transduction	40.8451	4	no
GO:0022607	cellular component assembly	40.1408	4	yes
GO:0009893	positive regulation of metabolic process	39.4366	4	no
GO:0031325	positive regulation of cellular metabolic process	35.9155	5	no
GO:0051246	regulation of protein metabolic process	35.2113	5	no
GO:0042981	regulation of apoptotic process	34.5070	5	yes
GO:0043067	regulation of programmed cell death	34.5070	4	yes
GO:0009892	negative regulation of metabolic process	34.5070	4	no
GO:0019219	regulation of nucleobase-containing compound metabolic process	34.5070	5	no
GO:0010604	positive regulation of macromolecule metabolic process	34.5070	5	no
GO:0008104	protein localization	33.8028	4	no
GO:0010605	negative regulation of macromolecule metabolic process	32.3944	5	no
GO:0031324	negative regulation of cellular metabolic process	31.6901	5	no

Showing 1 to 25 of 83 entries

Disease

No data found.

Show entries

Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
1433G_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
1433S_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
1433Z_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
2AAA_HUMAN	[view entry] [view interactions]	High throughput	yes	no
AA2AR_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AAKB1_HUMAN	[view interactions]	High throughput	no	yes
AAPK1_HUMAN	[view interactions]	High throughput	no	no
ACE2_HUMAN	[view interactions]	High throughput	no	no
ACHA_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
ACTB_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
ACTN1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ACTN2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ACTN3_HUMAN	[view entry] [view interactions]	High throughput	yes	no
ACTN4_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ADIP_HUMAN	[view interactions]	Low throughput	no	yes
AGAP2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AGR2_HUMAN	[view interactions]	High throughput	no	no
AGRIN_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AKAP1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ALMS1_HUMAN	[view interactions]	High throughput	no	no
AMRA1_HUMAN	[view interactions]	High throughput	no	yes
ANKR1_HUMAN	[view interactions]	High throughput	no	no
ANLN_HUMAN	[view interactions]	High throughput	no	yes
APBP2_HUMAN	[view interactions]	High throughput	no	yes
APC_HUMAN	[view entry] [view interactions]	High throughput	yes	no

Showing 1 to 25 of 360 entries

ACTN1_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

Fingerprint

Molecular function

Biological process

Disease

All partners