AGAP2_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Interacting regions
Canonical [AGAP2_HUMAN]
Isoform [Q99490-2] alignment
Isoform [J3KNM6] alignment
Isoform [H0YHB1] alignment
Isoform [F8VVT9] alignment
LOADING 55%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGAP2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.5714 | 4 | yes |
| GO:0000166 | nucleotide binding | 29.1429 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 29.1429 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.1429 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.4286 | 4 | yes |
| GO:0043169 | cation binding | 27.4286 | 4 | yes |
| GO:0046872 | metal ion binding | 26.2857 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.7143 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.7143 | 5 | yes |
| GO:0019900 | kinase binding | 21.1429 | 4 | yes |
| GO:0005524 | ATP binding | 20.0000 | 5 | yes |
| GO:0019901 | protein kinase binding | 17.7143 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 14.2857 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 10.8571 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 10.8571 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 10.8571 | 6 | yes |
| GO:0003924 | GTPase activity | 9.7143 | 7 | yes |
| GO:0005096 | GTPase activator activity | 9.1429 | 4 | yes |
| GO:0019001 | guanyl nucleotide binding | 8.5714 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 8.5714 | 5 | yes |
| GO:0005525 | GTP binding | 8.0000 | 5 | yes |
| GO:0019887 | protein kinase regulator activity | 5.7143 | 4 | yes |
| GO:0019209 | kinase activator activity | 2.8571 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 2.8571 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGAP2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.5714 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 59.4286 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 49.7143 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.5714 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.7143 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.8571 | 4 | yes |
| GO:0051049 | regulation of transport | 37.1429 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 34.8571 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.8571 | 4 | no |
| GO:0006996 | organelle organization | 33.7143 | 4 | yes |
| GO:0022607 | cellular component assembly | 33.7143 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.1429 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.1429 | 4 | no |
| GO:0008104 | protein localization | 32.5714 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.2857 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.2857 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.7143 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.7143 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.1429 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.4286 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 26.8571 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 26.8571 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.8571 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A0A590UK10_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHGI_HUMAN | [view interactions] | High throughput | no | no |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |