Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IQEC3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Acts as a guanine nucleotide exchange factor (GEF) for ARF1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IQEC3_HUMAN
GO:0046872 metal ion binding 38.4615 4 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0005524 ATP binding 30.7692 5 no
GO:0017076 purine nucleotide binding 30.7692 4 no
GO:0030554 adenyl nucleotide binding 30.7692 5 no
GO:0032555 purine ribonucleotide binding 30.7692 4 no
GO:0032559 adenyl ribonucleotide binding 30.7692 5 no
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 no
GO:0030695 GTPase regulator activity 23.0769 4 yes
GO:0001664 G protein-coupled receptor binding 23.0769 4 no
GO:0035254 glutamate receptor binding 23.0769 4 no
GO:0019902 phosphatase binding 23.0769 4 no
GO:0016301 kinase activity 23.0769 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IQEC3_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 69.2308 4 no
GO:0060255 regulation of macromolecule metabolic process 69.2308 4 no
GO:0080090 regulation of primary metabolic process 69.2308 4 no
GO:0048522 positive regulation of cellular process 69.2308 4 no
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0009966 regulation of signal transduction 61.5385 4 yes
GO:0010646 regulation of cell communication 61.5385 4 yes
GO:0031399 regulation of protein modification process 61.5385 6 no
GO:0051128 regulation of cellular component organization 61.5385 4 no
GO:0051246 regulation of protein metabolic process 61.5385 5 no
GO:0008104 protein localization 61.5385 4 no
GO:0019220 regulation of phosphate metabolic process 53.8462 6 no
GO:0051174 regulation of phosphorus metabolic process 53.8462 5 no
GO:0006996 organelle organization 53.8462 4 yes
GO:0009893 positive regulation of metabolic process 53.8462 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.8462 5 no
GO:0031344 regulation of cell projection organization 53.8462 5 no
GO:0031401 positive regulation of protein modification process 53.8462 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 53.8462 5 no
GO:0051247 positive regulation of protein metabolic process 53.8462 6 no
GO:0051049 regulation of transport 53.8462 4 no
GO:0010562 positive regulation of phosphorus metabolic process 46.1538 6 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0042325 regulation of phosphorylation 46.1538 7 no
GO:0045937 positive regulation of phosphate metabolic process 46.1538 7 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 46.1538 6 no
GO:0001932 regulation of protein phosphorylation 46.1538 7 no
GO:0022603 regulation of anatomical structure morphogenesis 38.4615 4 no
GO:0042327 positive regulation of phosphorylation 38.4615 8 no
GO:0043085 positive regulation of catalytic activity 38.4615 4 no
GO:0072657 protein localization to membrane 38.4615 4 no
GO:0007010 cytoskeleton organization 38.4615 5 yes
GO:0009892 negative regulation of metabolic process 38.4615 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0010975 regulation of neuron projection development 38.4615 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 38.4615 5 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0043269 regulation of ion transport 38.4615 5 no
GO:0044057 regulation of system process 38.4615 4 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0001934 positive regulation of protein phosphorylation 38.4615 8 no
GO:0033674 positive regulation of kinase activity 30.7692 6 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0045860 positive regulation of protein kinase activity 30.7692 7 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0051347 positive regulation of transferase activity 30.7692 5 no
GO:0043113 receptor clustering 30.7692 5 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 yes
GO:0030030 cell projection organization 30.7692 4 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0036211 protein modification process 30.7692 4 no
GO:0043412 macromolecule modification 30.7692 4 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 no
GO:0007268 chemical synaptic transmission 30.7692 6 no
GO:0010959 regulation of metal ion transport 30.7692 6 no
GO:0022898 regulation of transmembrane transporter activity 30.7692 4 no
GO:0032412 regulation of ion transmembrane transporter activity 30.7692 5 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0034765 regulation of ion transmembrane transport 30.7692 5 no
GO:0043270 positive regulation of ion transport 30.7692 5 no
GO:0050804 modulation of chemical synaptic transmission 30.7692 5 no
GO:0098916 anterograde trans-synaptic signaling 30.7692 5 no
GO:0099177 regulation of trans-synaptic signaling 30.7692 4 no
GO:0099537 trans-synaptic signaling 30.7692 4 no
GO:1904062 regulation of cation transmembrane transport 30.7692 6 no
GO:2001257 regulation of cation channel activity 30.7692 6 no
GO:0030334 regulation of cell migration 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:2000145 regulation of cell motility 23.0769 4 no
GO:0031346 positive regulation of cell projection organization 23.0769 6 no
GO:1990778 protein localization to cell periphery 23.0769 5 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0010468 regulation of gene expression 23.0769 5 no
GO:0032990 cell part morphogenesis 23.0769 4 no
GO:0048812 neuron projection morphogenesis 23.0769 7 no
GO:0048858 cell projection morphogenesis 23.0769 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.0769 6 no
GO:0006936 muscle contraction 23.0769 4 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010038 response to metal ion 23.0769 4 no
GO:0010647 positive regulation of cell communication 23.0769 5 no
GO:0023056 positive regulation of signaling 23.0769 4 no
GO:0031644 regulation of nervous system process 23.0769 5 no
GO:0035418 protein localization to synapse 23.0769 6 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0051924 regulation of calcium ion transport 23.0769 7 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0099601 regulation of neurotransmitter receptor activity 23.0769 4 no
GO:1902414 protein localization to cell junction 23.0769 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DMD_HUMAN [view entry] [view interactions] Low throughput yes no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
RFOX3_HUMAN [view interactions] Computational no yes
GEPH_HUMAN [view entry] [view interactions] Computational yes yes