Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DEND_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004377 LIG_SH3_CIN85_PxpxPR_1 LIG 143 148 -
ELMI004377 LIG_SH3_CIN85_PxpxPR_1 LIG 143 148 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DEND_HUMAN
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0017124 SH3 domain binding 22.2222 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0031690 adrenergic receptor binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in DEND_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0010646 regulation of cell communication 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 44.4444 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 yes
GO:0080090 regulation of primary metabolic process 44.4444 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 44.4444 4 no
GO:0098657 import into cell 44.4444 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 no
GO:0009968 negative regulation of signal transduction 44.4444 5 no
GO:0010648 negative regulation of cell communication 44.4444 5 no
GO:0023057 negative regulation of signaling 44.4444 4 no
GO:0048523 negative regulation of cellular process 44.4444 4 no
GO:0048585 negative regulation of response to stimulus 44.4444 4 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 yes
GO:0051252 regulation of RNA metabolic process 33.3333 5 yes
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0006898 receptor-mediated endocytosis 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 yes
GO:0006915 apoptotic process 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0007015 actin filament organization 22.2222 5 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0002090 regulation of receptor internalization 22.2222 7 no
GO:0007264 small GTPase-mediated signal transduction 22.2222 5 no
GO:0007265 Ras protein signal transduction 22.2222 6 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0031623 receptor internalization 22.2222 5 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0048259 regulation of receptor-mediated endocytosis 22.2222 6 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0072594 establishment of protein localization to organelle 22.2222 4 no
GO:0009416 response to light stimulus 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0043113 receptor clustering 22.2222 5 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0050808 synapse organization 22.2222 5 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAGI1_HUMAN [view interactions] Low throughput no no
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KIBRA_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
RALA_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
CD2AP_HUMAN [view interactions] High throughput no no