Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MAGI2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MAGI2_HUMAN
GO:0030165 PDZ domain binding 25.0000 4 no
GO:0005216 monoatomic ion channel activity 20.8333 4 no
GO:0015267 channel activity 20.8333 4 no
GO:0001664 G protein-coupled receptor binding 12.5000 4 yes
GO:0031690 adrenergic receptor binding 8.3333 5 yes
GO:0019902 phosphatase binding 6.2500 4 yes
GO:0031697 beta-1 adrenergic receptor binding 6.2500 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MAGI2_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 64.5833 4 yes
GO:0009966 regulation of signal transduction 54.1667 4 yes
GO:0050804 modulation of chemical synaptic transmission 47.9167 5 no
GO:0099177 regulation of trans-synaptic signaling 47.9167 4 no
GO:0008104 protein localization 41.6667 4 yes
GO:0010647 positive regulation of cell communication 41.6667 5 no
GO:0023056 positive regulation of signaling 41.6667 4 no
GO:0051049 regulation of transport 37.5000 4 yes
GO:0051128 regulation of cellular component organization 37.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 yes
GO:0099536 synaptic signaling 37.5000 4 no
GO:0099537 trans-synaptic signaling 37.5000 5 no
GO:0009893 positive regulation of metabolic process 35.4167 4 yes
GO:0031323 regulation of cellular metabolic process 35.4167 4 yes
GO:0080090 regulation of primary metabolic process 35.4167 4 yes
GO:0007268 chemical synaptic transmission 35.4167 7 no
GO:0098916 anterograde trans-synaptic signaling 35.4167 6 no
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0022607 cellular component assembly 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 yes
GO:0051246 regulation of protein metabolic process 31.2500 5 yes
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 yes
GO:1902531 regulation of intracellular signal transduction 29.1667 5 yes
GO:0072657 protein localization to membrane 27.0833 4 yes
GO:0034330 cell junction organization 25.0000 4 no
GO:0050808 synapse organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 yes
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0050806 positive regulation of synaptic transmission 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0044057 regulation of system process 22.9167 4 no
GO:0051247 positive regulation of protein metabolic process 22.9167 6 yes
GO:0009889 regulation of biosynthetic process 22.9167 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.9167 4 no
GO:0030030 cell projection organization 22.9167 4 no
GO:0044087 regulation of cellular component biogenesis 22.9167 4 no
GO:0050807 regulation of synapse organization 20.8333 5 no
GO:0035418 protein localization to synapse 20.8333 6 no
GO:1902414 protein localization to cell junction 20.8333 5 no
GO:0010648 negative regulation of cell communication 20.8333 5 yes
GO:0023057 negative regulation of signaling 20.8333 4 yes
GO:0031344 regulation of cell projection organization 20.8333 5 yes
GO:0031399 regulation of protein modification process 20.8333 6 yes
GO:0048585 negative regulation of response to stimulus 20.8333 4 yes
GO:0098657 import into cell 20.8333 4 yes
GO:0006996 organelle organization 20.8333 4 no
GO:0050890 cognition 20.8333 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 20.8333 6 no
GO:0051960 regulation of nervous system development 20.8333 5 no
GO:0019220 regulation of phosphate metabolic process 18.7500 6 yes
GO:0042127 regulation of cell population proliferation 18.7500 4 yes
GO:0043085 positive regulation of catalytic activity 18.7500 4 yes
GO:0051174 regulation of phosphorus metabolic process 18.7500 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 18.7500 6 yes
GO:0008285 negative regulation of cell population proliferation 16.6667 5 yes
GO:0009968 negative regulation of signal transduction 16.6667 5 yes
GO:0010975 regulation of neuron projection development 16.6667 7 yes
GO:0031401 positive regulation of protein modification process 16.6667 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 14.5833 6 yes
GO:0030334 regulation of cell migration 14.5833 5 yes
GO:0045937 positive regulation of phosphate metabolic process 14.5833 7 yes
GO:0071363 cellular response to growth factor stimulus 14.5833 4 yes
GO:2000145 regulation of cell motility 14.5833 4 yes
GO:0031346 positive regulation of cell projection organization 12.5000 6 yes
GO:0043113 receptor clustering 12.5000 5 yes
GO:0141124 intracellular signaling cassette 12.5000 4 yes
GO:1902532 negative regulation of intracellular signal transduction 12.5000 6 yes
GO:0006898 receptor-mediated endocytosis 10.4167 4 yes
GO:0010976 positive regulation of neuron projection development 10.4167 7 yes
GO:0016055 Wnt signaling pathway 10.4167 4 yes
GO:0051050 positive regulation of transport 10.4167 4 yes
GO:0051336 regulation of hydrolase activity 10.4167 4 yes
GO:0007399 nervous system development 8.3333 4 yes
GO:0030336 negative regulation of cell migration 8.3333 6 yes
GO:0040013 negative regulation of locomotion 8.3333 4 yes
GO:0051345 positive regulation of hydrolase activity 8.3333 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 8.3333 6 yes
GO:0060627 regulation of vesicle-mediated transport 8.3333 4 yes
GO:2000146 negative regulation of cell motility 8.3333 5 yes
GO:0030100 regulation of endocytosis 6.2500 5 yes
GO:0038179 neurotrophin signaling pathway 6.2500 4 yes
GO:0038180 nerve growth factor signaling pathway 6.2500 5 yes
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 6.2500 7 yes
GO:1990089 response to nerve growth factor 6.2500 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 6.2500 5 yes
GO:0002064 epithelial cell development 4.1667 4 yes
GO:0002090 regulation of receptor internalization 4.1667 7 yes
GO:0045807 positive regulation of endocytosis 4.1667 5 yes
GO:0048259 regulation of receptor-mediated endocytosis 4.1667 6 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 4.1667 5 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 4.1667 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AVR2A_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLL1_HUMAN [view interactions] Low throughput no no
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
CTND2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE3_HUMAN [view entry] [view interactions] Low throughput yes no
EF1A1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SV2A_HUMAN [view entry] [view interactions] Low throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRD3_HUMAN [view interactions] Low throughput no no
DLL4_HUMAN [view interactions] Low throughput no no
RPGF2_HUMAN [view entry] [view interactions] Low throughput yes no
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
CRFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRID1_HUMAN [view entry] [view interactions] Low throughput yes no
TGFA_HUMAN [view interactions] Low throughput no yes
DEND_HUMAN [view entry] [view interactions] Low throughput yes no
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] Low throughput yes no
DLGP3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF1B_HUMAN [view entry] [view interactions] Low throughput yes yes
ATN1_HUMAN [view interactions] Low throughput no yes
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD3_HUMAN [view interactions] Low throughput no yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
IQEC3_HUMAN [view entry] [view interactions] Low throughput yes no
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
CCG3_HUMAN [view entry] [view interactions] Low throughput yes no
CCG4_HUMAN [view entry] [view interactions] Low throughput yes no
CCG8_HUMAN [view entry] [view interactions] Low throughput yes no
CSMD2_HUMAN [view entry] [view interactions] Low throughput yes no
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
KDIS_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHGG_HUMAN [view interactions] Low throughput no yes
ARHGQ_HUMAN [view interactions] Low throughput no yes
TMG4_HUMAN [view interactions] High throughput no yes
DSCL1_HUMAN [view interactions] High throughput no yes
PLXB3_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
AMOL1_HUMAN [view interactions] High throughput no no
RPB1_HUMAN [view interactions] High throughput no no
RPB2_HUMAN [view interactions] High throughput no yes
NRX2A_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DSCAM_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
PDZ11_HUMAN [view interactions] High throughput no yes
RSMB_HUMAN [view interactions] High throughput no yes
MORN4_HUMAN [view interactions] High throughput no yes
PKHF2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RHBL1_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
TTBK1_HUMAN [view interactions] High throughput no yes
FHL5_HUMAN [view interactions] High throughput no no
NCK1_HUMAN [view interactions] High throughput no yes
CASL_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SHSA7_HUMAN [view entry] [view interactions] High throughput yes no