Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IQEC3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Acts as a guanine nucleotide exchange factor (GEF) for ARF1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IQEC3_HUMAN
GO:0043169 cation binding 46.6667 4 no
GO:0046872 metal ion binding 46.6667 5 no
GO:0019900 kinase binding 40.0000 4 no
GO:0000166 nucleotide binding 26.6667 4 no
GO:0005524 ATP binding 26.6667 5 no
GO:0017076 purine nucleotide binding 26.6667 5 no
GO:0030554 adenyl nucleotide binding 26.6667 6 no
GO:0032555 purine ribonucleotide binding 26.6667 4 no
GO:0032559 adenyl ribonucleotide binding 26.6667 5 no
GO:0035639 purine ribonucleoside triphosphate binding 26.6667 4 no
GO:0043168 anion binding 26.6667 4 no
GO:0001664 G protein-coupled receptor binding 26.6667 4 no
GO:0019901 protein kinase binding 26.6667 5 no
GO:0030695 GTPase regulator activity 20.0000 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 13.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IQEC3_HUMAN
GO:0031323 regulation of cellular metabolic process 73.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 73.3333 4 no
GO:0048522 positive regulation of cellular process 73.3333 4 no
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0006996 organelle organization 60.0000 4 yes
GO:0009966 regulation of signal transduction 60.0000 4 yes
GO:0010646 regulation of cell communication 60.0000 4 yes
GO:0008104 protein localization 60.0000 4 no
GO:0031399 regulation of protein modification process 53.3333 6 no
GO:0051246 regulation of protein metabolic process 53.3333 5 no
GO:0048523 negative regulation of cellular process 53.3333 4 no
GO:0009892 negative regulation of metabolic process 46.6667 4 no
GO:0009893 positive regulation of metabolic process 46.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 46.6667 5 no
GO:0031344 regulation of cell projection organization 46.6667 5 no
GO:0031401 positive regulation of protein modification process 46.6667 7 no
GO:0051247 positive regulation of protein metabolic process 46.6667 6 no
GO:0019220 regulation of phosphate metabolic process 46.6667 6 no
GO:0022607 cellular component assembly 46.6667 4 no
GO:0051174 regulation of phosphorus metabolic process 46.6667 5 no
GO:0051049 regulation of transport 46.6667 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.0000 6 no
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0042325 regulation of phosphorylation 40.0000 7 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0099536 synaptic signaling 40.0000 4 no
GO:0043933 protein-containing complex organization 40.0000 4 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0065003 protein-containing complex assembly 40.0000 5 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0030030 cell projection organization 26.6667 4 no
GO:0032880 regulation of protein localization 26.6667 5 no
GO:0050807 regulation of synapse organization 26.6667 5 no
GO:0060341 regulation of cellular localization 26.6667 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.6667 5 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 no
GO:0006796 phosphate-containing compound metabolic process 26.6667 4 no
GO:0042327 positive regulation of phosphorylation 26.6667 8 no
GO:0141124 intracellular signaling cassette 26.6667 4 no
GO:0010038 response to metal ion 26.6667 4 no
GO:0043549 regulation of kinase activity 26.6667 5 no
GO:0050804 modulation of chemical synaptic transmission 26.6667 5 no
GO:0051338 regulation of transferase activity 26.6667 4 no
GO:0099177 regulation of trans-synaptic signaling 26.6667 4 no
GO:0043113 receptor clustering 26.6667 5 no
GO:0010959 regulation of metal ion transport 26.6667 6 no
GO:0022898 regulation of transmembrane transporter activity 26.6667 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 26.6667 5 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0043269 regulation of monoatomic ion transport 26.6667 5 no
GO:0043270 positive regulation of monoatomic ion transport 26.6667 5 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0030334 regulation of cell migration 26.6667 5 no
GO:2000145 regulation of cell motility 26.6667 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DMD_HUMAN [view entry] [view interactions] Low throughput yes no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no